Systemic manifestations in localized scleroderma.

abstract：:Silicone-gel breast implant rupture is common. Silicone-gel from ruptured implants may escape the scar capsule that forms around breast implants and become "extracapsular silicone." Our previously published study found that women with extracapsular silicone gel were at higher risk of reporting that they were diagnosed...

journal_title：Current rheumatology reports

authors： Brown SL,Duggirala HJ,Pennello G

更新日期：2002-08-01 00:00:00

abstract：:Management of the pregnant patient with antiphospholipid antibody (aPL) is reviewed, with emphasis on recent randomized controlled clinical trials. These support the use of subcutaneous heparin and low dose aspirin, current standard therapy for women with aPL and a history of fetal loss. Prednisone is rarely used due ...

journal_title：Current rheumatology reports

authors： Sammaritano LR

更新日期：2001-06-01 00:00:00

abstract：:Hereditary hemochromatosis is a frequent disease in Caucasian populations. It leads to progressive iron overload in a variety of organs. The most common cause is the C282Y homozygous mutation in the HFE gene. The classical triad of skin hyperpigmentation, diabetes, and liver cirrhosis is nowadays rare but musculoskele...

journal_title：Current rheumatology reports

authors： Husar-Memmer E,Stadlmayr A,Datz C,Zwerina J

更新日期：2014-01-01 00:00:00

abstract：:Transforming growth factor-beta (TGF beta) plays a critical role in the development of tissue fibrosis. Its expression is consistently elevated in affected organs and correlates with increased extracellular matrix deposition. During the last few years, tremendous progress has been made in understanding the molecular a...

journal_title：Current rheumatology reports

authors： Verrecchia F,Mauviel A

更新日期：2002-04-01 00:00:00

abstract：:Bone is not structurally normal in osteoarthritis (OA). Periarticular bone in OA has increased turnover, decreased bone mineral content and stiffness, and decreased trabecular numbers. The increased turnover of collagen, in particular, may affect the biomechanical competence of bone and is driven by a number of proces...

journal_title：Current rheumatology reports

authors： Hunter DJ,Spector TD

更新日期：2003-02-01 00:00:00

abstract：:Erosive osteoarthritis (OA) is a subcategory of OA in which destructive changes occur in the joints, probably as a result of a combination of inflammatory inciters and phenomena. The major changes occur in the distal and proximal interphalangeal joints, root joints of the thumb, and less commonly other hand and centri...

journal_title：Current rheumatology reports

authors： Ehrlich GE

更新日期：2001-12-01 00:00:00

abstract：:Acupuncture has been used for millennia in traditional Chinese medicine as a technique believed to restore the balance of energy in the body caused by disease through the use of needles inserted into specific points or energy channels. This energy is called the de qi. The use of acupuncture for the treatment of pain i...

journal_title：Current rheumatology reports

authors： Amezaga Urruela M,Suarez-Almazor ME

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoarthritis (OA) is the most common form of arthritis and a major source of pain and disability worldwide. OA-associated pain is usually refractory to classically used analgesics, and disease-modifying therapies are still lacking. Therefore, a better understanding of mechanisms and mediators contri...

journal_title：Current rheumatology reports

authors： Syx D,Tran PB,Miller RE,Malfait AM

更新日期：2018-02-26 00:00:00

abstract：:Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid i...

journal_title：Current rheumatology reports

authors： Shah A,Keenan RT

更新日期：2010-04-01 00:00:00

abstract：:To date, most studies examining cell death during the development of osteoarthritis (OA) have focused on death of chondrocytes and have primarily examined advanced stages of the disease. Very good evidence suggests that chondrocyte death does occur at some point in the pathogenesis of OA and that it can be due to apop...

journal_title：Current rheumatology reports

authors： Del Carlo M Jr,Loeser RF

更新日期：2008-01-01 00:00:00

abstract：:Congenital heart block (CHB) can occur in association with structural heart disease, such as atrioventricular septal defects, left atrial isomerism, and abnormalities of the great arteries, with tumors, such as mesotheliomas, or as an isolated defect. In 1928, Aylward reported the occurrence of CHB in two children who...

journal_title：Current rheumatology reports

authors： Buyon JP,Friedman DM

更新日期：2003-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with a heightened risk of cardiovascular disease (CVD) events, presumably related to a greater burden of atherosclerosis, as well as atherosclerotic plaques that tend to be inflamed and rupture prone. Many of the inflammatory pathways underlying the pathobiology of RA are also r...

journal_title：Current rheumatology reports

authors： Giles JT

更新日期：2016-05-01 00:00:00

abstract：:Osteoporosis and related fractures represent a major, and growing, public health concern for the United States and worldwide. The pathogenesis of osteoporosis is complex, requiring attention to the different life phases involved in growth, maintenance, and loss of bone, in addition to non-skeletal factors associated w...

journal_title：Current rheumatology reports

authors： Samelson EJ,Hannan MT

更新日期：2006-02-01 00:00:00

abstract：:Activation of the complement system plays a fundamental role in the pathogenesis of systemic lupus erythematosus (SLE). For the past several decades, quantifying this process has focused primarily on determination of serum C3 and C4, although the utility of these assays for diagnosis and monitoring disease activity is...

