Identification of a new repetitive element in Staphylococcus aureus.

abstract：:Controversy persists over the role that the capsular polysaccharide plays in the pathogenesis of Staphylococcus aureus infections. To address this issue, we compared the mouse virulence of S. aureus Reynolds and capsule-defective mutant strains cultivated under conditions of high or low capsule expression. Strain Reyn...

journal_title：Infection and immunity

authors： Thakker M,Park JS,Carey V,Lee JC

更新日期：1998-11-01 00:00:00

abstract：:The Lyme disease spirochete, Borrelia burgdorferi, controls protein expression patterns during its tick-mammal infection cycle. Earlier studies demonstrated that B. burgdorferi synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably changing production of several infection-...

journal_title：Infection and immunity

authors： Arnold WK,Savage CR,Antonicello AD,Stevenson B

更新日期：2015-04-01 00:00:00

abstract：:Intestinal mucus is postulated to play a role in preventing colonization of the gastrointestinal tract by microbial pathogens. To evaluate the ability of both crude mucus and purified mucin, a glycoprotein of goblet cell origin, to inhibit mucosal adherence of enteric pathogens, we examined whether mucus and mucin der...

journal_title：Infection and immunity

authors： Drumm B,Roberton AM,Sherman PM

更新日期：1988-09-01 00:00:00

abstract：:Whooping cough results from infection of the respiratory tract with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacterium to establish infection. Despite extensive study of the mechanism of ACT cytotoxicity and its effects over a range of concentrations in vitro, ACT has n...

journal_title：Infection and immunity

authors： Eby JC,Gray MC,Warfel JM,Paddock CD,Jones TF,Day SR,Bowden J,Poulter MD,Donato GM,Merkel TJ,Hewlett EL

更新日期：2013-05-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a common cause of otitis media and respiratory tract infections. Outer membrane proteins (OMP) and lipooligosaccharide (LOS) are major surface antigens of NTHi and potential vaccine candidates. De-O-acylated LOS (dLOS) or oligosaccharide (OS) was coupled to total OMP to for...

journal_title：Infection and immunity

authors： Wu TH,Gu XX

更新日期：1999-10-01 00:00:00

abstract：:Pulmonary washings from rabbits were freed of cells and added to the monolayers of homologous alveolar macrophages (AM). At 1 h after incubation with the pulmonary washings, many more cells adhered to glass, spread out, and showed enhanced Nitro Blue Tetrazolium reduction. The maximal effect of the pulmonary washings ...

journal_title：Infection and immunity

authors： Ando M,Suga M,Shima K,Sugimoto M,Tokuomi H

更新日期：1978-05-01 00:00:00

abstract：:Increased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovis is a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovis infections of cattle in the United Kingdom, and...

journal_title：Infection and immunity

authors： Clark S,Cross ML,Nadian A,Vipond J,Court P,Williams A,Hewinson RG,Aldwell FE,Chambers MA

更新日期：2008-08-01 00:00:00

abstract：:We studied seven strains of group G streptococci isolated from clinically severe bacteremic infections in six intravenous drug abusers. These group G strains multiplied luxuriantly in fresh human blood. On electron microscopy, they exhibited surface fibrillae similar to those observed in M-protein-rich group A strepto...

journal_title：Infection and immunity

authors： Bisno AL,Craven DE,McCabe WR

更新日期：1987-03-01 00:00:00

abstract：:The C-terminal 19-kDa domain of merozoite surface protein 1 (MSP1₁₉) is the target of protective antibodies but alone is poorly immunogenic. Previously, using the Plasmodium yoelii murine model, we fused P. yoelii MSP1₁₉ (PyMSP1₁₉) with full-length P. yoelii merozoite surface protein 8 (MSP8). Upon immunization, the M...

journal_title：Infection and immunity

authors： Alaro JR,Angov E,Lopez AM,Zhou H,Long CA,Burns JM Jr

更新日期：2012-07-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a genetic disorder of NADPH oxidase in which phagocytes are defective in generating reactive oxidants. CGD patients suffer from recurrent infections and exuberant and persistent tissue granuloma formation. We hypothesized that abnormal granulomata in CGD may result from aberrant ...

journal_title：Infection and immunity

authors： Segal BH,Doherty TM,Wynn TA,Cheever AW,Sher A,Holland SM

更新日期：1999-04-01 00:00:00

abstract：:We have compared the intraleukocytic survival of isogenic strains of Salmonella typhimurium, whose outer membrane lipopolysaccharide differed in O antigen and lipid A composition and whose susceptibility to nonoxidative antimicrobial granule proteins of human polymorphonuclear neutrophilis (PMN) could be established. ...

