Abstract：
:We have found that thiamine-deficient (TD) rats show significant impairment of avoidance learning on the 25th day after the start of TD diet, as measured by passive-avoidance task. Administration of physostigmine (0.1 mg/kg, i.p.) from the 14th day after the start of TD diet improved the impairment of avoidance learning to the pair-fed (PF) control level by the 25th day. However, the recovery effect of physostigmine did not occur on the 25th day when the treatment was begun on the 21st day. To ascertain the correlation between the cholinergic neuronal function in rat brain and the avoidance learning impairment induced by TD, the immunohistochemical distribution of brain choline acetyltransferase (ChAT) was determined by fluorescence intensity using two-dimensional microphotometry. The intensity of the ChAT fluorescence started to decrease in the cortex and hippocampus on the 14th day and showed a marked decrease in the cortex, hippocampus and thalamus on the 25th day of TD feeding in comparison with PF controls. The intensity of the somatostatin (SST) fluorescence was unchanged on the 14th day of TD feeding, but on the 25th day, SST was significantly decreased in comparison with PF controls. Furthermore, physostigmine treatment from 14th day after the start of TD diet reversed SST fluorescence intensity to the control level by the 25th day. These results suggest that the impairment of avoidance learning induced by TD may involve not only cholinergic but also somatostatinergic systems.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Nakagawasai O,Tadano T,Hozumi S,Tan-No K,Niijima F,Kisara Kdoi
10.1016/s0361-9230(00)00248-3keywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
189-96issue
3eissn
0361-9230issn
1873-2747pii
S0361-9230(00)00248-3journal_volume
52pub_type
杂志文章abstract：:The direct monosynaptic pathway which exists between vasoactive intestinal peptide (VIP) and GnRH neurons in the hypothalamic preoptic area provides a neuroanatomical background for the modulatory effects of VIP exerted on GnRH neurons activity. Though central microinjection of VIP revealed its involvement in the modu...
journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0361-9230(84)90209-0
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.04.002
更新日期：2008-08-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(87)90014-1
更新日期：1987-03-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1981-12-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1985-06-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90272-d
更新日期：1993-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90168-w
更新日期：1992-12-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2011.05.009
更新日期：2011-07-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2016.04.008
更新日期：2016-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2005.12.003
更新日期：2006-03-31 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.03.007
更新日期：2007-07-12 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Brain research bulletin
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更新日期：2016-10-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2020-12-25 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2005-09-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2019.08.013
更新日期：2019-11-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2012.06.004
更新日期：2012-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(96)00034-2
更新日期：1996-01-01 00:00:00
