ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells.

abstract：:Using epitope mapping we have demonstrated that a high molecular weight protein (Mr approximately 115 x 10(3)) present in brain and spinal cord is a member of the tau family of microtubule-associated proteins. Antibodies directed against the amino-terminal, middle and carboxyl-terminal portions of tau recognize this p...

journal_title：Journal of cell science

authors： Georgieff IS,Liem RK,Mellado W,Nunez J,Shelanski ML

更新日期：1991-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is encoded by multiple mRNA variants whose differential subcellular distribution constitutes a 'spatial code' for local translation of BDNF and selective morphological remodeling of dendrites. Here, we investigated where BDNF translation takes place and what are the signaling p...

journal_title：Journal of cell science

authors： Baj G,Pinhero V,Vaghi V,Tongiorgi E

更新日期：2016-07-15 00:00:00

abstract：:At the onset of development, the single cells of the eukaryotic micro-organism Dictyostelium discoideum secrete proteolytic activity which can be assayed using the insoluble substrate remazolbrilliant blue hide. The activity is not secreted by exponentially growing cells, but does appear extracellularly at the onset o...

journal_title：Journal of cell science

authors： Rossomando EF,Maldonado B,Crean EV,Kollar EJ

更新日期：1978-04-01 00:00:00

abstract：:While the basic cellular contributions to bone differentiation and mineralization are widely accepted, the regulation of these processes at the intracellular level remains inadequately understood. Our laboratory recently identified annexin 2 as a protein involved in osteoblastic mineralization. Annexin 2 was overexpre...

journal_title：Journal of cell science

authors： Gillette JM,Nielsen-Preiss SM

更新日期：2004-01-26 00:00:00

abstract：:The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis and tissue homeostasis. The two organelles are mutually exclusive. The centriole/basal body is found at the core of the centrosome (centriole) or at the base of the cilium (basal bod...

journal_title：Journal of cell science

authors： de Saram P,Iqbal A,Murdoch JN,Wilkinson CJ

更新日期：2017-10-01 00:00:00

abstract：:During the prometaphase stage of mitosis, the cell builds a bipolar spindle of microtubules that mechanically segregates sister chromatids between two daughter cells in anaphase. The spindle assembly checkpoint (SAC) is a quality control mechanism that monitors proper attachment of microtubules to chromosome kinetocho...

journal_title：Journal of cell science

authors： Courtheoux T,Diallo A,Damodaran AP,Reboutier D,Watrin E,Prigent C

更新日期：2018-04-12 00:00:00

abstract：:The small GTP-binding protein Rho rapidly stimulates the formation of focal adhesions and actin stress fibres when microinjected into serum-starved Swiss 3T3 fibroblasts. This response is inhibited by tyrosine kinase inhibitors. Addition of growth factors such as lysophosphatidic acid and bombesin to Swiss 3T3 cells s...

journal_title：Journal of cell science

authors： Flinn HM,Ridley AJ

更新日期：1996-05-01 00:00:00

abstract：:Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 microm in diameter. In addition to its role in immunological responses, phagocytosis is also necessary for tissue remodeling and repair. To prevent catastrophic autoimmune reactions, phagocytosis must be tightly regulated. I...

journal_title：Journal of cell science

authors： Beningo KA,Wang YL

更新日期：2002-02-15 00:00:00

abstract：:Epithelia are compact tissues comprising juxtaposed cells that function as mechanical and chemical barriers between the body and the environment. This barrier relies, in part, on adhesive contacts within adherens junctions, which are formed and stabilized by E-cadherin and catenin proteins linked to the actomyosin cyt...

journal_title：Journal of cell science

authors： Le Bras S,Le Borgne R

更新日期：2014-12-15 00:00:00

abstract：:SNAREs such as VAMP, SNAP-25 and syntaxin are essential for intracellular trafficking, but what are their exact molecular roles and how are their interactions with other proteins manifest? Capitalizing on the differential sensitivity of SNAREs to exogenous proteases, we quantified the selective removal of identified S...

journal_title：Journal of cell science

authors： Coorssen JR,Blank PS,Albertorio F,Bezrukov L,Kolosova I,Chen X,Backlund PS Jr,Zimmerberg J

更新日期：2003-05-15 00:00:00

abstract：:It has been suggested by many studies that Ca2+ signaling plays an important role in regulating key steps in cell division. In order to study the down stream components of calcium signaling, we have fused the gene of calmodulin (CaM) with that of green fluorescent protein (GFP) and expressed it in HeLa cells. The GFP-...

