Recent progress in protocadherin research.


:Protocadherins constitute a large family belonging to the cadherin superfamily and function in different tissues of a wide variety of multicellular organisms. Protocadherins have unique features that are not found in classic cadherins. Expression of protocadherins is spatiotemporally regulated and they are localized at synapses in the CNS. Although protocadherins have Ca(2+)-dependent homophilic interaction activity, the activities are relatively weak. Some protocadherins have heterophilic interaction activity and the cytoplasmic domains associate with the unique cytoplasmic proteins, which are essential for their biological functions. Given the characteristic properties, the large size, and the diversity of members of the protocadherin family, protocadherins may participate in various biological processes. In particular, protocadherins seem to play a central role(s) in the CNS as related to synaptic function.


Exp Cell Res


Suzuki ST





Has Abstract


2000-11-25 00:00:00














  • Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells.

    abstract::Eps8 controls actin dynamics directly through its barbed end capping and actin-bundling activity, and indirectly by regulating Rac-activation when engaged into a trimeric complex with Eps8-Abi1-Sos1. Recently, Eps8 has been associated with promotion of various solid malignancies, but neither its mechanisms of action n...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Welsch T,Younsi A,Disanza A,Rodriguez JA,Cuervo AM,Scita G,Schmidt J

    更新日期:2010-07-15 00:00:00

  • Simvastatin induces differentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways.

    abstract::Statins are competitive inhibitors of hydroxy-methyl-glutaryl Coenzyme A (HMG-CoA) reductase, a key enzyme involved in the conversion of HMG-CoA to the cholesterol precursor mevalonate. Some statins, such as simvastatin (simvastatin), have been shown to have anti-cancer and anti-inflammatory effects, reducing cartilag...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Han Y,Kim SJ

    更新日期:2016-08-15 00:00:00

  • Localization of the nerve growth factor receptor on fetal human Schwann cells in culture.

    abstract::Previous studies have established that Schwann cells (SC) in culture express an NGF receptor. In this study, cultures of fetal human SC were established from fetal nerves and various light microscopic (LM) and electron microscopic (EM) techniques were used to localize the NGF receptor on the SC. Results indicate that ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Assouline JG,Pantazis NJ

    更新日期:1989-06-01 00:00:00

  • Cellular responses to disruption of the permeability barrier in a three-dimensional organotypic epidermal model.

    abstract::Repeated injury to the stratum corneum of mammalian skin (caused by friction, soaps, or organic solvents) elicits hyperkeratosis and epidermal thickening. Functionally, these changes serve to restore the cutaneous barrier and protect the organism. To better understand the molecular and cellular basis of this response,...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Ajani G,Sato N,Mack JA,Maytin EV

    更新日期:2007-08-15 00:00:00

  • Centrosomal association of histone macroH2A1.2 in embryonic stem cells and somatic cells.

    abstract::The histone 2A variant macroH2A1.2 is expressed in female and male mammals and is implicated in X-chromosome inactivation and autosomal gene silencing. In undifferentiated and early differentiating murine embryonic stem (ES) cells a cytosolic pool of macroH2A1.2 has recently been reported and found to be associated wi...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Mermoud JE,Tassin AM,Pehrson JR,Brockdorff N

    更新日期:2001-08-15 00:00:00

  • Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance.

    abstract::Ets variant gene 5 (ETV5) and glial cell-derived neurotrophic factor (GDNF) are produced in Sertoli cells and required for maintenance and self-renewal of spermatogonial stem cells (SSCs) in mice. Fibroblast growth factors (FGFs) have been reported to stimulate Etv5 mRNA expression, and FSH was shown to stimulate Gdnf...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Simon L,Ekman GC,Tyagi G,Hess RA,Murphy KM,Cooke PS

    更新日期:2007-08-15 00:00:00

  • Growth and differentiation potential of main- and side-population cells derived from murine skeletal muscle.

    abstract::Skeletal muscle-derived CD34+/45- (Sk-34) cells were identified as a new candidate for stem cells. However, the relationship between Sk-34 cells and side-population (SP) cells is unknown. Here, we demonstrate that Sk-34 cells prepared from murine skeletal muscles consist wholly of main-population (MP) cells. The Sk-34...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Tamaki T,Akatsuka A,Okada Y,Matsuzaki Y,Okano H,Kimura M

