Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.

abstract：:Uridine at the first anticodon position (U34) of glutamate, lysine and glutamine transfer RNAs is universally modified by thiouridylase into 2-thiouridine (s2U34), which is crucial for precise translation by restricting codon-anticodon wobble during protein synthesis on the ribosome. However, it remains unclear how th...

journal_title：Nature

authors： Numata T,Ikeuchi Y,Fukai S,Suzuki T,Nureki O

更新日期：2006-07-27 00:00:00

abstract：:The site of action of the antispastic drug baclofen has long been considered to reside in the spinal cord although supraspinal effects have also been reported. This beta-chlorophenyl derivative of the neurotransmitter gamma-aminobutyric acid (GABA) depresses both monosynaptic and polysynaptic transmission in the cord ...

journal_title：Nature

authors： Price GW,Wilkin GP,Turnbull MJ,Bowery NG

更新日期：1984-01-05 00:00:00

abstract：:Trophic control over the expression and membrane distribution of voltage-dependent ion channels is one of the principal organizing events underlying the maturation of excitable cells. The myelin sheath is a major structural determinant of regional ion channel topography in central axons, but the exact molecular signal...

journal_title：Nature

authors： Noebels JL,Marcom PK,Jalilian-Tehrani MH

更新日期：1991-08-01 00:00:00

abstract：:Landscapes modified by glacial erosion show a distinct distribution of surface area with elevation (hypsometry). In particular, the height of these regions is influenced by climatic gradients controlling the altitude where glacial and periglacial processes are the most active, and as a result, surface area is focused ...

journal_title：Nature

authors： Pedersen VK,Egholm DL

更新日期：2013-01-10 00:00:00

abstract：:Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10-15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (brea...

journal_title：Nature

authors： Dilley RL,Verma P,Cho NW,Winters HD,Wondisford AR,Greenberg RA

更新日期：2016-11-03 00:00:00

abstract：:A magnetic field penetrates a superconductor through an array of 'vortices', each of which carries one quantum of flux that is surrounded by a circulating supercurrent. In this vortex state, the resistivity is determined by the dynamical properties of the vortex 'matter'. For the high-temperature copper oxide supercon...

journal_title：Nature

authors： Bouquet F,Marcenat C,Steep E,Calemczuk R,Kwok WK,Welp U,Crabtree GW,Fisher RA,Phillips NE,Schilling A

更新日期：2001-05-24 00:00:00

abstract：:A consequence of relativity is that in the presence of an electric field, the spin and momentum states of an electron can be coupled; this is known as spin-orbit coupling. Such an interaction opens a pathway to the manipulation of electron spins within non-magnetic semiconductors, in the absence of applied magnetic fi...

journal_title：Nature

authors： Kato Y,Myers RC,Gossard AC,Awschalom DD

更新日期：2004-01-01 00:00:00

abstract：:A CENTRAL assumption about long-term potentiation in the hippocampus is that the two classes of glutamate-receptor ion channel, the N-methyl-D-aspartate (NMDA) and the kainate/quisqualate (non-NMDA) subtypes, are co-localized at individual excitatory synapses. This assumption is important because of the perceived inte...

journal_title：Nature

authors： Bekkers JM,Stevens CF

更新日期：1989-09-21 00:00:00

abstract：:Planetary formation theories suggest that the giant planets formed on circular and coplanar orbits. The eccentricities of Jupiter, Saturn and Uranus, however, reach values of 6 per cent, 9 per cent and 8 per cent, respectively. In addition, the inclinations of the orbital planes of Saturn, Uranus and Neptune take maxi...

journal_title：Nature

authors： Tsiganis K,Gomes R,Morbidelli A,Levison HF

更新日期：2005-05-26 00:00:00

abstract：:The nature and length scales of charge screening in complex oxides are fundamental to a wide range of systems, spanning ceramic voltage-dependent resistors (varistors), oxide tunnel junctions and charge ordering in mixed-valence compounds. There are wide variations in the degree of charge disproportionation, length sc...

