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Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain.

Abstract：

:Subtractive library construction and differential screening were used to identify a cDNA for a cell type-specific immediate early gene induced in rat PC12 pheochromocytoma cells. Sequencing identified the protein product of this gene as rat synaptotagmin IV (SytIV). Synaptotagmins are synaptic vesicle proteins thought to play a role in depolarization-induced, calcium-mediated exocytosis and neurotransmitter release. SytIV mRNA accumulation is transiently induced in PC12 cells by potassium depolarization, calcium ionophore, ATP, and forskolin. In contrast, growth factors and phorbol 12-myristate 13-acetate induce little or no SytIV mRNA accumulation. Kainic acid-induced seizures in rats are followed by accumulation of SytIV message in the hippocampus and piriform cortex. The SytIV gene may provide a direct link between depolarization-induced neuronal gene expression and subsequent modulation of synaptic structure and function.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Vician L,Lim IK,Ferguson G,Tocco G,Baudry M,Herschman HR

doi

10.1073/pnas.92.6.2164

subject

Has Abstract

pub_date

1995-03-14 00:00:00

pages

2164-8

issue

6

eissn

0027-8424

issn

1091-6490

journal_volume

92

pub_type

杂志文章

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