mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes.

abstract：:Keratins 8 and 18 (collectively referred to as K8/K18) are the major components of intermediate filaments of simple epithelial cells. Recent studies have revealed the function of K8/K18 in apoptosis modulation. Here, we show that eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation...

journal_title：Journal of cell science

authors： Lin YM,Chen YR,Lin JR,Wang WJ,Inoko A,Inagaki M,Wu YC,Chen RH

更新日期：2008-07-15 00:00:00

abstract：:ABCG2 belongs to the ATP-binding cassette superfamily of transmembrane proteins and is ubiquitously expressed in stem cells including those in the developing nervous system. The ability of ABCG2 to preferentially exclude DNA-intercalating dyes is regarded to be the basis for the enrichment of stem cells or progenitors...

journal_title：Journal of cell science

authors： Bhattacharya S,Das A,Mallya K,Ahmad I

更新日期：2007-08-01 00:00:00

abstract：:Using a series of chimeric and truncated N-acetylglucosaminyltransferase I (NAGT I) molecules we have shown that part of the lumenal stalk region is both necessary and sufficient for kin recognition of mannosidase II and retention in the Golgi stack. The membrane-spanning domain was not required for retention, but rep...

journal_title：Journal of cell science

authors： Nilsson T,Rabouille C,Hui N,Watson R,Warren G

更新日期：1996-07-01 00:00:00

abstract：:The GGGGCC (G4C2) repeat expansion mutation in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Transcription of the repeat and formation of nuclear RNA foci, which sequester specific RNA-binding proteins, is one of the possible pathological me...

journal_title：Journal of cell science

authors： Bajc Česnik A,Darovic S,Prpar Mihevc S,Štalekar M,Malnar M,Motaln H,Lee YB,Mazej J,Pohleven J,Grosch M,Modic M,Fonovič M,Turk B,Drukker M,Shaw CE,Rogelj B

更新日期：2019-03-07 00:00:00

abstract：:The actin-dependent sensory and response elements of stromal cells that are involved in mechanical signal transduction are poorly understood. To study mechanotransduction we have described previously a collagen-magnetic bead model in which application of well-defined forces to integrins induces an immediate (< 1 secon...

journal_title：Journal of cell science

authors： Glogauer M,Arora P,Yao G,Sokholov I,Ferrier J,McCulloch CA

更新日期：1997-01-01 00:00:00

abstract：:Nemaline myopathy (NM) is a congenital myopathy with an estimated incidence of 150,000 live births. It is caused by mutations in thin filament components, including nebulin, which accounts for about 50% of the cases. The identification of NM cases with nonsense mutations resulting in loss of the extreme C-terminal SH3...

journal_title：Journal of cell science

authors： Yamamoto DL,Vitiello C,Zhang J,Gokhin DS,Castaldi A,Coulis G,Piaser F,Filomena MC,Eggenhuizen PJ,Kunderfranco P,Camerini S,Takano K,Endo T,Crescenzi M,Luther PK,Lieber RL,Chen J,Bang ML

更新日期：2013-12-01 00:00:00

abstract：:It is now becoming clear that additional transmembrane components can modify integrin-mediated adhesion. Syndecan-4 is a transmembrane heparan sulfate proteoglycan whose external glycosaminoglycan chains can bind extracellular matrix ligands and whose core protein cytoplasmic domain can signal during adhesion. Two pap...

journal_title：Journal of cell science

authors： Couchman JR,Woods A

更新日期：1999-10-01 00:00:00

abstract：:Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous system, facilitates water movement into and out of the brain. Here, we identify a novel role for aquaporin-4 in astroglial cell migration, as occurs during glial scar formation. Astroglia cultured from the neocortex of aquaporin...

journal_title：Journal of cell science

authors： Saadoun S,Papadopoulos MC,Watanabe H,Yan D,Manley GT,Verkman AS

更新日期：2005-12-15 00:00:00

abstract：:Annexins are cytosolic phospholipid-binding proteins that can be found on the outer leaflet of the plasma membrane. The extracellular functions of annexin include modulating fibrinolysis activity and cell migration. Despite having well-described extracellular functions, the mechanism of annexin transport from the cyto...

journal_title：Journal of cell science

authors： Stewart SE,Ashkenazi A,Williamson A,Rubinsztein DC,Moreau K

更新日期：2018-07-19 00:00:00

abstract：:In adipocytes and muscle cells, the GLUT4 glucose transporter isoform is present in intracellular vesicles which continuously recycle between an intracytoplasmic location and the plasma membrane. It is not clear whether the GLUT4-vesicles represent a specific kind of vesicle or resemble typical secretory granules or s...

journal_title：Journal of cell science

authors： Thorens B,Roth J

更新日期：1996-06-01 00:00:00

abstract：:Current methodologies for targeting the mitochondrial genome for research and/or therapy development in mitochondrial diseases are restricted by practical limitations and technical inflexibility. A molecular toolbox for CRISPR-mediated mitochondrial genome editing is desirable, as this could enable targeting of mtDNA ...

