Specific activation of a STAT family member in Xiphophorus melanoma cells.

abstract：:We have been studying mouse F9 embryonic carcinoma cells which contain no detectable vinculin protein (5.51 cells), and compared them with F9 wild-type cells. Employing atomic force microscopy, we probed the elastic properties of individual F9 wild-type and 5.51 cells by measuring the dynamic response of controlled lo...

journal_title：Experimental cell research

authors： Goldmann WH,Ezzell RM

更新日期：1996-07-10 00:00:00

abstract：:Neurons require adhesive scaffolds for their growth and differentiation. Laminins are a major cell adhesive component of basement membranes and have various biological activities in the peripheral and central nervous systems. Here, we evaluated the biological activities of 5 peptides derived from laminin-111 as a scaf...

journal_title：Experimental cell research

authors： Hayashi H,Horinokita I,Yamada Y,Hamada K,Takagi N,Nomizu M

更新日期：2020-12-22 00:00:00

abstract：:The insoluble cytoskeletal material remaining after detergent lysis of 'Normal' Murine Mammary Gland (NMuMG) cells, growing on plastic or collagen gel substrata, was analyzed by two-dimensional gel electrophoresis. The identity of the cytoskeletal elements was determined by their solubility properties, electrophoretic...

journal_title：Experimental cell research

authors： Hall HG,Bissell MJ

更新日期：1986-02-01 00:00:00

abstract：:The protein kinase mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation and growth, with the ribosomal subunit S6 kinase 1 (S6K1) as one of the key downstream signaling effectors. A critical role of mTOR signaling in skeletal muscle differentiation has been identified recently, and an unus...

journal_title：Experimental cell research

authors： Park IH,Erbay E,Nuzzi P,Chen J

更新日期：2005-09-10 00:00:00

abstract：:After epithelial disruption by tissue injury, keratinocytes migrate from the wound edge into a provisional matrix. This process is stimulated by growth factors that signal through epidermal growth factor (EGF) receptor, including EGF, heparin-binding EGF-like growth factor (HB-EGF) and transforming growth factor-alpha...

journal_title：Experimental cell research

authors： Koivisto L,Jiang G,Häkkinen L,Chan B,Larjava H

更新日期：2006-09-10 00:00:00

abstract：:By a sequential mutation and selection utilizing N-methyl-N'-nitro-N-nitrosoguanidine as a mutagen, we succeeded in separating a poly(ADP ribose) polymerase-defective mutant clone (Cl-3527) from a mouse L1210 cell clone (Cl-3). The enzyme activity per cell in Cl-3527 cells was only 8% of that in wild type L1210 (CCL 2...

journal_title：Experimental cell research

authors： Yoshihara K,Itaya A,Hironaka T,Sakuramoto S,Tanaka Y,Tsuyuki M,Inada Y,Kamiya T,Ohnishi K,Honma M

更新日期：1992-05-01 00:00:00

abstract：:Tpr is a 267-kDa protein of unknown function recently identified as a constitutive component of the nuclear pore complex (NPC2)-attached intranuclear filaments. Secondary structure predictions suggest that the protein is divided into a large, coiled-coil forming aminoterminal domain and a shorter, highly acidic carbox...

journal_title：Experimental cell research

authors： Cordes VC,Hase ME,Müller L

更新日期：1998-11-25 00:00:00

abstract：:The effect of the physiological vitamin D metabolite 24R, 25-dihydroxyvitamin D3 [24R,25(OH)2D3] on human osteoblastic cells was assessed. Physiological concentrations (10(-9)-10(-8) M) of 24R, 25(OH)2D3 significantly increased the cyclic guanosine 5'-monophosphate (cGMP) content in the human osteoblastic cells by app...

journal_title：Experimental cell research

authors： Yamamoto T,Ozono K,Shima M,Yamaoka K,Okada S

更新日期：1998-10-10 00:00:00

abstract：:RalGPS2 is a Ras-independent Guanine Nucleotide Exchange Factor (GEF) for RalA containing a PH domain and an SH3-binding region and it is involved in several cellular processes, such as cytokinesis, control of cell cycle progression, differentiation, cytoskeleton organization and rearrangement. Up to now, few data hav...

journal_title：Experimental cell research

authors： D'Aloia A,Berruti G,Costa B,Schiller C,Ambrosini R,Pastori V,Martegani E,Ceriani M

更新日期：2018-01-15 00:00:00

abstract：:In studies of the ontogeny of fibroblast-epithelial interactions during late fetal lung rat lung development, we have identified two subpopulations of fibroblasts which differed in their ability to promote epithelial cell proliferation or differentiation. As glycosaminoglycans (GAGs) have been implicated in the regula...

