The nonimmunosuppressive cyclosporin analogs NIM811 and UNIL025 display nanomolar potencies on permeability transition in brain-derived mitochondria.

abstract：:The topic of human adult neural plasticity and neurogenesis is of great interest for medical and scientific community, but it is also largely debated. In the last years, an increasing interest has been paid to the olfactory system, and particularly to the plasticity of the olfactory bulb (OB). While the molecular/cell...

journal_title：Journal of bioenergetics and biomembranes

authors： Huart C,Rombaux P,Hummel T

更新日期：2019-02-01 00:00:00

abstract：:Liver plasma membranes isolated from rats with chronic dietary iron overload showed a large modification of their phospholipid fatty acid composition. Specifically, a significant decrease in polyunsaturated fatty acids and a parallel increase in saturated fatty acids was observed. This pattern was consistent with the ...

journal_title：Journal of bioenergetics and biomembranes

authors： Pietrangelo A,Tripodi A,Carulli N,Tomasi A,Ceccarelli D,Ventura E,Masini A

更新日期：1989-08-01 00:00:00

abstract：:The presence of additional subunits in cytochrome oxidase distinguish the multicellular eukaryotic enzyme from that of a simple unicellular bacterial enzyme. The number of these additional subunits increases with increasing evolutionary stage of the organism. Subunits I-III of the eukaryotic enzyme are related to the ...

journal_title：Journal of bioenergetics and biomembranes

authors： Kadenbach B,Stroh A,Hüther FJ,Reimann A,Steverding D

更新日期：1991-04-01 00:00:00

abstract：:Electron transport from Photosystem II to Photosystem I of spinach chloroplasts can be stimulated by bicarbonate and various carbonyl or carboxyl compounds. Monovalent or divalent cations, which have hitherto been implicated in the energy distribution between the two photosystems, i.e., "spillover" phenomena at low li...

journal_title：Journal of bioenergetics and biomembranes

authors： Barr R,Melhem R,Lezotte AL,Crane FL

更新日期：1980-08-01 00:00:00

abstract：:In this review, I focus on the bioenergetics of the methanogenic bacteria, with particular attention directed to the roles of transmembrane electrochemical gradients of sodium and proton. In addition, the mechanism of coupling ATP synthesis to methanogenic electron transfer is addressed. Evidence is reviewed which sug...

journal_title：Journal of bioenergetics and biomembranes

authors： Lancaster JR Jr

更新日期：1989-12-01 00:00:00

abstract：:Vacuolar H+ ATPases participate in renal hydrogen ion secretion in both the proximal and distal nephron. These plasma membrane forms of the vacuolar H+ ATPase are regulated physiologically to maintain the acid-base balance of the organism. Proton transporting renal cells have requirements for constitutive acidificatio...

journal_title：Journal of bioenergetics and biomembranes

authors： Gluck SL

更新日期：1992-08-01 00:00:00

abstract：:A study of NADH ferricyanide reductase activity in oriented vesicles or open ghosts of human and porcine erythrocytes shows that the dehydrogenase activity can have three types of orientation in the membrane. There is activity which responds only to acceptors and NADH exclusively on the inside face, or exclusively on ...

journal_title：Journal of bioenergetics and biomembranes

authors： Crane FL,Crane HE,Sun IL,MacKellar WC,Grebing C,Löw H

更新日期：1982-12-01 00:00:00

abstract：:Gap junction channels have long been viewed as static structures containing a large-diameter, aqueous pore. This pore has a high permeability to hydrophilic molecules of approximately 900 daltons in molecular weight and a weak ionic selectivity. The evidence leading to these conclusions is reviewed in the context of m...

journal_title：Journal of bioenergetics and biomembranes

authors： Veenstra RD

更新日期：1996-08-01 00:00:00

abstract：:Hepatic iron toxicity because of iron overload seems to be mediated by lipid peroxidation of biological membranes and the associated organelle dysfunctions. However, the basic mechanisms underlying this process in vivo are still little understood. Gerbils were dosed with weekly injections of iron-dextran alone or in c...

journal_title：Journal of bioenergetics and biomembranes

authors： Masini A,Ceccarelli D,Giovannini F,Montosi G,Garuti C,Pietrangelo A

更新日期：2000-04-01 00:00:00

abstract：:The ATP synthetase of chloroplast membranes binds ADP and ATP with high affinity, and the binding becomes quasi-irreversible under certain conditions. One explanation of the function of these nucleotides is that they are transiently tightly bound during ATP synthesis as part of the catalytic process, and that the rele...

journal_title：Journal of bioenergetics and biomembranes

authors： Tiefert MA,Shavit N

更新日期：1983-10-01 00:00:00

abstract：:Research on VDAC has accelerated as evidence grows of its importance in mitochondrial function and in apoptosis. New investigators entering the field are often confounded by the VDAC literature and its many apparent conflicts and contradictions. This review is an effort to shed light on the situation and identify reli...

