Abstract:
:The inhibitory effect of human immunodeficiency virus (HIV) proteinase inhibitors amprenavir and saquinavir and antifungal agents terbinafine, ketoconazole, amphotericin B and ciclopiroxolamine on aspartyl proteinases (Saps) secreted by Candida albicans was tested in an in vitro spectophotometric assay. As expected, both HIV proteinase inhibitors showed a significant inhibitory effect on Sap activity, which was comparable to that of the classical aspartyl proteinase inhibitor pepstatin A (P < 0.001). Antifungal drugs such as ketoconazole, terbinafine and amphotericin B had no, or only minor, inhibitory effects on proteolytic activity. In contrast, a significant reduction in Sap activity could be demonstrated during treatment with the antifungal agent ciclopiroxolamine (P < 0.001). These results point to a multiple effect of this antimycotic agent and might explain the reduced adherence of C. albicans to human epithelial cells at subinhibitory doses.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Schaller M,Krnjaic N,Niewerth M,Hamm G,Hube B,Korting HCdoi
10.1099/jmm.0.05048-0keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
247-249issue
Pt 3eissn
0022-2615issn
1473-5644journal_volume
52pub_type
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