Roles of calcium, serum, plasma, and folic acid in the control of proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts.

abstract：:The cellular basis of the magnetic sense remains an unsolved scientific mystery. One theory that aims to explain how animals detect the magnetic field is the magnetite hypothesis. It argues that intracellular crystals of the iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman NB,Fritz T,Nimpf S,Pichler P,Lauwers M,Hickman RW,Papadaki-Anastasopoulou A,Ushakova L,Heuser T,Resch GP,Saunders M,Shaw JA,Keays DA

更新日期：2015-01-06 00:00:00

abstract：:Selection is widely accepted as the principal force shaping phenotypic variation within populations. Its importance in speciation and macroevolution has been questioned, however, because phenotypic differences between species or higher taxa sometimes appear to be nonadaptive. Here, we use the quantitative trait locus ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rieseberg LH,Widmer A,Arntz AM,Burke JM

更新日期：2002-09-17 00:00:00

abstract：:The formation and migration of disconnections (line defects constrained to the grain boundary [GB] plane with both dislocation and step character) control many of the kinetic and dynamical properties of GBs and the polycrystalline materials of which they are central constituents. We demonstrate that GBs undergo a fini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen K,Srolovitz DJ,Han J

更新日期：2020-12-29 00:00:00

abstract：:The p21(WAF1) (p21) cyclin-dependent kinase inhibitor plays a major role in regulating cell cycle arrest. It was recently reported that the p53-independent elevation of p21 protein levels is essential in mediating the G(1) arrest resulting from signal transduction events initiated by the crosslinking of membrane IgM o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marches R,Hsueh R,Uhr JW

更新日期：1999-07-20 00:00:00

abstract：:Population growth rate is a fundamental ecological and evolutionary characteristic of living organisms, but individuals must balance the metabolism devoted to biosynthesis and reproduction against the maintenance of existing structure and other functionality. Here we present a mathematical model that relates metabolic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kempes CP,Dutkiewicz S,Follows MJ

更新日期：2012-01-10 00:00:00

abstract：:The expression of interleukin 2 receptors (IL-2R) is a critical step leading to normal lymphocyte proliferation. Since thymosin fraction 5 (TF5), a thymic hormone preparation, enhances lymphoproliferative responses of human cells, we examined the effects of TF5 on the expression of IL-2R on mitogen-stimulated human ly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sztein MB,Serrate SA,Goldstein AL

更新日期：1986-08-01 00:00:00

abstract：:Mouse tumor C1300 has been established in tissue culture. The cells have a round cell morphology in both the subcutaneous tumor and in suspension culture. However, when given a surface on which to attach, they send out processes up to 3 mm in length and assume the morphology of mature neurons. The attached cells are s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schubert D,Humphreys S,Baroni C,Cohn M

更新日期：1969-09-01 00:00:00

abstract：:Purified diphtheria toxin is shown to inhibit protein synthesis in Ehrlich-Lettré ascites carcinoma cells in vitro. Protein synthesis in Ehrlich-Lettré cells is at least 10,000 times more sensitive to toxin than protein synthesis in normal mouse spleen or thymus cells. This sensitivity correlates with the observation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iglewski BH,Rittenberg MB

更新日期：1974-07-01 00:00:00

abstract：:Antigen-specific activation of T lymphocytes, via stimulation of the T-cell antigen receptor (TCR) complex, is marked by a rapid and sustained increase in the concentration of cytoplasmic free Ca2+ ([Ca2+]i). It has been suggested that the second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR stimulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaraman T,Ondriasová E,Ondrias K,Harnick DJ,Marks AR

更新日期：1995-06-20 00:00:00

abstract：:Loss of IκB kinase (IKK) β-dependent NF-κB signaling in hematopoietic cells is associated with increased granulopoiesis. Here we identify a regulatory cytokine loop that causes neutrophilia in Ikkβ-deficient mice. TNF-α-dependent apoptosis of myeloid progenitor cells leads to the release of IL-1β, which promotes Th17 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mankan AK,Canli O,Schwitalla S,Ziegler P,Tschopp J,Korn T,Greten FR