journal_title：Journal of bioenergetics and biomembranes

authors： Rostovtseva TK,Tan W,Colombini M

更新日期：2005-06-01 00:00:00

abstract：:Many previous investigations have consistently reported that caloric restriction (40%), which increases maximum longevity, decreases mitochondrial reactive species (ROS) generation and oxidative damage to mitochondrial DNA (mtDNA) in laboratory rodents. These decreases take place in rat liver after only seven weeks of...

journal_title：Journal of bioenergetics and biomembranes

authors： Sanz A,Gómez J,Caro P,Barja G

更新日期：2006-12-01 00:00:00

abstract：:The P515 absorbance change upon single-turnover light flashes has been studied in intact leaves and isolated chloroplasts from spinach. A comparative study of the effects of preillumination on the kinetics of the P515 response and on the activity of the chloroplast ATPase has been made. The slow component (reaction 2)...

journal_title：Journal of bioenergetics and biomembranes

authors： Peters RL,Bossen M,van Kooten O,Vredenberg WJ

更新日期：1983-12-01 00:00:00

abstract：:Direct and indirect evidences show that elevated glucose concentrations in airway surface liquid (ASL) promote lung infection by pathogens, playing a role in the progression of the Cystic Fibrosis (CF) disease. The joint action of transporter/s for glucose and of the cellular enzymes is essential in order to try to lo...

journal_title：Journal of bioenergetics and biomembranes

authors： Favia M,de Bari L,Lassandro R,Atlante A

更新日期：2019-06-01 00:00:00

abstract：:Mitochondria are both targets and sources of oxidative stress. This dual relationship is particularly evident in experimental paradigms modeling ischemic brain injury. One mitochondrial metabolic enzyme that is particularly sensitive to oxidative inactivation is pyruvate dehydrogenase. This reaction is extremely impor...

journal_title：Journal of bioenergetics and biomembranes

authors： Fiskum G,Rosenthal RE,Vereczki V,Martin E,Hoffman GE,Chinopoulos C,Kowaltowski A

更新日期：2004-08-01 00:00:00

abstract：:Arsenic trioxide is an effective treatment for acute promyelocytic leukemia, but resistance to metalloid salts is found in humans. Using atomic absorption spectroscopy, we have measured the rate of uptake of arsenic trioxide and of antimony tartrate in GLC4 and GLC4/ADR cells overexpressing MRP1 and the rate of their ...

journal_title：Journal of bioenergetics and biomembranes

authors： Salerno M,Petroutsa M,Garnier-Suillerot A

更新日期：2002-04-01 00:00:00

abstract：:Subunit II of cytochrome c oxidase (Cox2) is usually encoded in the mitochondrial genome, synthesized in the organelle, inserted co-translationally into the inner mitochondrial membrane, and assembled into the respiratory complex. In chlorophycean algae however, the cox2 gene was split into the cox2a and cox2b genes, ...

journal_title：Journal of bioenergetics and biomembranes

authors： Jiménez-Suárez A,Vázquez-Acevedo M,Miranda-Astudillo H,González-Halphen D

更新日期：2017-12-01 00:00:00

abstract：:The purification of the channel-forming component of the mitochondrial calcium uniporter and its channel properties are described. After ethanol and 50% ethanol-water extraction of mitochondria from beef heart or perfused rat liver, the extract was passed through thiopropyl-Sepharose 6B column, and absorbed components...

journal_title：Journal of bioenergetics and biomembranes

authors： Mironova GD,Baumann M,Kolomytkin O,Krasichkova Z,Berdimuratov A,Sirota T,Virtanen I,Saris NE

更新日期：1994-04-01 00:00:00

abstract：:The fungal plasma membrane contains a proton-translocating ATPase that is closely related, both structurally and functionally, to the [Na+, K+]-, [H+, K+]-, and [Ca2+]-ATPases of animal cells, the plasma-membrane [H+]-ATPase of higher plants, and several bacterial cation-transporting ATPases. This review summarizes cu...

journal_title：Journal of bioenergetics and biomembranes

authors： Nakamoto RK,Slayman CW

更新日期：1989-10-01 00:00:00

abstract：:Bioenergetics of tomato (Lycopersicon esculentum) development on the plant was followed from the early growing stage to senescence in wild type (climacteric) and nonripening mutant (nor, non-climacteric) fruits. Fruit development was expressed in terms of evolution of chlorophyll a content allowing the assessment of a...

journal_title：Journal of bioenergetics and biomembranes

authors： Almeida AM,Navet R,Jarmuszkiewicz W,Vercesi AE,Sluse-Goffart CM,Sluse FE

