Mechanism of T-cell lymphomagenesis: transformation of growth-factor-dependent T-lymphoblastoma cells to growth-factor-independent T-lymphoma cells.

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes malignant and inflammatory diseases in ∼10% of infected people. A typical host has between 10(4) and 10(5) clones of HTLV-1-infected T lymphocytes, each clone distinguished by the genomic integration site of the single-copy HTLV-1 provirus. The HTL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Satou Y,Miyazato P,Ishihara K,Yaguchi H,Melamed A,Miura M,Fukuda A,Nosaka K,Watanabe T,Rowan AG,Nakao M,Bangham CR

更新日期：2016-03-15 00:00:00

abstract：:Nature is rife with networks that are functionally optimized to propagate inputs to perform specific tasks. Whether via genetic evolution or dynamic adaptation, many networks create functionality by locally tuning interactions between nodes. Here we explore this behavior in two contexts: strain propagation in mechanic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rocks JW,Ronellenfitsch H,Liu AJ,Nagel SR,Katifori E

更新日期：2019-02-12 00:00:00

abstract：:Induction of differentiation and apoptosis in cancer cells through ligands of nuclear hormone receptors (NHRs) is a novel and promising approach to cancer therapy. All-trans-retinoic acid (ATRA), an RA receptor-specific NHR ligand, is now used for selective cancers. The NHR, peroxisome proliferator-activated receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elstner E,Müller C,Koshizuka K,Williamson EA,Park D,Asou H,Shintaku P,Said JW,Heber D,Koeffler HP

更新日期：1998-07-21 00:00:00

abstract：:We have developed a color complementation assay that allows rapid screening of specific genomic DNA sequences. It is based on the simultaneous amplification of two or more DNA segments with fluorescent oligonucleotide primers such that the generation of a color, or combination of colors, can be visualized and used for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chehab FF,Kan YW

更新日期：1989-12-01 00:00:00

abstract：:Chemical coding in the sympathetic nervous system involves both noradrenergic and, for a minority of neurons, cholinergic neurotransmission. The expression of the cholinergic phenotype in the developing sympathetic nervous system was examined to determine if coding for cholinergic transmission occurs before or after i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schäfer MK,Schütz B,Weihe E,Eiden LE

更新日期：1997-04-15 00:00:00

abstract：:Negative cooperativity has been observed in CTP synthetase, an allosteric enzyme which contains a regulatory site. Thus, the same enzyme exhibits negative cooperativity for GTP (an effector) and glutamine (a substrate) and positive cooperativity for ATP and UTP (both substrates). In the process of the delineation of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levitzki A,Koshland DE Jr

更新日期：1969-04-01 00:00:00

abstract：:Classical feed-forward inhibition involves an excitation-inhibition sequence that enhances the temporal precision of neuronal responses by narrowing the window for synaptic integration. In the input layer of the cerebellum, feed-forward inhibition is thought to preserve the temporal fidelity of granule cell spikes dur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duguid I,Branco T,Chadderton P,Arlt C,Powell K,Häusser M

更新日期：2015-10-20 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) is important in reproduction, although the mechanism of central hypogonadism in humans remains unclear. Because the GnRH neuron originates from the olfactory placode and migrates to the hypothalamus during development, central hypogonadism in humans could be caused by failure in n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radovick S,Wray S,Lee E,Nicols DK,Nakayama Y,Weintraub BD,Westphal H,Cutler GB Jr,Wondisford FE

更新日期：1991-04-15 00:00:00

abstract：:The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. Here we show that γδ intraepithelial lymphocytes (γδ IEL) of the small intestine produc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ismail AS,Severson KM,Vaishnava S,Behrendt CL,Yu X,Benjamin JL,Ruhn KA,Hou B,DeFranco AL,Yarovinsky F,Hooper LV

