Abstract:
:Nonspecific vasodilatation during iontophoresis is an important confounding factor in experimental pharmacology. In this investigation, we studied the involvement of sensory nerves and histamine-related reactions in causing nonspecific vasodilatation in a model of anodal and cathodal iontophoresis of sodium chloride. Firstly, we applied a mixture of local anesthetic (EMLA) cream to confirm its suppressive effect on nonspecific vasodilatation and to measure its efficacy in three different dosages (duration: 1, 2, and 3 h). We then investigated the role of histamine in nonspecific vasodilatation by giving an oral antihistamine drug (cetirizine) to subjects who had and had not been given EMLA. We found substantial suppression of the nonspecific vasodilatation in all EMLA-treated groups (all dosages) compared with untreated controls (with suppression rates of 60-65%). Dosage had no significant effect. A further suppression of nonspecific vasodilatation was seen after oral cetirizine during anodal and cathodal iontophoresis in both EMLA-treated and untreated groups. The antihistamine effect was most pronounced during anodal iontophoresis. These results suggest a histaminergic increase in perfusion that may be independent of neurogenic mechanisms and depend on polarity (anode or cathode). Local nerve blocks (EMLA) together with cetirizine may therefore be used to reduce nonspecific vasodilatation in both anodal and cathodal iontophoresis.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Horiuchi Y,Droog EJ,Henricson J,Wikström T,Lennquist S,Sjöberg Fdoi
10.1016/j.mvr.2003.12.002keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
192-6issue
2eissn
0026-2862issn
1095-9319pii
S0026286203001213journal_volume
67pub_type
杂志文章abstract::Developing tissue engineering approaches to generate functional vascular networks is important for improving treatments of peripheral and cardiovascular disease. Endothelial colony forming cells (ECFCs) are an endothelial progenitor cell (EPC) population defined by high proliferative potential and an ability to vascul...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2010.03.001
更新日期:2010-07-01 00:00:00
abstract::We examined the influence of local cooling (-15 degrees C, 60 sec) on blood flow velocity in nailfold capillaries and on laser Doppler flux (LDF) at the fingertip in 12 patients with primary Raynaud's phenomenon (PRP) and 13 patients with secondary Raynaud's (SRP) in comparison with 10 health controls. Skin temperatur...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1993.1060
更新日期:1993-11-01 00:00:00
abstract::This study determined the contribution of cytochrome P450 (CP450) 4A enzyme metabolites of arachidonic acid in mediating the constriction of isolated rat skeletal muscle resistance arteries in response to elevated PO2. Gracilis arteries (GA) were viewed via television microscopy and constrictor responses to elevated P...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2001.2341
更新日期:2001-11-01 00:00:00
abstract::The purpose of this study was to elucidate the mechanism by which bradykinin (BK) enhances prostacyclin (PGI(2)) production in human umbilical vein endothelial cells (HUVEC). BK-induced enhancement of PGI(2) synthesis was observed in a dose- and time-dependent manner, and it also increased [Ca(2+)](i) followed by enha...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2163
更新日期:1999-09-01 00:00:00
abstract::In preeclampsia, invasion of intrauterine decidual blood vessels by placental cytotrophoblasts is significantly reduced. This study examined the secretion of matrix metalloproteinases (MMP) by cultured human decidual endothelial cells from normal (NDEC) and preeclamptic (PEDEC) pregnancies. MMPs secreted into the cult...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1998.2142
更新日期:1999-05-01 00:00:00
abstract::Angiotensin II (Ang II), the dominant effector of the renin-angiotensin system, elicits numerous inflammatory-proliferative responses, thereby being involved in angiogenesis. T cells play an important role in angiogenesis as well by delivering vascular endothelial growth factor (VEGF) to inflammatory sites. Since we h...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2006.03.001
更新日期:2006-05-01 00:00:00
abstract::P120 catenin (p120ctn) belongs to the family of Armadillo repeat-containing proteins, which are believed to have dual functions of cell-cell adhesion and transcriptional regulation. In vascular endothelium, p120ctn is mostly recognized for its cell-cell adhesion function through its ability to regulate VE-cadherin. Th...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2010.04.001
更新日期:2010-09-01 00:00:00
