Abstract：
:Angiotensin II (Ang II), the dominant effector of the renin-angiotensin system, elicits numerous inflammatory-proliferative responses, thereby being involved in angiogenesis. T cells play an important role in angiogenesis as well by delivering vascular endothelial growth factor (VEGF) to inflammatory sites. Since we have previously shown that pigment-epithelium-derived factor (PEDF) blocks the Ang II signaling in endothelial cells, we studied here whether PEDF could inhibit the Ang-II-induced VEGF expression in MOLT-3 T and examined the potential mechanism of PEDF inhibitory effects. Ang II significantly up-regulated VEGF mRNA levels in MOLT-3 T cells, which was inhibited by PEDF or olmesartan, an Ang II type 1 receptor blocker. PEDF blocked the Ang-II-induced reactive oxygen species (ROS) generation in MOLT-3 T cells. Furthermore, H(2)O(2) was found to up-regulate VEGF mRNA levels in MOLT-3 T cells in a dose-dependent manner. These results demonstrate that PEDF could inhibit the Ang-II-induced VEGF expression in MOLT-3 T cells via suppression of ROS generation. Blockade by PEDF of VEGF expression in T cells may become a novel therapeutic target for pathological angiogenesis.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Yamagishi S,Matsui T,Nakamura K,Yoshida T,Shimizu K,Takegami Y,Shimizu T,Inoue H,Imaizumi Tdoi
10.1016/j.mvr.2006.03.001subject
Has Abstractpub_date
2006-05-01 00:00:00pages
222-6issue
3eissn
0026-2862issn
1095-9319pii
S0026-2862(06)00025-2journal_volume
71pub_type
杂志文章abstract：:To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.03.004
更新日期：2004-07-01 00:00:00
abstract：:Using the laser-Doppler method we measured blood flow on the nailfold skin to compare the reactivity of cutaneous microcirculation in three groups of normotensive subjects: 11 subjects with a familial predisposition to hypertension without a previous record of high blood pressure, 6 predisposed subjects with a previou...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2279
更新日期：2000-11-01 00:00:00
abstract：:The microfibrils of anchoring filaments, a typical ultrastructural feature of initial lymphatic vessels, consist mainly of fibrillin and are similar to the microfibrils of elastic fibers. As we previously demonstrated, they radiate from focal adhesions of lymphatic endothelium to the perivascular elastic network. Alth...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2002.2397
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:Hypertension and hypercholesterolemia elicit inflammatory and thrombogenic responses in the microvasculature. However, little is known about whether and how risk factor combinations alter microvascular function. We examined how the actions of HTN+HCh on the microvasculature differ from the responses elicited ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.01.002
更新日期：2016-05-01 00:00:00
abstract：:Spontaneous contractions and those elicited by electrical stimulation were studied in isolated segments of bovine mesenteric lymphatic vessels. The effects of three general anesthetics, pentobarbitone, halothane, and ether, on these spontaneous and evoked contractions were studied. Pentobarbitone and halothane inhibit...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90073-3
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:Microvascular perfusion is indispensable for the growth and remodulation of membrane bone. Trauma, inflammation and surgical interventions may alter periosteal perfusion. However, there is not much known about periosteal perfusion in membrane bones. Therefore, the aim of this study was to establish a new chro...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2008.09.008
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:The conjunctival microcirculation is a readily-accessible vascular bed for quantitative haemodynamic assessment and has been studied previously using a digital charge-coupled device (CCD). Smartphone video imaging of the conjunctiva, and haemodynamic parameter quantification, represents a novel approach. We rep...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103907
更新日期：2019-11-01 00:00:00
abstract：:An increasing body of evidence suggests that the deleterious effects of Acute Kidney Injury (AKI) on remote organ function could, at least in part, be due to loss of the normal balance of immune, inflammatory, and soluble mediator metabolism that attends injury of the tubular epithelium. Such dysregulation, acting at ...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2008.09.001
更新日期：2009-01-01 00:00:00
abstract：:Excessive generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), by activated neutrophils and endothelial cells, has been implicated in the pathophysiology of endothelial barrier dysfunction. Disruption of the integrity of this barrier markedly increases permeability to fluids, solutes and in...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2008.10.005
更新日期：2009-01-01 00:00:00
abstract：:The concept of anti-angiogenesis therapy was introduced by Judah Folkman in 1971 and since then, a plethora of pro- and anti-angiogenic factors have been identified. In the recent years, it has become clear that angiogenesis, the formation of new capillaries from a pre-existing capillary network, is highly regulated b...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2007.05.005
更新日期：2007-09-01 00:00:00
abstract：:Histone acetylation/deacetylation is a key mechanism for regulating transcription, which plays an important role in the control of gene expression, tissue growth, and development. In particular, histone deacetylase 7 (HDAC7), a member of class IIa HDACs, is crucial in maintaining vascular integrity. Endothelial progen...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.10.006
更新日期：2014-01-01 00:00:00
abstract：:A novel first-pass imaging method for studying blood flow in tumors and normal tissues in mouse dorsal window chamber preparations is reported in this study. A fluorescence-labeled macromolecule is administered i.v. as a bolus dose, and the signal generated by the bolus is detected as the bolus passes through the vasc...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2007.06.009
更新日期：2008-03-01 00:00:00
abstract：:Capillaries are often assumed to be indistensible. Only recently has the error caused by capillary distensibility in the measurement of hydraulic conductance been considered. An oil-drop method was used to measure simultaneously distensibility and hydraulic conductance (Lp) of mesenteric capillaries of 40 cranially pi...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90013-7
更新日期：1989-07-01 00:00:00