journal_title：Journal of cell science

authors： Antón Z,Mullally G,Ford HC,van der Kamp MW,Szczelkun MD,Lane JD

更新日期：2020-09-16 00:00:00

abstract：:Actin polymerization is a crucial process during sperm capacitation. We have recently described the participation of FAK during actin polymerization in guinea pig spermatozoa. However, the mechanism by which FAK mediates these processes is unknown. Our previous data have shown that MAPK1 (hereafter referred to as ERK2...

journal_title：Journal of cell science

authors： Salgado-Lucio ML,Ramírez-Ramírez D,Jorge-Cruz CY,Roa-Espitia AL,Hernández-González EO

更新日期：2020-04-28 00:00:00

abstract：:Fine-tuning of NMDA glutamatergic receptor signalling strategically controls crucial brain functions. This process depends on several ligands and modulators, one of which unexpectedly includes the serine protease tissue-type plasminogen activator (tPA). In vitro, tPA increases NMDA-receptor-mediated calcium influx by ...

journal_title：Journal of cell science

authors： Benchenane K,Castel H,Boulouard M,Bluthé R,Fernandez-Monreal M,Roussel BD,Lopez-Atalaya JP,Butt-Gueulle S,Agin V,Maubert E,Dantzer R,Touzani O,Dauphin F,Vivien D,Ali C

更新日期：2007-02-15 00:00:00

abstract：:Recent biochemical and molecular approaches have begun to establish the protein interactions that lead to desmosome assembly. To determine whether these associations occur in native desmosomes we have performed ultrastructural localisation of specific domains of the major desmosomal components and have used the result...

journal_title：Journal of cell science

authors： North AJ,Bardsley WG,Hyam J,Bornslaeger EA,Cordingley HC,Trinnaman B,Hatzfeld M,Green KJ,Magee AI,Garrod DR

更新日期：1999-12-01 00:00:00

abstract：:It has been claimed repeatedly that gamma-tubulin is exclusively localized at the spindle poles in mitotic animal cells, where it plays a role in microtubule nucleation. In addition to this localization, we have observed a gamma-tubulin-specific staining of the mitotic spindle in several animal cells (human, kangaroo ...

journal_title：Journal of cell science

authors： Lajoie-Mazenc I,Tollon Y,Detraves C,Julian M,Moisand A,Gueth-Hallonet C,Debec A,Salles-Passador I,Puget A,Mazarguil H

更新日期：1994-10-01 00:00:00

abstract：:Transcripts containing expanded CNG repeats, which are found in several neuromuscular diseases, are not exported from the nucleus and aggregate as ribonuclear inclusions by an unknown mechanism. Using the MS2-GFP system, which tethers fluorescent proteins to a specific mRNA, we followed the dynamics of single CUG-repe...

journal_title：Journal of cell science

authors： Querido E,Gallardo F,Beaudoin M,Ménard C,Chartrand P

更新日期：2011-05-15 00:00:00

abstract：:The possible involvement of osmotically generated hydrostatic pressure in driving actin-rich extensions of the cell surface was examined using cultures of chick neurons. Estimation of the excess internal osmotic pressure of chick neural tissue by vapor pressure deficit osmometry, and of the excess internal hydrostatic...

journal_title：Journal of cell science

authors： Bray D,Money NP,Harold FM,Bamburg JR

更新日期：1991-04-01 00:00:00

abstract：:Of the classical compartments of eukaryotic cells, peroxisomes were the last to be discovered. They are small, single-membrane-bound vesicles involved in cellular metabolism, most notably the beta-oxidation of fatty acids. Characterization of their properties and behavior has progressed rather slowly. However, during ...

journal_title：Journal of cell science

authors： van der Zand A,Braakman I,Geuze HJ,Tabak HF

更新日期：2006-03-15 00:00:00

abstract：:We report the first direct analysis of the endogenous β-catenin phosphorylation activity in colon cancer SW480 cells. By comparing parental SW480 cells that harbor a typical truncated adenomatous polyposis coli (APC) form, cells expressing full-length APC and APC-depleted cells, we provide the formal demonstration tha...

journal_title：Journal of cell science

authors： Wang L,Liu X,Gusev E,Wang C,Fagotto F

更新日期：2014-04-15 00:00:00

abstract：:The main neuropathological features of Parkinson's disease are dopaminergic nigrostriatal neuron degeneration, and intraneuronal and intraneuritic proteinaceous inclusions named Lewy bodies and Lewy neurites, respectively, which mainly contain α-synuclein (α-syn, also known as SNCA). The neuronal phosphoprotein synaps...