更新日期：2011-05-24 00:00:00

abstract：:A labile selenium donor compound monoselenophosphate is synthesized from selenide and ATP by selenophosphate synthetase (SPS). In the present study, Sps1 and Sps2 were cloned from a cDNA library prepared from human lung adenocarcinoma cells (NCIH441). The human lung Sps1 has been cloned as an ORF of 1,179 bp, identica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamura T,Yamamoto S,Takahata M,Sakaguchi H,Tanaka H,Stadtman TC,Inagaki K

更新日期：2004-11-16 00:00:00

abstract：:One of the technical bottlenecks in producing nonhuman primate models is that current assisted reproductive techniques, such as in vitro culture and frozen conservation of multicell-stage embryos, often result in poor embryo quality and subsequently lead to low birth rates. We investigated whether pronuclear embryo tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun Q,Dong J,Yang W,Jin Y,Yang M,Wang Y,Wang PL,Hu Y,Tsien JZ

更新日期：2008-09-02 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:The origin-binding protein (OBP) from herpes simplex virus 1 is a member of the SF2 helicase superfamily and is required for the initiation of DNA synthesis from a viral origin of DNA replication (oriS). The high-affinity binding sites for OBP in oriS, boxes I and II, are separated by an A+T-rich spacer. We used the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustafsson CM,Hammarsten O,Falkenberg M,Elias P

更新日期：1994-05-24 00:00:00

abstract：:A recently discovered family of natural anion channelrhodopsins (ACRs) have the highest conductance among channelrhodopsins and exhibit exclusive anion selectivity, which make them efficient inhibitory tools for optogenetics. We report analysis of flash-induced absorption changes in purified wild-type and mutant ACRs,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sineshchekov OA,Li H,Govorunova EG,Spudich JL

更新日期：2016-04-05 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:We report substantially improved performance of high-power quantum cascade lasers (QCLs) by using epitaxial-side-down mounting that provides superior heat dissipation properties. We used aluminum nitride as the heatsink material and gold-tin eutectic solder. We have obtained continuous wave power output of 450 mW at 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsekoun A,Go R,Pushkarsky M,Razeghi M,Patel CK

更新日期：2006-03-28 00:00:00

abstract：:Ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid have been attached covalently to the 5' terminus of the deoxynucleotide sequence C-A-C-A-A-T-T-C-C-A-C-A-C-A-A-C (16-mer) via an ethylenediamine linker. In the presence of Fe2+ and dithiothreitol, these reagents bring about the hybridization-depend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu BC,Orgel LE

更新日期：1985-02-01 00:00:00

abstract：:Rat serine dehydratase cDNA clones were isolated from a lambda gt11 cDNA library on the basis of their reactivity with monospecific immunoglobulin to the purified enzyme. Using the cDNA insert from a clone that encoded the serine dehydratase subunit as a probe, additional clones were isolated from the same library by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa H,Miller DA,Dunn T,Su Y,Burcham JM,Peraino C,Fujioka M,Babcock K,Pitot HC

更新日期：1988-08-01 00:00:00

abstract：:Operating rooms (ORs) are inhabited by hierarchical, mixed-gender clinical teams that are often prone to conflict. In evolutionary terms, one expects more within- than between-gender rivalries, especially since the OR is a place where all sorts of social interactions occur, not merely technical communications. To docu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones LK,Jennings BM,Higgins MK,de Waal FBM

更新日期：2018-07-17 00:00:00

abstract：:Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations. Herein, we report a strategy for the site-specific chemical attachment of ubiquitin to preassembled nucleosomes. This allowed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holt MT,David Y,Pollock S,Tang Z,Jeon J,Kim J,Roeder RG,Muir TW

更新日期：2015-08-18 00:00:00

abstract：:The mechanism of Ca2+-dependent protein-protein interaction and enzyme activation by calmodulin was investigated with the phosphoprotein phosphatase, calcineurin. Dimethylaminonaphthalene (dansyl)-calmodulin, a fluorescent derivative used to monitor complex formation, produced similar maximal activation (10- to 12-fol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kincaid RL,Vaughan M

