Poly(ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3.

abstract：:Cells undergoing apoptosis are recognized and rapidly phagocytosed by macrophages before their degradation, thus preventing the inflammatory reaction and protecting tissues from the damaging effects of released potentially harmful intracellular contents. In spite of growing interest in the mechanisms leading to the en...

journal_title：Experimental cell research

authors： Falasca L,Bergamini A,Serafino A,Balabaud C,Dini L

更新日期：1996-04-10 00:00:00

abstract：:Profilin is one of the major components controlling actin polymerization. Here, profilin I was located in fibroblasts and HeLa cells by the use of two different sets of affinity-purified antibodies. Both antibody preparations labeled nuclei in a speckle-like pattern and displayed extensive colocalization with small nu...

journal_title：Experimental cell research

authors： Skare P,Kreivi JP,Bergström A,Karlsson R

更新日期：2003-05-15 00:00:00

abstract：:Poly (ADP-ribose) polymerase-1 (PARP1) is a DNA damage sensor that gets activated in proportion to the damage, helping cells to determine whether to repair the damage or initiate cell death processes. We have previously shown PARP1's significance in the developmental processes of Dictyostelium discoideum in addition t...

journal_title：Experimental cell research

authors： Mir H,Rajawat J,Vohra I,Vaishnav J,Kadam A,Begum R

更新日期：2020-12-15 00:00:00

abstract：:The process of DNA synthesis in normal and endoreduplicating mammalian cells are very similar. Both types of chromosomes are replicated in defined units termed chromosomal replicons, and in the same sequences along their lengths. The sister chromosomes of the diplochromosomes are replicated synchronously in identical ...

journal_title：Experimental cell research

authors： Lau YF

更新日期：1983-07-01 00:00:00

abstract：:The importance of the cytoskeleton in protein synthesis was studied in differentiating L6 rat myoblasts. Soluble and cytoskeletal fractions obtained after gentle, non-ionic detergent lysis of myoblasts and myotubes were analysed for the presence of ribosomes and mRNPs. Polysomal mRNPs were predominantly associated wit...

journal_title：Experimental cell research

authors： Bagchi T,Larson DE,Sells BH

更新日期：1987-01-01 00:00:00

abstract：:UDP-glucose dehydrogenase (UGDH) catalyzes oxidation of UDP-glucose to yield UDP-glucuronic acid, a precursor of hyaluronic acid (HA) and other glycosaminoglycans (GAGs) in extracellular matrix. Although association of extracellular matrix with cell proliferation and migration has been well documented, the importance ...

journal_title：Experimental cell research

authors： Wang TP,Pan YR,Fu CY,Chang HY

更新日期：2010-10-15 00:00:00

abstract：:In contrast to extensive studies on the roles of molecular chaperones, such as heat shock proteins, there are only a few reports about the roles of GRP78/BiP, an endoplasmic reticulum (ER) stress-induced molecular chaperone, in mammalian cell responses to DNA-damaging stresses. To investigate whether GRP78/BiP is invo...

journal_title：Experimental cell research

authors： Zhai L,Kita K,Wano C,Wu Y,Sugaya S,Suzuki N

更新日期：2005-05-01 00:00:00

abstract：:In this communication, we have studied a 72,000 mol w (p72) host protein which reacts with a mouse monoclonal antibody (PAb6) directed against antigenic determinants on the Simian virus 40 (SV40) large T antigen protein that map 5' of 0.42 map units on the viral genome. The p72 protein is an abundant basic (pI greater...

journal_title：Experimental cell research

authors： Ullrich SJ,Appella E,Mercer WE

更新日期：1988-10-01 00:00:00

abstract：:Based on recent studies showing that PLCgamma associates to insulin receptor, we investigated its role in insulin stimulation of glucose transport in brown adipocytes. Insulin stimulation induced rapid PLCgamma association to phosphorylated insulin receptor, and activation of PLCgamma, as assessed by the mobilization ...

journal_title：Experimental cell research

authors： Lorenzo M,Teruel T,Hernandez R,Kayali AG,Webster NJ

更新日期：2002-08-15 00:00:00

abstract：:Xenopus oocytes carry IGF-I receptors, and undergo meiotic maturation in response to binding of IGF-I or insulin to the IGF-I receptor. Maturation is initiated upon activation of the IGF-I receptor tyrosine kinase and requires tyrosine dephosphorylation of p34cdc2, the kinase component of maturation promoting factor (...

journal_title：Experimental cell research

authors： Hainaut P,Giorgetti S,Kowalski A,Ballotti R,Van Obberghen E

更新日期：1991-07-01 00:00:00

abstract：:The program of biochemical and molecular events necessary for commitment to erythroid cell differentiation is particularly well characterized in murine Friend erythroleukemia cell lines. Commitment to hemoglobin synthesis in response to a variety of chemical inducers, including hexamethylene bisacetamide and dimethyl ...

