Abstract:
:Programmed cell death regulates a number of biological phenomena, and the apoptotic signal must itself be tightly controlled to avoid inappropriate cell death. We established a genetic screen to search for molecules that inhibit the apoptotic signal from the Fas receptor. Here we report the isolation of a gene, LFG, that protects cells uniquely from Fas but not from the mechanistically related tumor necrosis factor alpha death signal. LFG is widely distributed, but remarkably is highly expressed in the hippocampus. LFG can bind to the Fas receptor, but does not regulate Fas expression or interfere with binding of an agonist antibody. Furthermore LFG does not inhibit binding of FADD to Fas.
journal_name
Proc Natl Acad Sci U S Aauthors
Somia NV,Schmitt MJ,Vetter DE,Van Antwerp D,Heinemann SF,Verma IMdoi
10.1073/pnas.96.22.12667keywords:
subject
Has Abstractpub_date
1999-10-26 00:00:00pages
12667-72issue
22eissn
0027-8424issn
1091-6490journal_volume
96pub_type
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