Abstract：
:The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis and tissue homeostasis. The two organelles are mutually exclusive. The centriole/basal body is found at the core of the centrosome (centriole) or at the base of the cilium (basal body) and to change which organelle is present in a cell requires modification to the centriole/basal body both in terms of composition and sub-cellular localisation. While many protein components required for centrosome and cilium biogenesis have been described, there are far fewer known inhibitors of ciliogenesis. Here, we show that a protein called BCAP and labelled in the sequence databases as ODF2-like (ODF2L) is a ciliation inhibitor. We show that it is a centriolar satellite protein. Furthermore, our data suggest that BCAP exists as two isoforms with subtly different roles in inhibition of ciliogenesis. Both are required to prevent ciliogenesis and one additionally controls cilium length after ciliogenesis has completed.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
de Saram P,Iqbal A,Murdoch JN,Wilkinson CJdoi
10.1242/jcs.196642subject
Has Abstractpub_date
2017-10-01 00:00:00pages
3360-3373issue
19eissn
0021-9533issn
1477-9137pii
jcs.196642journal_volume
130pub_type
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