Interpretation of the binding of carbon monoxide to hemoglobin under photodissociating conditions.

abstract：:The evolution of insect resistance to pesticides poses a continuing threat to agriculture and human health. While much is known about the proximate molecular and biochemical mechanisms that confer resistance, far less is known about the regulation of the specific genes/gene families involved, particularly by trans-act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang X,Deng S,Wei X,Yang J,Zhao Q,Yin C,Du T,Guo Z,Xia J,Yang Z,Xie W,Wang S,Wu Q,Yang F,Zhou X,Nauen R,Bass C,Zhang Y

更新日期：2020-05-12 00:00:00

abstract：:Tubular membrane structures are widespread in eukaryotic cells, but the mechanisms underlying their formation and stability are not well understood. Previous work has focused on tube extrusion from cells and model membranes under the application of external forces. Here, we present novel membrane/polymer systems, wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Lipowsky R,Dimova R

更新日期：2011-03-22 00:00:00

abstract：:A typical molecular ion mass spectrum consists of a sum of signals from species of various possible isotopic compositions. Only the monoisotopic peak (e.g., all carbons are 12C; all nitrogens are 14N, etc.) has a unique elemental composition. Every other isotope peak at approximately integer multiples of approximately...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi SD,Hendrickson CL,Marshall AG

更新日期：1998-09-29 00:00:00

abstract：:Cellular and molecular signals involved in axon elongation versus collateral and arbor formation may be intrinsic to developing neurons, or they may derive from targets. To identify signals regulating axon growth modes, we have developed a culture system in which trigeminal ganglion cells are challenged by various tar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Erzurumlu RS,Jhaveri S,Takahashi H,McKay RD

更新日期：1993-08-01 00:00:00

abstract：:The allocation of carbon and nitrogen resources to the synthesis of plant proteins, carbohydrates, and lipids is complex and under the control of many genes; much remains to be understood about this process. QQS (Qua-Quine Starch; At3g30720), an orphan gene unique to Arabidopsis thaliana, regulates metabolic processes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Zheng W,Zhu Y,Ye H,Tang B,Arendsee ZW,Jones D,Li R,Ortiz D,Zhao X,Du C,Nettleton D,Scott MP,Salas-Fernandez MG,Yin Y,Wurtele ES

更新日期：2015-11-24 00:00:00

abstract：:Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks DG,Walsh KB,Elsaesser H,Oldstone MB

更新日期：2010-02-16 00:00:00

abstract：:Cleavage of the group-specific antigen (Gag) polyprotein by HIV-1 protease represents the critical first step in the conversion of immature noninfectious viral particles to mature infectious virions. Selective pressure exerted by HIV-1 protease inhibitors, a mainstay of current anti-HIV-1 therapies, results in the acc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh L,Louis JM,Ghirlando R,Clore GM

更新日期：2016-11-01 00:00:00

abstract：:The combination of lutropin (LH; luteinizing hormone) alpha and beta subunits was examined in rat pituitaries incubated with [35S]methionine or [35S]sulfate. Combination was assessed by using antiserum directed against the beta subunit. The data show that combination of most of the subunits proceeds rapidly, well befo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshina H,Boime I

更新日期：1982-12-01 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) binds to specific receptors on GH4C1 pituitary tumor cells. A fluorescently labeled analog of TRH was synthesized by coupling pGlu-His-ProNH(CH2)6NH2 to fluorescein isothiocyanate. The fluorescein-labeled peptide (FL-TRH) stimulated prolactin synthesis and release by GH4C1 cultures ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern J,Hinkle PM

更新日期：1981-01-01 00:00:00

abstract：:Formation of duplex DNA from varphiX174 single-stranded DNA by extracts of E. coli was previously shown to require the gene product of dna B. Using as an assay the stimulation of varphiX174 DNA-dependent synthesis in inactivated extracts of dna B temperature-sensitive cells, we purified the dna B gene product from wil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright M,Wickner S,Hurwitz J

