Abstract:
:Acinetobacter baumannii is an opportunist nosocomial pathogen of world-wide importance and produces severe infections in immunocompromised patients. However, the virulence factors contributing to its pathogenic properties are not well known. The effect of normal human serum against 18 clinical isolates of the most prevalent biotypes of A. baumannii in Chile was investigated. The effect of pre-treatment of the cells with ethylene diamine tetraacetic acid (EDTA) or bismuth subsalicylate (BSS), compounds known to decrease the amount of lipopolysaccharide (LPS) and bacterial capsular polysaccharide (CPS), respectively, in other gram-negative bacteria, was evaluated. Most isolates (16 of 18) showed resistance to normal human serum. Prior treatment with EDTA rendered nine of these isolates susceptible to serum, while seven isolates maintained their resistance. Pre-treatment with BSS did not modify the serum-resistant behaviour of the isolates. The results suggest that LPS might be involved in the resistance of A. baumannii to human serum whereas CPS does not seem to contribute to this property.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
García A,Solar H,González C,Zemelman Rdoi
10.1099/0022-1317-49-11-1047keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
1047-1050issue
11eissn
0022-2615issn
1473-5644journal_volume
49pub_type
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