更新日期：1986-03-01 00:00:00

abstract：:Calls for the eradication of malaria require the development of global and regional strategies based on a strong and consistent evidence base. Evidence from the previous global malaria eradication program and more recent transborder control campaigns have shown the importance of accounting for human movement in introd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatem AJ,Smith DL

更新日期：2010-07-06 00:00:00

abstract：:Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure. Antiepileptic drugs (AEDs), used to treat seizures in children, infants, and pregnant women, cause cognitive impairment, microcephaly, and birth defects. The cause of unwan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bittigau P,Sifringer M,Genz K,Reith E,Pospischil D,Govindarajalu S,Dzietko M,Pesditschek S,Mai I,Dikranian K,Olney JW,Ikonomidou C

更新日期：2002-11-12 00:00:00

abstract：:Adjacent paraffin sections of rat hypothalami fixed in Bouin's fluid were treated either with buffer or with luteinizing hormone-releasing hormone (LHRH) before immunocytochemical staining with anti-LHRH. Upon buffer pretreatment, pituitary gonadotrophs were unstained and hypothalamic fibers were stained. Upon LHRH pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternberger LA,Greenwald JL,Hock D,Elger K,Forssmann WG

更新日期：1981-08-01 00:00:00

abstract：:We examine how presentations of organ donation cases in the media may affect people's willingness to sign organ donation commitment cards, donate the organs of a deceased relative, support the transition to an "opt-out" policy, or donate a kidney while alive. We found that providing identifying information about the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harel I,Kogut T,Pinchas M,Slovic P

更新日期：2017-05-16 00:00:00

abstract：:Homeodomain-interacting protein kinase-2 (HIPK2) is a serine/threonine kinase involved in transcriptional regulation and apoptosis. The transcriptional corepressor CtBP (carboxyl-terminal binding protein) also plays a fundamental role in these processes. Our previous studies indicate that HIPK2 participates in a pathw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Q,Nottke A,Goodman RH

更新日期：2005-02-22 00:00:00

abstract：:Intrathymic T-cell development requires temporally regulated rearrangement and expression of T-cell receptor (TCR) genes. To assess the role of the TCR beta gene transcriptional enhancer (Ebeta) in this process, mouse strains in which Ebeta is deleted were generated using homologous recombination techniques. We report...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bouvier G,Watrin F,Naspetti M,Verthuy C,Naquet P,Ferrier P

更新日期：1996-07-23 00:00:00

abstract：:The one-sided multipliers of an operator space X are a key to "latent operator algebraic structure" in X. We begin with a survey of these multipliers, together with several of the applications that they have had to operator algebras. We then describe several new results on one-sided multipliers, and new applications, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blecher DP,Zarikian V

更新日期：2004-01-20 00:00:00

abstract：:Staphylococcus aureus colonizes the skin of the majority of patients with atopic dermatitis (AD), and its presence increases disease severity. Adhesion of S. aureus to corneocytes in the stratum corneum is a key initial event in colonization, but the bacterial and host factors contributing to this process have not bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Towell AM,Feuillie C,Vitry P,Da Costa TM,Mathelié-Guinlet M,Kezic S,Fleury OM,McAleer MA,Dufrêne YF,Irvine AD,Geoghegan JA

更新日期：2021-01-05 00:00:00

abstract：:Whereas target-specific drugs are available for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no tailored therapy exists for hormone receptor- and ERBB2-negative ("triple-negative") mammary carcinomas. Triple-negative tumors account for 15% of all breast cancers and frequently harbor defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rottenberg S,Jaspers JE,Kersbergen A,van der Burg E,Nygren AO,Zander SA,Derksen PW,de Bruin M,Zevenhoven J,Lau A,Boulter R,Cranston A,O'Connor MJ,Martin NM,Borst P,Jonkers J

更新日期：2008-11-04 00:00:00