abstract：:This study determined the contribution of cytochrome P450 (CP450) 4A enzyme metabolites of arachidonic acid in mediating the constriction of isolated rat skeletal muscle resistance arteries in response to elevated PO2. Gracilis arteries (GA) were viewed via television microscopy and constrictor responses to elevated P...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2001.2341
更新日期：2001-11-01 00:00:00
abstract：:Reduced lung capillary expression of angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, and of caveolin-1, an important regulator of endothelial cell signalling, has been demonstrated in various models of pulmonary arterial hypertension (PAH). We addressed the relationship between P...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.008
更新日期：2010-09-01 00:00:00
abstract：:The aim of our study was to evaluate the feasibility of laser Doppler flowmetry (LDF) coupled with iontophoresis in exploring the skin vasodilator activity of exogenous calcitonin gene-related peptide (CGRP) in healthy subjects and to investigate the mechanisms involved in the skin vasodilator activity of this peptide...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.10.006
更新日期：2007-03-01 00:00:00
abstract：:This study was undertaken to determine if coronary vascular permeability (CVP) increases and if myocardial edema develops in the canine heart after local exposure to histamine. Histamine (50 or 15 micrograms/min) or compound 48/80 (0.1-0.2 mg/kg) was infused into the left anterior descending coronary artery (LAD) of o...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(91)90034-9
更新日期：1991-05-01 00:00:00
abstract：:Although microvascular dysfunction (MVD) has been well characterized in individual organs as different disease entities, clinical evidence is mounting in support of an underlying systemic process. To address this hypothesis, we systematically searched PubMed and Medline for studies in adults published between 2014 and...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2020.104123
更新日期：2021-03-01 00:00:00
abstract：:Microvascular dysfunction contributes to the development of cardiovascular and metabolic disease. This study tested the hypothesis that young obese (BMI>30 kg m(-2)), otherwise healthy, adults (N=15) have impaired microvascular function relative to age and sex matched, lean (BMI<25 kg m(-2)) individuals (N=14). Partic...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.11.007
更新日期：2016-03-01 00:00:00
abstract：:This article describes the interaction between solid particles and blood propagating through a capillary. A slip condition is considered on the walls of the capillary. The rheological features of the blood are discussed by considering as a two-phase Newtonian fluid model, i.e., the suspension of cells in plasma. A per...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.04.004
更新日期：2018-09-01 00:00:00
abstract：:The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cel...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2008.06.003
更新日期：2008-11-01 00:00:00
abstract：:In this paper we quantitatively investigate the hypothesis proposed by Michel (Exp. Physiol. 82, 1-30, 1997) and Weinbaum (Ann. Biomed. Eng. 26, 1-17, 1998) that the Starling forces are determined by the local difference in the hydrostatic and colloid osmotic pressure across the endothelial surface glycocalyx, which w...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2177
更新日期：1999-11-01 00:00:00
abstract：:An intravital microscopic method for quantitative measurement of interstitial concentrations of fluorescent tracers has been applied to the investigation of microvascular permeability in the hamster cheek pouch. Some nanoliters of FITC-dextran mean mol wt (Mw) 20,000, 3000, or sodium fluorescein (Mw 376) were injected...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(86)90009-9
更新日期：1986-01-01 00:00:00
abstract：:The steroid hormone estradiol is suggested to play a protective role in intestinal injury during systemic inflammation (sepsis). Our aim was to determine the effects of specific estradiol receptor (ER-α and ER-ß) agonists on the intestinal microcirculation during experimental sepsis. Male and sham ovariectomized femal...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.10.002
更新日期：2013-01-01 00:00:00
abstract：:Since the internal carotid artery supplies blood to both the eye and the brain, ocular microvascular hemodynamics can be altered due to ischemic stroke. The purpose of the current study was to establish the feasibility of conjunctival microcirculation imaging for detection of inter-ocular differences in microvascular ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.04.007
更新日期：2015-07-01 00:00:00
abstract：:Angiotensin II is considered to have angiogenic properties. Nevertheless, several authors reported an increase in coronary capillary density after treatment with ACE inhibitors. The aim of the present study was to evaluate the effect of treatment with low doses of ACE inhibitor perindopril, low doses of the diuretic i...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2224
更新日期：2000-03-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) was originally discovered as vascular permeability factor because of its ability to increase microvascular permeability to plasma proteins. Since then, it has been shown to induce proliferation and migration in endothelial cells. Placenta growth factor (PlGF) is a member of th...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2298
更新日期：2001-03-01 00:00:00
abstract：:The aim of this study was to evaluate whether streptokinase (SK) may produce beneficial effects at the level of microvascular circulation in addition to coronary recanalization. Twenty mongrel dogs weighing 28.4 +/- 4.6 kg were randomized to receive SK (16,000-72,000 U/kg) or 20 ml saline (control) in an open-chest an...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2236
更新日期：2000-07-01 00:00:00
abstract：:Techniques of intravital microscopy were used to assess the effect of the nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin and ibuprofen, on the microcirculation. Hemodynamics in venules of the rat mesentery were studied in terms of vessel diameter, red blood cell velocity, and leukocyte-endothelium interac...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1016
更新日期：1993-03-01 00:00:00
abstract：:A mathematical model of nonsteady-state fluid movement in the lung interstitium during hydrodynamic loading is evaluated. The model is based on experimental results obtained in isolated perfused canine lungs. The interstitium is treated as a porous phase with an elastic framework, able to relax; all resistance to flux...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(91)90071-i
更新日期：1991-07-01 00:00:00