journal_title：Nature

authors： Ohtomo A,Muller DA,Grazul JL,Hwang HY

更新日期：2002-09-26 00:00:00

abstract：:TMV RNA is not an efficient template for translation of the viral coat protein, in spite of containing nucleotide sequences coding for the protein. Efficient translation requires the prior synthesis within infected cells of a smaller RNA carrying only a portion of the information encoded in the whole genome. ...

journal_title：Nature

authors： Hunter TR,Hunt T,Knowland J,Zimmern D

更新日期：1976-04-29 00:00:00

abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...

journal_title：Nature

authors： Carter P,Wells JA

更新日期：1988-04-07 00:00:00

abstract：:The rare Egyptian vulture (Neophron percnopterus) stands out among the Old World vultures (Family Accipitridae) because of its brightly ornamented head, which is coloured yellow by carotenoid pigments, and its practice of feeding on faeces. Here we show that Egyptian vultures obtain these pigments from the excrement o...

journal_title：Nature

authors： Negro JJ,Grande JM,Tella JL,Garrido J,Hornero D,Donázar JA,Sanchez-Zapata JA,BenItez JR,Barcell M

更新日期：2002-04-25 00:00:00

abstract：:Folding of two monomeric enzymes mediated by groE has been reconstituted in vitro. The groEL protein stabilizes the polypeptides in a conformation resembling the 'molten globule' state. Mg-ATP and groES then promote the acquisition of ordered tertiary structure at the surface of groEL. Folding requires the hydrolysis ...

journal_title：Nature

authors： Martin J,Langer T,Boteva R,Schramel A,Horwich AL,Hartl FU

更新日期：1991-07-04 00:00:00

abstract：:The generation of a double-strand break in the Saccharomyces cerevisiae genome is a potentially catastrophic event that can induce cell-cycle arrest or ultimately result in loss of cell viability. The repair of such lesions is strongly dependent on proteins encoded by the RAD52 epistasis group of genes (RAD50-55, RAD5...

journal_title：Nature

authors： New JH,Sugiyama T,Zaitseva E,Kowalczykowski SC

更新日期：1998-01-22 00:00:00

abstract：:RecBCD is a multi-functional enzyme complex that processes DNA ends resulting from a double-strand break. RecBCD is a bipolar helicase that splits the duplex into its component strands and digests them until encountering a recombinational hotspot (Chi site). The nuclease activity is then attenuated and RecBCD loads Re...

journal_title：Nature

authors： Singleton MR,Dillingham MS,Gaudier M,Kowalczykowski SC,Wigley DB

更新日期：2004-11-11 00:00:00

abstract：:We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. ...

journal_title：Nature

authors： Aach J,Bulyk ML,Church GM,Comander J,Derti A,Shendure J

更新日期：2001-02-15 00:00:00

abstract：:Synapse assembly requires trans-synaptic signals between the pre- and postsynapse, but our understanding of the essential organizational molecules involved in this process remains incomplete. Teneurin proteins are conserved, epidermal growth factor (EGF)-repeat-containing transmembrane proteins with large extracellula...

journal_title：Nature

authors： Mosca TJ,Hong W,Dani VS,Favaloro V,Luo L

更新日期：2012-03-18 00:00:00

abstract：:In metazoans, the Ras-Raf-MEK (mitogen-activated protein-kinase kinase)-ERK (extracellular signal-regulated kinase) signalling pathway relays extracellular stimuli to elicit changes in cellular function and gene expression. Aberrant activation of this pathway through oncogenic mutations is responsible for a large prop...

journal_title：Nature

authors： Brennan DF,Dar AC,Hertz NT,Chao WC,Burlingame AL,Shokat KM,Barford D

更新日期：2011-04-21 00:00:00

abstract：:A type Ia supernova is thought to be a thermonuclear explosion of either a single carbon-oxygen white dwarf or a pair of merging white dwarfs. The explosion fuses a large amount of radioactive (56)Ni (refs 1-3). After the explosion, the decay chain from (56)Ni to (56)Co to (56)Fe generates γ-ray photons, which are rep...

journal_title：Nature

authors： Churazov E,Sunyaev R,Isern J,Knödlseder J,Jean P,Lebrun F,Chugai N,Grebenev S,Bravo E,Sazonov S,Renaud M