更新日期：2011-04-19 00:00:00

abstract：:Mouse blastocyst functions have been shown to be disrupted by in vitro exposure to N-methyl-N-nitrosourea (MeNU). After exposure, the chemically treated blastocysts were transferred to the uteri of pseudopregnant surrogate mothers. Implantation rate and birth rate have been shown previously to decrease in a concentrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bossert NL,Iannaccone PM

更新日期：1985-12-01 00:00:00

abstract：:Previous studies have identified human breast tumor particles possessing many of the features characteristic of RNA tumor viruses. In addition to the expected size (600 S) and density (1.16 g/ml) these include possession of an outer membrane and an inner one surrounding a "core" containing a DNA polymerase and a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno T,Sweet RW,Dejak D,Spiegelman S

更新日期：1977-02-01 00:00:00

abstract：:We examine the quantum confinement in the photoemission ionization energy in air and optical band gap of carbon nanoparticles (CNPs). Premixed, stretched-stabilized ethylene flames are used to generate the CNPs reproducibly over the range of 4-23 nm in volume median diameter. The results reveal that flame-formed CNPs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Singh AV,Saggese C,Tang Q,Chen D,Wan K,Vinciguerra M,Commodo M,De Falco G,Minutolo P,D'Anna A,Wang H

更新日期：2019-06-25 00:00:00

abstract：:Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in mammals with 16 isoforms that differ in terms of catalytic activity as well as cellular and tissue distribution. CAs catalyze the conversion of CO2 to bicarbonate and protons and are involved in various physiological processes, including learning and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt SD,Costa A,Rani B,Godfried Nachtigall E,Passani MB,Carta F,Nocentini A,de Carvalho Myskiw J,Furini CRG,Supuran CT,Izquierdo I,Blandina P,Provensi G

更新日期：2020-07-07 00:00:00

abstract：:The likelihood with which an action potential elicits neurotransmitter release, the release probability (p(r)), is an important component of synaptic strength. Regulatory mechanisms controlling several steps of synaptic vesicle (SV) exocytosis may affect p(r), yet their relative importance in determining p(r) and elic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matz J,Gilyan A,Kolar A,McCarvill T,Krueger SR

更新日期：2010-05-11 00:00:00

abstract：:Phenotypic capacitance refers to the ability of a genome to accumulate mutations that are conditionally hidden and only reveal phenotype-altering effects after certain environmental or genetic changes. Capacitance has important implications for the evolution of novel forms and functions, but experimentally studied mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayden EJ,Bendixsen DP,Wagner A

更新日期：2015-10-06 00:00:00

abstract：:Genomic RNA from the human prototype strain H of the hepatitis C virus (HCV-H) has been molecularly cloned and sequenced. The HCV-H sequence reported consists of 9416 nucleotides including the 5' and 3' untranslated regions. HCV-H shows 96% amino acid identity with the American isolate HCV-1 but only 84.9% with the Ja...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inchauspe G,Zebedee S,Lee DH,Sugitani M,Nasoff M,Prince AM

更新日期：1991-11-15 00:00:00

abstract：:The ability of cocaine to inhibit the dopamine transporter (DAT) appears to be crucial for its reinforcing properties. The potential use of drugs that produce long-lasting inhibition of the DAT as a mean of preventing the "high" and reducing drug-seeking behavior has become a major strategy in medication development. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkow ND,Wang GJ,Fowler JS,Gatley SJ,Ding YS,Logan J,Dewey SL,Hitzemann R,Lieberman J

更新日期：1996-09-17 00:00:00

abstract：:The refractoriness of acute promyelocytic leukemia (APL) with t(11;17)(q23;q21) to all-trans retinoic acid (ATRA)-based therapy concerns clinicians and intrigues basic researchers. By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα) and RARα/PLZF fusio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiao B,Ren ZH,Liu P,Chen LJ,Shi JY,Dong Y,Ablain J,Shi L,Gao L,Hu JP,Ren RB,de Thé H,Chen Z,Chen SJ

更新日期：2013-02-26 00:00:00

abstract：:Salicylic acid (SA) plays an important role in activating various plant defense responses, including expression of the pathogenesis-related (PR) genes and systemic acquired resistance. A critical positive regulator of the SA signaling pathway in Arabidopsis is encoded by the NPR1 gene. However, there is growing eviden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kachroo P,Shanklin J,Shah J,Whittle EJ,Klessig DF

