Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin.

abstract：:The development or maturation of intercellular adhesions following their initiation has received very little attention even though this is an area of significance for a variety of in vivo processes. Using Ca2(+)-induced desmosome formation in MDCK cells as a study system it is shown that, following its initiation, des...

journal_title：Journal of cell science

authors： Mattey DL,Burdge G,Garrod DR

更新日期：1990-12-01 00:00:00

abstract：:Lysosomal cysteine proteases from mammalian cells and plants are regulated by endogenous tight-binding inhibitors from the cystatin superfamily. The presence of cystatin-like inhibitors in lower eukaryotes such as protozoan parasites has not yet been demonstrated, although these cells express large quantities of cyste...

journal_title：Journal of cell science

authors： Monteiro AC,Abrahamson M,Lima AP,Vannier-Santos MA,Scharfstein J

更新日期：2001-11-01 00:00:00

abstract：:A comprehensive analysis of the molecular network of cellular factors establishing and maintaining pluripotency as well as self renewal of pluripotent stem cells is key for further progress in understanding basic stem cell biology. Nanog is necessary for the natural induction of pluripotency in early mammalian develop...

journal_title：Journal of cell science

authors： Münst B,Thier MC,Winnemöller D,Helfen M,Thummer RP,Edenhofer F

更新日期：2016-03-01 00:00:00

abstract：:Endothelial cell-based angiogenesis requires activation of survival signals that generate resistance to external apoptotic stimuli, such as tumor necrosis factor-alpha (TNF-alpha), during pathobiologic settings. Mechanisms by which this is achieved are not fully defined. Here, we use a model in which the multifunction...

journal_title：Journal of cell science

authors： Kang-Decker N,Cao S,Chatterjee S,Yao J,Egan LJ,Semela D,Mukhopadhyay D,Shah V

更新日期：2007-02-01 00:00:00

abstract：:Deleted in liver cancer 1 (DLC1) is a multi-modular Rho-GTPase-activating protein (RhoGAP) and a tumor suppressor. Besides its RhoGAP domain, functions of other domains in DLC1 remain largely unknown. By protein precipitation and mass spectrometry, we identified eukaryotic elongation factor 1A1 (EF1A1) as a novel part...

journal_title：Journal of cell science

authors： Zhong D,Zhang J,Yang S,Soh UJ,Buschdorf JP,Zhou YT,Yang D,Low BC

更新日期：2009-02-01 00:00:00

abstract：:The extracellular environment and tissue architecture contribute to proper cell function and growth control. Cells growing in monolayers on standard polystyrene tissue culture plates differ in their shape, growth rate and response to external stimuli, compared with cells growing in vivo. Here, we showed that the EGFR ...

journal_title：Journal of cell science

authors： Mizushima H,Wang X,Miyamoto S,Mekada E

更新日期：2009-12-01 00:00:00

abstract：:A high molecular weight tight junction-associated protein, ZO-1, has been demonstrated in liver (hepatocytes) and in both epithelium and endothelium. We carried out studies to examine the presence of the protein in vascular endothelial cell cultures and several other types of cultured cells, and the relationship betwe...

journal_title：Journal of cell science

authors： Li CX,Poznansky MJ

更新日期：1990-10-01 00:00:00

abstract：:Alpha-satellite (alphoid) DNA is necessary for de novo formation of human artificial chromosomes (HACs) in human cultured cells. To investigate the relationship among centromeric, transcriptionally permissive and non-permissive chromatin assemblies on de novo HAC formation, we constructed bacterial artificial chromoso...

journal_title：Journal of cell science

authors： Nakashima H,Nakano M,Ohnishi R,Hiraoka Y,Kaneda Y,Sugino A,Masumoto H

更新日期：2005-12-15 00:00:00

abstract：:Several cell types express inducible nitric oxide synthase (NOS2) in response to exogenous insults such as bacterial lipopolysaccharide (LPS) or proinflammatory cytokines. For instance, muscular cells treated with LPS and interferon gamma (IFN-gamma) respond by increasing the mRNA and protein levels of NOS2, and synth...

journal_title：Journal of cell science

authors： Navarro-Lérida I,Portolés MT,Barrientos AA,Gavilanes F,Boscá L,Rodríguez-Crespo I

更新日期：2004-04-01 00:00:00

abstract：:The semaphorin family comprises soluble and membrane-bound proteins originally identified as axonal guidance cues that function during neuronal development. Emerging evidence suggests that a subset of semaphorins, called 'immune semaphorins', function in the immune system. The class IV semaphorins Sema4D/CD100 and Sem...