journal_title：Experimental cell research

authors： Mallia CM,Aguirre V,McGary E,Tang Y,Scandurro AB,Liu C,Noguchi CT,Beckman BS

更新日期：1999-02-01 00:00:00

abstract：:The segregation of the chick-specific HPRT gene was studied in three Chinese hamster-chick red blood cell hybrid lines. The three lines showed individual segregation kinetics, the segregation taking place in an exponential-like fashion. Bromodeoxyuridine becomes incorporated into the nuclear DNA and increases the spon...

journal_title：Experimental cell research

authors： Raskó I,Péter SL,Dallmann L,Bajszár G,Péter S,Burg K

更新日期：1978-05-01 00:00:00

abstract：:A monoclonal antibody Pr-28 was prepared, which recognized an antigen present only in proliferating cells. Immunofluorescence analysis of Pr-28 antigen showed that the antigen was localized mainly in perinuclear cytoplasm. Although Pr-28 antibody was produced against a chicken cell antigen, it reacts not only with chi...

journal_title：Experimental cell research

authors： Matsuhashi S,Watanabe T,Hori K

更新日期：1987-06-01 00:00:00

abstract：:Human PHA-stimulated mononuclear cells produce a factor which inhibits synovial cell collagen and non-collagen protein synthesis, whereas it enhances hyaluronic acid (HA) production. Indomethacin (10(-4)-10(-6) M), a cyclo-oxygenase inhibitor, suppresses this effect, suggesting that the mechanism is prostaglandin-medi...

journal_title：Experimental cell research

authors： Pujol JP,Penfornis H,Arenzana-Seisdedos F,Bocquet J,Farjanel J,Rattner A,Brisset M,Virelizier JL,Beliard R,Loyau G

更新日期：1985-05-01 00:00:00

abstract：:Scavenger receptor class A (SR-A) facilitates the development of atherosclerosis, which might be due to its role in the uptake of modified low-density lipoproteins. However, the receptor is also suggested to be important for cell adhesion, thereby potentially influencing the residence time of cells in vivo. Using SR-A...

journal_title：Experimental cell research

authors： van Velzen AG,Suzuki H,Kodama T,van Berkel TJ

更新日期：1999-07-10 00:00:00

abstract：:There is increasing evidence that the hypersensitive response during plant-pathogen interactions is a form of programmed cell death. In an attempt to understand the biochemical nature of this form of programmed cell death in the cowpea-cowpea rust fungus system, proteolytic activity in extracts of fungus-infected and ...

journal_title：Experimental cell research

authors： D'Silva I,Poirier GG,Heath MC

更新日期：1998-12-15 00:00:00

abstract：:Two HL60 clones (C12 and C13) totally insensitive to differentiation induction by dimethylsulfoxide (Me2SO) are described. They have been growing continuously in the presence of the inducer for more than 6 months. The morphological and cytochemical features of the two populations are quite similar to those of the orig...

journal_title：Experimental cell research

authors： Ferrero D,Gallo E,Lanfrancone L,Tarella C

更新日期：1983-08-01 00:00:00

abstract：:A two-site radio-immunoassay for beta NGF demonstrated 5-10 pg of NGF in the normal, adult rat iris. Ciliarectomy or sympathectomy did not significantly alter the amount of NGF after 10 days. However, denervation including all sensory axons (stereotactic lesion distal to the trigeminal ganglion) increased the level to...

journal_title：Experimental cell research

authors： Ebendal T,Olson L,Seiger A

更新日期：1983-10-15 00:00:00

abstract：:The 37 kDa/67 kDa laminin receptor (LRP/LR) is over-expressed in tumor cells and has been implicated in several tumourigenic processes such as metastasis and telomerase activation, however, more importantly the focus of the present study is on the maintenance of cellular viability and the evasion of apoptosis. The aim...

journal_title：Experimental cell research

authors： Rebelo TM,Vania L,Ferreira E,Weiss SFT

更新日期：2018-07-01 00:00:00

abstract：:T51B rat liver epithelial cells were stimulated with extracellular ATP. Changes in cytoplasmic free Ca2+ concentration [( Ca2+]i) were measured by fura-2 both in a large population of cells on coverslips in a cuvette and in single cells in a microscopic system. Extracellular ATP evoked a prompt increase in [Ca2+]i in ...

journal_title：Experimental cell research

authors： Boynton AL,Cooney RV,Hill TD,Nilsson T,Arkhammar P,Berggren PO

更新日期：1989-03-01 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (RB) is activated/dephosphorylated to mediate cell cycle inhibition in response to antimitogenic signals. To elucidate the mode of RB action at this critical transition, we utilized cell lines that can be induced to express a constitutively active allele of RB (PSM-RB). As e...

