Rab GTPases coordinate endocytosis.

abstract：:The mixed lineage leukemia (MLL) proto-oncogenic protein is a histone-lysine N-methyltransferase that is produced by proteolytic cleavage and self-association of the respective functionally distinct subunits (MLL(N) and MLL(C)) to form a holocomplex involved in epigenetic transcriptional regulation. On the basis of st...

journal_title：Journal of cell science

authors： Yokoyama A,Ficara F,Murphy MJ,Meisel C,Naresh A,Kitabayashi I,Cleary ML

更新日期：2011-07-01 00:00:00

abstract：:The Schizosaccaromyces pombe protein Flp1p belongs to a conserved family of serine-threonine-phosphatases. The founding member of this family, Saccharomyces cerevisiae Cdc14p, is required for inactivation of mitotic CDKs and reversal of CDK mediated phosphorylation at the end of mitosis, thereby bringing about the M-G...

journal_title：Journal of cell science

authors： Esteban V,Blanco M,Cueille N,Simanis V,Moreno S,Bueno A

更新日期：2004-05-15 00:00:00

abstract：:Mitotic spindle assembly in animal cells is orchestrated by a chromosome-dependent pathway that directs microtubule stabilization. RanGTP generated at chromosomes releases spindle assembly factors from inhibitory complexes with importins, the nuclear transport factors that facilitate protein import into the nucleus du...

journal_title：Journal of cell science

authors： Wu Z,Jiang Q,Clarke PR,Zhang C

更新日期：2013-08-01 00:00:00

abstract：:Survivin, a human inhibitor of apoptosis protein (IAP), plays an important role in both cell cycle regulation and inhibition of apoptosis. Survivin is expressed in cells during the G(2)/M phase of the cell cycle, followed by rapid decline of both mRNA and protein levels at the G(1) phase. It has been suggested that ce...

journal_title：Journal of cell science

authors： Zhao J,Tenev T,Martins LM,Downward J,Lemoine NR

更新日期：2000-12-01 00:00:00

abstract：:Most tissues harbor a substantial population of resident macrophages. Here, we elucidate a functional link between the Slc7a7 cationic amino acid transporter and tissue macrophages. We identified a mutant zebrafish devoid of microglia due to a mutation in the slc7a7 gene. We found that in Slc7a7-deficient larvae, macr...

journal_title：Journal of cell science

authors： Demy DL,Carrère M,Noche R,Tauzin M,Le Bris M,Baek C,Leshchiner I,Goessling W,Herbomel P

更新日期：2020-10-22 00:00:00

abstract：:Multinucleated muscle fibres arise by fusion of precursor cells called myoblasts. We previously showed that CKIP-1 ectopic expression in C2C12 myoblasts increased cell fusion. In this work, we report that CKIP-1 depletion drastically impairs C2C12 myoblast fusion in vitro and in vivo during zebrafish muscle developmen...

journal_title：Journal of cell science

authors： Baas D,Caussanel-Boude S,Guiraud A,Calhabeu F,Delaune E,Pilot F,Chopin E,Machuca-Gayet I,Vernay A,Bertrand S,Rual JF,Jurdic P,Hill DE,Vidal M,Schaeffer L,Goillot E

更新日期：2012-08-15 00:00:00

abstract：:Ezrin/radixin/moesin (ERM) proteins are thought to play an important role in organizing cortical actin-based cytoskeletons through cross-linkage of actin filaments with integral membrane proteins. Recent in vitro biochemical studies have revealed that ERM proteins phosphorylated on their COOH-terminal threonine residu...

journal_title：Journal of cell science

authors： Hayashi K,Yonemura S,Matsui T,Tsukita S

更新日期：1999-04-01 00:00:00

abstract：:A UV-damaged DNA binding protein (UV-DDB) is the major source of UV-damaged DNA binding activity in mammalian cell extracts. This activity is defective in at least some xeroderma pigmentosum group E (XP-E) patients; microinjection of the UV-DDB protein into their fibroblasts corrects nucleotide excision repair (NER). ...

journal_title：Journal of cell science

authors： Otrin VR,McLenigan M,Takao M,Levine AS,Protić M

更新日期：1997-05-01 00:00:00

abstract：:Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their ...

journal_title：Journal of cell science

authors： Bernkopf DB,Hadjihannas MV,Behrens J

更新日期：2015-01-01 00:00:00

abstract：:The plasma membrane of cells is composed of lateral heterogeneities, patches and microdomains. These membrane microdomains or lipid rafts are enriched in glycosphingolipids and cholesterol and have been implicated in cellular processes such as membrane sorting and signal transduction. In this study we investigated the...

