Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.

abstract：:Carbon nanotube (CNT) membranes were employed as the active element of a switchable transdermal drug delivery device that can facilitate more effective treatments of drug abuse and addiction. Due to the dramatically fast flow through CNT cores, high charge density, and small pore dimensions, highly efficient electroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Paudel KS,Strasinger C,Hammell D,Stinchcomb AL,Hinds BJ

更新日期：2010-06-29 00:00:00

abstract：:The nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is an important coordinator of glucose homeostasis through its function in different organs such as the endocrine pancreas, adipose tissue, skeletal muscle, and liver. Recently we have demonstrated that COUP-TFII expression in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabra-Makke L,Maritan M,Planchais J,Boutant M,Pégorier JP,Even PC,Vasseur-Cognet M,Bossard P

更新日期：2013-03-12 00:00:00

abstract：:The brain continuously influences and perceives the physiological condition of the body. Related cortical representations have been proposed to shape emotional experience and guide behavior. Although previous studies have identified brain regions recruited during autonomic processing, neurological lesion studies have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo CC,Sturm VE,Zhou J,Gennatas ED,Trujillo AJ,Hua AY,Crawford R,Stables L,Kramer JH,Rankin K,Levenson RW,Rosen HJ,Miller BL,Seeley WW

更新日期：2016-04-26 00:00:00

abstract：:We have synthesized 175-nucleotide-long probes for the DNA of human histocompatibility antigens HLA-DR alpha and beta by extending on poly(A)+ mRNA from B-cell lines with short synthetic deoxyribonucleotide primers complementary to the predicted nucleotide sequence of the NH2 terminus of both polypeptides. The synthes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das HK,Biro PA,Cohen SN,Erlich HA,von Gabain A,Lawrance SK,Lemaux PG,McDevitt HO,Peterlin BM,Schulz MF,Sood AK,Weissman SM

更新日期：1983-03-01 00:00:00

abstract：:Osteoclasts, bone-resorptive multinucleated cells derived from hematopoietic stem cells, are associated with many bone-related diseases, such as osteoporosis. Osteoclast-targeting small-molecule inhibitors are valuable tools for studying osteoclast biology and for developing antiresorptive agents. Here, we have discov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawatani M,Okumura H,Honda K,Kanoh N,Muroi M,Dohmae N,Takami M,Kitagawa M,Futamura Y,Imoto M,Osada H

更新日期：2008-08-19 00:00:00

abstract：:Worldwide, 90% of HIV-1 infections are transmitted heterosexually. Because the genital mucosa are the sites of initial contact with HIV-1 for most exposed individuals, study of the virus from the genital tract is critical for the development of vaccines and therapeutics. Previous analyses of HIV-1 in various tissues h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kemal KS,Foley B,Burger H,Anastos K,Minkoff H,Kitchen C,Philpott SM,Gao W,Robison E,Holman S,Dehner C,Beck S,Meyer WA 3rd,Landay A,Kovacs A,Bremer J,Weiser B

更新日期：2003-10-28 00:00:00

abstract：:Fatty acid compositions of phospholipids of heart, liver, kidney, aorta, and serum from rats having streptozotocin-induced diabetes were determined and compared with those of nondiabetic controls. Linoleic and dihomo-gamma-linolenic acids were increased whereas arachidonic acid was decreased in most tissues, suggestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holman RT,Johnson SB,Gerrard JM,Mauer SM,Kupcho-Sandberg S,Brown DM

更新日期：1983-04-01 00:00:00

abstract：:Fungi of the recently defined order Sebacinales (Basidiomycota) are involved in a wide spectrum of mutualistic symbioses (including mycorrhizae) with various plants, thereby exhibiting a unique potential for biocontrol strategies. The axenically cultivable root endophyte Piriformospora indica is a model organism of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh S,Hückelhoven R,Schäfer P,Imani J,Sharma M,Weiss M,Waller F,Kogel KH

更新日期：2006-12-05 00:00:00

abstract：:Chloroplasts have evolved from a cyanobacterial endosymbiont and been retained for more than 1 billion years by coordinated chloroplast division in multiplying eukaryotic cells. Chloroplast division is performed by ring structures at the division site, encompassing both the inside and the outside of the two envelopes....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyagishima SY,Kuwayama H,Urushihara H,Nakanishi H

