Abstract:
BACKGROUND:Oxygen (O2) uptake at peak exercise (VO2 peak) is an objective measurement of functional capacity in patients with chronic heart failure (CHF). The significance of recovery O2 kinetics parameters in predicting exercise capacity, and the parameters of submaximal exercise testing have not been thoroughly examined. METHODS AND RESULTS:Thirty-six patients (mean age = 48+/-14 years) with CHF and New York Heart Association functional class I, II, or III, and eight healthy volunteers (mean age = 39+/-13 years) were studied with maximal and submaximal cardiopulmonary exercise testing (CPET). The first degree slope of O2 uptake decay during early recovery from maximal (VO2/t-slope), and submaximal exercise (VO2/t-slope)(sub), were calculated, along with VO2 half-time (T(1/2)VO2). Patients with CHF had a longer recovery of O2 uptake after exercise than healthy volunteers, expressed by a lower VO2/t-slope (0.616+/-0.317 vs. 0.956+/-0.347 l min(-1) min(-1), P=0.029) and greater T(1/2)VO2 (1.28+/-0.30 vs. 1.05+/-0.15 min, P = 0.005). VO2/t-slope correlated with the VO2 peak (r = 0.84, P<0.001), anaerobic threshold (r = 0.79, P<0.001), and T(1/2)VO2, a previously established estimate of recovery O2 kinetics (r = -0.59, P<0.001). (VO2/t-slope)(sub) was highly correlated with VO2/t-slope after maximal exercise (r=0.87, P<0.001), with the VO2 peak (r=0.87, P<0.001) and with T(1/2)VO2 after maximal exercise (r=-0.62, P<0.001). VO2/t-slope after maximal and submaximal exercise was reduced in patients with severe exercise intolerance (F=9.3, P<0.001 and F=12.8, P<0.001, respectively). CONCLUSIONS:Early recovery O2 kinetics parameters after maximal and submaximal exercise correlate closely with established indices of exercise capacity in patients with CHF and in healthy volunteers. These findings support the use of early recovery O2 kinetics after submaximal exercise testing as an index of functional capacity in patients with CHF.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Nanas S,Nanas J,Kassiotis C,Nikolaou C,Tsagalou E,Sakellariou D,Terovitis I,Papazachou O,Drakos S,Papamichalopoulos A,Roussos Cdoi
10.1016/s1388-9842(01)00187-8keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
685-92issue
6eissn
1388-9842issn
1879-0844pii
S1388-9842(01)00187-8journal_volume
3pub_type
杂志文章abstract:AIMS:Liver X receptors (LXRs) transcriptionally regulate inflammation, metabolism, and immunity. Synthetic LXR agonists have been evaluated for their efficacy in the cardiovascular system; however, they elicit prolipogenic side effects which substantially limit their therapeutic use. AZ876 is a novel high-affinity LXR ...
journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
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更新日期:2005-03-02 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章
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