journal_title：Journal of cell science

authors： Triantafilou M,Miyake K,Golenbock DT,Triantafilou K

更新日期：2002-06-15 00:00:00

abstract：:Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteolytic enzymes are implicated in a variety of physiological processes, such as collagen maturation, organogenesis, angiogenesis, reproduction and inflammation. Moreover, deficiency or overexpression of certain ADAMTS ...

journal_title：Journal of cell science

authors： Llamazares M,Obaya AJ,Moncada-Pazos A,Heljasvaara R,Espada J,López-Otín C,Cal S

更新日期：2007-10-15 00:00:00

abstract：:Actin-based myosin motors have a pivotal role in intracellular trafficking in eukaryotic cells. The parasitic protozoan organism Leishmania expresses a novel class of myosin, myosin XXI (Myo21), which is preferentially localized at the proximal region of the flagellum. However, its function in this organism remains la...

journal_title：Journal of cell science

authors： Katta SS,Tammana TV,Sahasrabuddhe AA,Bajpai VK,Gupta CM

更新日期：2010-06-15 00:00:00

abstract：:A line of null mice has been produced which fails to express the transmembrane chondroitin sulfate proteoglycan NG2. Homozygous NG2 null mice do not exhibit gross phenotypic differences from wild-type mice, suggesting that detailed analyses are required to detect subtle alterations caused by the absence of NG2. Accord...

journal_title：Journal of cell science

authors： Grako KA,Ochiya T,Barritt D,Nishiyama A,Stallcup WB

更新日期：1999-03-01 00:00:00

abstract：:The roles of P21-activated kinase (PAK) in the regulation of axon outgrowth downstream of extracellular matrix (ECM) proteins are poorly understood. Here we show that PAK1-3 and PIX are expressed in the developing spinal cord and differentially localize to point contacts and filopodial tips within motile growth cones....

journal_title：Journal of cell science

authors： Santiago-Medina M,Gregus KA,Gomez TM

更新日期：2013-03-01 00:00:00

abstract：:Cryo-ultramicrotomy and X-ray microanalysis were used to study the elemental composition of HeLa S3 cells. Quantitation was achieved by reference to elemental standards of known concentration made up in 25% gelatin. Analysis of standards showed linear calibration for each of the elements studied: Na, P, S, Cl, K. Stan...

journal_title：Journal of cell science

authors： Warley A,Stephen J,Hockaday A,Appleton TC

更新日期：1983-03-01 00:00:00

abstract：:During pre-mRNA splicing, introns are removed and exons are ligated to form an mRNA. Exon choice is determined by different nuclear protein concentrations varying among tissues and cell types or by developmental stage. These can be altered by different cellular circumstances such as physiological stimuli, environmenta...

journal_title：Journal of cell science

authors： Shomron N,Alberstein M,Reznik M,Ast G

更新日期：2005-03-15 00:00:00

abstract：:Chloroquine resistance in the human malaria parasite, Plasmodium falciparum, arises from decreased accumulation of the drug in the ;digestive vacuole' of the parasite, an acidic compartment in which chloroquine exerts its primary toxic effect. It has been proposed that changes in the pH of the digestive vacuole might ...

journal_title：Journal of cell science

authors： Hayward R,Saliba KJ,Kirk K

更新日期：2006-03-15 00:00:00

abstract：:The small GTPase Rac contributes to regulation of cytoskeletal rearrangement during chemokine-induced lymphocyte adhesion and migration in a multi-step process that is very precisely coordinated. Chimaerins are Rac1-specific GTPase-activating proteins of unknown biological function, which have a canonical diacylglycer...

journal_title：Journal of cell science

authors： Siliceo M,García-Bernal D,Carrasco S,Díaz-Flores E,Coluccio Leskow F,Teixidó J,Kazanietz MG,Mérida I

更新日期：2006-01-01 00:00:00

abstract：:Mechanical cues are essential for the regulation of cell and tissue physiology. Hence, it has become an utmost necessity for cell biologists to account for those mechanical parameters when investigating biological processes and they need devices to manipulate cells accordingly. Here, we report a simple mechanical cell...

journal_title：Journal of cell science

authors： Boulter E,Tissot FS,Dilly J,Pisano S,Féral CC

更新日期：2020-01-06 00:00:00

abstract：:The end1 mutant belongs to a group of four vacuolar protein sorting mutants (class C vps) that lack a morphologically distinguishable and functional vacuole. These mutants share several other phenotypes, such as the inability to grow at 37 degrees C or on nonfermentable carbon sources. We show that, as in the case of ...