    更新日期:2003-11-15 00:00:00

  • Microinjected anti-actin antibodies decrease gap junctional intercellular commmunication in cultured astrocytes.

    abstract::The purpose of the present study was to investigate the influence of the actin cytoskeleton on gap junctional intercellular communication (GJIC) in cultured astrocytes. This report describes an decrease of GJIC following microinjection of anti-actin antibodies or cytochalasin D treatment. Dye transfer of microinjected...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Theiss C,Meller K

    更新日期:2002-12-10 00:00:00

  • Adhesion of human amnion epithelial cells to extracellular matrix. Evidence for multiple mechanisms.

    abstract::Human amnion epithelial cells attach and flatten slowly (approximately 65 min) onto plastic in the presence of serum but much more rapidly (20-30 min) onto subcellular matrix (SCM) deposited by the same cells. This matrix contains both fibronectin and laminin, but neither molecule on its own can reproduce its adhesive...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Aplin JD,Campbell S,Foden LJ

    更新日期:1984-08-01 00:00:00

  • Zebrafish and Xenopus tadpoles: small animal models to study angiogenesis and lymphangiogenesis.

    abstract::Small vertebrate organisms have emerged as key players in the post-genomic era for the functional characterization of novel genes on a high-throughput scale. In this context, the zebrafish embryos and Xenopus tadpoles represent attractive and valuable models to rapidly identify and characterize novel genes involved in...

    journal_title:Experimental cell research

    pub_type: 杂志文章,评审


    authors: Ny A,Autiero M,Carmeliet P

    更新日期:2006-03-10 00:00:00

  • Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans.

    abstract::We report here the identification and characterization of STIP, a multi-domain nuclear protein that contains a G-patch, a coiled-coil, and several short tryptophan-tryptophan repeats highly conserved in metazoan species. To analyze their functional role in vivo, we cloned nematode stip-1 genes and determined the spati...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Ji Q,Huang CH,Peng J,Hashmi S,Ye T,Chen Y

    更新日期:2007-04-15 00:00:00

  • Distinct hydrophobic "patches" in the N- and C-tails of beta-catenin contribute to nuclear transport.

    abstract::β-catenin is a key mediator of Wnt signaling and its deregulated nuclear accumulation can drive cancer progression. While the central armadillo (Arm) repeats of β-catenin stimulate nuclear entry, the N- and C-terminal "tail" sequences are thought to regulate turnover and transactivation. We show here that the N- and C...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Sharma M,Jamieson C,Lui C,Henderson BR

    更新日期:2016-11-01 00:00:00

  • Sendai virus envelope glycoproteins become laterally mobile on the surface of human erythrocytes following fusion.

    abstract::Fluorescence photobleaching recovery has been employed to study the lateral mobility of the Sendai virus envelope glycoproteins (HN, neuraminidase/hemagglutinin protein (HN) fusion protein (F) on the surface of human erythrocytes. Our results indicate that the two viral glycoproteins are laterally immobile on the cell...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Henis YI,Gutman O,Loyter A

    更新日期:1985-10-01 00:00:00

  • Human immunodeficiency virus type 1 Tat protein modulates cell cycle and apoptosis in Epstein-Barr virus-immortalized B cells.

    abstract::Patients infected with human immunodeficiency virus type 1 (HIV-1) develop a spectrum of B cell lymphoproliferative disorders ranging from polyclonal B cell activation to B cell lymphomas. While a direct role of Epstein-Barr virus (EBV) is well recognized for most of these lesions, recent findings have suggested that ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Colombrino E,Rossi E,Ballon G,Terrin L,Indraccolo S,Chieco-Bianchi L,De Rossi A

    更新日期:2004-05-01 00:00:00

  • The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor.

    abstract::Activation of growth factor receptors, such as platelet-derived growth factor (PDGF) receptors, has a major impact on the motile behavior of vertebrate cells. The WASP family of proteins has been recognized as important regulators of actin polymerization via the activation of the Arp2/3 complex. The activity of the WA...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Aspenström P

