Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease.

abstract：:Programmed cell death regulates a number of biological phenomena, and the apoptotic signal must itself be tightly controlled to avoid inappropriate cell death. We established a genetic screen to search for molecules that inhibit the apoptotic signal from the Fas receptor. Here we report the isolation of a gene, LFG, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somia NV,Schmitt MJ,Vetter DE,Van Antwerp D,Heinemann SF,Verma IM

更新日期：1999-10-26 00:00:00

abstract：:The type II cell of the alveolar epithelium of adult rats has been studied by electron microscopy to determine its ability to endocytose electron-dense tracers of differing molecular charge and size. The tracers studied were native (anionic) ferritin, cationic ferritin, 70-kilodalton dextran, and colloidal carbon. Alv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams MC

更新日期：1984-10-01 00:00:00

abstract：:F(o)F(1)-ATP synthase manufactures the energy "currency," ATP, of living cells. The soluble F(1) portion, called F(1)-ATPase, can act as a rotary motor, with ATP binding, hydrolysis, and product release, inducing a torque on the gamma-subunit. A coarse-grained plastic network model is used to show at a residue level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pu J,Karplus M

更新日期：2008-01-29 00:00:00

abstract：:A site that is preferentially cleaved by the single-strand-specific endonuclease from Aspergillus oryzae was located in vitro 180 base pairs upstream from the 5' end of the chicken pro-alpha 2(I) collagen gene. It is found in supercoiled plasmids with a negative superhelical density of -0.024 or more but not in linear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finer MH,Fodor EJ,Boedtker H,Doty P

更新日期：1984-03-01 00:00:00

abstract：:Deletion of 5 residues (Delta5) from the central cytoplasmic loop of the lactose permease of Escherichia coli has no significant effect on expression or activity, whereas Delta12 leads to increased rates of permease turnover after membrane insertion and decreased transport activity, and Delta20 abolishes insertion and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinglass AB,Kaback HR

更新日期：2000-08-01 00:00:00

abstract：:Interspersed repeated sequences (Alu and Kpn) were used as probes to detect a set of Not I restriction fragments of human chromosome 21 from the hybrid cell line WAV17. Forty different Not I fragments, ranging in size from less than 0.05 megabase (Mb) to 7.0 Mb, were identified. The total length of these fragments was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sainz J,Pevny L,Wu Y,Cantor CR,Smith CL

更新日期：1992-02-01 00:00:00

abstract：:Diisopropyl fluorophosphate (DFP) causes neurotoxicity related to an irreversible inhibition of acetylcholinesterase (AChE). Management of this intoxication includes: (i) pretreatment with reversible blockers of AChE, (ii) blockade of muscarinic receptors with atropine, and (iii) facilitation of GABA(A) receptor signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pibiri F,Kozikowski AP,Pinna G,Auta J,Kadriu B,Costa E,Guidotti A

更新日期：2008-09-16 00:00:00

abstract：:The very low density lipoprotein (VLDL) receptor is a recently cloned member of the low density lipoprotein (LDL) receptor family that mediates the binding and uptake of VLDL when overexpressed in animal cells. Its sequence is 94% identical in humans and rabbits and 84% identical in humans and chickens, implying a con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frykman PK,Brown MS,Yamamoto T,Goldstein JL,Herz J

更新日期：1995-08-29 00:00:00

abstract：:DNA barcoding systems employ a short, standardized gene region to identify species. A 648-bp segment of mitochondrial cytochrome c oxidase 1 (CO1) is the core barcode region for animals, but its utility has not been tested in fungi. This study began with an examination of patterns of sequence divergences in this gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert KA,Samson RA,Dewaard JR,Houbraken J,Lévesque CA,Moncalvo JM,Louis-Seize G,Hebert PD

更新日期：2007-03-06 00:00:00

abstract：:The dendritic building blocks with a focal pyrene unit self-organize into vesicles in aqueous phase. The in situ inclusion of the focal pyrene units into the cavity of beta- or gamma-cyclodextrin (CD) induces self-assembled organic nanotubes with an average outer diameter of approximately 45 nm and inner diameter of 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park C,Lee IH,Lee S,Song Y,Rhue M,Kim C