journal_title：Journal of cell science

authors： Zaltieri M,Grigoletto J,Longhena F,Navarria L,Favero G,Castrezzati S,Colivicchi MA,Della Corte L,Rezzani R,Pizzi M,Benfenati F,Spillantini MG,Missale C,Spano P,Bellucci A

更新日期：2015-07-01 00:00:00

abstract：:The atomic force microscope (AFM) was used to directly image hippocampal neurons and glia. Using chemically fixed and living cells it was possible to reconstruct three-dimensional cell structure and detect sub-cellular features such as the nucleus, mitochondria and filaments. By repeatedly scanning a single living cel...

journal_title：Journal of cell science

authors： Parpura V,Haydon PG,Henderson E

更新日期：1993-02-01 00:00:00

abstract：:Cyclic AMP-dependent protein kinase (cAPK) is the intracellular mediator of signal transduction events involving the adenylate cyclase-cyclic AMP system. A monoclonal antibody (MAb BB1) to the type II regulatory subunit (RII) of cAPK was used in a post-embedding immunogold-labeling procedure to determine the ultrastru...

journal_title：Journal of cell science

authors： Hand AR,Mednieks MI

更新日期：1989-08-01 00:00:00

abstract：:HT-29 cells selected by adaptation to 10(-5) M methotrexate (HT-29 MTX) are a homogeneous cell population producing high amounts of mucin. Intracellular mucins and proteoglycans were isolated from these cells by ultracentrifugation of cell lysates on a cesium bromide gradient and further separated by anion-exchange hi...

journal_title：Journal of cell science

authors： Huet G,Kim I,de Bolos C,Lo-Guidice JM,Moreau O,Hemon B,Richet C,Delannoy P,Real FX,Degand P

更新日期：1995-03-01 00:00:00

abstract：:During neuronal development, netrin and its receptors UNC5 and DCC (deleted in colorectal cancer) guide axonal growth cones in navigating to their targets. Netrin also plays important roles in the regulation of cell migration, tissue morphogenesis and tumor growth. Here, we show that netrin induces UNC5 tyrosine phosp...

journal_title：Journal of cell science

authors： Li W,Aurandt J,Jürgensen C,Rao Y,Guan KL

更新日期：2006-01-01 00:00:00

abstract：:Recently, we demonstrated in cultured endothelial cells and in vivo that deficiency of an isoform of intersectin-1, ITSN-1s, impairs caveolae and clathrin-mediated endocytosis and functionally upregulates compensatory pathways and their morphological carriers (i.e. enlarged endocytic structures, membranous rings or tu...

journal_title：Journal of cell science

authors： Bardita C,Predescu DN,Sha F,Patel M,Balaji G,Predescu SA

更新日期：2015-04-15 00:00:00

abstract：:Iron (Fe(2+), Fe(3+)) homeostasis is a tightly regulated process, involving precise control of iron influx and egress from cells. Although the mechanisms of its import into cells by iron carrier molecules are well characterized, iron export remains poorly understood. The current paradigm envisages unique functions ass...

journal_title：Journal of cell science

authors： Sheokand N,Malhotra H,Kumar S,Tillu VA,Chauhan AS,Raje CI,Raje M

更新日期：2014-10-01 00:00:00

abstract：:Structures retaining many of the morphological features of nuclei may be released by gently lysing human cells in solutions containing non-ionic detergents and high concentrations of salt. These nucleoids contain superhelical DNA. Using a double-labelling procedure we have compared, at different salt concentrations, t...

journal_title：Journal of cell science

authors： Levin JM,Jost E,Cook PR

更新日期：1978-02-01 00:00:00

abstract：:The novel concept of a centrosomal anchoring complex, which is distinct from the gamma-tubulin nucleating complex, has previously been proposed following studies on cochlear epithelial cells. In this investigation we present evidence from two different cell systems which suggests that the centrosomal protein ninein is...

journal_title：Journal of cell science

authors： Mogensen MM,Malik A,Piel M,Bouckson-Castaing V,Bornens M

更新日期：2000-09-01 00:00:00

abstract：:Myogenic differentiation in adult muscle is normally suppressed and can be activated by myogenic cues in a subset of activated satellite cells. The switch mechanism that turns myogenesis on and off is not defined. In the present study, we demonstrate that tissue inhibitor of metalloproteinase 3 (TIMP3), the endogenous...

journal_title：Journal of cell science

authors： Liu H,Chen SE,Jin B,Carson JA,Niu A,Durham W,Lai JY,Li YP

更新日期：2010-09-01 00:00:00

abstract：:Myofibrillar proteins assemble to form the highly ordered repetitive contractile structural unit known as a sarcomere. Studies of myogenesis in vertebrate cell culture and embryonic developmental systems have identified some of the processes involved during sarcomere formation. However, isoform changes during vertebra...

journal_title：Journal of cell science

authors： Nongthomba U,Clark S,Cummins M,Ansari M,Stark M,Sparrow JC

更新日期：2004-04-01 00:00:00