更新日期：2001-07-31 00:00:00

abstract：:Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for exter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosmans F,Milescu M,Swartz KJ

更新日期：2011-12-13 00:00:00

abstract：:Tumor metastasis is the cause of most cancer deaths. Although metastases can form in multiple end organs, the liver is recognized as a highly permissive organ. Nevertheless, there is evidence for immune cell-mediated mechanisms that function to suppress liver metastasis by certain tumors, although the underlying mecha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura Y,Inoue A,Hangai S,Saijo S,Negishi H,Nishio J,Yamasaki S,Iwakura Y,Yanai H,Taniguchi T

更新日期：2016-12-06 00:00:00

abstract：:Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of Ras is tightly maintained by regulatory factors to promote regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JG,Pappu K,Campbell SL

更新日期：2003-05-27 00:00:00

abstract：:We applied the directional tag PCR subtractive hybridization method to construct a rat hypothalamic cDNA library from which cerebellar and hippocampal sequences had been depleted, enriching 20-30-fold for sequences expressed selectively in the hypothalamus. We studied a sample of 94 clones selected for enrichment in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautvik KM,de Lecea L,Gautvik VT,Danielson PE,Tranque P,Dopazo A,Bloom FE,Sutcliffe JG

更新日期：1996-08-06 00:00:00

abstract：:cDNA clones for the (S)-tetrahydroberberine (H4Ber) oxidase of cultured berberine-producing Coptis japonica cells were isolated by screening a C. japonica cDNA library with synthetic nucleotides that can encode the NH2-terminal sequence of this enzyme. Analyses of the nucleotide sequences of the cloned cDNA inserts re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada N,Koizumi N,Tanaka T,Ohkubo H,Nakanishi S,Yamada Y

更新日期：1989-01-01 00:00:00

abstract：:Single-cell RNA sequencing (scRNA-seq) enables the quantification of each gene's expression distribution across cells, thus allowing the assessment of the dispersion, nonzero fraction, and other aspects of its distribution beyond the mean. These statistical characterizations of the gene expression distribution are cri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang J,Huang M,Torre E,Dueck H,Shaffer S,Murray J,Raj A,Li M,Zhang NR

更新日期：2018-07-10 00:00:00

abstract：:Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification because of its exclusive arterial blood supply. Although TACE achieves substantial necrosis of the tumor, complete tumor necrosis is uncommon, and the res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin WH,Yeh SH,Yeh KH,Chen KW,Cheng YW,Su TH,Jao P,Ni LC,Chen PJ,Chen DS

更新日期：2016-10-18 00:00:00

abstract：:Asexual freshwater planarians reproduce by tearing themselves into two pieces by a process called binary fission. The resulting head and tail pieces regenerate within about a week, forming two new worms. Understanding this process of ripping oneself into two parts poses a challenging biomechanical problem. Because pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malinowski PT,Cochet-Escartin O,Kaj KJ,Ronan E,Groisman A,Diamond PH,Collins ES

更新日期：2017-10-10 00:00:00

abstract：:Four cell types from Vicia faba Linnaeus "Long Pod" leaflets were assayed for three enzymes unique to the photosynthetic carbon reduction pathway. The enzymes were ribulosebisphosphate carboxylase [3-phospho-D-glycerate carboxy-lyase (dimerizing), EC 4.1.1.39], phosphoribulokinase (ATP:D-ribulose-5-phosphate 1-phospho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Outlaw WH,Manchester J,Dicamelli CA,Randall DD,Rapp B,Veith GM

更新日期：1979-12-01 00:00:00

abstract：:We provide evidence that citrate anions bridge between mineral platelets in bone and hypothesize that their presence acts to maintain separate platelets with disordered regions between them rather than gradual transformations into larger, more ordered blocks of mineral. To assess this hypothesis, we take as a model fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davies E,Müller KH,Wong WC,Pickard CJ,Reid DG,Skepper JN,Duer MJ

更新日期：2014-04-08 00:00:00