Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.

abstract：:The concept of gametic isolation has its origins in the 1937 edition of T. Dobzhansky's Genetics and the Origin of Species. Involving either positive assortative fertilization (as opposed to self-incompatibility) or negative assortative fertilization, it occurs after mating but prior to fertilization. Gametic isolatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markow TA

更新日期：1997-07-22 00:00:00

abstract：:Phase separation of multivalent protein and RNA molecules underlies the biogenesis of biomolecular condensates such as membraneless organelles. In vivo, these condensates encompass hundreds of distinct types of molecules that typically organize into multilayered structures supporting the differential partitioning of m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boeynaems S,Holehouse AS,Weinhardt V,Kovacs D,Van Lindt J,Larabell C,Van Den Bosch L,Das R,Tompa PS,Pappu RV,Gitler AD

更新日期：2019-04-16 00:00:00

abstract：:Precipitates of hemoglobin, termed Heinz bodies, occur in a fraction of erythrocytes after removal of the spleen and are also observed in aged erythrocytes. This implies that precipitates of hemoglobin might play a particular role in senescent cell recognition. By using immunofluorescence microscopy, evidence is prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlüter K,Drenckhahn D

更新日期：1986-08-01 00:00:00

abstract：:Changes in the expression of Hox genes have been widely linked to the evolution of animal body plans, but functional demonstrations of this relationship have been impeded by the lack of suitable model organisms. A classic case study involves the repeated evolution of specialized feeding appendages, called maxillipeds,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pavlopoulos A,Kontarakis Z,Liubicich DM,Serano JM,Akam M,Patel NH,Averof M

更新日期：2009-08-18 00:00:00

abstract：:Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability. However, the mechanism for regulation of the enzymatic activity of SUV39H1 in cancer cells is not yet well known. In this stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Zhou J,Liu X,Lu D,Shen C,Du Y,Wei FZ,Song B,Lu X,Yu Y,Wang L,Zhao Y,Wang H,Yang Y,Akiyama Y,Zhang H,Zhu WG

更新日期：2013-04-02 00:00:00

abstract：:Based largely on studies in xenograft models, lipocalin-2 (Lcn2) has been implicated in the progression of multiple types of human tumors, including breast cancer. Here we examine the role of Lcn2 in mammary tumorigenesis and lung metastasis using an in vivo molecular genetics approach. We crossed a well-characterized...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berger T,Cheung CC,Elia AJ,Mak TW

更新日期：2010-02-16 00:00:00

abstract：:Inorganic elements, although required only in trace amounts, permit life and primary productivity because of their functions in catalysis. Every organism has a minimal requirement of each metal based on the intracellular abundance of proteins that use inorganic cofactors, but elemental sparing mechanisms can reduce th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kropat J,Gallaher SD,Urzica EI,Nakamoto SS,Strenkert D,Tottey S,Mason AZ,Merchant SS

更新日期：2015-03-03 00:00:00

abstract：:Hearing loss is the main limitation of radiation therapy for vestibular schwannoma (VS), and identifying treatment options that minimize hearing loss are urgently needed. Treatment with bevacizumab is associated with tumor control and hearing improvement in neurofibromatosis type 2 (NF2) patients; however, its effect ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Zhao Y,Stemmer-Rachamimov AO,Liu H,Huang P,Chin S,Selig MK,Plotkin SR,Jain RK,Xu L

更新日期：2015-11-24 00:00:00

abstract：:The amounts of mRNAs encoding alpha 1, alpha 6, beta 2, beta 3, gamma 2, and delta subunits of gamma-aminobutyrate type A (GABAA) receptors and the gold immunolabeling density of their translation products were monitored during the growth of neonatal rat granule cells in primary culture. We investigated possible corre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng TM,Zhu WJ,Puia G,Vicini S,Grayson DR,Costa E,Caruncho HJ

更新日期：1994-11-08 00:00:00

abstract：:We examine the quantum confinement in the photoemission ionization energy in air and optical band gap of carbon nanoparticles (CNPs). Premixed, stretched-stabilized ethylene flames are used to generate the CNPs reproducibly over the range of 4-23 nm in volume median diameter. The results reveal that flame-formed CNPs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Singh AV,Saggese C,Tang Q,Chen D,Wan K,Vinciguerra M,Commodo M,De Falco G,Minutolo P,D'Anna A,Wang H

