Ciliary neurotrophic factor combined with soluble receptor inhibits synthesis of proinflammatory cytokines and prostaglandin-E2 in vitro.

abstract：:Stress-activated protein (SAP) kinases and the mitochondrial pro-apoptotic Bcl-2 protein Bak are important regulators of apoptosis. Reduced expression of Bak increases cellular resistance to the anticancer agent cisplatin, and we report here that mouse embryo fibroblasts deficient in the SAP kinase jnk1 are highly res...

journal_title：Experimental cell research

authors： Ihrlund LS,Hernlund E,Viktorsson K,Panaretakis T,Barna G,Sabapathy K,Linder S,Shoshan MC

更新日期：2006-05-15 00:00:00

abstract：:Infection with Kaposi's sarcoma-associated herpesvirus (KSHV) is a prerequisite for Kaposi's sarcoma, a multicentric endothelial tumor of mixed blood vessel-lymphatic phenotype with a marked production of endothelial basement membrane proteins. The viral K1 gene encodes a unique transmembrane protein capable of transf...

journal_title：Experimental cell research

authors： Mebrahtu S,Eriksson U,Rauch U,Warenholt J,Bendsöe N,Dictor M

更新日期：2004-01-15 00:00:00

abstract：:The altered patterns of expression of gangliosides during density-dependent growth inhibition, oncogenic transformation, and embryogenesis suggest that gangliosides, sialylated membrane glycolipids, may affect cellular proliferation and differentiation. Gangliosides of the "b" pathway of ganglioside synthesis, includi...

journal_title：Experimental cell research

authors： Paller AS,Arnsmeier SL,Fisher GJ,Yu QC

更新日期：1995-03-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase inhibitors have been shown to affect endocytosis or subsequent intracellular sorting in various receptor systems. Agonist-activated beta(2)-adrenergic receptors undergo desensitization by mechanisms that include the phosphorylation, endocytosis and degradation of receptors. Following endo...

journal_title：Experimental cell research

authors： Awwad HO,Iyer V,Rosenfeld JL,Millman EE,Foster E,Moore RH,Knoll BJ

更新日期：2007-07-15 00:00:00

abstract：:A temperature-sensitive mutant, tsJT60, grew exponentially at both 34 degrees and 39.5 degrees C, but when stimulated from the resting state it entered S phase at 34 degrees but not at 39.5 degrees C. The mutated function appeared to be a prerequisite throughout from 0 to 9 h following the stimulation, in order that G...

journal_title：Experimental cell research

authors： Ninomiya-Tsuji J,Goto Y,Ishibashi S,Ide T

更新日期：1986-07-01 00:00:00

abstract：:Chronic lymphocytic leukemia lymphocytes were used to study mechanisms involved in apoptosis (programmed cell death). Apoptosis, which was determined by morphological changes including cell death and by internucleosomal DNA fragmentation, occurred during culture for 1 to 2 days in a portion of the cells from three of ...

journal_title：Experimental cell research

authors： Forbes IJ,Zalewski PD,Giannakis C,Cowled PA

更新日期：1992-02-01 00:00:00

abstract：:Malignant melanoma (MM) remains the leading cause of skin cancer related death, which has very poor prognosis because of locoregional recurrence and distant metastasis. DEPDC1B (DEP domain-containing protein 1B), has been proved to be associated with some types of malignant tumors. However, the role of DEPDC1B in MM i...

journal_title：Experimental cell research

authors： Xu Y,Sun W,Zheng B,Liu X,Luo Z,Kong Y,Xu M,Chen Y

更新日期：2019-06-01 00:00:00

abstract：:In a previous paper (Barboro et al., 1993, Biophys. J. 65, 1690-1699) we have shown that cancer development in the resistant hepatocyte model of Solt and Farber is characterized by the progressive unfolding of the higher-order structure of chromatin. A possible functional role of decondensation phenomena in cell trans...

journal_title：Experimental cell research

authors： Barboro P,Alberti I,Sanna P,Parodi S,Balbi C,Allera C,Patrone E

更新日期：1996-06-15 00:00:00

abstract：:The effect of retinoic acid treatment on cell attachment to plastic substrates precoated with fibronectin, gelatin, laminin, and type IV collagen was investigated. Both retinoic acid-treated and control cells attached efficiently to fibronectin or gelatin substrates without any significant difference. In contrast, ret...

journal_title：Experimental cell research

authors： Kato S,De Luca LM

更新日期：1987-12-01 00:00:00

abstract：:Microfilament-associated proteins and membrane-microfilament interactions are being investigated in microvilli isolated from 13,762 rat mammary ascites tumor cells. "Phalloidin shift" analyses on velocity sedimentation gradients of Triton X-100 extracts of [3H]-glucosamine-labeled microvilli identified a 120-kDa cell-...

