Effect of Coccinia indica leaves on antioxidant status in streptozotocin-induced diabetic rats.

Abstract:

:The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in liver and kidney of streptozotocin diabetic rats, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide

journal_name

J Ethnopharmacol

authors

Venkateswaran S,Pari L

doi

10.1016/s0378-8741(02)00294-5

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

163-8

issue

2-3

eissn

0378-8741

issn

1872-7573

pii

S0378874102002945

journal_volume

84

pub_type

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