更新日期：2006-01-31 00:00:00

abstract：:WOPR-domain proteins are found throughout the fungal kingdom where they function as master regulators of cell morphology and pathogenesis. Genetic and biochemical experiments previously demonstrated that these proteins bind to specific DNA sequences and thereby regulate transcription. However, their primary sequence s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lohse MB,Rosenberg OS,Cox JS,Stroud RM,Finer-Moore JS,Johnson AD

更新日期：2014-07-22 00:00:00

abstract：:Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene MITF (micropthalmia-asso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ploper D,Taelman VF,Robert L,Perez BS,Titz B,Chen HW,Graeber TG,von Euw E,Ribas A,De Robertis EM

更新日期：2015-02-03 00:00:00

abstract：:cDNA clones specific for the light subunit of porcine calpain I have been isolated from a porcine kidney cDNA library. The complete primary structure of the light subunit has been revealed by nucleotide sequence analysis of the cDNA clones isolated and amino acid sequence analysis of peptides isolated from the purifie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakihama T,Kakidani H,Zenita K,Yumoto N,Kikuchi T,Sasaki T,Kannagi R,Nakanishi S,Ohmori M,Takio K

更新日期：1985-09-01 00:00:00

abstract：:High molecular weight proteins extracted from the walking nerves of the shore crab (Carcinus maenas) exhibit a cycle of phosphorylation-dephosphorylation that is influenced by neurotropic compounds and inorganic ions. The net phosphorylation state of the proteins is increased in the presence of K+ ions and decreased w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoffeniels E,Dandrifosse G

更新日期：1980-02-01 00:00:00

abstract：:In order to define the protease domain of human immunodeficiency virus 1, various regions of the pol open reading frame were cloned and expressed in Escherichia coli. Antiserum directed against the conserved retroviral protease active site was used to identify pol precursor and processed species containing the presume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves MC,Lim JJ,Heimer EP,Kramer RA

更新日期：1988-04-01 00:00:00

abstract：:Controlling the effects of proactive interference (PI), the deleterious effect of prior mental activity on current memory representations, is believed to be a key function of the prefrontal cortex. This view is supported by neuroimaging evidence for a correlation between the longer reaction times caused by high PI con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feredoes E,Tononi G,Postle BR

更新日期：2006-12-19 00:00:00

abstract：:Human genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the demic diffusion of agriculture from the Near East, and gene flow from Africa. Using SNP data from 2,099 individuals in 43 populations, we show that estimates o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Botigué LR,Henn BM,Gravel S,Maples BK,Gignoux CR,Corona E,Atzmon G,Burns E,Ostrer H,Flores C,Bertranpetit J,Comas D,Bustamante CD

更新日期：2013-07-16 00:00:00

abstract：:The atomic displacements associated with the freezing of metals and salts are calculated by treating crystal growth as an assignment problem through the use of an optimal transport algorithm. Converting these displacements into timescales based on the dynamics of the bulk liquid, we show that we can predict the activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun G,Hawken A,Harrowell P

更新日期：2020-02-18 00:00:00

abstract：:The objective of this study has been to determine which Na,K-ATPase isoforms are expressed in red blood cells and whether kinetic differences in the uncoupled sodium efflux mode between the human red blood cell Na,K-ATPase and other preparations can be explained by differences in the underlying subunit composition. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stengelin MK,Hoffman JF

更新日期：1997-05-27 00:00:00

abstract：:Pertussis toxin (PT), a protein produced by Bordetella pertussis, was studied for its effect on lipolysis in isolated rat epididymal adipocytes. Exposure of adipocytes to pertussis toxin resulted in a significant increase in cyclic AMP levels and lipolysis after a lag of 1-2 hr. Both the maximal rate of lipolysis and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olansky L,Myers GA,Pohl SL,Hewlett EL