journal_title：Journal of cell science

authors： Dulić V,Riezman H

更新日期：1990-11-01 00:00:00

abstract：:Cardiac fibrosis is linked to fibroblast-to-myofibroblast phenoconversion and proliferation but the mechanisms underlying this are poorly understood. Ski is a negative regulator of TGF-β-Smad signaling in myofibroblasts, and might redirect the myofibroblast phenotype back to fibroblasts. Meox2 could alter TGF-β-mediat...

journal_title：Journal of cell science

authors： Cunnington RH,Northcott JM,Ghavami S,Filomeno KL,Jahan F,Kavosh MS,Davies JJ,Wigle JT,Dixon IM

更新日期：2014-01-01 00:00:00

abstract：:Junction dynamics of endothelial cells are based on the integration of signal transduction, cytoskeletal remodeling and contraction, which are necessary for the formation and maintenance of monolayer integrity, but also enable repair and regeneration. The VE-cadherin-catenin complex forms the molecular basis of the ad...

journal_title：Journal of cell science

authors： Cao J,Schnittler H

更新日期：2019-01-03 00:00:00

abstract：:The oligosaccharyltransferase (OST) complex catalyses the N-glycosylation of polypeptides entering the endoplasmic reticulum, a process essential for the productive folding and trafficking of many secretory and membrane proteins. In eukaryotes, the OST typically comprises a homologous catalytic STT3 subunit complexed ...

journal_title：Journal of cell science

authors： Roboti P,High S

更新日期：2012-01-01 00:00:00

abstract：:Errors in mitotic chromosome segregation can lead to DNA damage and aneuploidy, both hallmarks of cancer. To achieve synchronous error-free segregation, mitotic chromosomes must align at the metaphase plate with stable amphitelic attachments to microtubules emanating from opposing spindle poles. The astrin-kinastrin (...

journal_title：Journal of cell science

authors： Geraghty Z,Barnard C,Uluocak P,Gruneberg U

更新日期：2021-01-08 00:00:00

abstract：:Major histocompatibility complex class I (MHC-I) molecules signal infection or transformation by engaging receptors on T lymphocytes. The spatial organization of MHC-I on the plasma membranes is important for this engagement. We and others have shown that MHC-I molecules, like other membrane proteins, are not uniforml...

journal_title：Journal of cell science

authors： Blumenthal D,Edidin M,Gheber LA

更新日期：2016-09-01 00:00:00

abstract：:Tetrahymena thermophila swims by the coordinated beating of hundreds of cilia that cover its body. It has been proposed that the outer arm dyneins of the ciliary axoneme control beat frequency, whereas the inner arm dyneins control waveform. To test the role of one of these inner arms, dynein heavy chain 7 protein (Dy...

journal_title：Journal of cell science

authors： Wood CR,Hard R,Hennessey TM

更新日期：2007-09-01 00:00:00

abstract：:During meiotic prophase in the ciliate Tetrahymena thermophila micronuclei dramatically elongate and form thread-like crescents. The arrangement of the chromosomes within the crescent as well as the timing of chromosome pairing and recombination with respect to the elongation process have been subjects of ongoing deba...

journal_title：Journal of cell science

authors： Loidl J,Scherthan H

更新日期：2004-11-15 00:00:00

abstract：:p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide array of cell biology. p63 isoforms are implicated in lineage specification, proliferative potential, differentiation, cell death and ...

journal_title：Journal of cell science

authors： Fisher ML,Balinth S,Mills AA

更新日期：2020-09-11 00:00:00

abstract：:Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGFβ1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK) is a central adapter recruited to integrin β1 tails in focal adhesions mediating the communication between cells and extracellular matrix. Here, we...

journal_title：Journal of cell science

authors： Blumbach K,Zweers MC,Brunner G,Peters AS,Schmitz M,Schulz JN,Schild A,Denton CP,Sakai T,Fässler R,Krieg T,Eckes B

更新日期：2010-11-15 00:00:00

abstract：:T cell activation is accompanied by actin-mediated receptor clustering and reorganization of lipid rafts. It has been suggested that costimulatory molecules might be involved in these processes. We here provide evidence that engagement of the adhesion molecule CD44 initiates cytoskeletal rearrangement and membrane reo...

journal_title：Journal of cell science

authors： Föger N,Marhaba R,Zöller M

更新日期：2001-03-01 00:00:00