Na,K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin Darby canine kidney cells.

abstract：:In eukaryotic cells, RAD52 protein plays a central role in genetic recombination and DNA repair by (i) promoting the annealing of complementary single-stranded DNA and (ii) stimulation of the RAD51 recombinase. The single-strand annealing domain resides in the N-terminal region of the protein and is highly conserved, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singleton MR,Wentzell LM,Liu Y,West SC,Wigley DB

更新日期：2002-10-15 00:00:00

abstract：:Delayed implantation (embryonic diapause) occurs when the embryo at the blastocyst stage achieves a state of suspended animation. During this period, blastocyst growth is very slow, with minimal or no cell division. Nearly 100 mammals in seven different orders undergo delayed implantation, but the underlying molecular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamatani T,Daikoku T,Wang H,Matsumoto H,Carter MG,Ko MS,Dey SK

更新日期：2004-07-13 00:00:00

abstract：:The activities of cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase [3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acylating), EC 4.1.3.5] and microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase[mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1.1.34], two sequential enzymes in the chole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasubramaniam S,Goldstein JL,Brown MS

更新日期：1977-04-01 00:00:00

abstract：:Mate attraction in Aplysia involves a long-distance water-borne signal (the protein pheromone attractin), which is released during egg laying. Aplysia californica attractin attracts species that produce closely related attractins, such as Aplysia brasiliana, whose geographic distribution does not overlap that of A. ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Painter SD,Cummins SF,Nichols AE,Akalal DB,Schein CH,Braun W,Smith JS,Susswein AJ,Levy M,de Boer PA,ter Maat A,Miller MW,Scanlan C,Milberg RM,Sweedler JV,Nagle GT

更新日期：2004-05-04 00:00:00

abstract：:Evolutionary thinking can be applied to both cultural microevolution and macroevolution. However, much of the current literature focuses on cultural microevolution. In this article, we argue that the growing availability of large cross-cultural datasets facilitates the use of computational methods derived from evoluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray RD,Watts J

更新日期：2017-07-25 00:00:00

abstract：:The overall structure of the transition-state and intermediate ensembles observed experimentally for dihydrofolate reductase and interleukin-1beta can be obtained by using simplified models that have almost no energetic frustration. The predictive power of these models suggests that, even for these very large proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clementi C,Jennings PA,Onuchic JN

更新日期：2000-05-23 00:00:00

abstract：:Metabolomic markers associated with incident central adiposity gain were investigated in young adults. In a 9-mo prospective study of university freshmen (n = 264). Blood samples and anthropometry measurements were collected in the first 3 d on campus and at the end of the year. Plasma from individuals was pooled by p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hootman KC,Trezzi JP,Kraemer L,Burwell LS,Dong X,Guertin KA,Jaeger C,Stover PJ,Hiller K,Cassano PA

更新日期：2017-05-23 00:00:00

abstract：:Whole-cell and single-channel recording techniques were used to study the action of the anticonvulsant drug MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine maleate) on responses to excitatory amino acids in rat neocortical neurons in cell culture. MK-801 caused a progressive, long-lasting bl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huettner JE,Bean BP

更新日期：1988-02-01 00:00:00

abstract：:In organisms possessing a dispersal phase the processes of mating, competition, feeding, and predation are often carried out within "trait-groups," defined as populations enclosed in areas smaller than the boundaries of the deme. A simple model shows that this can lead to the selection of "altruistic" traits that favo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson DS

更新日期：1975-01-01 00:00:00

abstract：:Cellular communities in living tissues act in concert to establish intricate microenvironments, with complexity difficult to recapitulate in vitro. We report a method for docking numerous cellularized hydrogel shapes (100-1,000 µm in size) into hydrogel templates to construct 3D cellular microenvironments. Each shape ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eng G,Lee BW,Parsa H,Chin CD,Schneider J,Linkov G,Sia SK,Vunjak-Novakovic G