journal_title：Experimental cell research

authors： Vanderpuye OA,Carraway CA,Carraway KL

更新日期：1988-10-01 00:00:00

abstract：:There are a number of low-abundance small nuclear RNAs (snRNAs) in eukaryotic cells. Many of them have been assigned functions in the biogenesis of cellular RNAs, such as splicing and 3' end processing. Here, we present the sequence of Xenopus U12 snRNA and compare the secondary structures of the low-abundance U11 and...

journal_title：Experimental cell research

authors： Yu YT,Tarn WY,Yario TA,Steitz JA

更新日期：1996-12-15 00:00:00

abstract：:The fruit fly Drosophila melanogaster has recently emerged as an excellent system to investigate the genetics of cardiovascular development and disease. Drosophila provides an inexpensive and genetically-tractable in vivo system with a large number of conserved features. In addition, the Drosophila embryo is transpare...

journal_title：Experimental cell research

authors： McFaul CMJ,Fernandez-Gonzalez R

更新日期：2017-09-01 00:00:00

abstract：:High throughput RNA sequencing techniques have revealed that a large fraction of the genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding genes, lncRNAs do not contain long open reading frames (ORFs) and tend to be poorly conserved across species. However, many of them contain sma...

journal_title：Experimental cell research

authors： Ruiz-Orera J,Villanueva-Cañas JL,Albà MM

更新日期：2020-06-01 00:00:00

abstract：:Advanced stage neuroblastomas (NB) exhibit a tissue inhibitor of metalloproteinase (TIMP)-2/matrix metalloproteinase (MMP) imbalance, considered a prerequisite for MMP involvement in tumor progression in vivo. Human SH-SY5Y NB cells exhibit a similar TIMP-2/MMP imbalance that promotes in vitro invasive behavior that i...

journal_title：Experimental cell research

authors： Cappabianca L,Farina AR,Tacconelli A,Mantovani R,Gulino A,Mackay AR

更新日期：2003-06-10 00:00:00

abstract：:The importance of mononuclear leukocyte (MO) adhesion to dysfunctional endothelium and migration to the subendothelial space in the early phases of atherogenesis is well established. Few studies have addressed the relevance of polymorphonuclear leukocytes (PMNs) in the context of evolving lesions, and nothing is known...

journal_title：Experimental cell research

authors： Donetti E,Baetta R,Comparato C,Altana C,Sartore S,Paoletti R,Castano P,Gabbiani G,Corsini A

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Our purpose was to investigate the role of the nitric oxide (NO) signaling pathway in the regulation of ciliary beat frequency (CBF) in mouse nasal and tracheal epithelial cells. METHODS:We studied the effects of the NO donor l-arginine (L-Arg) and specific inhibitors of the NO signaling pathway on CBF of b...

journal_title：Experimental cell research

authors： Jiao J,Wang H,Lou W,Jin S,Fan E,Li Y,Han D,Zhang L

更新日期：2011-10-15 00:00:00

abstract：:Interleukin 3 (IL-3) stimulates the growth of various types of hemopoietic progenitors. In vitro, survival of a series of murine cell lines derived from either neoplastic or nonneoplastic hemopoietic tissue shows a strict IL-3 dependence. In order to test the implication of energy metabolism in this dependence as clai...

journal_title：Experimental cell research

authors： Reisbach G,Ellwart J,Dörmer P

更新日期：1990-10-01 00:00:00

abstract：:The measurement of chromomycin A3/DAPI fluorescence ratios is shown to allow base content determinations in eu- and heterochromatic regions of interphase cell nuclei. The base content values obtained in chromocenters and euchromatin of Scilla sibirica agree with those measured earlier [12] on the band and non-band are...

journal_title：Experimental cell research

authors： Leemann U,Ruch F

更新日期：1983-09-01 00:00:00

abstract：:DNA methylation in F9 embryonal carcinoma cells at various stages of retinoic acid-induced differentiation was compared to that in immortalized differentiated derivatives of this cell line. Different repetitive sequences, such as L1 LINE, GAPDH pseudogenes, and major and minor satellite DNA, lost their methylation to ...

journal_title：Experimental cell research

authors： Teubner B,Schulz WA

更新日期：1994-02-01 00:00:00

abstract：:Alternative splicing is an important mechanism that can disrupt cell cycle control resulting in tumorigenesis. Although many alterations of Transforming Growth Factor Beta (TGFβ) signaling are reported in cancers, the role of splice aberrations in destabilizing this signaling is the least understood mechanism. In this...

