Model studies directed toward the boron neutron-capture therapy of cancer: boron delivery to murine tumors with liposomes.

abstract：:The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papahadjopoulos D,Allen TM,Gabizon A,Mayhew E,Matthay K,Huang SK,Lee KD,Woodle MC,Lasic DD,Redemann C

更新日期：1991-12-15 00:00:00

abstract：:Osteoclasts, bone-resorptive multinucleated cells derived from hematopoietic stem cells, are associated with many bone-related diseases, such as osteoporosis. Osteoclast-targeting small-molecule inhibitors are valuable tools for studying osteoclast biology and for developing antiresorptive agents. Here, we have discov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawatani M,Okumura H,Honda K,Kanoh N,Muroi M,Dohmae N,Takami M,Kitagawa M,Futamura Y,Imoto M,Osada H

更新日期：2008-08-19 00:00:00

abstract：:Osedax is a recently discovered group of siboglinid annelids that consume bones on the seafloor and whose evolutionary origins have been linked with Cretaceous marine reptiles or to the post-Cretaceous rise of whales. Here we present whale bones from early Oligocene bathyal sediments exposed in Washington State, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiel S,Goedert JL,Kahl WA,Rouse GW

更新日期：2010-05-11 00:00:00

abstract：:Biological membranes are highly dynamic and complex lipid bilayers, responsible for the fate of living cells. To achieve this function, the hydrating environment is crucial. However, membrane imaging typically neglects water, focusing on the insertion of probes, resonant responses of lipids, or the hydrophobic core. O...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarun OB,Hannesschläger C,Pohl P,Roke S

更新日期：2018-04-17 00:00:00

abstract：:An analysis of taxonomic longevity for species of the two Cenozoic radiations of Caribbean planktonic foraminifera shows strong similarity in longevity for extinct taxa, though extant species of the latter radiation are biased towards longer-lived forms. In this case, the present is not the key to the past. A simple o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinton JS,Ginzburg L

更新日期：1984-09-01 00:00:00

abstract：:Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the function of distinct ion-transport mechanisms at the cell plasma membrane. Active Na(+) and K(+) exchange in sperm is under the control of the Na,K-ATPase. Two mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jimenez T,McDermott JP,Sánchez G,Blanco G

更新日期：2011-01-11 00:00:00

abstract：:The Hippo pathway is an evolutionarily conserved regulator of organ growth and tumorigenesis. In Drosophila, oncogenic RasV12 cooperates with loss-of-cell polarity to promote Hippo pathway-dependent tumor growth. To identify additional factors that modulate this signaling, we performed a genetic screen utilizing the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo X,Sun Y,Azad T,Janse van Rensburg HJ,Luo J,Yang S,Liu P,Lv Z,Zhan M,Lu L,Zhou Y,Ma X,Zhang X,Yang X,Xue L

更新日期：2020-12-01 00:00:00

abstract：:The BAG6 complex was first identified as an upstream loading factor for tail-anchored membrane proteins entering the TRC40-dependent pathway for posttranslational delivery to the endoplasmic reticulum. Subsequently, BAG6 was shown to enhance the proteasomal degradation of mislocalized proteins by selectively promoting...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leznicki P,High S

更新日期：2012-11-20 00:00:00

abstract：:We describe a 98-base-pair region (-38 to +60) in the long terminal repeat of the Drosophila gypsy retrotransposon that is sufficient for accurate normal-level transcription. We find that, unlike most RNA polymerase II (pol II) promoters, the gypsy promoter includes downstream sequences that are required for full acti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarrell KA,Meselson M

更新日期：1991-01-01 00:00:00

abstract：:Antimicrobial peptides are postulated to disrupt microbial phospholipid membranes. The prevailing molecular model is based on the formation of stable or transient pores although the direct observation of the fundamental processes is lacking. By combining rational peptide design with topographical (atomic force microsc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rakowska PD,Jiang H,Ray S,Pyne A,Lamarre B,Carr M,Judge PJ,Ravi J,Gerling UI,Koksch B,Martyna GJ,Hoogenboom BW,Watts A,Crain J,Grovenor CR,Ryadnov MG

