Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning.

abstract：:Combined effects of two drugs present simultaneously are usually expressed as summation, synergism or potentiation, and antagonism. When the sum of the effects of each drug present separately equals the combined effect of the two drugs present simultaneously, the action is called additive or summation. However, the ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamaya H,Ueda I,Eyring H

更新日期：1976-06-01 00:00:00

abstract：:Expression of the bovine papillomavirus E2 regulatory protein in human cervical carcinoma cell lines repressed expression of the resident human papillomavirus E6 and E7 oncogenes and within a few days caused essentially all of the cells to synchronously display numerous phenotypic markers characteristic of cells under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodwin EC,Yang E,Lee CJ,Lee HW,DiMaio D,Hwang ES

更新日期：2000-09-26 00:00:00

abstract：:In vitro translation of cellular poly(A)+ RNA coupled with immunoprecipitation was developed as a technique for characterizing 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] receptors and assessing receptor mRNA activity. Cell-free translation of poly(A)+ RNA isolated from chicken intestine revealed two immunoprecipitable fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangelsdorf DJ,Pike JW,Haussler MR

更新日期：1987-01-01 00:00:00

abstract：:Genomic mapping has been used to identify a region of the host genome that determines resistance to fusiform rust disease in loblolly pine where no discrete, simply inherited resistance factors had been previously found by conventional genetic analysis over four decades. A resistance locus, behaving as a single domina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilcox PL,Amerson HV,Kuhlman EG,Liu BH,O'Malley DM,Sederoff RR

更新日期：1996-04-30 00:00:00

abstract：:The downstream box (DB) is a sequence element that enhances translation of several bacterial and phage mRNAs. It has been proposed that the DB enhances translation by base pairing transiently to bases 1469-1483 of 16S rRNA, the so-called anti-DB, during the initiation phase of translation. We have tested this model of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Connor M,Asai T,Squires CL,Dahlberg AE

更新日期：1999-08-03 00:00:00

abstract：:Tail-anchored (TA) membrane proteins are involved in a variety of important cellular functions, including membrane fusion, protein translocation, and apoptosis. The ATPase Get3 (Asna1, TRC40) was identified recently as the endoplasmic reticulum targeting factor of TA proteins. Get3 consists of an ATPase and alpha-heli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bozkurt G,Stjepanovic G,Vilardi F,Amlacher S,Wild K,Bange G,Favaloro V,Rippe K,Hurt E,Dobberstein B,Sinning I

更新日期：2009-12-15 00:00:00

abstract：:An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of Drosophila melanogaster. The boss protein is proposed to contain a large N-terminal ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart AC,Harrison SD,Van Vactor DL Jr,Rubin GM,Zipursky SL

更新日期：1993-06-01 00:00:00

abstract：:Molecular dynamics simulations of the response to oscillating electric field elicited from an altitudinal dipolar molecular rotor mounted on the Au(111) surface and previously studied experimentally in static fields show unidirectional rotation in one of the three pairs of conformational enantiomers. The simulations a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horinek D,Michl J

更新日期：2005-10-04 00:00:00

abstract：:The feeling of being observed or merely participating in an experiment can affect individuals' behavior. Referred to as the Hawthorne effect, this inconsistently observed phenomenon can both provide insight into individuals' behavior and confound the interpretation of experimental manipulations. Here, we pursue both t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz D,Fischhoff B,Krishnamurti T,Sowell F

更新日期：2013-09-17 00:00:00

abstract：:One of the major surprises of the molecular analysis of major histocompatibility complex (MHC) genes is the large number of class I (K/D)-related sequences in the genome. Both restriction fragment length polymorphisms and cosmid cloning experiments showed them all to be closely linked to the MHC. Until now little info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schepart BS,Woodward JG,Palmer MJ,Macchi MJ,Basta P,McLaughlin-Taylor E,Frelinger JA