journal_title：Journal of cell science

authors： Li CJ,Heim R,Lu P,Pu Y,Tsien RY,Chang DC

更新日期：1999-05-01 00:00:00

abstract：:Axonemal dyneins are multisubunit molecular motors that provide the driving force for flagellar motility. Dynein light chain 1 (LC1) has been well studied in Chlamydomonas reinhardtii and is unique among all dynein components as the only protein known to bind directly to the catalytic motor domain of the dynein heavy ...

journal_title：Journal of cell science

authors： Baron DM,Kabututu ZP,Hill KL

更新日期：2007-05-01 00:00:00

abstract：:We have recently shown that leukotriene D(4) (LTD(4)) increases cell survival in intestinal epithelial cells. Here we report and explore the complementary finding that LTD(4) also enhances proliferation in these cells. This proliferative response was approximately half of that induced by epidermal growth factor (EGF) ...

journal_title：Journal of cell science

authors： Paruchuri S,Hallberg B,Juhas M,Larsson C,Sjölander A

更新日期：2002-05-01 00:00:00

abstract：:Postsynaptic density protein 95 (PSD-95/SAP-90) is a palmitoylated membrane-associated guanylate kinase that oligomerizes and clusters ion channels and associated signaling machinery at excitatory synapses in brain. However, the mechanism for PSD-95 oligomerization and its relationship to ion channel clustering remain...

journal_title：Journal of cell science

authors： Christopherson KS,Sweeney NT,Craven SE,Kang R,El-Husseini Ael-D,Bredt DS

更新日期：2003-08-01 00:00:00

abstract：:Glomerular basement membrane (GBM) and podocalyxin are essential for podocyte morphology. We provide evidence of functional interconnections between basement membrane components (collagen IV and laminin), the expression of podocalyxin and the morphology of human glomerular epithelial cells (podocytes). We demonstrated...

journal_title：Journal of cell science

authors： Economou CG,Kitsiou PV,Tzinia AK,Panagopoulou E,Marinos E,Kershaw DB,Kerjaschki D,Tsilibary EC

更新日期：2004-07-01 00:00:00

abstract：:Protein kinase CK2, a vital, pleiotropic and highly conserved serine/threonine phosphotransferase is involved in transcription-directed signaling, gene control and cell cycle regulation and is suspected to play a role in global processes. Searching for these global roles, we analyzed the involvement of CK2 in gene exp...

journal_title：Journal of cell science

authors： Barz T,Ackermann K,Dubois G,Eils R,Pyerin W

更新日期：2003-04-15 00:00:00

abstract：:Polarization of the motile cell is associated with the formation of a distinct plasma membrane domain, the pseudopod, whose stabilization determines the directionality of cell movement. The rapid movement of cells over a substrate requires that an essential aspect of cell motility must be the supply of the necessary m...

journal_title：Journal of cell science

authors： Nabi IR

更新日期：1999-06-01 00:00:00

abstract：:Here, we identify a role for the matrilin-2 (Matn2) extracellular matrix protein in controlling the early stages of myogenic differentiation. We observed Matn2 deposition around proliferating, differentiating and fusing myoblasts in culture and during muscle regeneration in vivo. Silencing of Matn2 delayed the express...

journal_title：Journal of cell science

authors： Deák F,Mátés L,Korpos E,Zvara A,Szénási T,Kiricsi M,Mendler L,Keller-Pintér A,Ozsvári B,Juhász H,Sorokin L,Dux L,Mermod N,Puskás LG,Kiss I

更新日期：2014-08-01 00:00:00

abstract：:Melanotransferrin (p97) is an iron-binding membrane glycoprotein with 40% homology to transferrin and lactoferrin. It was first identified on the basis of its high level of expression in melanoma cells, as compared to normal melanocytes. It is also present in many cultured cell types. In normal tissues, p97 is express...

journal_title：Journal of cell science

authors： Alemany R,Vilá MR,Francí C,Egea G,Real FX,Thomson TM

更新日期：1993-04-01 00:00:00

abstract：:We use the fungus Ashbya gossypii to investigate how its polar growth machinery is organized to achieve sustained hyphal growth. In slowly elongating hyphae exocyst, cell polarity and polarisome proteins permanently localize as cortical cap at hyphal tips, thus defining the zone of secretory vesicle fusion. In tenfold...

journal_title：Journal of cell science

authors： Köhli M,Galati V,Boudier K,Roberson RW,Philippsen P

更新日期：2008-12-01 00:00:00

abstract：:We have used MPM-2, a monoclonal antibody raised against mitotic HeLa cells, to stain a Drosophila cell line, whole mounts of Drosophila embryos, and sectioned tissue from embryonic and larval stages of development. MPM-2 recognizes a major phosphoprotein of approximately 125 X 10(3) Mr in Drosophila tissue culture ce...

