Recent progress in protocadherin research.

Abstract:

:Protocadherins constitute a large family belonging to the cadherin superfamily and function in different tissues of a wide variety of multicellular organisms. Protocadherins have unique features that are not found in classic cadherins. Expression of protocadherins is spatiotemporally regulated and they are localized at synapses in the CNS. Although protocadherins have Ca(2+)-dependent homophilic interaction activity, the activities are relatively weak. Some protocadherins have heterophilic interaction activity and the cytoplasmic domains associate with the unique cytoplasmic proteins, which are essential for their biological functions. Given the characteristic properties, the large size, and the diversity of members of the protocadherin family, protocadherins may participate in various biological processes. In particular, protocadherins seem to play a central role(s) in the CNS as related to synaptic function.

journal_name

Exp Cell Res

authors

Suzuki ST

doi

10.1006/excr.2000.5039

keywords:

subject

Has Abstract

pub_date

2000-11-25 00:00:00

pages

13-8

issue

1

eissn

0014-4827

issn

1090-2422

pii

S0014-4827(00)95039-0

journal_volume

261

pub_type

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