更新日期：1973-11-01 00:00:00

abstract：:A translocation involving human chromosome 10, band q24, in a subset of T-cell acute leukemias disrupts a region surrounding the putative oncogene HOX11, which encodes a protein with a homeodomain. The HOX11 protein binds to a specific DNA sequence, it localizes to the cell nucleus, and it transactivates transcription...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dear TN,Sanchez-Garcia I,Rabbitts TH

更新日期：1993-05-15 00:00:00

abstract：:This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at the ends of chromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang ACY,Chang ACH,Kirillova A,Sasagawa K,Su W,Weber G,Lin J,Termglinchan V,Karakikes I,Seeger T,Dainis AM,Hinson JT,Seidman J,Seidman CE,Day JW,Ashley E,Wu JC,Blau HM

更新日期：2018-09-11 00:00:00

abstract：:RelB is an NF-κB family transcription factor activated in the noncanonical pathway downstream of NF-κB-inducing kinase (NIK) and TNF receptor family members including lymphotoxin-β receptor (LTβR) and CD40. Early analysis suggested that RelB is required for classical dendritic cell (cDC) development based on a severe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA 3rd,Novack DV,Murphy TL,Murphy KM

更新日期：2017-04-11 00:00:00

abstract：:The understanding of mechanisms controlling zinc absorption and metabolism at the molecular level has advanced recently. Kinetics of zinc transport have been investigated for many years, but only recently have genes coding for proteins thought to be involved in the transport process been cloned. Four putative zinc tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMahon RJ,Cousins RJ

更新日期：1998-04-28 00:00:00

abstract：:We describe here the 1.7-A resolution structure of a single-chain antibody variable domain (scFv) molecule, based on the carbohydrate-binding antibody Se155-4, complexed with the trisaccharide ligand alpha-D-Gal(1-->2)[alpha-D-Abe(1-->3)]alpha-D-Manp1-->OMe, where Abe is abequose. The scFv expressed in Escherichia col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zdanov A,Li Y,Bundle DR,Deng SJ,MacKenzie CR,Narang SA,Young NM,Cygler M

更新日期：1994-07-05 00:00:00

abstract：:What can be done to reduce unhealthy eating among adolescents? It was hypothesized that aligning healthy eating with important and widely shared adolescent values would produce the needed motivation. A double-blind, randomized, placebo-controlled experiment with eighth graders (total n = 536) evaluated the impact of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryan CJ,Yeager DS,Hinojosa CP,Chabot A,Bergen H,Kawamura M,Steubing F

更新日期：2016-09-27 00:00:00

abstract：:The effective management of marine fisheries is an ongoing challenge at the intersection of biology, economics, and policy. One way in which fish stocks-and their habitats-can be protected is through the establishment of marine reserves, areas that are closed to fishing. Although the potential economic benefits of suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herrera GE,Moeller HV,Neubert MG

更新日期：2016-04-05 00:00:00

abstract：:The G protein-coupled free fatty acid receptor-1 (FFA1/GPR40) plays a major role in the regulation of insulin secretion by fatty acids. GPR40 is considered a potential therapeutic target to enhance insulin secretion in type 2 diabetes; however, its mode of regulation is essentially unknown. The aims of this study were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kebede M,Ferdaoussi M,Mancini A,Alquier T,Kulkarni RN,Walker MD,Poitout V

更新日期：2012-02-14 00:00:00

abstract：:The recently characterized corticosteroid receptor on amphibian neuronal membranes appears to mediate rapid, stress-induced changes in male reproductive behaviors. Because the transduction mechanisms associated with this receptor are unknown, we performed radioligand binding studies to determine whether this steroid r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orchinik M,Murray TF,Franklin PH,Moore FL

更新日期：1992-05-01 00:00:00

abstract：:Alternative ribosome subunit proteins are prevalent in the genomes of diverse bacterial species, but their functional significance is controversial. Attempts to study microbial ribosomal heterogeneity have mostly relied on comparing wild-type strains with mutants in which subunits have been deleted, but this approach ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YX,Xu ZY,Ge X,Sanyal S,Lu ZJ,Javid B