更新日期：2019-06-25 00:00:00

abstract：:The three-dimensional structure of alpha-cobra-toxin, the "long" neurotoxin from the venom of Naja naja siamensis, has been determined at 2.8-A resolution. Crystals grown as hexagonal needles have space group P6522 with unit cell parameters a = b = 74.59 A, c = 42.89 A; one molecule per asymmetric unit. Phases were de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walkinshaw MD,Saenger W,Maelicke A

更新日期：1980-05-01 00:00:00

abstract：:The mitochondrial contact site and cristae organizing system (MICOS) is a multisubunit protein complex that is essential for the proper architecture of the mitochondrial inner membrane. MICOS plays a key role in establishing and maintaining crista junctions, tubular or slit-like structures that connect the cristae mem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pape JK,Stephan T,Balzarotti F,Büchner R,Lange F,Riedel D,Jakobs S,Hell SW

更新日期：2020-08-25 00:00:00

abstract：:Kinetic analysis of the in vitro reconstitution of glyceraldehyde-3-phosphate dehydrogenase [D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12] from yeast showed that both oxidized and reduced coenzyme enhance the transconformation reaction, which is rate limiting in the sequential foldin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaenicke R,Krebs H,Rudolph R,Woenckhaus C

更新日期：1980-04-01 00:00:00

abstract：:The levels of the neural axis from which parasympathetic and orthosympathetic neurons and adrenomedullary cells are derived under normal developmental conditions were determined in avian embryos by a biological labeling technique. The technique is based on nuclear differences between two species of birds, the chick an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Douarin NM,Renaud D,Teillet MA,Le Douarin GH

更新日期：1975-02-01 00:00:00

abstract：:The mammalian protein ZnT3 resides on synaptic vesicle membranes of zinc-containing neurons, suggesting its possible role in vesicular zinc transport. We show here that histochemically reactive zinc, corresponding to the zinc found within synaptic vesicles, was undetectable in the brains of mice with targeted disrupti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole TB,Wenzel HJ,Kafer KE,Schwartzkroin PA,Palmiter RD

更新日期：1999-02-16 00:00:00

abstract：:Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug TNP-470 displays striking cell-type specificity insofar as it induces the expression of p21(CIP/WAF), a cyclin-dependent ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh JR,Mohan R,Crews CM

更新日期：2000-11-07 00:00:00

abstract：:The coding sequence for Anabaena 7120 glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.1] are shown to be contained within a 7.5-kilobase-pair (kbp) HindIII fragment that has been cloned by plaque hybridization. The hybridization probe for the cyanobacterial gene was a recombinant plasmid conta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisher R,Tuli R,Haselkorn R

更新日期：1981-06-01 00:00:00

abstract：:Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron microscopy of pure mitochondrial Lon from Saccharomyces cerevisiae identify Lon as a flexible ring-shaped heptamer. In the presence of ATP or 5'-adenylylimidodiphosphate, most of the rings are symmetric and resemble ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stahlberg H,Kutejová E,Suda K,Wolpensinger B,Lustig A,Schatz G,Engel A,Suzuki CK

更新日期：1999-06-08 00:00:00

abstract：:We created a high-throughput modality of photoactivated localization microscopy (PALM) that enables automated 3D PALM imaging of hundreds of synchronized bacteria during all stages of the cell cycle. We used high-throughput PALM to investigate the nanoscale organization of the bacterial cell division protein FtsZ in l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holden SJ,Pengo T,Meibom KL,Fernandez Fernandez C,Collier J,Manley S

更新日期：2014-03-25 00:00:00

abstract：:Recent work with prion diseases and synucleinopathies indicates that accurate diagnostic methods for protein-folding diseases can be based on the ultrasensitive, amplified measurement of pathological aggregates in biospecimens. A better understanding of the physicochemical factors that control the seeded polymerizatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metrick MA 2nd,do Carmo Ferreira N,Saijo E,Hughson AG,Kraus A,Orrú C,Miller MW,Zanusso G,Ghetti B,Vendruscolo M,Caughey B