更新日期：2013-05-28 00:00:00

abstract：:Arylhydrazinopyrimidines inhibit DNA synthesis in Bacillus subtilis by promoting formation of a specific, long-lived ternary complex with DNA polymerase III and the template-primer DNA. DNA polymerase III contains an associated, single-strand-selective exonuclease which generates 5'-mononucleotides. Drug inhibition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Low RL,Rashbaum SA,Cozzarelli NR

更新日期：1974-08-01 00:00:00

abstract：:This study demonstrates that significantly shortened telomeres are a hallmark of cardiomyocytes (CMs) from individuals with end-stage hypertrophic cardiomyopathy (HCM) or dilated cardiomyopathy (DCM) as a result of heritable defects in cardiac proteins critical to contractile function. Positioned at the ends of chromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang ACY,Chang ACH,Kirillova A,Sasagawa K,Su W,Weber G,Lin J,Termglinchan V,Karakikes I,Seeger T,Dainis AM,Hinson JT,Seidman J,Seidman CE,Day JW,Ashley E,Wu JC,Blau HM

更新日期：2018-09-11 00:00:00

abstract：:The heme-copper oxidases constitute a superfamily of terminal dioxygen-reducing enzymes located in the inner mitochondrial or in the bacterial cell membrane. The presence of a mechanistically important covalent bond between a histidine ligand of the copper ion (Cu(B)) in the active site and a generally conserved tyros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rauhamäki V,Baumann M,Soliymani R,Puustinen A,Wikström M

更新日期：2006-10-31 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)-regulated gene expression is stimulated independently by the cellular trans-activator NF-kappa B and the viral protein Tat. Noncytotoxic concentrations of the drug pentoxifylline (PTX) inhibited interaction of NF-kappa B with its motif and the stim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biswas DK,Ahlers CM,Dezube BJ,Pardee AB

更新日期：1993-12-01 00:00:00

abstract：:Accurate and timely surface precipitation measurements are crucial for water resources management, agriculture, weather prediction, climate research, as well as ground validation of satellite-based precipitation estimates. However, the majority of the land surface of the earth lacks such data, and in many parts of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Overeem A,Leijnse H,Uijlenhoet R

更新日期：2013-02-19 00:00:00

abstract：:In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase accompanied by higher Beck Depression Inventory and seasonality s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang L,Hirano A,Hsu PK,Jones CR,Sakai N,Okuro M,McMahon T,Yamazaki M,Xu Y,Saigoh N,Saigoh K,Lin ST,Kaasik K,Nishino S,Ptáček LJ,Fu YH

更新日期：2016-03-15 00:00:00

abstract：:Previous studies have shown changes in membrane properties of neurons in rat deep cerebellar nuclei (DCN) as a function of development, but due to technical difficulties in obtaining viable DCN slices from adult animals, it remains unclear whether there are learning-related alterations in the membrane properties of DC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Smith-Bell CA,Burhans LB,O'Dell DE,Bell RW,Schreurs BG

更新日期：2018-10-02 00:00:00

abstract：:Cell surface receptor membrane localization is strongly dependent on protein-protein interactions often involving regulation by phosphorylation/dephosphorylation of the intracellular domains of membrane proteins. The present study was carried out to identify metabotropic glutamate receptor (mGluR) 3 regulatory binding...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flajolet M,Rakhilin S,Wang H,Starkova N,Nuangchamnong N,Nairn AC,Greengard P

更新日期：2003-12-23 00:00:00

abstract：:Chronic morphine administration is associated with the development of tolerance, both clinically and in animal models. Many assume that tolerance is a continually progressive response to chronic opioid dosing. However, clinicians have long appreciated the ability to manage cancer pain in patients for months on stable ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu J,Faskowitz AJ,Rossi GC,Xu M,Lu Z,Pan YX,Pasternak GW

更新日期：2015-01-06 00:00:00

abstract：:Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devany E,Zhang X,Park JY,Tian B,Kleiman FE