abstract::A simple model has been developed for simulation of oxygen transport to and from blood flowing in conduits of the diameter of arterioles and larger (greater than or equal to 20 microns). The basis is the large capillary model (LCAP) of P.K. Nair, et al. 1989 which has been validated experimentally. Detailed calculatio...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(90)90070-8
更新日期:1990-03-01 00:00:00
abstract::This study was undertaken to determine if coronary vascular permeability (CVP) increases and if myocardial edema develops in the canine heart after local exposure to histamine. Histamine (50 or 15 micrograms/min) or compound 48/80 (0.1-0.2 mg/kg) was infused into the left anterior descending coronary artery (LAD) of o...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(91)90034-9
更新日期:1991-05-01 00:00:00
abstract::The fluidity (the inverse of viscosity) of red blood cell (RBC) suspensions in vivo was estimated by means of microcirculatory measurements such as RBC flow velocity, micropressure in arterioles and venules, and vessel geometry, and by means of simultaneous macrocirculatory measurements such as volume flow and perfusi...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(88)90051-9
更新日期:1988-01-01 00:00:00
abstract::The first description of endothelial progenitor cells (EPC) in 1997 led rapidly to substantial changes in our understanding of angiogenesis, and within 5 years to the first clinical studies in humans using bone marrow derived EPC to enhance coronary neovascularisation and cardiac function after myocardial ischemia. Ho...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2009.12.004
更新日期:2010-05-01 00:00:00
abstract::Quantum dots (QDs) are fluorescent semiconductor nanocrystals that possess a number of superior fluorescent properties compared to more established organic dyes and fluorescent proteins. As a result, QDs are being studied for use in a wide range of biological applications. We have examined QDs for one such application...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2006.09.003
更新日期:2007-03-01 00:00:00
abstract::Concentration-response curves are often used as indicators of vascular reactivity and receptor sensitivity. Some investigators use ethylenediaminetetraacetate (EDTA) or ascorbic acid (ASC) to prevent catecholamine oxidation but many others do not. This difference may affect estimates of reactivity. We tested the effec...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(83)90057-2
更新日期:1983-07-01 00:00:00
abstract::Since the internal carotid artery supplies blood to both the eye and the brain, ocular microvascular hemodynamics can be altered due to ischemic stroke. The purpose of the current study was to establish the feasibility of conjunctival microcirculation imaging for detection of inter-ocular differences in microvascular ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.04.007
更新日期:2015-07-01 00:00:00
abstract::Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, in part, by equilibrative nucleoside transporter subtype 1 (ENT1; SLC29A1) and by equilibrative nucleobase transporter ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.06.008
更新日期:2014-09-01 00:00:00
abstract::Hypoxia-induced arginase elevation plays an essential role in several vascular diseases but influence of arginase on hypoxia-mediated angiogenesis is completely unknown. In this study, in vitro network formation in bovine aortic endothelial cells (BAEC) was examined after exposure to hypoxia for 24h with or without ar...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.11.002
更新日期:2015-03-01 00:00:00
abstract::Thermal injuries of more than 20% body surface area (BSA) result in systemic capillary leakage with subsequent edema. This can similarly be induced by burn plasma transfer (BPT) from burned individuals to healthy rats. We evaluated if cerium nitrate (CN) bathing can prevent edema after BPT. Therefore, donor rats (DR) ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.07.006
更新日期:2009-12-01 00:00:00
abstract::IL-20 is an arteriogenic cytokine that remodels collateral networks in vivo, and plays a role in cellular organization. Here, we investigate its role in lymphangiogenesis using a lymphatic endothelial cell line, hTERT-HDLEC, which expresses the lymphatic markers LYVE-1 and podoplanin. Upon stimulation of hTERT-HDLEC w...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.02.007
更新日期:2009-06-01 00:00:00
abstract::Oxygen pressure histograms were determined with the multiwire surface electrode from the gastrocnemius muscle in patients with arterial occlusive disease and compared with those of healthy volunteers. Seven out of 22 patients had normally distributed histograms like volunteers, but the mean PO2 values were lower than ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(85)90024-x