journal_title：Journal of cell science

authors： Kumanogoh A,Kikutani H

更新日期：2003-09-01 00:00:00

abstract：:Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous system, facilitates water movement into and out of the brain. Here, we identify a novel role for aquaporin-4 in astroglial cell migration, as occurs during glial scar formation. Astroglia cultured from the neocortex of aquaporin...

journal_title：Journal of cell science

authors： Saadoun S,Papadopoulos MC,Watanabe H,Yan D,Manley GT,Verkman AS

更新日期：2005-12-15 00:00:00

abstract：:Axonemal precursor tubulin is the major protein component of the detergent-soluble membrane/matrix fraction of sea urchin embryonic cilia. Its unusual abundance may reflect the rapid turnover of these cilia, a process that is further documented here. However, whether during induced regeneration or normal turnover and ...

journal_title：Journal of cell science

authors： Stephens RE

更新日期：1994-02-01 00:00:00

abstract：:Host/symbiont specificity has been investigated in non-symbiotic and aposymbiotic brown and green hydra infected with various free-living and symbiotic species and strains of Chlorella and Chlorococcum. Morphology and ultrastructure of the symbioses obtained have been compared. Aposymbiotic Swiss Hydra viridis and Jap...

journal_title：Journal of cell science

authors： Rahat M,Reich V

更新日期：1986-12-01 00:00:00

abstract：:Export out of the endoplasmic reticulum (ER) involves the Sar1 and COPII machinery acting at ER exit sites (ERES). Whether and how cargo proteins are recruited upstream of Sar1 and COPII is unclear. Two models are conceivable, a recruitment model where cargo is actively transported through a transport factor and hande...

journal_title：Journal of cell science

authors： Yonemura Y,Li X,Müller K,Krämer A,Atigbire P,Mentrup T,Feuerhake T,Kroll T,Shomron O,Nohl R,Arndt HD,Hoischen C,Hemmerich P,Hirschberg K,Kaether C

更新日期：2016-10-15 00:00:00

abstract：:The repair of injured tissue must occur rapidly to prevent microbial invasion and maintain tissue integrity. Epithelial tissues in particular, which serve as a barrier against the external environment, must repair efficiently in order to restore their primary function. Here we analyze the effect of different parameter...

journal_title：Journal of cell science

authors： Abreu-Blanco MT,Verboon JM,Liu R,Watts JJ,Parkhurst SM

更新日期：2012-12-15 00:00:00

abstract：:Although the 11.5 kDa Zn(2+)-binding protein (ZnBP, parathymosin-alpha) possesses a functional bipartite nuclear localization signal it was found in most tissues in the cytoplasm. The cultivation of freshly isolated rat hepatocytes for 24 hours under standard conditions was associated with an almost complete transloca...

journal_title：Journal of cell science

authors： Trompeter HI,Schiermeyer A,Blankenburg G,Hennig E,Söling HD

更新日期：1999-11-01 00:00:00

abstract：:The sclerotome portion of the differentiating embryonic chick somite becomes infiltrated by neural crest cells prior to its dispersal towards the embryonic axis. This means that sclerotome cells explanted into culture for the purpose of examining their interactions in vitro are contaminated with a proportion of neural...

journal_title：Journal of cell science

authors： Sanders EJ,Cheung E

更新日期：1988-05-01 00:00:00

abstract：:Podosomes are actin-rich adhesion and invasion structures. Especially in macrophages, podosomes exist in two subpopulations, large precursors at the cell periphery and smaller podosomes (successors) in the cell interior. To date, the mechanisms that differentially regulate these subpopulations are largely unknown. Her...

journal_title：Journal of cell science

authors： Bhuwania R,Cornfine S,Fang Z,Krüger M,Luna EJ,Linder S

更新日期：2012-05-01 00:00:00

abstract：:Autophagy is a pivotal cytoprotective process that secures cellular homeostasis, fulfills essential roles in development, immunity and defence against pathogens, and determines the lifespan of eukaryotic organisms. However, autophagy also crucially contributes to the development of age-related human pathologies, inclu...

journal_title：Journal of cell science

authors： Proikas-Cezanne T,Takacs Z,Dönnes P,Kohlbacher O

更新日期：2015-01-15 00:00:00

abstract：:An electron microscopic investigation of the events associated with meiosis in Lilium has revealed a number of changes in both the organellar population and the other cytoplasmic components. Ribosome numbers decrease significantly in early prophase and are later replenished in the tetrads, a process most likely involv...