更新日期：1985-08-01 00:00:00

abstract：:An established line of mouse fibroblasts, C3H/10T1/2 cells, was used for the assessment in vitro of oncogenic transformations caused by single and split doses of x-rays. The shape of the dose-response relationship was determined over the range from 0.1 to 10 Gy. It was found that splitting the x-ray dose into two equa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller RC,Hall EJ,Rossi HH

更新日期：1979-11-01 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSEs), or prion diseases, are mammalian neurodegenerative disorders characterized by a posttranslational conversion and brain accumulation of an insoluble, protease-resistant isoform (PrP(Sc)) of the host-encoded cellular prion protein (PrP(C)). Human and animal TSE agents ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casalone C,Zanusso G,Acutis P,Ferrari S,Capucci L,Tagliavini F,Monaco S,Caramelli M

更新日期：2004-03-02 00:00:00

abstract：:Plant morphogenesis requires coordinated cytoplasmic growth, oriented cell wall extension, and cell cycle progression, but it is debated which of these processes are primary drivers for tissue growth and directly targeted by developmental genes. Here, we used ChIP high-throughput sequencing combined with transcriptome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiessl K,Muiño JM,Sablowski R

更新日期：2014-02-18 00:00:00

abstract：:The rotational strengths of the four longer wavelength transitions, B(2u), B(1u), and the two E(1u), of adenosine derivatives constrained in the syn form have been investigated theoretically and experimentally. The theory combines a complete neglect of differential overlap version S (CNDO/S) description of the base wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Farmer M,Eyring H

更新日期：1980-06-01 00:00:00

abstract：:The activities of cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase [3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acylating), EC 4.1.3.5] and microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase[mevalonate:NADP+ oxidoreductase (CoA-acylating), EC 1.1.1.34], two sequential enzymes in the chole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasubramaniam S,Goldstein JL,Brown MS

更新日期：1977-04-01 00:00:00

abstract：:Plants adapt to alterations in light conditions by controlling their gene expression profiles. Expression of light-inducible genes is transcriptionally induced by transcription factors such as HY5. However, few detailed analyses have been carried out on the control of transcription start sites (TSSs). Of the various w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurihara Y,Makita Y,Kawashima M,Fujita T,Iwasaki S,Matsui M

更新日期：2018-07-24 00:00:00

abstract：:A yeast gene has been identified by screening for DNA replication mutants using a permeabilized cell replication assay. The mutant is temperature sensitive for growth and shows a cell cycle phenotype typical of DNA replication mutants. RNA synthesis is normal in the mutant but DNA synthesis ceases upon shift to the no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Budd ME,Campbell JL

更新日期：1995-08-15 00:00:00

abstract：:Thiazides and related diuretics inhibit NaCl reabsorption in the distal tubule through an unknown mechanism. We report here that [3H]metolazone, a diuretic with a thiazide-like mechanism of action, labels a site in rat kidney membranes that has characteristics of the thiazide-sensitive ion transporter. [3H]Metolazone ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beaumont K,Vaughn DA,Fanestil DD

更新日期：1988-04-01 00:00:00

abstract：:Low-dimensional objects such as molecular strands, ladders, and sheets have intrinsic features that affect their propensity to fold into 3D objects. Understanding this relationship remains a challenge for de novo design of functional structures. Using molecular dynamics simulations, we investigate the refolding of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodd PM,Damasceno PF,Glotzer SC

更新日期：2018-07-17 00:00:00

abstract：:In virtually every real-life situation humans are confronted with complex and cluttered visual environments that contain a multitude of objects. Because of the limited capacity of the visual system, objects compete for neural representation and cognitive processing resources. Previous work has shown that such attentio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaiser D,Stein T,Peelen MV

更新日期：2014-07-29 00:00:00

abstract：:A general model is proposed for genetic recombination. Its essential new feature is the hypothesis that recombination is initiated by a single-strand (or asymmetric) transfer, which may, after isomerization, become a two-strand (or symmetric) exchange. The likelihood of this transition from asymmetric to symmetric str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meselson MS,Radding CM

