Abstract:
:Synergy between fluvastatin, at clinically unachievable concentrations, and fluconazole against Candida albicans has been reported. The purpose of the present study was to evaluate the in-vitro activity of fluconazole alone and in combination with clinically achievable concentrations of pravastatin and fluvastatin against C. albicans. In-vitro susceptibility and synergy testing were performed against clinical isolates of C. albicans with fluconazole, pravastatin and fluvastatin. Both checkerboard method and time-kill studies were performed. MICs for fluconazole ranged from 0.5 (susceptible) to >256 mg/L (resistant) at 24 h. All isolates had MICs >2 mg/L for both statins. No synergy or antagonism was observed with fluconazole in combination with either agent against any isolate of C. albicans by the checkerboard assay or time-kill studies. Clinically achievable concentrations of pravastatin and fluvastatin did not affect the in-vitro activity of fluconazole against C. albicans.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Nash JD,Burgess DS,Talbert RLdoi
10.1099/0022-1317-51-2-105keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
105-109issue
2eissn
0022-2615issn
1473-5644journal_volume
51pub_type
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