journal_title：Experimental cell research

authors： Sivadas VP,Gulati S,Varghese BT,Balan A,Kannan S

更新日期：2014-09-10 00:00:00

abstract：:Specific cholecystokinin (CCK) receptor and gastrin receptor antagonists were used to assess what role, if any, these receptors have in autocrine cell growth. Although the cholecystokinin receptor antagonist, L-364,718, inhibited cell proliferation in a broad spectrum of cell lines, the gastrin antagonist, L-365,260, ...

journal_title：Experimental cell research

authors： Thumwood CM,Hong J,Baldwin GS

更新日期：1991-01-01 00:00:00

abstract：:Xenopus oocytes carry IGF-I receptors, and undergo meiotic maturation in response to binding of IGF-I or insulin to the IGF-I receptor. Maturation is initiated upon activation of the IGF-I receptor tyrosine kinase and requires tyrosine dephosphorylation of p34cdc2, the kinase component of maturation promoting factor (...

journal_title：Experimental cell research

authors： Hainaut P,Giorgetti S,Kowalski A,Ballotti R,Van Obberghen E

更新日期：1991-07-01 00:00:00

abstract：:Acetylcholine receptors (AChRs) of rat muscle cells grown in culture for 4 days were labeled with 125I-alpha-bungarotoxin and their degradation rate measured. Two AChR populations, a rapidly degrading one (Rr,t1/2 approximately 1 day) and a slowly degrading one (Rs, t1/2 approximately 4 days) were identified at a rati...

journal_title：Experimental cell research

authors： O'Malley JP,Rubin LL,Salpeter MM

更新日期：1993-09-01 00:00:00

abstract：:Members of the Bcl-2 family of proteins are key regulators of apoptosis. Some of these proteins undergo posttranslational modification, such as phosphorylation or proteolysis, that serves to alter their function. Caspases are known to cleave Bid, a proapoptotic family member, as well as Bcl-2 and Bcl-X(L), two prosurv...

journal_title：Experimental cell research

authors： Wood DE,Newcomb EW

更新日期：2000-05-01 00:00:00

abstract：:Previous studies have indicated that space flight affects the activation of lymphocytes from humans, monkeys, and rodents. In rats, where lymphocytes from blood, spleen, and lymph nodes have been tested, the accumulated data suggest that the effects of flight on various cells are lymphoid organ-specific. Thus, cells m...

journal_title：Experimental cell research

authors： Grove DS,Pishak SA,Mastro AM

更新日期：1995-07-01 00:00:00

abstract：:A polypeptide growth factor has been isolated from serum-free medium conditioned by mouse PC13 embryonal carcinoma cells, which is strongly mitogenic for Swiss 3T3 fibroblasts. On a CM-2-SW high-performance liquid chromatography cation-exchange column at low pH, this growth factor elutes at a salt concentration very c...

journal_title：Experimental cell research

authors： van Veggel JH,van Oostwaard TM,de Laat SW,van Zoelen EJ

更新日期：1987-04-01 00:00:00

abstract：:We performed liquid chromatography-tandem mass spectrometry (LC-MS/MS) on control and TGF-β1-exposed rat lung fibroblasts to identify proteins differentially expressed between cell populations. A total of 196 proteins were found to be differentially expressed in response to TGF-β1 treatment. Guided by these results, w...

journal_title：Experimental cell research

authors： Na M,Hong X,Fuyu J,Dingjie X,Sales D,Hui Z,Zhongqiu W,Shifeng L,Xuemin G,Wenchen C,Dan L,Guizhen Z,Bonan Z,Lijuan Z,Shumin L,Ying Z,Jin W,Mingwang R,Summer R,Fang Y

更新日期：2019-02-15 00:00:00

abstract：:Galectin-3, a beta-galactoside-binding protein, has been shown to be involved in multiple biological processes through interaction with its complementary glycoconjugates. Here we provide the first evidence of galectin-3 as a mitogen. Incubation of quiescent cultures of normal human lung fibroblast IMR-90 cells with re...

journal_title：Experimental cell research

authors： Inohara H,Akahani S,Raz A

更新日期：1998-12-15 00:00:00

abstract：:Local regulation of the cortical cytoskeleton controls cell surface dynamics. GAP-43 and MARCKS are two abundant cytosolic protein kinase C substrates that are anchored to the cell membrane via acyl groups and interact with the cortical cytoskeleton. Each of them has been implicated in several forms of motility involv...

journal_title：Experimental cell research

authors： Wiederkehr A,Staple J,Caroni P

更新日期：1997-10-10 00:00:00

abstract：:Replication protein A (RPA), a stable complex of three polypeptides, is the single-stranded DNA-binding protein essential for DNA replication in eukaryotic cells. Previous studies of the subcellular distribution and stability of the RPA heterotrimer during the mammalian cell cycle have produced conflicting results. He...

journal_title：Experimental cell research

authors： Dimitrova DS,Gilbert DM

更新日期：2000-02-01 00:00:00