Trypanosoma cruzi-induced immunosuppression: selective triggering of CD4+ T-cell death by the T-cell receptor-CD3 pathway and not by the CD69 or Ly-6 activation pathway.


:In a model of experimental Chagas' disease induced with metacyclic forms of Trypanosoma cruzi, CD4+ but not CD8+ T cells undergo T-cell receptor (TCR)-CD3-mediated activation-induced cell death (AICD) in vitro. CD4+ T cells from T. cruzi-infected mice also developed unresponsiveness in proliferative responses to TCR-CD3-mediated stimulation. A linear correlation was found between extent of proliferative unresponsiveness and loss of CD4+ T-cell viability. CD4+ T-cell activation through the CD69 or Ly-6 A/E pathway, on the other hand, did not result in proliferative unresponsiveness compared with controls. Lack of suppression in proliferation assays correlated with lack of AICD by cells stimulated through the CD69 or Ly-6 A/E pathway. Concomitant stimulation through CD69, however, did not rescue CD4+ T cells from CD3-induced death. Flow cytometry study of cells stimulated in vitro showed no defect in interleukin-2 receptor expression by CD4+ T cells from infected donors, which escaped TCR-mediated AICD. In vivo injection of anti-CD3 into acutely infected mice, but not into control mice, led to splenocyte DNA fragmentation and failed to increase splenic CD4+ T-cell numbers. These results show that TCR-CD3-mediated AICD is involved in CD4+ T-cell unresponsiveness in vitro following infection with T. cruzi. In addition, successful activation of these cells through the CD69 and Ly-6 pathways is due to differences in the inability of these stimuli to trigger AICD. Since TCR-CD3-mediated AICD can be induced in vivo in infected mice, these findings may be relevant for the onset of immunological disturbances in the host.


Infect Immun


Infection and immunity


Lopes MF,DosReis GA




Has Abstract


1996-05-01 00:00:00












  • Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination.

    abstract::We investigated the ability of two overlapping fragments of staphylococcal enterotoxin B (SEB), which encompass the whole toxin, to induce protection and also examined if passive transfer of chicken anti-SEB antibodies raised against the holotoxin could protect rhesus monkeys against aerosolized SEB. Although both fra...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: LeClaire RD,Hunt RE,Bavari S

    更新日期:2002-05-01 00:00:00

  • Outer membrane protein expression profile in Helicobacter pylori clinical isolates.

    abstract::The gram-negative gastric pathogen Helicobacter pylori is equipped with an extraordinarily large set of outer membrane proteins (OMPs), whose role in the infection process is not well understood. The Hop (Helicobacter outer membrane porins) and Hor (Hop-related proteins) groups constitute a large paralogous family con...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Odenbreit S,Swoboda K,Barwig I,Ruhl S,Borén T,Koletzko S,Haas R

    更新日期:2009-09-01 00:00:00

  • Human galectin-3 promotes Trypanosoma cruzi adhesion to human coronary artery smooth muscle cells.

    abstract::Human galectin-3 binds to the surface of Trypanosoma cruzi trypomastigotes and human coronary artery smooth muscle (CASM) cells. CASM cells express galectin-3 on their surface and secrete it. Exogenous galectin-3 increased the binding of T. cruzi to CASM cells. Trypanosome binding to CASM cells was enhanced when eithe...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kleshchenko YY,Moody TN,Furtak VA,Ochieng J,Lima MF,Villalta F

    更新日期:2004-11-01 00:00:00

  • Comparisons between colony phase variation of Neisseria gonorrhoeae FA1090 and pilus, pilin, and S-pilin expression.

    abstract::The gonococcal pilus is a primary virulence factor, providing the initial attachment of the bacterial cell to human mucosal tissues. Pilin, the major subunit of the pilus, can carry a wide spectrum of primary amino acid sequences which are generated by the action of a complex antigenic variation system. Changes in the...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Long CD,Madraswala RN,Seifert HS

    更新日期:1998-05-01 00:00:00

  • Fractionation of Schistosoma japonicum soluble egg antigen glycoproteins by hydrophobic interaction chromatography.

    abstract::We are currently studying the soluble egg antigens of Schistosoma japonicum in an attempt to determine which antigens are potent immunogens. Previously, we demonstrated by Ouchterlony immunodiffusion and inhibition of the circumoval precipitin test that the glycoprotein fraction of soluble egg antigens contains the an...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Long GW,Lewert RM,Pelley RP

