Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production.

abstract：:We tested the possibility that insulin-like growth factor I (IGF-I) acts as a neuromodulator in the adult cerebellar cortex since previous observations indicated that IGF-I is located in the olivo-cerebellar system encompassing the inferior olive and Purkinje cells. We found that conjoint administration of IGF-I and g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castro-Alamancos MA,Torres-Aleman I

更新日期：1993-08-01 00:00:00

abstract：:Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galantucci L,Baggaley AW,Parker NG,Barenghi CF

更新日期：2019-06-18 00:00:00

abstract：:The self-association of Toll/interleukin-1 receptor/resistance protein (TIR) domains has been implicated in signaling in plant and animal immunity receptors. Structure-based studies identified different TIR-domain dimerization interfaces required for signaling of the plant nucleotide-binding oligomerization domain-lik...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang X,Bernoux M,Bentham AR,Newman TE,Ve T,Casey LW,Raaymakers TM,Hu J,Croll TI,Schreiber KJ,Staskawicz BJ,Anderson PA,Sohn KH,Williams SJ,Dodds PN,Kobe B

更新日期：2017-03-07 00:00:00

abstract：:Loss-of-function mutations in the genes associated with primary microcephaly (MCPH) reduce human brain size by about two-thirds, without producing gross abnormalities in brain organization or physiology and leaving other organs largely unaffected [Woods CG, et al. (2005) Am J Hum Genet 76:717-728]. There is also evide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rimol LM,Agartz I,Djurovic S,Brown AA,Roddey JC,Kähler AK,Mattingsdal M,Athanasiu L,Joyner AH,Schork NJ,Halgren E,Sundet K,Melle I,Dale AM,Andreassen OA,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2010-01-05 00:00:00

abstract：:Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rupprecht CE,Wiktor TJ,Johnston DH,Hamir AN,Dietzschold B,Wunner WH,Glickman LT,Koprowski H

更新日期：1986-10-01 00:00:00

abstract：:The 16S rRNA genes of Pyrobaculum aerophilum and Pyrobaculum islandicum were amplified by the polymerase chain reaction, and the resulting products were sequenced directly. The two organisms are closely related by this measure (over 98% similar). However, they differ in that the (lone) 16S rRNA gene of Pyrobaculum aer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burggraf S,Larsen N,Woese CR,Stetter KO

更新日期：1993-03-15 00:00:00

abstract：:Oncogene-induced senescence (OIS) is a critical tumor-suppressing mechanism that restrains cancer progression at premalignant stages, in part by causing telomere dysfunction. Currently it is unknown whether this proliferative arrest presents a stable and therefore irreversible barrier to cancer progression. Here we de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel PL,Suram A,Mirani N,Bischof O,Herbig U

更新日期：2016-08-23 00:00:00

abstract：:The cytochrome bc1 and related complexes are essential energy-conserving components of mitochondrial and bacterial electron transport chains. They orchestrate a complex sequence of electron and proton transfer reactions resulting in the oxidation of quinol, the reduction of a mobile electron carrier, and the transloca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cape JL,Bowman MK,Kramer DM

更新日期：2007-05-08 00:00:00

abstract：:Adult cardiomyocytes are irreversibly postmitotic but respond to a variety of stimuli by hypertrophic growth, which is associated with an increase in cell size and protein content, organization of sarcomeres, and activation of a fetal gene program. Recently, we described a novel cardiac helicase activated by MEF2 prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu ZP,Olson EN

更新日期：2002-02-19 00:00:00

abstract：:Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical loading. Pathological mechanical stress can lead to maladaptive ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee W,Leddy HA,Chen Y,Lee SH,Zelenski NA,McNulty AL,Wu J,Beicker KN,Coles J,Zauscher S,Grandl J,Sachs F,Guilak F,Liedtke WB

更新日期：2014-11-25 00:00:00

abstract：:Actin-myosin (actomyosin) generates mechanical force by consuming ATP molecules. We apply the energy landscape perspective to address a controversial issue as to whether the myosin head moves with multiple steps after a single ATP hydrolysis or only a single mechanical event of the lever-arm swinging follows a single ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terada TP,Sasai M,Yomo T

更新日期：2002-07-09 00:00:00

abstract：:Activation of class II gene transcription may involve alleviation of transcription repression as well as stimulation of the assembly and function of the general RNA polymerase (RNAP) II transcription machinery. Here, we investigated whether activator-reversible transcription repression by NC2 (Dr1/DRAP1) contributes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castaño E,Gross P,Wang Z,Roeder RG,Oelgeschläger T

更新日期：2000-06-20 00:00:00

abstract：:One of the core features of human speech is that words cause listeners to retrieve corresponding visual mental images. However, whether vocalizations similarly evoke mental images in animal communication systems is surprisingly unknown. Japanese tits (Parus minor) produce specific alarm calls when and only when encoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki TN

更新日期：2018-02-13 00:00:00

abstract：:Granulosa cells from immature hypophysectomized diethylstilbestrol-treated rats displayed pronounced intracellular and intercellular changes after 48 hr of exposure to follicle-stimulating hormone (FSH) in vitro. As determined by light and electron microscopy, most of the FSH-treated cells became highly aggregated and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amsterdam A,Knecht M,Catt KJ

