Corneal collagen fibril structure in three dimensions: Structural insights into fibril assembly, mechanical properties, and tissue organization.

abstract：:Glutamyl-tRNA (Glu-tRNA), formed by Glu-tRNA synthetase (GluRS), is a substrate for protein biosynthesis and tetrapyrrole formation by the C(5) pathway. In this route Glu-tRNA is transformed to delta-aminolevulinic acid, the universal precursor of tetrapyrroles (e.g., heme and chlorophyll) by the action of Glu-tRNA re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levicán G,Katz A,de Armas M,Núñez H,Orellana O

更新日期：2007-02-27 00:00:00

abstract：:Cyclotides are plant defense peptides that have been extensively investigated for pharmaceutical and agricultural applications, but key details of their posttranslational biosynthesis have remained elusive. Asparaginyl endopeptidases are crucial in the final stage of the head-to-tail cyclization reaction, but the enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rehm FBH,Jackson MA,De Geyter E,Yap K,Gilding EK,Durek T,Craik DJ

更新日期：2019-04-16 00:00:00

abstract：:A model is presented for age-specific selection on the genotypes in a population. Each genotype is assigned a life table that specifies the viability and fecundity of its age classes. Breeding and reproduction occur at regular intervals, and generations overlap. Examples were generated on a digital computer. Gene freq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WW,King CE

更新日期：1970-07-01 00:00:00

abstract：:Evolution of an oxygenic atmosphere required primordial life to accommodate the toxicity associated with reactive oxygen species. We have characterized an archaeal antioxidant from the hyperthermophilic acidophile Sulfolobus solfataricus. The amino acid sequence of this approximately 22-kDa protein shares little seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiedenheft B,Mosolf J,Willits D,Yeager M,Dryden KA,Young M,Douglas T

更新日期：2005-07-26 00:00:00

abstract：:Recent theory suggests that animals should switch facultatively among canonical movement modes as a complex function of internal state, landscape characteristics, motion capacity, and navigational capacity. We tested the generality of this paradigm for free-ranging elk (Cervus elaphus) over 5 orders of magnitude in ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fryxell JM,Hazell M,Börger L,Dalziel BD,Haydon DT,Morales JM,McIntosh T,Rosatte RC

更新日期：2008-12-09 00:00:00

abstract：:Lesion of the sciatic nerve caused a rapid increase in c-fos and c-jun mRNA that was followed about 2 hr later by an increase in nerve growth factor (NGF) mRNA. To evaluate whether the initial increase in c-fos mRNA is causally related to the subsequent increase in NGF mRNA, we performed experiments with fibroblasts o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hengerer B,Lindholm D,Heumann R,Rüther U,Wagner EF,Thoenen H

更新日期：1990-05-01 00:00:00

abstract：:In epithelial cells, sorting of membrane proteins to the basolateral surface depends on the presence of a basolateral sorting signal (BaSS) in their cytoplasmic domain. Amyloid precursor protein (APP), a basolateral protein implicated in the pathogenesis of Alzheimer's disease, contains a tyrosine-based BaSS, and muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng P,Eastman J,Vande Pol S,Pimplikar SW

更新日期：1998-12-08 00:00:00

abstract：:The primary structure of the Escherichia coli hemolysin polypeptide (HlyA) is used to predict intramolecular structures involved in the secretion and cytolytic activity of the molecule. The C-terminal region of HlyA contains a repeated, 8-amino acid chain represented by the consensus sequence Leu-Xaa-Gly-Gly-Xaa-Gly-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felmlee T,Welch RA

更新日期：1988-07-01 00:00:00

abstract：:Molecular recognition by proteins is fundamental to molecular biology. Dissection of the thermodynamic energy terms governing protein-ligand interactions has proven difficult, with determination of entropic contributions being particularly elusive. NMR relaxation measurements have suggested that changes in protein con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caro JA,Harpole KW,Kasinath V,Lim J,Granja J,Valentine KG,Sharp KA,Wand AJ

