In vivo effect of mutations at the PRPP binding site of the Bacillus subtilis purine repressor.

Abstract:

:The Bacillus subtilis PurR mediates adenine repression and guanosine induction of purA. PRPP inhibits binding of PurR to DNA in vitro. Mutations in the PRPP binding motif of PurR caused strong repression regardless of purine exclusions or additions, establishing the role of PRPP as regulator of PurR.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Rappu P,Pullinen T,Mäntsälä P

doi

10.1128/jb.185.22.6728-6731.2003

keywords:

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

6728-31

issue

22

eissn

0021-9193

issn

1098-5530

journal_volume

185

pub_type

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