更新日期：2002-12-01 00:00:00

abstract：:Mitochondria are dynamic structures for which fusion and fission are well characterized for rapidly dividing cells in culture. Based on these data, it has recently been proposed that high respiratory activity is the result of fusion and formation of mitochondrial reticulum, while fission results in fragmented mitochon...

journal_title：Journal of bioenergetics and biomembranes

authors： Varikmaa M,Guzun R,Grichine A,Gonzalez-Granillo M,Usson Y,Boucher F,Kaambre T,Saks V

更新日期：2013-08-01 00:00:00

abstract：:Advanced glycation end products (AGEs) and methylglyoxal (MG), an important intermediate in AGEs synthesis, are thought to contribute to protein aging and to the pathogenesis of age-and diabetes-associated complications. This study was intended to investigate brain mitochondria bioenergetics and oxidative status of ra...

journal_title：Journal of bioenergetics and biomembranes

authors： Cardoso S,Carvalho C,Marinho R,Simões A,Sena CM,Matafome P,Santos MS,Seiça RM,Moreira PI

更新日期：2014-10-01 00:00:00

abstract：:We have studied changes in plasma membrane NAD(P)H:quinone oxidoreductases of HL-60 cells under serum withdrawal conditions, as a model to analyze cell responses to oxidative stress. Highly enriched plasma membrane fractions were obtained from cell homogenates. A major part of NADH-quinone oxidoreductase in the plasma...

journal_title：Journal of bioenergetics and biomembranes

authors： Forthoffer N,Gómez-Díaz C,Bello RI,Burón MI,Martín SF,Rodríguez-Aguilera JC,Navas P,Villalba JM

更新日期：2002-06-01 00:00:00

abstract：:A great deal of progress has been made in understanding both the structure and the mechanism of F1-ATPase. The primary structure is now fully known for at least five species. Sequence comparison between chloroplast, photobacteria, aerobic bacteria, and mitochondrial representatives allow us to infer more general funct...

journal_title：Journal of bioenergetics and biomembranes

authors： Ysern X,Amzel LM,Pedersen PL

更新日期：1988-08-01 00:00:00

abstract：:Transformation of 3T3 cells by SV40 virus changes the properties of the transplasma membrane electron transport activity which can be assayed by reduction of external ferric salts. After 42 h of culture and before the growth rate is maximum, the transformed cells have a much slower rate of ferric reduction. The change...

journal_title：Journal of bioenergetics and biomembranes

authors： Löw H,Crane FL,Grebing C,Isaksson M,Lindgren A,Sun IL

更新日期：1991-12-01 00:00:00

abstract：:Complete initial steady state kinetics of NADH-decylubiquinone (DQ) oxidoreductase reaction between pH 6.5 and 9.0 show an ordered sequential mechanism in which the order of substrate bindings and product releases is NADH-DQ-DQH2-NAD+. NADH binding to the free enzyme is accelerated by protonation of an amino acid (pos...

journal_title：Journal of bioenergetics and biomembranes

authors： Hano N,Nakashima Y,Shinzawa-Itoh K,Terada H,Yoshikawa S

更新日期：2003-10-01 00:00:00

abstract：:Recent progress regarding the structure of the Ca(2+)-translocating ATPase of sarcoplasmic reticulum in several conformational states, and a substantial accumulation of biochemical information about this and other P-type ATPases, have put everything in place for the final convergence of biochemistry and structure that...

journal_title：Journal of bioenergetics and biomembranes

authors： Scarborough GA

更新日期：2003-06-01 00:00:00

abstract：:Cytoplasmic male sterility arises when mitochondrial activities are disrupted that are essential for pollen development. Rearrangements in the mitochondrial genome that create novel open reading frames are strongly correlated with CMS phenotypes in a number of systems. The morphological aberrations which indicate CMS-...

journal_title：Journal of bioenergetics and biomembranes

authors： Conley CA,Hanson MR

更新日期：1995-08-01 00:00:00

abstract：:Idebenone (IDE), a synthetic analog of coenzyme Q, strongly activates glycerol phosphate (GP) oxidation in brown adipose tissue mitochondria. GP oxidase, GP cytochrome c oxidoreductase and GP dehydrogenase activities were all significantly stimulated by 13 muM IDE. Substituted derivatives of IDE acetyl- and methoxyide...

journal_title：Journal of bioenergetics and biomembranes

authors： Rauchová H,Drahota Z,Bergamini C,Fato R,Lenaz G

更新日期：2008-04-01 00:00:00

abstract：:Specific molecular interactions that determine many of the functions of a biomembrane have a high probability of occurring at the surface of that membrane. However, unlike their hydrophobic core, the polar-apolar interface of biomembranes has been somewhat neglected experimentally. Reasons for this are that the chemic...

journal_title：Journal of bioenergetics and biomembranes

authors： Watts A

更新日期：1987-12-01 00:00:00