更新日期：2017-06-20 00:00:00

abstract：:Immediate postretrieval bilateral blockade of long-acting voltage-dependent calcium channels (L-VDCCs), but not of glutamatergic NMDA receptors, in the dorsal CA1 region of the hippocampus hinders retention of long-term spatial memory in the Morris water maze. Immediate postretrieval bilateral inhibition of calcium/ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Da Silva WC,Cardoso G,Bonini JS,Benetti F,Izquierdo I

更新日期：2013-04-16 00:00:00

abstract：:The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presumed to act primarily through protein-protein interactions. We, and others, have identified a widely expressed protein, Ldb1, whose C-terminal 76-residues are sufficient to mediate interactio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Visvader JE,Mao X,Fujiwara Y,Hahm K,Orkin SH

更新日期：1997-12-09 00:00:00

abstract：:Two issues long debated among Pacific and American prehistorians are (i) whether there was a pre-Columbian introduction of chicken (Gallus gallus) to the Americas and (ii) whether Polynesian contact with South America might be identified archaeologically, through the recovery of remains of unquestionable Polynesian or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Storey AA,Ramírez JM,Quiroz D,Burley DV,Addison DJ,Walter R,Anderson AJ,Hunt TL,Athens JS,Huynen L,Matisoo-Smith EA

更新日期：2007-06-19 00:00:00

abstract：:VIP21/caveolin is localized to both caveolae and apical transport vesicles and presumably cycles between the cell surface and the Golgi complex. We have studied the lipid interactions of this protein by reconstituting Escherichia coli-expressed VIP21/caveolin into liposomes. Surprisingly, the protein reconstituted onl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murata M,Peränen J,Schreiner R,Wieland F,Kurzchalia TV,Simons K

更新日期：1995-10-24 00:00:00

abstract：:Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) has been implicated in Parkinson's disease (PD) and is present in neurofibrillary tangles or Lewy bodies. However, the molecular basis for UCH-L1s involvement in proteinacious fibril formation is still elusive, especially in regard to the pathogenicity of the I93M muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koharudin LM,Liu H,Di Maio R,Kodali RB,Graham SH,Gronenborn AM

更新日期：2010-04-13 00:00:00

abstract：:Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we investigated its possible involvement in the brain's response to focal cerebral ischemia. Ischemia was induced by occlusion of the middle cerebral artery in the rat for 90 min, and proliferating...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin K,Minami M,Lan JQ,Mao XO,Batteur S,Simon RP,Greenberg DA

更新日期：2001-04-10 00:00:00

abstract：:Physiological properties of the flagellar rotary motor have been taken to indicate a tightly coupled mechanism in which each revolution is driven by a fixed number of energizing ions. Measurements that would directly test the tight-coupling hypothesis have not been made. Energizing ions flow through membrane-bound com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boschert R,Adler FR,Blair DF

更新日期：2015-04-14 00:00:00

abstract：:Orchids employing sexual deceit attract males of their pollinator species through specific volatile signals that mimic female-released sex pheromones. One of these signals proved to be 2-ethyl-5-propylcyclohexan-1,3-dione (chiloglottone1), a new natural product that was shown to be most important in the relations betw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franke S,Ibarra F,Schulz CM,Twele R,Poldy J,Barrow RA,Peakall R,Schiestl FP,Francke W

更新日期：2009-06-02 00:00:00

abstract：:A three-step purification procedure for the isolation of heart muscle chalones is described. The method uses ultrafiltration followed by concanavalin A-Sepharose affinity chromatography and subsequent sucrose density gradient centrifugation. Analytical ultracentrifugation of the highly purified chalone fraction indica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriek JA,van der Walt BJ,Bester AJ

更新日期：1981-07-01 00:00:00

abstract：:O(6)-methylguanine (O(6)meG) and related modifications of guanine in double-stranded DNA are functionally severe lesions that can be produced by many alkylating agents, including N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a potent carcinogen. O(6)meG is repaired through its demethylation by the O(6)-alkylguanine-DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CS,Shemorry A,Varshavsky A

更新日期：2009-02-17 00:00:00

abstract：:T cell-dependent B-cell responses decline with age, suggesting defective CD4 T-cell function. CD4 memory T cells from individuals older than 65 y displayed increased and sustained transcription of the dual-specific phosphatase 4 (DUSP4) that shortened expression of CD40-ligand (CD40L) and inducible T-cell costimulator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu M,Li G,Lee WW,Yuan M,Cui D,Weyand CM,Goronzy JJ