更新日期：2008-09-30 00:00:00

abstract：:We analyzed the relationship of genetic factors determining the expression of endogenous type-C RNA tumor viruses and other host-gene markers to tumorigenesis. A hybridization experiment was performed with mice of strains AKR/J and C57L, the first filial (F(1)) generation hybrids, the second filial (F(2)) generation h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meier H,Taylor BA,Cherry M,Buebner RJ

更新日期：1973-05-01 00:00:00

abstract：:Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel gene, cause chromosome 7-linked LQT. Heterologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanguinetti MC,Curran ME,Spector PS,Keating MT

更新日期：1996-03-05 00:00:00

abstract：:C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30% decrease in the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallorga P,Tallman JF,Henneberry RC,Hirata F,Strittmatter WT,Axelrod J

更新日期：1980-03-01 00:00:00

abstract：:To attempt to locate functionally important regions of the interferon (IFN) molecule, recombinant human IFN-alpha 2 was subjected to proteolytic digestion. The bacterial proteinase thermolysin produced two major complementary fragments, HuIFN-alpha 2-(1-110) and HuIFN-alpha 2-(111-153). After reduction with 2-mercapto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ackerman SK,Zur Nedden D,Heintzelman M,Hunkapiller M,Zoon K

更新日期：1984-02-01 00:00:00

abstract：:Using electron microscopy and fitting of crystal structures, we present the 3D reconstruction of ligand-induced dimers of intact receptor tyrosine kinase, KIT. We observe that KIT protomers form close contacts throughout the entire structure of ligand-bound receptor dimers, and that the dimeric receptors adopt multipl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Opatowsky Y,Lax I,Tomé F,Bleichert F,Unger VM,Schlessinger J

更新日期：2014-02-04 00:00:00

abstract：:Many experiments have been done to determine how far and how freely holes can move along the stack of base pairs in DNA. The results of these experiments are usually described in terms of a parameter beta under the assumption that it describes an exponential decay with distance. The reported values range from beta < 0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conwell EM,Rakhmanova SV

更新日期：2000-04-25 00:00:00

abstract：:In Saccharomyces cerevisiae Mediator, a subgroup of proteins (Srb8, Srb9, Srb10, and Srb11) form a module, which is involved in negative regulation of transcription. Homologues of Srb10 and Srb11 are found in some mammalian Mediator preparations, whereas no clear homologues have been reported for Srb8 and Srb9. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelsen CO,Baraznenok V,Khorosjutina O,Spahr H,Kieselbach T,Holmberg S,Gustafsson CM

更新日期：2003-05-27 00:00:00

abstract：:Four monoclonal anti-parathyroid antibodies were generated after immunization of mice with intact cells from human parathyroid tissue. All four monoclonal antibodies reacted in immunohistochemistry with structures present on parathyroid epithelial cells and proximal-tubule cells of the kidney but were unreactive with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juhlin C,Holmdahl R,Johansson H,Rastad J,Akerström G,Klareskog L

更新日期：1987-05-01 00:00:00

abstract：:Oligothiophenes incorporating MM quadruple bonds have been prepared from the reactions between Mo(2)(TiPB)(4) (TiPB = 2,4,6-triisopropyl benzoate) and 3',4'-dihexyl-2,2'-:5',2''-terthiophene-5,5''-dicarboxylic acid. The oligomers of empirical formula Mo(2)(TiPB)(2)(O(2)C(Th)-C(4)(n-hexyl)(2)S-(Th)CO(2)) are soluble in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burdzinski GT,Chisholm MH,Chou PT,Chou YH,Feil F,Gallucci JC,Ghosh Y,Gustafson TL,Ho ML,Liu Y,Ramnauth R,Turro C

更新日期：2008-10-07 00:00:00

abstract：:All immunoglobulins and T-cell receptors throughout phylogeny share regions of highly conserved amino acid sequence. To identify possible primitive immunoglobulins and immunoglobulin-like molecules, we utilized 3' RACE (rapid amplification of cDNA ends) and a highly conserved constant region consensus amino acid seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berstein RM,Schluter SF,Shen S,Marchalonis JJ

更新日期：1996-04-16 00:00:00

abstract：:In organisms possessing a dispersal phase the processes of mating, competition, feeding, and predation are often carried out within "trait-groups," defined as populations enclosed in areas smaller than the boundaries of the deme. A simple model shows that this can lead to the selection of "altruistic" traits that favo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson DS