更新日期：2013-03-19 00:00:00

abstract：:Previous work has shown that the kinetoplast minicircle DNA of Leishmania species exhibits species-specific sequence divergence and this observation has led to the development of a DNA probe-based diagnostic test for leishmaniasis. In the work reported here, we demonstrate that the minicircle is composed of three type...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers WO,Wirth DF

更新日期：1987-01-01 00:00:00

abstract：:Perceptual decisions are better when they take uncertainty into account. Uncertainty arises not only from the properties of sensory input but also from cognitive sources, such as different levels of attention. However, it is unknown whether humans appropriately adjust for such cognitive sources of uncertainty during p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denison RN,Adler WT,Carrasco M,Ma WJ

更新日期：2018-10-23 00:00:00

abstract：:The antiangiogenic agent fumagillin (Fg) and its analog TNP-470 bind to intracellular metalloprotease methionine aminopeptidase-2 (MetAP-2) and inhibit endothelial cell growth in a p53-dependent manner. To confirm the role of MetAP-2 in endothelial cell proliferation and to validate it as a physiological target for th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh JJ,Ju R,Brdlik CM,Zhang W,Zhang Y,Matyskiela ME,Shotwell JD,Crews CM

更新日期：2006-07-05 00:00:00

abstract：:Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking. We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenoca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SJ,Glover TW,Zhu XX,Kuick R,Thoraval D,Orringer MB,Beer DG,Hanash S

更新日期：1998-10-13 00:00:00

abstract：:Superresolution fluorescence microscopy overcomes the diffraction resolution barrier and allows the molecular intricacies of life to be revealed with greatly enhanced detail. However, many current superresolution techniques still face limitations and their implementation is typically associated with a steep learning c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dedecker P,Mo GC,Dertinger T,Zhang J

更新日期：2012-07-03 00:00:00

abstract：:Marine Archaea are important players among microbial plankton and significantly contribute to biogeochemical cycles, but details regarding their community structure and long-term seasonal activity and dynamics remain largely unexplored. In this study, we monitored the interannual archaeal community composition of abun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hugoni M,Taib N,Debroas D,Domaizon I,Jouan Dufournel I,Bronner G,Salter I,Agogué H,Mary I,Galand PE

更新日期：2013-04-09 00:00:00

abstract：:Peroxisome proliferators cause rapid and coordinated transcriptional activation of genes encoding peroxisomal beta-oxidation system enzymes by activating peroxisome proliferator-activated receptor (PPAR) isoform(s). Since the thyroid hormone (T3; 3,3',5-triiodothyronine) receptor (TR), another member of the nuclear ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu R,Madison LD,Lin Y,Kopp P,Rao MS,Jameson JL,Reddy JK

更新日期：1995-12-05 00:00:00

abstract：:What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Here we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly corr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirase H,Leinekugel X,Czurkó A,Csicsvari J,Buzsáki G

更新日期：2001-07-31 00:00:00

abstract：:The livers of insulin-resistant, diabetic mice manifest selective insulin resistance, suggesting a bifurcation in the insulin signaling pathway: Insulin loses its ability to block glucose production (i.e., it fails to suppress PEPCK and other genes of gluconeogenesis), yet it retains its ability to stimulate fatty aci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li S,Brown MS,Goldstein JL

更新日期：2010-02-23 00:00:00

abstract：:Two virus-specific RNA species of 7.5 and 7.0 kilobases have been identified in avian myeloblastosis virus (AMV) by denaturing gel electrophoresis and blot hybridization analysis, and they were found to be in a 10:1 ratio. The individual RNAs direccted the cell-free synthesis of the 76,000-dalton "gag" protein and the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz RA,Chirikjian JG,Papas TS

更新日期：1981-04-01 00:00:00

abstract：:In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes. TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnida...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan JJ,Messerschmidt JL,Williams LM,Matthews BJ,Reynoso M,Gilmore TD