journal_title：Journal of cell science

authors： Millar SE,Freeman M,Glover DM

更新日期：1987-02-01 00:00:00

abstract：:Endocytosis is characterized by vesicular transport along numerous pathways. Common steps in each pathway include membrane budding to form vesicles, transport to a particular destination, and ultimately docking and fusion with the target membrane. Specificity of vesicle targeting is rendered in part by associated Rab ...

journal_title：Journal of cell science

authors： Somsel Rodman J,Wandinger-Ness A

更新日期：2000-01-01 00:00:00

abstract：:According to the hypothesis of contact inhibition of movement, cells in a confluent monolayer are restrained from major overlapping by a directional inhibition of locomotion. This explanation of monolayering proposes that contact between 2 cells locally paralyses the locomotory function, preventing movement in the dir...

journal_title：Journal of cell science

authors： Timpe L,Martz E,Steinberg MS

更新日期：1978-04-01 00:00:00

abstract：:When human cells enter S-phase, overlapping differential inhibitory mechanisms downregulate the replication licensing factors ORC1, CDC6 and Cdt1. Such regulation prevents re-replication so that deregulation of any individual factor alone would not be expected to induce overt re-replication. However, this has been cha...

journal_title：Journal of cell science

authors： Sugimoto N,Yoshida K,Tatsumi Y,Yugawa T,Narisawa-Saito M,Waga S,Kiyono T,Fujita M

更新日期：2009-04-15 00:00:00

abstract：:The current model for hemoglobin ingestion and transport by intraerythrocytic Plasmodium falciparum malaria parasites shares similarities with endocytosis. However, the model is largely hypothetical, and the mechanisms responsible for the ingestion and transport of host cell hemoglobin to the lysosome-like food vacuol...

journal_title：Journal of cell science

authors： Lazarus MD,Schneider TG,Taraschi TF

更新日期：2008-06-01 00:00:00

abstract：:A polyclonal antibody was raised to the C-terminal region of fission yeast BiP. The use of this antibody for immunoprecipitation, western blotting and immunofluorescence has confirmed and extended the observations made previously with an epitope-tagged BiP molecule. A fraction of BiP protein is glycosylated in Schizos...

journal_title：Journal of cell science

authors： Pidoux AL,Armstrong J

更新日期：1993-08-01 00:00:00

abstract：:Activation of the yeast cell wall integrity (CWI) pathway induces an adaptive transcriptional programme that is largely dependent on the transcription factor Rlm1 and the mitogen-activated protein kinase (MAPK) Slt2. Upon cell wall stress, the transcription factor Rlm1 is recruited to the promoters of RLM1 and SLT2, a...

journal_title：Journal of cell science

authors： García R,Sanz AB,Rodríguez-Peña JM,Nombela C,Arroyo J

更新日期：2016-04-15 00:00:00

abstract：:NADH:ubiquinone oxidoreductases catalyse the first step within the diverse pathways of mitochondrial NADH oxidation. In addition to the energy-conserving form commonly called complex I, fungi and plants contain much simpler alternative NADH:ubiquinone oxido-reductases that catalyze the same reaction but do not translo...

journal_title：Journal of cell science

authors： Kerscher SJ,Okun JG,Brandt U

更新日期：1999-07-01 00:00:00

abstract：:Cell surface glycans are believed to play a role in tumour invasion and metastasis. Yet, we have previously shown that the inhibitors of N-linked glycan processing swainsonine (SW) and 1-deoxynojirimycin (dNM) did not prevent invasion of chick heart fragments by MO4 murine fibrosarcoma cells in organ culture. We now p...

journal_title：Journal of cell science

authors： Bruyneel EA,De Mets M,Dragonetti CH,Hooghe RJ,Di Virgilio S,Mareel MM

更新日期：1990-02-01 00:00:00

abstract：:Cilia and flagella are eukaryotic organelles involved in multiple cellular functions. The primary cilium is generally non motile and found in numerous vertebrate cell types where it controls key signalling pathways. Despite a common architecture, ultrastructural data suggest some differences in their organisation. Her...

journal_title：Journal of cell science

authors： Molla-Herman A,Ghossoub R,Blisnick T,Meunier A,Serres C,Silbermann F,Emmerson C,Romeo K,Bourdoncle P,Schmitt A,Saunier S,Spassky N,Bastin P,Benmerah A

更新日期：2010-05-15 00:00:00