更新日期：1975-01-01 00:00:00

abstract：:Ultrashort light pulses can selectively excite charges, spins, and phonons in materials, providing a powerful approach for manipulating their properties. Here we use femtosecond laser pulses to coherently manipulate the electron and phonon distributions, and their couplings, in the charge-density wave (CDW) material 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Shi X,You W,Tao Z,Zhong Y,Cheenicode Kabeer F,Maldonado P,Oppeneer PM,Bauer M,Rossnagel K,Kapteyn H,Murnane M

更新日期：2020-04-21 00:00:00

abstract：:High social status reduces stress responses in numerous species, but the stress-buffering effect of status may dissipate or even reverse during times of hierarchical instability. In an experimental test of this hypothesis, 118 participants (57.3% female) were randomly assigned to a high- or low-status position in a st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knight EL,Mehta PH

更新日期：2017-01-03 00:00:00

abstract：:Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efendić S,Wajngot A,Cerasi E,Luft R

更新日期：1980-12-01 00:00:00

abstract：:Tiazofurin (2-beta-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP dehydrogenase (IMP:NAD+ oxidoreductase; EC 1.1.1.205) and depletes guanylate levels, can activate the erythroid differentiation program of K-562 human leukemia cells. Tiazofurin-mediated cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olah E,Natsumeda Y,Ikegami T,Kote Z,Horanyi M,Szelenyi J,Paulik E,Kremmer T,Hollan SR,Sugar J

更新日期：1988-09-01 00:00:00

abstract：:Antibody-secreting plasma cells (PCs) arise rapidly during adaptive immunity to control infections. The early PCs are retained within the reactive lymphoid organ where their localization and homeostasis rely on extrinsic factors, presumably produced by local niche cells. While myeloid cells have been proposed to form ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang HY,Rivas-Caicedo A,Renevey F,Cannelle H,Peranzoni E,Scarpellino L,Hardie DL,Pommier A,Schaeuble K,Favre S,Vogt TK,Arenzana-Seisdedos F,Schneider P,Buckley CD,Donnadieu E,Luther SA

更新日期：2018-07-17 00:00:00

abstract：:Epstein-Barr virus (EBV), an oncogenic herpesvirus, encodes two small RNAs (EBERs) that are expressed at high levels during latent transformation of human B lymphocytes. Here we report that a 15-kDa cellular protein called EAP (for EBER associated protein), previously shown to bind EBER1, is in fact the ribosomal prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toczyski DP,Matera AG,Ward DC,Steitz JA

更新日期：1994-04-12 00:00:00

abstract：:The subventricular zone remains mitotically active throughout life in rodents. Studies with tritiated thymidine, which is incorporated into the DNA of mitotic cells, have revealed that the rodent subventricular zone produces neuroblasts that migrate toward the olfactory bulb along the rostral migratory stream. A simil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernier PJ,Bedard A,Vinet J,Levesque M,Parent A

更新日期：2002-08-20 00:00:00

abstract：:Mutant, but not wild-type p53 binds with high affinity to a variety of MAR-DNA elements (MARs), suggesting that MAR-binding of mutant p53 relates to the dominant-oncogenic activities proposed for mutant p53. MARs recognized by mutant p53 share AT richness and contain variations of an AATATATTT "DNA-unwinding motif," w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will K,Warnecke G,Wiesmüller L,Deppert W

更新日期：1998-11-10 00:00:00

abstract：:[Ala3-15N][Val1]Gramicidin A has been prepared by solid-phase peptide synthesis and studied by solid-state 15N nuclear magnetic resonance spectroscopy. The synthesis of desformyl[Ala3-15N][Val1]gramicidin A employed N-hydroxysuccinimide esters of 9-fluorenylmethoxycarbonyl-N alpha-amino acids and completely avoided th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fields GB,Fields CG,Petefish J,Van Wart HE,Cross TA

更新日期：1988-03-01 00:00:00

abstract：:The total amounts of type I and type II cytoplasmic cyclic AMP-dependent protein kinase activities were measured in various tissues of intact rats and rats subjected to castration, hypophysectomy, or adrenalectomy. After castration, the total amount of type I activity decreased rapidly in classifically steroid-respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuller DJ,Byus CV,Russell DH

更新日期：1978-01-01 00:00:00