更新日期：2017-11-21 00:00:00

abstract：:Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivator CDC20 (cell division cycle 20). To avoid chromosome missegregation, APC/C(CDC20) activation is tightly controlled. CDC20 only associates with APC/C in mitosis when APC/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiao R,Weissmann F,Yamaguchi M,Brown NG,VanderLinden R,Imre R,Jarvis MA,Brunner MR,Davidson IF,Litos G,Haselbach D,Mechtler K,Stark H,Schulman BA,Peters JM

更新日期：2016-05-10 00:00:00

abstract：:Most neurotransmission is mediated by action potentials, whereas sensory neurons propagate electrical signals passively and release neurotransmitter in a graded manner. Here, we demonstrate that Caenorhabditis elegans neuromuscular junctions release neurotransmitter in a graded fashion. When motor neurons were depolar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Q,Hollopeter G,Jorgensen EM

更新日期：2009-06-30 00:00:00

abstract：:M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang MH,Kweon MN,Iwatani K,Yamamoto M,Terahara K,Sasakawa C,Suzuki T,Nochi T,Yokota Y,Rennert PD,Hiroi T,Tamagawa H,Iijima H,Kunisawa J,Yuki Y,Kiyono H

更新日期：2004-04-20 00:00:00

abstract：:Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes. Here we studied some phenotypic features of a well-established animal model of type 2 diabetes, the leptin receptor-deficient db(-)/db(-) mouse, and also the effect of long-term (6 mo) treatment with coenzyme Q10 (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi TJ,Zhang MD,Zeberg H,Nilsson J,Grünler J,Liu SX,Xiang Q,Persson J,Fried KJ,Catrina SB,Watanabe M,Arhem P,Brismar K,Hökfelt TG

更新日期：2013-01-08 00:00:00

abstract：:The subdivision of all the experimental days of the Whitetop project into two approximately equal groups, group W with predominantly westerly winds aloft and group E with frequent easterly winds, shows a remarkable difference in the apparent effect of seeding. On W days there was no detectable effect of seeding on rai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovasich JL,Neyman J,Scott EL,Smith JA

更新日期：1969-11-01 00:00:00

abstract：:Protein S (ProS) and growth arrest-specific 6 (Gas6) bind to phosphatidylserine (PtdSer) and induce efferocytosis upon binding TAM-family receptors (Tyro3, Axl, and Mer). Here, we produced mouse ProS, Gas6, and TAM-receptor extracellular region fused to IgG fragment crystallizable region in HEK293T cells. ProS and Gas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yanagihashi Y,Segawa K,Maeda R,Nabeshima YI,Nagata S

更新日期：2017-08-15 00:00:00

abstract：:Breakage-fusion-bridge (BFB) is a mechanism of genomic instability characterized by the joining and subsequent tearing apart of sister chromatids. When this process is repeated during multiple rounds of cell division, it leads to patterns of copy number increases of chromosomal segments as well as fold-back inversions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zakov S,Kinsella M,Bafna V

更新日期：2013-04-02 00:00:00

abstract：:We study the physical origins of phase contrast in dynamic atomic force microscopy (dAFM) in liquids where low-stiffness microcantilever probes are often used for nanoscale imaging of soft biological samples with gentle forces. Under these conditions, we show that the phase contrast derives primarily from a unique ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melcher J,Carrasco C,Xu X,Carrascosa JL,Gómez-Herrero J,José de Pablo P,Raman A

更新日期：2009-08-18 00:00:00

abstract：:A mitochondrial ribosome with an approximate sedimentation coefficient of 60 S has been isolated from the ovary of the South African clawed toad, Xenopus laevis. This ribosome is active in a submitochondrial protein-synthesizing system. It contains two species of RNA, designated as "21S" and 13S RNA, which have sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson RF,Dawid IB

更新日期：1970-05-01 00:00:00