journal_title：Journal of cell science

authors： Bird J,Porter EK,Dickinson HG

更新日期：1983-01-01 00:00:00

abstract：:In Drosophila, telomere-capping proteins have the remarkable capacity to recognize chromosome ends in a sequence-independent manner. This epigenetic protection is essential to prevent catastrophic ligations of chromosome extremities. Interestingly, capping proteins occupy a large telomere chromatin domain of several k...

journal_title：Journal of cell science

authors： Dubruille R,Loppin B

更新日期：2015-05-15 00:00:00

abstract：:A major challenge in biology is to understand how genetic information is interpreted to direct the formation of specialized tissues within a multicellular organism. During differentiation, changes in chromatin structure and nuclear organization establish heritable patterns of gene expression in response to signals. Ep...

journal_title：Journal of cell science

authors： Arney KL,Fisher AG

更新日期：2004-09-01 00:00:00

abstract：:The myosin regulatory light chain (RLC) of Dictyostelium discoideum is phosphorylated at a single serine site in response to chemoattractant. To investigate the role of the phosphorylation of RLC in both motility and chemotaxis, mutants were generated in which the single phosphorylatable serine was replaced with a non...

journal_title：Journal of cell science

authors： Zhang H,Wessels D,Fey P,Daniels K,Chisholm RL,Soll DR

更新日期：2002-04-15 00:00:00

abstract：:Rab GTPases are key regulators of intracellular trafficking, and cycle between a GTP-bound active state and a GDP-bound inactive state. This cycle is regulated by guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Several efforts have been made in connecting the correct GEFs and GAPs to ...

journal_title：Journal of cell science

authors： Borg Distefano M,Hofstad Haugen L,Wang Y,Perdreau-Dahl H,Kjos I,Jia D,Morth JP,Neefjes J,Bakke O,Progida C

更新日期：2018-09-03 00:00:00

abstract：:Interaction of cationized ferritin with the anionic groups on the cell surface of Naegleria was studied using transmission electron microscopy in conjunction with fluorescence microscopy. Most of the experiments involved the use of fluorescein-labelled cationized ferritin (FITC-CF) incubated with living amoebae. Initi...

journal_title：Journal of cell science

authors： King CA,Preston TM

更新日期：1977-12-01 00:00:00

abstract：:Interstitial stem cells in Hydra are rapidly proliferating multipotent stem cells which continuously give rise to precursors for nerve and nematocyte differentiation. Growth of the stem cell population is controlled by the cell cycle time of the stem cells and the self-renewal probability, Ps (the fraction of stem cel...

journal_title：Journal of cell science

authors： Sproull F,David CN

更新日期：1979-08-01 00:00:00

abstract：:The intracellular protozoan parasite Toxoplasma gondii, like all members of the phylum Apicomplexa, is known to possess many organelles: in addition to mitochondria and the compartments of the secretory pathway, there is a reduced chloroplast (the apicoplast) and the phylum-specific components of the apical complex: d...

journal_title：Journal of cell science

authors： Ding M,Clayton C,Soldati D

更新日期：2000-07-01 00:00:00

abstract：:The alpha6beta4 integrin is located at the basal surface of keratinocytes, in hemidesmosomal structures that mediate stable adhesion of epidermal cells to the underlying basement membrane component laminin-5. The absence of alpha6beta4 integrin causes junctional epidermolysis bullosa, a severe blistering disease of th...

journal_title：Journal of cell science

authors： Raymond K,Kreft M,Janssen H,Calafat J,Sonnenberg A

更新日期：2005-03-01 00:00:00

abstract：:Previous studies have shown that the non-alpha-helical, amino-terminal head region of vimentin is essential for the formation and stability of vimentin intermediate filaments (IFs). In order to specify its target site on companion protein subunits, it was cut off from vimentin at amino acid position 96 with lysine-spe...

journal_title：Journal of cell science

authors： Traub P,Scherbarth A,Wiegers W,Shoeman RL

更新日期：1992-02-01 00:00:00

abstract：:We have previously shown that the total actin content of tumorigenic HeLa/fibroblast somatic cell hybrids is significantly lower than that of the non-tumorigenic hybrid cells. A measure of actin synthesis, relative to total protein synthesis, was obtained for these cells to determine whether the reduced actin content ...

journal_title：Journal of cell science

authors： Gowing LR,Tellam RL,Banyard MR

更新日期：1985-06-01 00:00:00