    更新日期:2002-09-10 00:00:00

  • Induction of neurite outgrowth in PC12 cells by gamma-lactam-related compounds via Ras-MAP kinase signaling pathway independent mechanism.

    abstract::Rat pheochromocytoma cells, PC12 cells, undergo differentiation in response to nerve growth factor (NGF). Although the Ras-MAP kinase signaling pathway has been shown to play a central role in the response to NGF, the precise mechanism which induces differentiation remains unclarified. Recently, several gamma-lactam-r...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Yao R,Osada H

    更新日期:1997-08-01 00:00:00

  • 1,25-dihydroxyvitamin D3 induces biphasic NF-kappaB responses during HL-60 leukemia cells differentiation through protein induction and PI3K/Akt-dependent phosphorylation/degradation of IkappaB.

    abstract::1,25-dihydroxyvitamin D(3) (VD(3)) induces differentiation in a number of leukemia cell lines and under various conditions is able to either stimulate or inhibit nuclear factor kappa B (NF-kappaB) activity. Here we report a time-dependent biphasic regulation of NF-kappaB in VD(3)-treated HL-60 leukemia cells. After VD...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Tse AK,Wan CK,Shen XL,Zhu GY,Cheung HY,Yang M,Fong WF

    更新日期:2007-05-01 00:00:00

  • Macaque trophoblast migration is regulated by RANTES.

    abstract::In human and non-human primates, migratory trophoblasts penetrate the uterine epithelium, invade the endometrium, enter the uterine vasculature, and migrate within the arteries. The mechanisms that regulate this directional migration are unknown. We have used early gestation macaque trophoblasts to test the hypothesis...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Thirkill TL,Lowe K,Vedagiri H,Blankenship TN,Barakat AI,Douglas GC

    更新日期:2005-05-01 00:00:00

  • Differential regulation of thyrotropin receptor and thyroglobulin mRNA accumulation at the cellular level: an in situ hybridization study.

    abstract::Regulation of TSH receptor (TSHr) mRNA accumulation has been investigated in canine thyrocytes in primary culture by in situ hybridization experiments; the effects of the mitogenic thyrotropin (TSH), epidermal growth factor (EGF), and phorbol ester TPA (12-O-tetradecanoylphorbol-13-acetate) have been compared. Apart f...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Pohl V,Maenhaut C,Gérard C,Vassart G,Dumont JE

    更新日期:1992-04-01 00:00:00

  • Fiber DNA studies of premeiotic mouse spermatogenesis.

    abstract::The technique of fiber DNA measurement was used to study the possibility that the lengthening of the DNA "S" phase previously reported for mouse premeiotic spermatogonia was due to a reduced number of initiation sites. The mean replicon size of neonatal mouse preleptotene cells was similar to sizes reported for adult ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Jagiello G,Sung WK,Van't Hof J

    更新日期:1983-07-01 00:00:00

  • Pivotal role of the RB family proteins in in vitro thyroid cell transformation.

    abstract::Rat thyroid differentiated cells (PC Cl 3) are an excellent model system with which to study the interaction between differentiation and cell transformation. We previously demonstrated that PC Cl 3 cells expressing the adenovirus E1A gene no longer depend on thyrotropin for growth and do not express thyroid differenti...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Iuliano R,Trapasso F,Stella A,Le Pera I,Melillo RM,Bruni P,Baldassarre G,Chiariotti L,Santoro M,Viglietto G,Fusco A

    更新日期:2000-11-01 00:00:00

  • FPR1 gene silencing suppresses cardiomyocyte apoptosis and ventricular remodeling in rats with ischemia/reperfusion injury through the inhibition of MAPK signaling pathway.

    abstract::Ischemia/reperfusion (I/R) injury, one of the leading health problems in the world, is defined as a cause of cardiomyocytes death. In the present study, we investigate the role of formyl peptide receptor 1 (FPR1) in cardiomyocyte apoptosis and ventricular remodeling of I/R injury rats and the underlying mechanism invo...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Zhou QL,Teng F,Zhang YS,Sun Q,Cao YX,Meng GW

    更新日期:2018-09-15 00:00:00

  • Functional characterization of the spontaneously transformed human umbilical vein endothelial cell line ECV304: use in an in vitro model of angiogenesis.