更新日期：2013-02-26 00:00:00

abstract：:A long-term electrophoretic survey of genetic variants of serum albumin has identified an alloalbumin in 589 unrelated individuals in Italy. The alloalbumins were classified electrophoretically into 17 types. The number of unrelated carriers for each type varied from 1 for several variants reported here to 103 for alb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galliano M,Minchiotti L,Porta F,Rossi A,Ferri G,Madison J,Watkins S,Putnam FW

更新日期：1990-11-01 00:00:00

abstract：:The int-1 and int-2 genes were first isolated as targets for transcriptional activation by proviral insertion mutations in mammary carcinomas induced by the mouse mammary tumor virus (MMTV). Since these proto-oncogenes are not expressed at detectable levels in previously tested normal tissues from adult mice, we sough...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jakobovits A,Shackleford GM,Varmus HE,Martin GR

更新日期：1986-10-01 00:00:00

abstract：:The high concentration of gonadotropin-releasing hormone (GnRH) in milk of several species implies that the mammary gland is either a site of synthesis for this neuropeptide or that it is efficiently concentrated from plasma by this organ. By PCR amplification of mammary gland cDNA, we have demonstrated expression of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmon A,Ben Aroya N,Tel-Or S,Burstein Y,Fridkin M,Koch Y

更新日期：1994-05-24 00:00:00

abstract：:In 2005 four outstanding multiple burials were discovered near Eulau, Germany. The 4,600-year-old graves contained groups of adults and children buried facing each other. Skeletal and artifactual evidence and the simultaneous interment of the individuals suggest the supposed families fell victim to a violent event. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haak W,Brandt G,de Jong HN,Meyer C,Ganslmeier R,Heyd V,Hawkesworth C,Pike AW,Meller H,Alt KW

更新日期：2008-11-25 00:00:00

abstract：:The basic theory of a newly discovered physical technique, steady-state electrophoresis, is described followed by analyses of several representative macro-ion systems with the technique. This method measures apparent moments of molar diminished charge (defined below) of solvated macro-ions from an analysis of a concen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Godfrey JE

更新日期：1989-06-01 00:00:00

abstract：:A lost navigator must identify its current location and recover its facing direction to restore its bearings. We tested the idea that these two tasks--place recognition and heading retrieval--might be mediated by distinct cognitive systems in mice. Previous work has shown that numerous species, including young childre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Julian JB,Keinath AT,Muzzio IA,Epstein RA

更新日期：2015-05-19 00:00:00

abstract：:We have isolated RNA ligands with low-nanomolar affinity and high specificity to basic fibroblast growth factor from a pool of 10(14) molecules containing 30 randomized positions by the systematic evolution of ligands by exponential enrichment (SELEX) procedure. High-affinity ligands could be classified into two famil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jellinek D,Lynott CK,Rifkin DB,Janjić N

更新日期：1993-12-01 00:00:00

abstract：:Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been reported, the full sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao J,Hu K,Chang Q,Wu H,Sherman NE,Martinowich K,Klose RJ,Schanen C,Jaenisch R,Wang W,Sun YE

更新日期：2009-03-24 00:00:00

abstract：:GPIbalpha binding to von Willebrand factor (VWF) exposed at a site of vascular injury is thought to be the first step in the formation of a hemostatic plug. However, our previous studies in VWF-deficient mice demonstrated delayed but not absent arterial thrombus formation, suggesting that, under these conditions, GPIb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bergmeier W,Piffath CL,Goerge T,Cifuni SM,Ruggeri ZM,Ware J,Wagner DD

更新日期：2006-11-07 00:00:00

abstract：:Lactate racemase is the first enzyme known to possess a metal pincer active site. The enzyme interconverts d- and l-lactic acid, which is important for the assembly of cell walls in many microorganisms. Here, we report a synthetic model of the active site of lactate racemase, which features a pyridinium-based SCS pinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu T,Wodrich MD,Scopelliti R,Corminboeuf C,Hu X

更新日期：2017-02-07 00:00:00