更新日期：1975-01-01 00:00:00

abstract：:Coagulation factor V is a high molecular weight plasma glycoprotein that participates as a cofactor in the conversion of prothrombin to thrombin by factor Xa. A phage lambda gt11 Hep G2 cell cDNA expression library was screened by using an affinity-purified antibody to human factor V, and 11 positive clones were isola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kane WH,Davie EW

更新日期：1986-09-01 00:00:00

abstract：:High-grade neuroendocrine lung malignancies (large-cell neuroendocrine cell carcinoma, LCNEC, and small-cell lung carcinoma, SCLC) are among the most deadly lung cancer conditions with no optimal clinical management. The biological relationships between SCLC and LCNEC are still largely unknown and a current matter of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lázaro S,Pérez-Crespo M,Lorz C,Bernardini A,Oteo M,Enguita AB,Romero E,Hernández P,Tomás L,Morcillo MÁ,Paramio JM,Santos M

更新日期：2019-10-29 00:00:00

abstract：:MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng Y,Dai Y,Hitchcock C,Yang X,Kassis ES,Liu L,Luo Z,Sun HL,Cui R,Wei H,Kim T,Lee TJ,Jeon YJ,Nuovo GJ,Volinia S,He Q,Yu J,Nana-Sinkam P,Croce CM

更新日期：2013-09-10 00:00:00

abstract：:The glycosyltransferases of the mammalian Golgi complex must recycle between the stacked cisternae of that organelle to maintain their proper steady-state localization. This trafficking is mediated by COPI-coated vesicles, but how the glycosyltransferases are incorporated into these transport vesicles is poorly unders...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Doray B,Kornfeld S

更新日期：2018-09-04 00:00:00

abstract：:Chemokine homologs are encoded by many large DNA viruses, suggesting that they contribute to control of host leukocyte transmigration and trafficking during viral infection. Murine cytomegalovirus carries a CC (beta) chemokine homolog gene giving rise to two related proteins, murine cytomegalovirus chemokine 1 and 2 (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saederup N,Lin YC,Dairaghi DJ,Schall TJ,Mocarski ES

更新日期：1999-09-14 00:00:00

abstract：:We report the results of crystallographic difference maps at 3.0-A resolution of complexes of metal-nucleoside triphosphates with aspartate carbamoyltransferase (carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2) from Escherichia coli. The complexes Gd3+-ATP, Al3+-ATP, and Gd3+-CTP bind to the allosteric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honzatko RB,Lipscomb WN

更新日期：1982-12-01 00:00:00

abstract：:Somatic copy number variations (CNVs) exist in the brain, but their genesis, prevalence, forms, and biological impact remain unclear, even within experimentally tractable animal models. We combined a transposase-based amplification (TbA) methodology for single-cell whole-genome sequencing with a bioinformatic approach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rohrback S,April C,Kaper F,Rivera RR,Liu CS,Siddoway B,Chun J

更新日期：2018-10-16 00:00:00

abstract：:XMAP215/Dis1 family proteins positively regulate microtubule growth. Repeats at their N termini, called TOG domains, are important for this function. While TOG domains directly bind tubulin dimers, it is unclear how this interaction translates to polymerase activity. Understanding the functional roles of TOG domains i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Widlund PO,Stear JH,Pozniakovsky A,Zanic M,Reber S,Brouhard GJ,Hyman AA,Howard J

更新日期：2011-02-15 00:00:00

abstract：:Reduced intake of nutrients [calorie restriction (CR)] extends longevity in organisms ranging from yeast to mammals. Mutations affecting somatotropic, insulin, or homologous signaling pathways can increase life span in worms, flies, and mice, and there is considerable evidence that reduced secretion of insulin-like gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonkowski MS,Rocha JS,Masternak MM,Al Regaiey KA,Bartke A

更新日期：2006-05-16 00:00:00