更新日期：2012-04-10 00:00:00

abstract：:Natural killer (NK) cells are key players in the innate response to viruses, including herpesviruses. In particular, the variety of viral strategies to modulate the recognition of certain herpesviruses witnesses the importance of NK cells in the control of this group of viruses. Still, NK evasion strategies have remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grauwet K,Cantoni C,Parodi M,De Maria A,Devriendt B,Pende D,Moretta L,Vitale M,Favoreel HW

更新日期：2014-11-11 00:00:00

abstract：:The pyridoxal 5'-phosphate cofactor of glycogen phosphorylase a (1,4-alpha-D-glucan:orthophosphate alpha-glucosyltransferase, EC2.4.1.1.) has been positioned on the protomer with x-ray diffraction data, chemical markers, and sequence information. The electron density was computed from 3.0-A resolution phases calculate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sygusch J,Madsen NB,Kasvinsky PJ,Fletterick RJ

更新日期：1977-11-01 00:00:00

abstract：:Almost all democratic societies evolved socially and politically out of authoritarian and nondemocratic regimes. These changes not only altered the allocation of economic resources in society but also the structure of political power. In this paper, we develop a framework for studying the dynamics of political and soc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acemoglu D,Egorov G,Sonin K

更新日期：2011-12-27 00:00:00

abstract：:Aggression is a universal social behavior important for the acquisition of food, mates, territory, and social status. Aggression in Drosophila is context-dependent and can thus be expected to involve inputs from multiple sensory modalities. Here, we use mechanical disruption and genetic approaches in Drosophila melano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Versteven M,Vanden Broeck L,Geurten B,Zwarts L,Decraecker L,Beelen M,Göpfert MC,Heinrich R,Callaerts P

更新日期：2017-02-21 00:00:00

abstract：:The thesis is developed that a low oxygen level Precambrian atmosphere presented early-evolving metazoan organisms with physiological connective tissue priorities resulting from the important molecular oxygen requirements in the biosynthesis of collagen hydroxyproline. Shells, cuticles, and carapaces which are not man...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Towe KM

更新日期：1970-04-01 00:00:00

abstract：:One of the principles that has emerged from experimental evolutionary studies of microorganisms is that polymorphic alleles or new mutations can sometimes possess a latent potential to respond to selection in different environments, although the alleles may be functionally equivalent or disfavored under typical condit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stebbins GL,Hartl DL

更新日期：1988-07-01 00:00:00

abstract：:[3H]Thymidine-labeled progeny DNA was isolated after infection of Escherichia coli with two different bacteriophage T4 mutants. These strands were isolated shortly after the initiation of DNA replication and hybridized to 15 different (EcoRI) T4 restriction fragments cloned in plasmid vectors. Uniformly labeled T4 [32...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halpern ME,Mattson T,Kozinski AW

更新日期：1979-12-01 00:00:00

abstract：:Two mutations are described that alter the pattern of inheritance of chloroplast genes in Chlamydomonas. The mutant gene mat-1 linked to the mating type allele mt(-) greatly increases the frequency of exceptional zygotes, i.e., zygotes that transmit chloroplast genes from the mt(-) (male) parent. In some crosses, 80-9...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sager R,Ramanis Z

更新日期：1974-12-01 00:00:00

abstract：:Resistance to the antibiotic fusidic acid (FA) in the human pathogen Staphylococcus aureus usually results from expression of FusB-type proteins (FusB or FusC). These proteins bind to elongation factor G (EF-G), the target of FA, and rescue translation from FA-mediated inhibition by an unknown mechanism. Here we show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox G,Thompson GS,Jenkins HT,Peske F,Savelsbergh A,Rodnina MV,Wintermeyer W,Homans SW,Edwards TA,O'Neill AJ

更新日期：2012-02-07 00:00:00

abstract：:We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of the induction of CO...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masferrer JL,Zweifel BS,Manning PT,Hauser SD,Leahy KM,Smith WG,Isakson PC,Seibert K

更新日期：1994-04-12 00:00:00