Abstract：
:Non-nucleoside reverse transcriptase inhibitors (NNRTIs) act quite specifically on human immunodeficiency virus type 1 (HIV-1). In general, they are not effective on human immunodeficiency virus type 2 (HIV-2) or simian immunodeficiency virus (SIV). Only SIV strains from African green monkeys are sensitive to several NNRTIs. Here we isolated NNRTI- and 3TC-resistant SIVagm variants. Viruses resistant to delavirdine contained V112I and M231I substitutions, while those resistant to 3TC contained a M 185I substitution. These amino acids are highly conserved in HIV-1, HIV-2, SIVmac and SIVagm, and the M184I (M185I in SIVagm) substitution was observed in 3TC-resistant HIV-1 and SIVmac. The roles of the observed mutations in NNRTI-resistance of SIVagm and HIV-1 were further confirmed by site-directed mutagenesis. The present results have provided a new insight into the common mechanism of sensitivity of HIV- 1 and SIVagm to NNRTIs.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Isaka Y,Miki S,Kawauchi S,Suyama A,Sugimoto H,Adachi A,Hayami M,Yoshie O,Fujiwara T,Sato Adoi
10.1007/s007050070003keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
2481-92issue
12eissn
0304-8608issn
1432-8798journal_volume
145pub_type
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