    更新日期:1981-11-01 00:00:00

  • In vivo studies with two phospholipase C fractions from Pseudomonas aeruginosa.

    abstract::Two phospholipase C fractions were detected in culture supernatants from Pseudomonas aeruginosa ATCC 19660, PAO1, and D10C by preparative polyacrylamide gel electrophoresis. Both hemolytic fractions from strain ATCC 19660 were isolated by polyacrylamide gel electrophoresis and were found to cause paralysis, death, der...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Berk RS,Brown D,Coutinho I,Meyers D

    更新日期:1987-07-01 00:00:00

  • Induction of specific T-cell responses, opsonizing antibodies, and protection against Plasmodium chabaudi adami infection in mice vaccinated with genomic expression libraries expressed in targeted and secretory DNA vectors.

    abstract::It has been proposed that a multivalent malaria vaccine is necessary to mimic the naturally acquired resistance to this disease observed in humans. A major experimental challenge is to identify the optimal components to be used in such a multivalent vaccine. Expression library immunization (ELI) is a method for screen...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Rainczuk A,Scorza T,Smooker PM,Spithill TW

    更新日期:2003-08-01 00:00:00

  • Different effects of phytohemagglutinin-activated lymphocytes and their culture supernatants on macrophage function.

    abstract::When rabbit peritoneal exudate cells were incubated for 24 and 48 h with phytohemagglutinin-activated lymphocytes or their culture supernatants, two times as many cells remained adherent to culture slides as in the controls. More spreading cells were found among the adherent cells in the stimulated cultures. Eighty pe...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Ando M,Suga M,Shima K,Sugimoto M,Higuchi S

    更新日期:1976-05-01 00:00:00

  • Babesia divergens and Plasmodium falciparum use common receptors, glycophorins A and B, to invade the human red blood cell.

    abstract::Babesiosis has long been recognized as an economically important disease of cattle, but only in the last 30 years has Babesia been recognized as an important pathogen in humans. Invasion of erythrocytes is an integral part of the Babesia life cycle. However, very little information is available on the molecules involv...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lobo CA

    更新日期:2005-01-01 00:00:00

  • Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum.

    abstract::We previously demonstrated that plasmid-deficient Chlamydia muridarum retains the ability to infect the murine genital tract but does not elicit oviduct pathology because it fails to activate Toll-like receptor 2 (TLR2). We derived a plasmid-cured derivative of the human genital isolate Chlamydia trachomatis D/UW-3/Cx...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: O'Connell CM,AbdelRahman YM,Green E,Darville HK,Saira K,Smith B,Darville T,Scurlock AM,Meyer CR,Belland RJ

    更新日期:2011-03-01 00:00:00

  • Adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells in vitro: differences in adhesive capacity among strains isolated from subjects with otitis media, septicemia, or meningitis or from healthy carriers.

    abstract::A method was developed to study the adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells. Epithelial cells from healthy persons, pneumococcal strains from patients with otitis media, meningitis, or septicemia, and pneumococcal cells from the nasopharynx of healthy carriers were used. Adhesion was ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Andersson B,Eriksson B,Falsen E,Fogh A,Hanson LA,Nylén O,Peterson H,Svanborg Edén C

    更新日期:1981-04-01 00:00:00

  • Role of intrachain disulfides in the activities of the CdtA and CdtC subunits of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans.

    abstract::The cytolethal distending toxin (Cdt) of Actinobacillus actinomycetemcomitans is an atypical A-B-type toxin consisting of a heterotrimer composed of the cdtA, cdtB, and cdtC gene products. The CdtA and CdtC subunits form two heterogeneous ricin-like lectin domains which bind the holotoxin to the target cell. Point mut...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Cao L,Volgina A,Korostoff J,DiRienzo JM

    更新日期:2006-09-01 00:00:00

  • Deviation of immune response to Chlamydia psittaci outer membrane protein in lipopolysaccharide-hyporesponsive mice.

    abstract::The outcome of infection is determined by both the quantity and the quality of an induced immune response. In particular, it has been demonstrated for selected pathogens that induction of TH1 or TH2 type helper T-cell subsets determines whether an immune response gives rise to protective immunity or disease-associated...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Westbay TD,Dascher CC,Hsia RC,Zauderer M,Bavoil PM