更新日期：2014-08-28 00:00:00

abstract：:Pairwise recognition of splice sites as a result of a scanning mechanism is an attractive model to explain the coordination of vertebrate splicing. Such a mechanism would predict a polarity-of-site recognition in the scanned unit, but no evidence for a polarity gradient across introns has been found. We have suggested...

journal_title：Nature

authors： Niwa M,MacDonald CC,Berget SM

更新日期：1992-11-19 00:00:00

abstract：:The collagens represent an interesting example of a structurally related but genetically distinct family of proteins. Type I, the most abundant of the vertebrate collagens, comprises two pro alpha 1(I) chains and one pro alpha 2(I) chain, each containing terminal propeptides and a central domain of 338 (Gly, X, Y) rep...

journal_title：Nature

authors： Chu ML,de Wet W,Bernard M,Ding JF,Morabito M,Myers J,Williams C,Ramirez F

更新日期：1984-07-26 00:00:00

abstract：:There is considerable interest in the existence and significance of alternative conformations of DNA to the right-handed B-form described originally by Watson and Crick. The indirect immunofluorescence observations of Nordheim et al., Arndt-Jovin et al. and Lemeunier et al. that antibodies against left-handed Z-DNA bi...

journal_title：Nature

authors： Hill RJ,Stollar BD

更新日期：1983-09-22 00:00:00

abstract：: ...

journal_title：Nature

authors： Ainsworth C

更新日期：2018-11-01 00:00:00

abstract：:Methane is a potent greenhouse gas that is produced in significant quantities by aerobic marine organisms. These bacteria apparently catalyse the formation of methane through the cleavage of the highly unreactive carbon-phosphorus bond in methyl phosphonate (MPn), but the biological or terrestrial source of this compo...

journal_title：Nature

authors： Kamat SS,Williams HJ,Dangott LJ,Chakrabarti M,Raushel FM

更新日期：2013-05-02 00:00:00

abstract：:An outstanding question is how cells control the number and size of membrane organelles. The small GTPase Rab5 has been proposed to be a master regulator of endosome biogenesis. Here, to test this hypothesis, we developed a mathematical model of endosome dependency on Rab5 and validated it by titrating down all three ...

journal_title：Nature

authors： Zeigerer A,Gilleron J,Bogorad RL,Marsico G,Nonaka H,Seifert S,Epstein-Barash H,Kuchimanchi S,Peng CG,Ruda VM,Del Conte-Zerial P,Hengstler JG,Kalaidzidis Y,Koteliansky V,Zerial M

更新日期：2012-05-23 00:00:00

abstract：:Somatic sexual differentiation in Drosophila melanogaster involves a cascade of regulated splicing events and provides an attractive model system for the analysis of alternative splicing mechanisms. The protein Sex-lethal (Sxl) activates a female-specific 3' splice site in the first intron of transformer (tra) pre-mRN...

journal_title：Nature

authors： Valcárcel J,Singh R,Zamore PD,Green MR

更新日期：1993-03-11 00:00:00

abstract：:Cytochrome c oxidase is a member of the haem copper oxidase superfamily (HCO). HCOs function as the terminal enzymes in the respiratory chain of mitochondria and aerobic prokaryotes, coupling molecular oxygen reduction to transmembrane proton pumping. Integral to the enzyme's function is the transfer of electrons from...

journal_title：Nature

authors： Lyons JA,Aragão D,Slattery O,Pisliakov AV,Soulimane T,Caffrey M

更新日期：2012-07-26 00:00:00

abstract：:Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single primary tumour. This evolutionary process culminates in the formation of metastases, which is the cause of 90% of cancer-related deaths. However, despite its clinical importance, little is known...

journal_title：Nature

authors： Gundem G,Van Loo P,Kremeyer B,Alexandrov LB,Tubio JMC,Papaemmanuil E,Brewer DS,Kallio HML,Högnäs G,Annala M,Kivinummi K,Goody V,Latimer C,O'Meara S,Dawson KJ,Isaacs W,Emmert-Buck MR,Nykter M,Foster C,Kote-Jarai Z,

更新日期：2015-04-16 00:00:00

abstract：:Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senesc...

journal_title：Nature

authors： Yu GL,Bradley JD,Attardi LD,Blackburn EH

更新日期：1990-03-08 00:00:00