更新日期:1985-05-01 00:00:00
abstract:PURPOSE:To examine the possible role of Klotho (Kl) in human microvasculature. METHODS:The expression level of Kl in primary human dermal microvascular endothelial cells (HDMECs) and primary human dermal fibroblasts (HFb) was detected by real-time polymerase chain reaction amplification (qRT-PCR), Western blot analyse...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2016.05.005
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:The relationship between NF-κB Interacting lncRNA (NKILA) and angiogenesis in breast cancer has never been studied. Our study aimed to investigate effect of NKILA on proliferation, migration, apoptosis, as well as angiogenesis in breast cancer. METHODS:NKILA was over-expressed in MDA-MB-231 cells by transfec...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103968
更新日期:2020-05-01 00:00:00
abstract::Microvascular blood flow is commonly calculated from a "centerline" velocity derived from the dual-slit method. This is done by relating the computed centerline velocity to an average velocity through an empirically derived conversion factor. To determine the physical basis of the conversion factor, we utilized a Four...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(89)90046-0
更新日期:1989-05-01 00:00:00
abstract::Although microvascular dysfunction (MVD) has been well characterized in individual organs as different disease entities, clinical evidence is mounting in support of an underlying systemic process. To address this hypothesis, we systematically searched PubMed and Medline for studies in adults published between 2014 and...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2020.104123
更新日期:2021-03-01 00:00:00
abstract:BACKGROUND:The proepicardium (PE), a transient embryonic structure crucial for the development of the epicardium and heart, contains its own population of endothelial cells (ECs). The aim of our study was to determine the pattern, anatomical orientation and phenotypic marker expression of the endothelial cell network w...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.08.007
更新日期:2015-11-01 00:00:00
abstract::Shear stress causes release of nitric oxide (NO) from microvascular endothelial cells in vivo and stimulates their growth in vitro. After chronic electrical stimulation of lower hind limb skeletal muscles in the rat, measurements of capillary diameters and red blood cell velocity indicated that shear stress is increas...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2193
更新日期:2000-01-01 00:00:00
abstract::The purpose of this study was to examine the distribution and extent of autoregulatory behavior among arterioles in the arcade network of the cat mesentery. We found that 71% of 169 arterioles studied dilated and 63% showed blood flow autoregulation with arterial pressure reduction to 55-60 mm Hg. There appeared to be...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(83)90050-x
更新日期:1983-07-01 00:00:00
abstract::Overexpression of EGFR plays a key-role in head and neck squamous cell carcinoma (HNSCC) and justifies the extensive use of cetuximab, a monoclonal anti-EGFR antibody, as well as EGFR-tyrosine kinase inhibitors (EGFR-TKI), which have been reported to inhibit tumor cell growth and the secretion of pro-angiogenic factor...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2011.07.008
更新日期:2012-03-01 00:00:00
abstract::A microfluidic device was developed for quantifying the migratory and deformability capabilities of a single tumor cell using direct imaging. It was fabricated using photolithography and is made of polydimethysiloxane. Chemotaxis approach was used for directing cell movement, using 10 microm microgaps to restrict the ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2006.06.003
更新日期:2006-11-01 00:00:00
abstract::Mesangium enlargement is a central feature of diabetic nephropathy and almost certainly plays a pathogenic role in this condition. Previous studies have shown that mesangium degradation is reduced in a high glucose mileau. Plasmin has been shown to play an important role in extracellular matrix degradation, both direc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1996.2006
更新日期:1997-03-01 00:00:00
abstract::H2O2 mediates autocrine and paracrine signaling in the vasculature and can propagate endothelial dysfunction. However, it is not clear how endothelial cells withstand H2O2 exposure and promote H2O2-induced vascular remodeling. To understand the innate ability of endothelial cells for sustaining excess H2O2 exposure, w...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.09.003
更新日期:2016-01-01 00:00:00