更新日期：1981-05-01 00:00:00

abstract：:Proteins, nucleic acids, and fluorescein-conjugated antibody are shown to be identifidable in situ via the fluorescence excited by the focused electron beam of a canning electron microscope. A molecular species is identified by its characteristic fluorescence spectrum and by a characteristic alteration of the spectrum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hough PV,McKinney WR,Ledbeter MC,Pollack RE,Moos HW

更新日期：1976-02-01 00:00:00

abstract：:The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insulin response to glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tominaga M,Komiya I,Johnson JH,Inman L,Alam T,Moltz J,Crider B,Stefan Y,Baetens D,McCorkle K

更新日期：1986-12-01 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus are the type species of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease and fatal encephalitis infections in humans, with case fatality rates approaching 75%. NiV contains two envelope glycoproteins, the receptor-binding G glycoprotei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu K,Rajashankar KR,Chan YP,Himanen JP,Broder CC,Nikolov DB

更新日期：2008-07-22 00:00:00

abstract：:Abelson murine leukemia virus (A-MuLV) is derived from the thymotropic Moloney leukemia virus. However, injection of mice with A-MuLV by conventional routes results in rapidly arising peripheral and bone marrow lymphomas, not thymomas or T cell tumors. In this study thymomas have been induced by intrathymic injection ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook WD

更新日期：1982-05-01 00:00:00

abstract：:Lentiviruses, including HIV-1, have transmembrane envelope (Env) glycoproteins with cytoplasmic tails that are quite long compared with those of other retroviruses. However, mainly because of the lack of biochemical studies performed in cell types that are targets for HIV-1 infection, no clear consensus exists regardi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami T,Freed EO

更新日期：2000-01-04 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate added to exponentially growing cells of Hemophilus influenzae strain Rd increases competence for transformation 100- to 10,000-fold. Cyclic AMP added to near-stationary or stationary cells does not increase competence over the high level normally found in the early stationary phase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Alexander SP,Powers M

更新日期：1973-02-01 00:00:00

abstract：:Natively unfolded proteins play key roles in normal and pathological biochemical processes. Despite their importance for function, this category of proteins remains beyond the reach of classical structural biology because of their inherent conformational heterogeneity. We present a description of the intrinsic conform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernadó P,Blanchard L,Timmins P,Marion D,Ruigrok RW,Blackledge M

更新日期：2005-11-22 00:00:00

abstract：:Selective blockade of gene expression by designed small molecules is a fundamental challenge at the interface of chemistry, biology, and medicine. Transcription factors have been among the most elusive targets in genetics and drug discovery, but the fields of chemical biology and genetics have evolved to a point where...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kushal S,Lao BB,Henchey LK,Dubey R,Mesallati H,Traaseth NJ,Olenyuk BZ,Arora PS

更新日期：2013-09-24 00:00:00

abstract：:Despite growing evidence for perceptual interactions between motion and position, no unifying framework exists to account for these two key features of our visual experience. We show that percepts of both object position and motion derive from a common object-tracking system--a system that optimally integrates sensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OS,Tadin D,Knill DC

更新日期：2015-06-30 00:00:00

abstract：:Signaling through the Toll receptor is required for dorsal/ventral polarity in Drosophila embryos, and also plays an evolutionarily conserved role in the immune response. Upon ligand binding, Toll appears to multimerize and activate the associated kinase, Pelle. However, the immediate downstream targets of Pelle have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen B,Liu H,Skolnik EY,Manley JL

更新日期：2001-07-17 00:00:00

abstract：:We recently reported that CD3- natural killer (NK) cells express the zeta chain of the T-cell receptor complex (zeta NK) in association with higher molecular weight structures whose expression differs between individual NK cell clones. Because NK cell cytolytic activity is known to be triggered by perturbation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson P,Caligiuri M,O'Brien C,Manley T,Ritz J,Schlossman SF

更新日期：1990-03-01 00:00:00

abstract：:Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exclusively at the two-strand stage and involves recombination of unduplicated chromosomes (i.e., during G1) or the unduplicated regions of chromosomes during the S phase of mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esposito MS

更新日期：1978-09-01 00:00:00

abstract：:Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for anticoagulants due t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao L,Wu M,Xiao C,Yang L,Zhou L,Gao N,Li Z,Chen J,Chen J,Liu J,Qin H,Zhao J

更新日期：2015-07-07 00:00:00

abstract：:The heart has not been regarded as a major target organ of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity notwithstanding that lethal cardiac dysfunction can occur in the absence of histopathological changes. To assess possible TCDD cardiotoxicity, we studied the effect of TCDD five days after treatment (10 micro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canga L,Levi R,Rifkind AB

更新日期：1988-02-01 00:00:00

abstract：:This study details the immune response to cartilage proteoglycan in experimental chronic IgG-induced immune synovitis. Antibodies reactive with purified rabbit proteoglycan monomer were observed in nine of nine rabbits with immune synovitis. IgG-immunized but nonsynovitic control animals with no pathology showed no an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoo JU,Kresina TF,Malemud CJ,Goldberg VM

更新日期：1987-02-01 00:00:00

abstract：:Here we test the hypothesis that high-altitude native resident Tibetan women with genotypes for high oxygen saturation of hemoglobin, and thus less physiological hypoxic stress, have higher Darwinian fitness than women with low oxygen saturation genotypes. Oxygen saturation and genealogical data were collected from re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beall CM,Song K,Elston RC,Goldstein MC

更新日期：2004-09-28 00:00:00