journal_title：Experimental cell research

authors： Caniggia I,Tanswell K,Post M

更新日期：1992-10-01 00:00:00

abstract：:The rapidity of the optional 90-min differentiation of Naegleria gruberi from amoebae to flagellates suggests the possibility of a free-running cascade of events from initiating stimulus through gene expression to organelle assembly and cell morphogenesis. Instead our experiments reveal two points early in the differe...

journal_title：Experimental cell research

authors： Fulton C,Lai EY

更新日期：1998-08-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) is a multicopy, maternally inherited, genome. Individuals frequently carry a mixture of genetically distinct mtDNA molecules whose proportions may vary between sexual generations or among tissues from the same individual. Analyses of the genetic composition of mitochondria have previously rel...

journal_title：Experimental cell research

authors： Cavelier L,Johannisson A,Gyllensten U

更新日期：2000-08-25 00:00:00

abstract：:MIST1 is a transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. Mice harboring a targeted deletion of the Mist1 gene (Mist1(-/-)) exhibit alterations in acinar regulated exocytosis and aberrant Ca(2+) signaling that are normally controlled by acinar cell Ca(2+)-ATPases. Previous s...

journal_title：Experimental cell research

authors： Garside VC,Kowalik AS,Johnson CL,DiRenzo D,Konieczny SF,Pin CL

更新日期：2010-10-15 00:00:00

abstract：:Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins catalysed by Poly(ADP-ribose) polymerases (PARP). A wealth of recent advances in the biochemical and functional characterization of the DNA-dependent PARP family members have highlighted their key contribution in the DNA damage respon...

journal_title：Experimental cell research

authors： Beck C,Robert I,Reina-San-Martin B,Schreiber V,Dantzer F

更新日期：2014-11-15 00:00:00

abstract：:High throughput RNA sequencing techniques have revealed that a large fraction of the genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding genes, lncRNAs do not contain long open reading frames (ORFs) and tend to be poorly conserved across species. However, many of them contain sma...

journal_title：Experimental cell research

authors： Ruiz-Orera J,Villanueva-Cañas JL,Albà MM

更新日期：2020-06-01 00:00:00

abstract：:Mutation R453W in A-type lamins, that are major nuclear envelope proteins, generates Emery-Dreifuss muscular dystrophy. We previously showed that mouse myoblasts expressing R453W-lamin A incompletely exit the cell cycle and differentiate into myocytes with a low level of multinucleation. Here we attempted to improve d...

journal_title：Experimental cell research

authors： Favreau C,Delbarre E,Courvalin JC,Buendia B

更新日期：2008-04-01 00:00:00

abstract：:Hypoxic conditions are common in solid tumors and have a significant effect on tumor progression, therapeutic and prognosis. Long noncoding RNAs (lncRNAs) are longer than 200 nucleotides and cannot be translated into proteins, which play important roles in some diseases including cancer. Although previous analysis hav...

journal_title：Experimental cell research

authors： Shen Y,Liu Y,Sun T,Yang W

更新日期：2017-09-15 00:00:00

abstract：:The alpha 3 beta 1 integrin has been implicated as a receptor for several matrix components, including collagen, fibronectin, and laminins. The function of alpha 3 beta 1 seems to be very versatile involving cell adhesion to or migration on ECM, establishment of cell-cell contacts in aggregates, as well as linkage to ...

journal_title：Experimental cell research

authors： Lichtner RB,Howlett AR,Lerch M,Xuan JA,Brink J,Langton-Webster B,Schneider MR

更新日期：1998-05-01 00:00:00

abstract：:Recent studies have demonstrated a central role for the exchange protein activated by cAMP (Epac) in the inhibition of Fcgamma-receptor-mediated phagocytosis and bacterial killing by prostaglandin E(2) (PGE(2)) in macrophages. However, the subcellular localization of Epac, and its primary target Rap1, has yet to be de...

journal_title：Experimental cell research

authors： Brock TG,Serezani CH,Carstens JK,Peters-Golden M,Aronoff DM

更新日期：2008-01-15 00:00:00

abstract：:Murine embryonal carcinoma F9 cells can be induced to differentiate by 2-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC). The differentiated phenotype is similar to that of retinoic acid (RA)-treated F9 cells. In contrast to F9 cells the differentiated cells secrete plasminog...

journal_title：Experimental cell research

authors： Jetten AM,Shirley JE

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Emerging studies demonstrate that long noncoding RNAs (lncRNAs) play crucial roles in hepatocarcinogenesis through various mechanisms. LncRNA CCAT2 was a newly discovered lncRNA and amplified in several cancers. However, the mechanisms involved in function of CCAT2 in hepatocellular carcinoma (HCC) remain to...