更新日期：2019-11-12 00:00:00

abstract：:Certain complex phenotypes appear repeatedly across diverse species due to processes of evolutionary conservation and convergence. In some contexts like developmental body patterning, there is increased appreciation that common molecular mechanisms underlie common phenotypes; these molecular mechanisms include highly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rittschof CC,Bukhari SA,Sloofman LG,Troy JM,Caetano-Anollés D,Cash-Ahmed A,Kent M,Lu X,Sanogo YO,Weisner PA,Zhang H,Bell AM,Ma J,Sinha S,Robinson GE,Stubbs L

更新日期：2014-12-16 00:00:00

abstract：:The class II transactivator (CIITA) is the master integrator of expression of MHC class II genes. It interacts with variety of basal transcription factors to initiate and elongate transcription of these genes. Among others, it recruits positive transcription elongation factor b (P-TEFb) to MHC class II promoters. In c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kohoutek J,Blazek D,Peterlin BM

更新日期：2006-11-14 00:00:00

abstract：:Twelve zeolitic imidazolate frameworks (ZIFs; termed ZIF-1 to -12) have been synthesized as crystals by copolymerization of either Zn(II) (ZIF-1 to -4, -6 to -8, and -10 to -11) or Co(II) (ZIF-9 and -12) with imidazolate-type links. The ZIF crystal structures are based on the nets of seven distinct aluminosilicate zeo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KS,Ni Z,Côté AP,Choi JY,Huang R,Uribe-Romo FJ,Chae HK,O'Keeffe M,Yaghi OM

更新日期：2006-07-05 00:00:00

abstract：:Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix-loop-helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Long X,Creemers EE,Wang DZ,Olson EN,Miano JM

更新日期：2007-10-16 00:00:00

abstract：:A detailed model of the G(2) DNA damage checkpoint (G2DDC) system is presented that includes complex regulatory networks of the mitotic kinase Cdc2, phosphatase Cdc25, Wee1 kinase, and damage signal transduction pathways involving Chk1 and p53. Assumptions on the kinetic equations of the G2DDC are made, and computer s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aguda BD

更新日期：1999-09-28 00:00:00

abstract：:Newly emerging plants provide the best forage for herbivores. To exploit this fleeting resource, migrating herbivores align their movements to surf the wave of spring green-up. With new technology to track migrating animals, the Green Wave Hypothesis has steadily gained empirical support across a diversity of migrator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geremia C,Merkle JA,Eacker DR,Wallen RL,White PJ,Hebblewhite M,Kauffman MJ

更新日期：2019-12-17 00:00:00

abstract：:In a culture medium of pH 7.4 and a folic acid concentration of 100 mug/liter that contains 5% heat-inactivated chicken plasma rather than serum, the rate of proliferation of normal chicken fibroblasts is determined by the concentration of calcium. Proliferation, rapid when the calcium concentration is physiological, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balk SD,Whitfield JF,Youdale T,Braun AC

更新日期：1973-03-01 00:00:00

abstract：:Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4(+) T cells into Th2 and Th17 cells. Using the infection model of Nippostrongyrus brasiliensis, we have confirmed the critical roles of IRF-4 in Th2 development in vivo by using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honma K,Kimura D,Tominaga N,Miyakoda M,Matsuyama T,Yui K

更新日期：2008-10-14 00:00:00

abstract：:We investigated the defensive behavior of honeybees under controlled experimental conditions. During an attack on two identical targets, the spatial distribution of stings varied as a function of the total number of stings, evincing the classic "pitchfork bifurcation" phenomenon of nonlinear dynamics. The experimental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millor J,Pham-Delegue M,Deneubourg JL,Camazine S

更新日期：1999-10-26 00:00:00

abstract：:The plant hormone indole-acetic acid (auxin) is essential for many aspects of plant development. Auxin-mediated growth regulation typically involves the establishment of an auxin concentration gradient mediated by polarly localized auxin transporters. The localization of auxin carriers and their amount at the plasma m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boutté Y,Jonsson K,McFarlane HE,Johnson E,Gendre D,Swarup R,Friml J,Samuels L,Robert S,Bhalerao RP

更新日期：2013-10-01 00:00:00