journal_title：Current rheumatology reports

authors： Liu CC,Manzi S,Danchenko N,Ahearn JM

更新日期：2004-10-01 00:00:00

abstract：:Behçet's syndrome is a systemic vasculitis with an unknown etiology affecting the small and large vessels of the venous and arterial systems. At least two clusters of disease expression have been described. The first includes superficial vein thrombosis, deep vein thrombosis, and dural sinus thrombi. The second includ...

journal_title：Current rheumatology reports

authors： Yazici Y,Yurdakul S,Yazici H

更新日期：2010-12-01 00:00:00

abstract：:Vasculitis is defined as inflammation of blood vessels and can affect multiple organs. Several classification systems exist to categorize vasculitis such as vessel size, presence of anti-neutrophil cytoplasmic antibody, pathogenesis of the inflammation, and type of inflammatory cell infiltrate. Cutaneous vasculitis oc...

journal_title：Current rheumatology reports

authors： Hayat S,Berney SM

更新日期：2005-08-01 00:00:00

abstract：:Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic...

journal_title：Current rheumatology reports

authors： Lu TT

更新日期：2012-02-01 00:00:00

abstract：:β2-glycoprotein I (β2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding β2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms b...

journal_title：Current rheumatology reports

authors： Giannakopoulos B,Mirarabshahi P,Krilis SA

更新日期：2011-02-01 00:00:00

abstract：:The inflammatory myopathies are a heterogeneous group of diseases including dermatomyositis, polymyositis, and inclusion body myositis. Few clinical trials have been conducted in myositis, making it difficult to provide clear recommendations on the treatment of these rare disorders. Although corticosteroids have not b...

journal_title：Current rheumatology reports

authors： Aggarwal R,Oddis CV

更新日期：2011-06-01 00:00:00

abstract：:As the body's largest organ and first line of defense against the environment, the skin plays a vital role in host immune defense. In addition to its function as a physical barrier, the skin contains an active immune surveillance network and can mount highly specific responses to eliminate invading organisms. In this ...

journal_title：Current rheumatology reports

authors： Fuhlbrigge RC,Chaiban R

更新日期：2011-04-01 00:00:00

abstract：:The normal process of aging brings about changes in immune function, hormonal status, overall metabolism, and enhanced occurrence of neuropsychiatric disorders. These alterations are also evident at an accelerating pace in chronic inflammatory diseases. Treatment with immunosuppressive therapeutics is often not suffic...

journal_title：Current rheumatology reports

authors： Härle P,Straub RH

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study was to provide the most up-to-date scientific evidence of the potential analgesic effects, or lack thereof, of the marijuana plant (cannabis) or cannabinoids, and of safety or tolerability of their long-term use. RECENT FINDINGS:We found that inhaled (smoked or vaporized) ca...

journal_title：Current rheumatology reports

authors： Romero-Sandoval EA,Kolano AL,Alvarado-Vázquez PA

更新日期：2017-10-05 00:00:00

abstract：:Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) is the first-ever international network created to design and conduct large-scale, multicenter clinical trials and research in persistently antiphospholipid antibody (aPL)-positive patients. Since its inception in 2010, th...

journal_title：Current rheumatology reports

authors： Barbhaiya M,Andrade D,Erkan D,APS ACTION.

更新日期：2016-10-01 00:00:00

abstract：:The recent increase in the number of patients taking opioids chronically for pain has not yielded the expected benefits in reduction of symptoms and improved function. Chronic pain patients typically respond well initially to opioid medications, but regular use is associated with adverse psychological and physical eff...

journal_title：Current rheumatology reports

authors： Krashin D,Sullivan M,Ballantyne J

更新日期：2013-03-01 00:00:00

abstract：:Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylit...

journal_title：Current rheumatology reports

authors： O'Rielly DD,Rahman P

更新日期：2013-08-01 00:00:00

abstract：:Recent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. Genome-wide association studies have expanded the number of validated RA risk loci beyond HLA-DRB1 "shared epitope" alleles to include additional major histocompatibility complex (MHC) risk alleles and more t...

journal_title：Current rheumatology reports

authors： Plenge RM

更新日期：2009-10-01 00:00:00

abstract：:Skin fibrosis occurs in a variety of human diseases, most notably systemic sclerosis (SSc). The end stage of scleroderma in human skin consists of excess collagen deposition in the dermis with loss of adnexal structures and associated adipose tissue. The initiating factors for this process and the early stages are bel...

journal_title：Current rheumatology reports

authors： Smith GP,Chan ES

更新日期：2010-02-01 00:00:00

abstract：:Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce infl...

journal_title：Current rheumatology reports

authors： Eppinga H,Konstantinov SR,Peppelenbosch MP,Thio HB

更新日期：2014-03-01 00:00:00

abstract：:There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning,...

journal_title：Current rheumatology reports

authors： Leung YY,Tam LS,Li EK

更新日期：2011-08-01 00:00:00

abstract：:Osteoarthritis causes tremendous individual suffering and staggering societal costs, but due to our limited understanding of the underlying molecular and cellular mechanisms, our avenues for treating this disease are very restricted. Recent years have seen a drastic increase in the use of genetically modified mice to ...

journal_title：Current rheumatology reports

authors： Moon PM,Beier F

更新日期：2015-08-01 00:00:00