journal_title：Experimental cell research

authors： Liu Y,Wang D,Li Y,Yan S,Dang H,Yue H,Ling J,Chen F,Zhao Y,Gou L,Tang P,Huang A,Tang H

更新日期：2019-06-01 00:00:00

abstract：:Protein C23 (also called nucleolin or 100-kDa nucleolar protein) is a major nucleolar phosphoprotein involved in ribosome biogenesis. To determine the effects of protein C23 on preribosomal RNA (pre-rRNA) synthesis anti-C23 antiserum was microinjected into nuclei of Chironomus tentans salivary glands. Transcription wa...

journal_title：Experimental cell research

authors： Egyhazi E,Pigon A,Chang JH,Ghaffari SH,Dreesen TD,Wellman SE,Case ST,Olson MO

更新日期：1988-10-01 00:00:00

abstract：:Most developing lymphocytes spontaneously die in the thymus during positive and negative selection of the T cell repertoire. By evaluating the expression of the proliferation antigens Ki-67 and PCNA, we demonstrated here that more than 95% of thymocytes are potentially proliferating. The coincidence within the same ce...

journal_title：Experimental cell research

authors： Pellicciari C,Bottone MG,Schaack V,Barni S,Manfredi AA

更新日期：1996-12-15 00:00:00

abstract：:Both hypoxia and overexpression of the urokinase plasminogen activator receptor (uPAR) are associated with a poor clinical outcome in human cancers. Hypoxia has been shown to induce uPAR expression in breast cancer cells and to increase their invasion through Matrigel, a phenomenon which can be blocked using an anti-u...

journal_title：Experimental cell research

authors： Maity A,Solomon D

更新日期：2000-03-15 00:00:00

abstract：:Using hybridization in situ with a ribo-probe recognizing transcripts of the chicken alpha A globin gene, we show here that in proliferating AEV-transformed erythroblasts this gene is strongly transcribed, but the corresponding transcripts are retained in the nuclei. Most surprisingly, this globin RNA accumulates in t...

journal_title：Experimental cell research

authors： Iarovaia O,Razin SV,Linares-Cruz G,Sjakste N,Scherrer K

更新日期：2001-11-01 00:00:00

abstract：:The pleiotropic cytokine interleukin (IL)-10 is best characterized by its ability to downregulate inflammation and promote peripheral tolerance. On the other hand, IL-10 was also found to maintain the effector response of CD8+ T cells and promote the expansion of tumor-resident CD8+ T cells. In diffuse large B cell ly...

journal_title：Experimental cell research

authors： Qiu H,Hu X,Gao L,Chen L,Chen J,Yuan J,Huang C,Xu X,Yang J

更新日期：2017-11-15 00:00:00

abstract：:The C6 rat glioma cell line is shown to consist of a mixed population of cells which either contain vimentin (80% of the cells) or completely lack any cytoplasmic intermediate filament (IF) proteins. Subclones could be established with both phenotypes, indicating that these IF protein expression patterns represent sta...

journal_title：Experimental cell research

authors： Röser K,Bohn W,Giese G,Mannweiler K

更新日期：1991-12-01 00:00:00

abstract：:Although 12-day-old chick embryo retinal pigment epithelial (RPE) cells in situ do not express the proliferating cell nuclear antigen (PCNA) which is known to function as an auxiliary protein of DNA polymerase delta, they do so when cultured on glass. Conversely, PCNA was not expressed by RPE cells of the same age mai...

journal_title：Experimental cell research

authors： Hergott GJ,Kalnins VI

更新日期：1991-08-01 00:00:00

abstract：:The growth rate of malignant F9 embryonal carcinoma cells slows considerably following all-trans-retinoic acid-induced differentiation into benign parietal endoderm. To determine the mechanism of this process, we examined the expression of cyclins D1, D2, and D3 and the activity of their associated kinases. Cyclin D1 ...

journal_title：Experimental cell research

authors： Li Y,Glozak MA,Smith SM,Rogers MB

更新日期：1999-12-15 00:00:00

abstract：:During pathological bone loss, factors that are both stimulatory and inhibitory for osteoclast differentiation are over-expressed. Despite the presence of inhibitory factors, osteoclast differentiation is significantly enhanced to bring about bone loss. To examine the hypothesis that stimulatory growth factors overcom...

journal_title：Experimental cell research

authors： Gorny G,Shaw A,Oursler MJ

更新日期：2004-03-10 00:00:00