更新日期：2020-08-11 00:00:00

abstract：:The population genetic consequences of nearest-neighbor pollination in an outcrossing plant species were investigated through computer simulations. The genetic system consisted of two alleles at a single locus in a self-incompatible plant that mates by random pollen transfer from a neighboring individual. Beginning wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner ME,Stephens JC,Anderson WW

更新日期：1982-01-01 00:00:00

abstract：:The localization of endothelin 1 mRNA and endothelin-like immunoreactivity was investigated in samples of neurologically normal nervous system tissue from 10 adults by using in situ hybridization and immunocytochemistry. Tissue sections of spinal cord and dorsal root ganglia were hybridized with an 35S-radiolabeled en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giaid A,Gibson SJ,Ibrahim BN,Legon S,Bloom SR,Yanagisawa M,Masaki T,Varndell IM,Polak JM

更新日期：1989-10-01 00:00:00

abstract：:The four core histones (H2A, H2B, H3, and H4) and DNA were assembled into nucleosome-like particles at physiological ionic strengths either by an extract of chromatin rich in nicking-closing activity or by the purified nicking-closing enzyme itself. When histone-DNA complexes were assembled in vitro from relaxed circu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Germond JE,Rouvière-Yaniv J,Yaniv M,Brutlag D

更新日期：1979-08-01 00:00:00

abstract：:Prothoracicotropic hormone (PTTH) is the central cerebral neurohormone in insect development. Its release has been believed for decades to be confined to one (or two) critical moments early in each developmental stage at which time it triggers prolonged activation of the prothoracic glands to synthesize and release th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vafopoulou X,Steel CG

更新日期：1996-04-16 00:00:00

abstract：:LTRs of endogenous retroviruses are known to affect expression of several human genes, typically as a relatively minor alternative promoter. Here, we report that an endogenous retrovirus LTR acts as one of at least two alternative promoters for the human beta1,3-galactosyltransferase 5 gene, involved in type 1 Lewis a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn CA,Medstrand P,Mager DL

更新日期：2003-10-28 00:00:00

abstract：:Ehrlich and Raven formally introduced the concept of stepwise coevolution using butterfly and angiosperm interactions in an attempt to account for the impressive biological diversity of these groups. However, many biologists currently envision butterflies evolving 50 to 30 million years (Myr) after the major angiosper...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wheat CW,Vogel H,Wittstock U,Braby MF,Underwood D,Mitchell-Olds T

更新日期：2007-12-18 00:00:00

abstract：:Cell aggregation in Dictyostelium discoideum appears to involve the production and detection of 3':5'-cyclic AMP. Two pertinent catalytic activities have been studied in concentrates from D. discoideum purified 50- to 100-fold. They are (i) adenylate cyclase and (ii) ATP pyrophosphohydrolase. ATP pyrophosphohydrolase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rossomando EF,Sussman M

更新日期：1973-04-01 00:00:00

abstract：:Both neocortical and hippocampal networks organize the firing patterns of their neurons by prominent oscillations during sleep, but the functional role of these rhythms is not well understood. Here, we show a robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirota A,Csicsvari J,Buhl D,Buzsáki G

更新日期：2003-02-18 00:00:00

abstract：:Two types of benzodiazepine receptors have been demonstrated in mammalian tissues, one which is localized on neuronal elements in brain and the other, on glial cells and in peripheral tissues such as kidney. In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline car...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Starosta-Rubinstein S,Ciliax BJ,Penney JB,McKeever P,Young AB

更新日期：1987-02-01 00:00:00

abstract：:The reactions catalyzed by Mo enzymes each find the product differing from the substrate by two electrons and two protons (or some multiple thereof). The coordination chemistry of Mo suggests that there is a distinct relationship between acid-base and redox properties of Mo complexes, and that a coupled electron-proto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiefel EI

更新日期：1973-04-01 00:00:00