    abstract::To gain insight into the role of the endothelial cell during the pathophysiology of the angiogenic response, investigators have isolated micro- and macrovascular endothelial cells from a wide range of both animal and human vessels, including the umbilical vein. Human umbilical vein endothelial cells (HUVECs) isolated ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Hughes SE

    更新日期:1996-05-25 00:00:00

  • An increase in the intracellular pH of fertilized eggs of Xenopus laevis is associated with inhibition of protein and DNA syntheses and followed by an arrest of embryonic development.

    abstract::In many systems, events participating in cell division are controlled by intracellular pH (pHi). In Xenopus eggs, fertilization is accompanied by an increase in pHi which occurs concomitantly with an increase in protein synthesis and a reinitiation of DNA synthesis, leading the embryo to cell division. In this paper, ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Grandin N,Charbonneau M

    更新日期:1989-12-01 00:00:00

  • Skeletal muscle: energy metabolism, fiber types, fatigue and adaptability.

    abstract::Skeletal muscles cope with a large range of activities, from being able to support the body weight during long periods of upright standing to perform explosive movements in response to an unexpected threat. This requires systems for energy metabolism that can provide energy during long periods of moderately increased ...

    journal_title:Experimental cell research

    pub_type: 杂志文章,评审


    authors: Westerblad H,Bruton JD,Katz A

    更新日期:2010-11-01 00:00:00

  • Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle.

    abstract::The Golgi apparatus undergoes extensive fragmentation during mitosis in animal cells. Protein kinases play a critical role during fragmentation of the Golgi apparatus. We reported here that Polo-like kinase 3 (Plk3) may be an important mediator during Golgi breakdown. Specifically, Plk3 was concentrated at the Golgi a...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Ruan Q,Wang Q,Xie S,Fang Y,Darzynkiewicz Z,Guan K,Jhanwar-Uniyal M,Dai W

    更新日期:2004-03-10 00:00:00

  • Improvement of calcium handling and changes in calcium-release properties after mini- or full-length dystrophin forced expression in cultured skeletal myotubes.

    abstract::Dystrophin is a cytoskeletal protein normally expressed underneath the sarcolemma of muscle fibers. The lack of dystrophin in Duchenne muscular Dystrophy (DMD) muscles results in fiber necrosis, which was proposed to be mediated by chronic calcium mishandling. The extensive comparison of dystrophic cells from human or...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Marchand E,Constantin B,Balghi H,Claudepierre MC,Cantereau A,Magaud C,Mouzou A,Raymond G,Braun S,Cognard C

    更新日期:2004-07-15 00:00:00

  • Toxic peptides in Frazer's fraction interact with the actin cytoskeleton and affect the targeting and function of intestinal proteins.

    abstract::Celiac disease (CD) is a multisystemic autoimmune inflammation of the intestinal tract induced by wheat gluten and related cereals in HLA-DQ2/8 positive individuals. An essential role in the pathogenesis of CD is played by a fraction of the peptic-tryptic digest of gluten, Frazer's Fraction (FF). Here, we investigate ...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Reinke Y,Zimmer KP,Naim HY

    更新日期:2009-11-15 00:00:00

  • Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1.

    abstract::Topoisomerase II is essential for cell proliferation and survival and has been a target of various anticancer drugs. ICRF-193 has long been used as a catalytic inhibitor to study the function of topoisomerase II. Here, we show that ICRF-193 treatment induces DNA damage signaling. Treatment with ICRF-193 induced G2 arr...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Park I,Avraham HK

    更新日期:2006-07-01 00:00:00

  • Defect in prereplicative phase of G0-specific ts mutant, tsJT60.

    abstract::A temperature-sensitive mutant, tsJT60, grew exponentially at both 34 degrees and 39.5 degrees C, but when stimulated from the resting state it entered S phase at 34 degrees but not at 39.5 degrees C. The mutated function appeared to be a prerequisite throughout from 0 to 9 h following the stimulation, in order that G...

    journal_title:Experimental cell research

    pub_type: 杂志文章


    authors: Ninomiya-Tsuji J,Goto Y,Ishibashi S,Ide T

    更新日期:1986-07-01 00:00:00