journal_title：Infection and immunity

authors： Stinavage P,Martin LE,Spitznagel JK

更新日期：1989-12-01 00:00:00

abstract：:Toxin B from Clostridium difficile is cytopathic in vitro for various types of cells, including polymorphonuclear cells, lymphocytes, and monocytes. Since intestine lamina propria is rich in macrophages, we studied the effect of toxin B on human monocytes and on human macrophages generated in vitro by long-term cultur...

journal_title：Infection and immunity

authors： Siffert JC,Baldacini O,Kuhry JG,Wachsmann D,Benabdelmoumene S,Faradji A,Monteil H,Poindron P

更新日期：1993-03-01 00:00:00

abstract：:The intravascular trematode Schistosoma mansoni is a causative agent of schistosomiasis, a disease that constitutes a major health problem globally. In this study we cloned and characterized the schistosome tegumental phosphodiesterase SmNPP-5 and evaluated its role in parasite virulence. SmNPP-5 is a 52.5-kDa protein...

journal_title：Infection and immunity

authors： Bhardwaj R,Krautz-Peterson G,Da'dara A,Tzipori S,Skelly PJ

更新日期：2011-10-01 00:00:00

abstract：:We recently determined that passive transfer of serum directed against a synthetic peptide called LB1 or a recombinant fusion protein immunogen [LPD-LB1(f)(2,1,3)] could prevent otitis media after challenge with a homologous nontypeable Haemophilus influenzae (NTHI) isolate. NTHI residing in the nasopharynx was rapidl...

journal_title：Infection and immunity

authors： Kennedy BJ,Novotny LA,Jurcisek JA,Lobet Y,Bakaletz LO

更新日期：2000-05-01 00:00:00

abstract：:Escherichia coli strains expressing the K1 capsule are a major cause of sepsis and meningitis in human neonates. The development of these diseases is dependent on the expression of a range of virulence factors, many of which remain uncharacterized. Here, we show that all but 1 of 34 E. coli K1 neonatal isolates carrie...

journal_title：Infection and immunity

authors： McCarthy AJ,Martin P,Cloup E,Stabler RA,Oswald E,Taylor PW

更新日期：2015-09-01 00:00:00

abstract：:Broth culture supernatants from Tox+ Helicobacter pylori strains induce vacuolation of HeLa cells in vitro and contain VacA in concentrations that are higher than those found in supernatants from Tox- H. pylori strains. To investigate the basis for this phenomenon, we analyzed the transcription of the vacuolating cyto...

journal_title：Infection and immunity

authors： Forsyth MH,Atherton JC,Blaser MJ,Cover TL

更新日期：1998-07-01 00:00:00

abstract：:To demonstrate local synthesis of anti-Mycobacterium leprae antibodies, biopsies from skin lesions of leprosy patients were cultured in vitro in a medium containing 14C-labeled lysine and isoleucine, and the culture fluids were analyzed by crossed immunoelectrophoresis with intermediate gel and autoradiography. The re...

journal_title：Infection and immunity

authors： Lai A Fat RF,Chan Pin Jin J,van Furth R,Harboe M

更新日期：1980-02-01 00:00:00

abstract：:Purified beta-toxin from Clostridium perfringens type C was found to be a single polypeptide chain protein with a molecular weight of approximately 30,000. The toxin was heat labile, with 75% of its activity being inactivated by incubation at 50 degrees C for 5 min. Biological activity of the purified toxin was comple...

journal_title：Infection and immunity

authors： Sakurai J,Duncan CL

更新日期：1978-08-01 00:00:00

abstract：:A crude complex containing group C polysaccharide, outer membrane proteins, and lipopolysaccharide (LPS) was isolated from the cell-free culture liquid of Neisseria meningitidis serogroup C, serotype 2a. Group C polysaccharide and LPS were removed from this complex, resulting in an outer membrane complex and a purifie...

journal_title：Infection and immunity

authors： Beuvery EC,Miedema F,van Delft RW,Haverkamp J,Leussink AB,te Pas BJ,Teppema KS,Tiesjema RH

更新日期：1983-04-01 00:00:00

abstract：:The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis. In addition to altered physiology, transformed cell lines are composed of a singl...