更新日期：1983-11-01 00:00:00

abstract：:The embryonic development of the optic nerve of the zebrafish, Brachydanio rerio, was studied by three-dimensional computer reconstruction from serial section electron micrographs. Growing fibers from retinal ganglion cells had growth cones in contact with more mature fibers from adjacent cell bodies. In the observed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bodick N,Levinthal C

更新日期：1980-07-01 00:00:00

abstract：:Heteroduplex molecules of pneumococcal DNA, prepared by cross-annealing resolved complementary strands, have been used as donors in transformation. A number of pairs of genetic markers are situated exclusively in the trans configuration in these heteroduplexes. Insertion of two markers from trans configuration into op...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roger M

更新日期：1972-02-01 00:00:00

abstract：:In a previous paper we described the induction by x-irradiation or radiation-induced leukemia virus-inoculation of two classes of lymphoid T-cell neoplasms: The first class, designated T-cell lymphoblastoma (TCLB), consists of growth-factor-dependent eudiploid cells that home to the spleen and give rise to splenic tum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haas M,Altman A,Rothenberg E,Bogart MH,Jones OW

更新日期：1984-03-01 00:00:00

abstract：:Interleukin (IL)-33 is an important member of the IL-1 family that has pleiotropic activities in innate and adaptive immune responses in host defense and disease. It signals through its ligand-binding primary receptor ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which are members of the IL-1 receptor fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Hammel M,He Y,Tainer JA,Jeng US,Zhang L,Wang S,Wang X

更新日期：2013-09-10 00:00:00

abstract：:Benthic foraminifers inhabit a wide range of aquatic environments including open marine, brackish, and freshwater environments. Here we show that several different and diverse foraminiferal groups (miliolids, rotaliids, textulariids) and Gromia, another taxon also belonging to Rhizaria, accumulate and respire nitrates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piña-Ochoa E,Høgslund S,Geslin E,Cedhagen T,Revsbech NP,Nielsen LP,Schweizer M,Jorissen F,Rysgaard S,Risgaard-Petersen N

更新日期：2010-01-19 00:00:00

abstract：:An evolutionary framework for viewing the formation, the stability, the organizational structure, and the social dynamics of biological families is developed. This framework is based upon three conceptual pillars: ecological constraints theory, inclusive fitness theory, and reproductive skew theory. I offer a set of 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emlen ST

更新日期：1995-08-29 00:00:00

abstract：:The Arabidopsis thaliana SOS2 and SOS3 genes are required for intracellular Na(+) and K(+) homeostasis and plant tolerance to high Na(+) and low K(+) environments. SOS3 is an EF hand type calcium-binding protein having sequence similarities with animal neuronal calcium sensors and the yeast calcineurin B. SOS2 is a se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halfter U,Ishitani M,Zhu JK

更新日期：2000-03-28 00:00:00

abstract：:The tumor suppressor Smad4/Dpc4 is a transcription activator that binds specific DNA sequences and whose nuclear localization is induced after exposure to type beta transforming growth factor-like cytokines. We explored an inducible system in which Smad4 protein is activated by translocation to the nucleus when cell l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dai JL,Bansal RK,Kern SE

更新日期：1999-02-16 00:00:00

abstract：:A cDNA sequence coding for murine granulocyte colony-stimulating factor (G-CSF) has been isolated from a cDNA library prepared with mRNA derived from murine fibrosarcoma NFSA cells, which produce G-CSF constitutively. Identification of murine G-CSF cDNA was based on the cross-hybridization with human G-CSF cDNA under ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuchiya M,Asano S,Kaziro Y,Nagata S

更新日期：1986-10-01 00:00:00

abstract：:Over the last two decades, the number of gene/protein sequences gleaned from sequencing projects of individual genomes and environmental DNA has grown exponentially. Only a tiny fraction of these predicted proteins has been experimentally characterized, and the function of most proteins remains hypothetical or only pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helbert W,Poulet L,Drouillard S,Mathieu S,Loiodice M,Couturier M,Lombard V,Terrapon N,Turchetto J,Vincentelli R,Henrissat B

更新日期：2019-03-26 00:00:00