    更新日期:1995-04-01 00:00:00

  • Microscopic characterization of ocular damage produced by Pseudomonas aeruginosa toxin A.

    abstract::The ocular damage in young adult mice produced by purified Pseudomonas aeruginosa exotoxin A was microscopically characterized at 1 and 5 h and at 1, 3, 5, 7, 10, 14, and 21 days after toxin A challenge, using light, transmission, and scanning electron microscopic techniques. Similarly to previously described infectio...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hazlett LD,Berk RS,Iglewski BH

    更新日期:1981-12-01 00:00:00

  • Methylthioadenosine Suppresses Salmonella Virulence.

    abstract::In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic Salmonella enterica serovar T...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Bourgeois JS,Zhou D,Thurston TLM,Gilchrist JJ,Ko DC

    更新日期:2018-08-22 00:00:00

  • Cloning and expression of the dnaK gene of Campylobacter jejuni and antigenicity of heat shock protein 70.

    abstract::Campylobacter jejuni is a leading cause of infectious diarrhea throughout the world. In addition, there is growing evidence that Guillain-Barré syndrome, an inflammatory demyelinating disease of the peripheral nervous system, is frequently preceded by C. jejuni infection. In the present study, the hrcA-grpE-dnaK gene ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Thies FL,Karch H,Hartung HP,Giegerich G

    更新日期:1999-03-01 00:00:00

  • Opacity-associated adhesin repertoire in hyperinvasive Neisseria meningitidis.

    abstract::The opacity (Opa) proteins mediate a variety of interactions between the bacterium Neisseria meningitidis and its human host. These interactions are thought to be of central importance in both the asymptomatic colonization of the nasopharynx and the sporadic occurrence of meningococcal disease. The receptor specificit...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Callaghan MJ,Jolley KA,Maiden MC

    更新日期:2006-09-01 00:00:00

  • Enhanced delivery of exogenous peptides into the class I antigen processing and presentation pathway.

    abstract::Current immunization strategies, using peptide or protein antigens, generally fail to elicit cytotoxic-T-lymphocyte responses, since these antigens are unable to access intracellular compartments where loading of major histocompatibility complex class I (MHC-I) molecules occurs. In an attempt to circumvent this, we in...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: De Haan L,Hearn AR,Rivett AJ,Hirst TR

    更新日期:2002-06-01 00:00:00

  • Generalized infection and lack of delayed hypersensitivity in BALB/c mice infected with Leishmania tropica major.

    abstract::The susceptibility of a few strains of mice to a subcutaneous injection of Leishmania tropica major, the causative agent of cutaneous leishmaniasis in humans, was studied. The infection in six strains (CBA, AKR/J, AKR/cu, C57BL/6, A/J, and C3H) remained cutaneous, and the animals recovered within 3 to 4 months. In con...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Nasseri M,Modabber FZ

    更新日期:1979-11-01 00:00:00

  • Pathogenic capacity of proteases from Serratia marcescens and Pseudomonas aeruginosa and their suppression by chicken egg white ovomacroglobulin.

    abstract::The pathogenicities of three proteases from Serratia marcescens, two proteases from Pseudomonas aeruginosa, and one thermolysin from Bacillus stearothermophilus were examined. All proteases tested caused acute liquefactive necrosis of the cornea and descemetocele formation in guinea pig eyes after intrastromal injecti...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Molla A,Matsumura Y,Yamamoto T,Okamura R,Maeda H

    更新日期:1987-10-01 00:00:00

  • Infection-induced airway fibrosis in two rat strains with differential susceptibility.

    abstract::Chronic infections play a significant role in the morbidity and mortality of patients with chronic airflow limitation. By stimulating airway inflammation, persistent infection has the potential to cause airway fibrosis. However, in patient this condition is most typically found in lungs damaged by other factors, such ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: McIntosh JC,Simecka JW,Ross SE,Davis JK,Miller EJ,Cassell GH

    更新日期:1992-07-01 00:00:00

  • Development of antitoxin with each of two complementary fragments of Clostridium botulinum type B derivative toxin.

    abstract::Two fragments with molecular weights of 111,000 (fragment I) and 59,000 (fragment II) were separated from each other by gel filtration of dithiothreitol and urea-treated, trypsinized derivative toxin (molecular weight, 170,000) of the proteolytic Okra strain of Clostridium botulinum type B on a column of Sephadex G-20...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kozaki S,Miyazaki S,Sakaguchi G