journal_title：Experimental cell research

authors： Angus SP,Fribourg AF,Markey MP,Williams SL,Horn HF,DeGregori J,Kowalik TF,Fukasawa K,Knudsen ES

更新日期：2002-06-10 00:00:00

abstract：:We have recently demonstrated that thrombin-activated FXIII (FXIIIA-subunit), a plasma transglutaminase, activates VEGFR-2 by crosslinking it with the alpha(v)beta(3) integrin on the surface of endothelial cells (EC), thereby stimulating angiogenesis. Tissue transglutaminase (tTG), which is functionally and structural...

journal_title：Experimental cell research

authors： Dardik R,Inbal A

更新日期：2006-10-01 00:00:00

abstract：:Mutations in PKHD1 (polycystic kidney and hepatic disease gene 1) gene cause the autosomal recessive polycystic kidney disease (ARPKD). Fibrocystin/polyductin (FPC), encoded by PKHD1, is a membrane-associated receptor-like protein. Although it is widely accepted that cystogenesis is mostly due to aberrant cell prolife...

journal_title：Experimental cell research

authors： Sun L,Wang S,Hu C,Zhang X

更新日期：2011-04-15 00:00:00

abstract：:The process of osteoblast differentiation and matrix mineralization requires a rise in alkaline phosphatase enzymatic activity resulting in the generation of free phosphate. The ability of inorganic phosphate to regulate gene transcription and cellular function represents a potentially novel extracellular signaling me...

journal_title：Experimental cell research

authors： Beck GR Jr,Moran E,Knecht N

更新日期：2003-08-15 00:00:00

abstract：:Transient activation of the signal transducers and activators of transcription (STAT) proteins in response to growth hormone (GH) and other type II cytokines plays a pivotal role on specific gene transcription. The negative regulation of STATs seems to be exerted at the GH receptor (GHR)/Janus Kinase (JAK) complex and...

journal_title：Experimental cell research

authors： Rico-Bautista E,Negrín-Martínez C,Novoa-Mogollón J,Fernández-Perez L,Flores-Morales A

更新日期：2004-03-10 00:00:00

abstract：:In the fungus Achlya, sexual development in the male strain E87 is mediated by the steroid hormone antheridiol. Treatment of vegetatively growing cells of E87 with antheridiol resulted in changes in the [35S]methionine labeling of several secreted proteins. The most heavily labeled group of proteins observed in the se...

journal_title：Experimental cell research

authors： Brunt SA,Silver JC

更新日期：1986-03-01 00:00:00

abstract：:The extraocular muscles (EOM) are spared from pathology in aging and many forms of muscular dystrophy. Despite many studies, this sparing remains an enigma. The EOM have a distinct embryonic lineage compared to somite-derived muscles, and we have shown that they continuously remodel throughout life, maintaining a popu...

journal_title：Experimental cell research

authors： Kallestad KM,Hebert SL,McDonald AA,Daniel ML,Cu SR,McLoon LK

更新日期：2011-04-01 00:00:00

abstract：:Long-term biological effects of epidermal growth factor (EGF), insulin, insulin-like growth factor-I (IGF-I), and transforming growth factor-beta (TGF-beta) were examined with human epidermoid carcinoma KB cells. EGF inhibited the growth of KB cells in both serum-containing and serum-free synthetic media by reducing t...

journal_title：Experimental cell research

authors： Koyasu S,Kadowaki T,Nishida E,Tobe K,Abe E,Kasuga M,Sakai H,Yahara I

更新日期：1988-05-01 00:00:00

abstract：:KRIT1 is a disease gene responsible for Cerebral Cavernous Malformations (CCM). It encodes for a protein containing distinct protein-protein interaction domains, including three NPXY/F motifs and a FERM domain. Previously, we isolated KRIT1B, an isoform characterized by the alternative splicing of the 15th coding exon...

journal_title：Experimental cell research

authors： Francalanci F,Avolio M,De Luca E,Longo D,Menchise V,Guazzi P,Sgrò F,Marino M,Goitre L,Balzac F,Trabalzini L,Retta SF

更新日期：2009-01-15 00:00:00

abstract：:Increased protein aggregation and altered cell signaling accompany many neurodegenerative diseases including Huntington's disease (HD). Cell stress is counterbalanced by signals mediating cell repair but the identity of these are not fully understood. We show here that the mammalian target of rapamycin (mTOR) pathway ...

journal_title：Experimental cell research

authors： Hyrskyluoto A,Reijonen S,Kivinen J,Lindholm D,Korhonen L

更新日期：2012-01-01 00:00:00