Abstract:
:Transfer of an Hly plasmid determining production of alpha haemolysin to a non-haemolytic strain of Escherichia coli increased the virulence of the strain for mice. Injections of non-toxic amounts of alpha haemolysin, phenylhydrazine, haemoglobin, iron or manganese salts simulated the effect of the Hly plasmid by stimulating bacterial growth. Active or passive immunisation against alpha haemolysin protected mice on challenge with haemolytic E. coli by inhibiting in-vivo proliferation of the strain. Protection was eliminated by administration of iron salts at the time of challenge. The Hly plasmid probably acts as a virulence factor by enabling haemolytic strains of E. coli to obtain iron for growth from the lysed erythrocytes of infected animals.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Linggood MA,Ingram PLdoi
10.1099/00222615-15-1-23subject
Has Abstractpub_date
1982-02-01 00:00:00pages
23-30issue
1eissn
0022-2615issn
1473-5644journal_volume
15pub_type
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doi:10.1099/0022-1317-49-8-681
更新日期:2000-08-01 00:00:00
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更新日期:1992-02-01 00:00:00
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更新日期:2011-02-01 00:00:00
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journal_title:Journal of medical microbiology
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abstract::The influence of six immunosuppressive agents on the occurrence of endogenous bacteraemia in mice was evaluated. The mortality rates in conventional ddY mice given cyclophosphamide (CY), fluorouracil (5-FU), methotrexate (MTX), cisplatin (CDDP) or FK-506 intraperitoneally, or dexamethasone (DXM) subcutaneously were 70...
journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
pub_type: 杂志文章,评审
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abstract::Infection of humans by Abiotrophia defectiva, a nutritionally variant streptococcus, most commonly takes the form of endocarditis, though a variety of other manifestations ranging from central nervous system abscesses to orthopaedic infections have been seen. We report here what we believe is the first case of bullous...
journal_title:Journal of medical microbiology
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更新日期:2012-07-01 00:00:00
abstract::Streptolysin O (SLO) is a potent cytolytic toxin produced by almost all strains of group A streptococci and is considered an important virulence factor for this organism. In this study we investigated the effect of allicin and aqueous garlic extracts on the haemolytic activity of SLO. All tested materials potentially ...
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journal_title:Journal of medical microbiology
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journal_title:Journal of medical microbiology
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更新日期:1987-12-01 00:00:00
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journal_title:Journal of medical microbiology
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更新日期:2012-06-01 00:00:00
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