    更新日期:1977-12-01 00:00:00

  • Characteristic age distribution of Plasmodium vivax infections after malaria elimination on Aneityum Island, Vanuatu.

    abstract::Resurgence is a major concern after malaria elimination. After the initiation of the elimination program on Aneityum Island in 1991, microscopy showed that Plasmodium falciparum disappeared immediately, whereas P. vivax disappeared from 1996 onward, until P. vivax cases were reported in January 2002. By conducting mal...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Kaneko A,Chaves LF,Taleo G,Kalkoa M,Isozumi R,Wickremasinghe R,Perlmann H,Takeo S,Tsuboi T,Tachibana S,Kimura M,Björkman A,Troye-Blomberg M,Tanabe K,Drakeley C

    更新日期:2014-01-01 00:00:00

  • Differential expression and transcriptional analysis of the alpha-2,3-sialyltransferase gene in pathogenic Neisseria spp.

    abstract::Alpha-2,3-sialyltransferase (Lst) is expressed on the outer membrane of Neisseria gonorrhoeae and Neisseria meningitidis and sialylates surface lipooligosaccharide (LOS), facilitating resistance to complement-mediated killing. The enzyme is constitutively expressed from a single gene (lst) and does not undergo antigen...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Packiam M,Shell DM,Liu SV,Liu YB,McGee DJ,Srivastava R,Seal S,Rest RF

    更新日期:2006-05-01 00:00:00

  • Opposite effects of human monocytes, macrophages, and polymorphonuclear neutrophils on replication of Blastomyces dermatitidis in vitro.

    abstract::The purpose of this study was to determine the effects of human monocytes, macrophages, and polymorphonuclear neutrophils (PMN) on the fungal pathogen Blastomyces dermatitidis in vitro. Peripheral blood monocyte monolayers significantly inhibited the replication of a virulent strain (V) and an avirulent strain (AV) of...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Brummer E,Stevens DA

    更新日期:1982-04-01 00:00:00

  • Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice.

    abstract::Evidence showing that neutrophils play a protective role in the host response to infection by different intracellular parasites has been published in the past few years. We assessed this issue with regard to the infection of mice with Mycobacterium tuberculosis. We found a chronic recruitment of neutrophils to the inf...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Pedrosa J,Saunders BM,Appelberg R,Orme IM,Silva MT,Cooper AM

    更新日期:2000-02-01 00:00:00

  • Role of Streptococcus gordonii amylase-binding protein A in adhesion to hydroxyapatite, starch metabolism, and biofilm formation.

    abstract::Interactions between bacteria and salivary components are thought to be important in the establishment and ecology of the oral microflora. alpha-Amylase, the predominant salivary enzyme in humans, binds to Streptococcus gordonii, a primary colonizer of the tooth. Previous studies have implicated this interaction in ad...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Rogers JD,Palmer RJ Jr,Kolenbrander PE,Scannapieco FA

    更新日期:2001-11-01 00:00:00

  • Enteropathogenic Escherichia coli inhibits phagocytosis.

    abstract::Enteropathogenic Escherichia coli (EPEC) interacts with intestinal epithelial cells, activating host signaling pathways leading to cytoskeletal rearrangements and ultimately diarrhea. In this study, we demonstrate that EPEC interacts with the macrophage-like cell line J774A.1 to inhibit phagocytosis by these cells. An...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Goosney DL,Celli J,Kenny B,Finlay BB

    更新日期:1999-02-01 00:00:00

  • Receptor-binding function of type 1 pili effects bladder colonization by a clinical isolate of Escherichia coli.

    abstract::The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene e...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Keith BR,Maurer L,Spears PA,Orndorff PE

    更新日期:1986-09-01 00:00:00

  • Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection.

    abstract::Isolated outer membranes of Borrelia burgdorferi 297 were utilized to obtain partial amino acid sequence information for a low-molecular-weight, outer membrane-associated polypeptide. Degenerate oligonucleotide primers based upon this information were used to amplify a 100-bp probe for detection of the corresponding f...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lahdenne P,Porcella SF,Hagman KE,Akins DR,Popova TG,Cox DL,Katona LI,Radolf JD,Norgard MV

    更新日期:1997-02-01 00:00:00