Abstract:
:High levels of inbreeding cause populations to become composed of homozygous, inbred lines. High levels of homozygosity limit the effectiveness of recombination, and therefore, retard the rate of decay of linkage (gametic phase) disequilibrium (LD) among mutations. Inbreeding and recombination interact to shape the expected pattern of LD. The actual extent of nucleotide sequence level LD within inbreeding species has only been studied in Arabidopsis, a weedy species whose global range has recently expanded. In the present study, we examine the levels of LD within and between 18 nuclear genes in 25 accessions from across the geographic range of wild barley, a species with a selfing rate of approximately 98%. In addition to examination of intralocus LD, we employ a resampling method to determine whether interlocus LD exceeds expectations. We demonstrate that, for the majority of wild barley loci, intralocus LD decays rapidly, i.e., at a rate similar to that observed in the outcrossing species, Zea mays (maize). Excess interlocus LD is observed at 15% of two-locus combinations; almost all interlocus LD involves loci with significant geographic structuring of mutational variation.
journal_name
Proc Natl Acad Sci U S Aauthors
Morrell PL,Toleno DM,Lundy KE,Clegg MTdoi
10.1073/pnas.0409804102keywords:
subject
Has Abstractpub_date
2005-02-15 00:00:00pages
2442-7issue
7eissn
0027-8424issn
1091-6490pii
0409804102journal_volume
102pub_type
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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