journal_title：Infection and immunity

authors： Ranganathan S,Doucet M,Grassel CL,Delaine-Elias B,Zachos NC,Barry EM

更新日期：2019-03-25 00:00:00

abstract：:Chlamydia trachomatis L2 is an obligate intracellular microorganism with a unique biphasic life cycle. The extracellular form, the elementary body (EB), is infectious but metabolically inactive. Attachment of EBs to host cells is medicated by a heparan sulfate-like glycosaminoglycan. Following attachment, the EB is in...

journal_title：Infection and immunity

authors： Birkelund S,Johnsen H,Christiansen G

更新日期：1994-11-01 00:00:00

abstract：:Phagocytosis of Borrelia burgdorferi by human polymorphonuclear leukocytes triggers oxygen-dependent and -independent mechanisms of potentially cidal outcome. Nevertheless, no factor or process has yet been singled out as being borreliacidal. We have studied the B. burgdorferi-killing ability of the myeloperoxidase-H2...

journal_title：Infection and immunity

authors： Garcia R,Gusmani L,Murgia R,Guarnaccia C,Cinco M,Rottini G

更新日期：1998-04-01 00:00:00

abstract：:We examined the reactivities of Clostridium butyricum neurotoxin to nine monoclonal antibodies against Clostridium botulinum type E neurotoxin which recognize the light chain or the amino-terminal half (H-1 fragment) or the carboxyl-terminal half (H-2 fragment) of the heavy chain of botulinum neurotoxin. Butyricum neu...

journal_title：Infection and immunity

authors： Kozaki S,Onimaru J,Kamata Y,Sakaguchi G

更新日期：1991-01-01 00:00:00

abstract：:The type III capsular polysaccharide of group B streptococci (GBS) consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid, or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought t...

journal_title：Infection and immunity

authors： Wessels MR,Haft RF,Heggen LM,Rubens CE

更新日期：1992-02-01 00:00:00

abstract：:Pathogen attachment to host cells is a key process during infection, and inhibition of pathogen adhesion is a promising approach to the prevention of infectious disease. We have previously shown that multivalent adhesion molecules (MAMs) are abundant in both pathogenic and commensal bacterial species, mediate early at...

journal_title：Infection and immunity

authors： Al-Saedi F,Stones DH,Vaz DP,Krachler AM

更新日期：2016-05-24 00:00:00

abstract：:Investigating the innate immune response mediators released in milk has manifold implications, spanning from elucidation of the role played by mammary epithelial cells (MECs) in fighting microbial infections to the discovery of novel diagnostic markers for monitoring udder health in dairy animals. Here, we investigate...

journal_title：Infection and immunity

authors： Addis MF,Pisanu S,Marogna G,Cubeddu T,Pagnozzi D,Cacciotto C,Campesi F,Schianchi G,Rocca S,Uzzau S

更新日期：2013-09-01 00:00:00

abstract：:In 2001, a bioterrorism attack involving Bacillus anthracis spore-laced letters resulted in 22 cases of inhalation anthrax, with five fatalities. This incident identified gaps in our health care system and precipitated a renewed interest in identifying both therapeutics and rapid diagnostic assays. To address those ga...

journal_title：Infection and immunity

authors： Rossi CA,Ulrich M,Norris S,Reed DS,Pitt LM,Leffel EK

更新日期：2008-12-01 00:00:00

abstract：:In a model of experimental Chagas' disease induced with metacyclic forms of Trypanosoma cruzi, CD4+ but not CD8+ T cells undergo T-cell receptor (TCR)-CD3-mediated activation-induced cell death (AICD) in vitro. CD4+ T cells from T. cruzi-infected mice also developed unresponsiveness in proliferative responses to TCR-C...

journal_title：Infection and immunity

authors： Lopes MF,DosReis GA

更新日期：1996-05-01 00:00:00

abstract：:The pathogenesis of middle ear inflammation caused by Streptococcus pneumoniae was explored in the chinchilla model with different pneumococcal cell wall (CW) preparations, including isolated native CW, M1 muramidase CW (M1-CW) digest, amidase CW digest, and M1 peptidoglycan (M1-PG) digest. Inflammatory cell and lysoz...

journal_title：Infection and immunity

authors： Carlsen BD,Kawana M,Kawana C,Tomasz A,Giebink GS

更新日期：1992-07-01 00:00:00

abstract：:Male ICR Swiss mice (2 to 3 months old) were fed Candida albicans in their drinking water for 3 days, followed by no treatment, antibiotics in their drinking water (daily), or immunosuppressants given by intraperitoneal injection (two to three times weekly) over a 3- to 4-week period. The organs of animals were proces...

journal_title：Infection and immunity

authors： Ekenna O,Sherertz RJ

更新日期：1987-07-01 00:00:00