A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.

abstract：:Peptide-specific conventional T cells have been major targets for designing most antimycobacterial vaccines. Immune responses mediated by conventional T cells exhibit a delayed onset upon primary infection and are highly variable in different human populations. In contrast, innate-like T cells quickly respond to patho...

journal_title：Frontiers in immunology

authors： Huang S

更新日期：2016-12-21 00:00:00

abstract：:[This corrects the article on p. 125 in vol. 6, PMID: 25852693.]. ...

journal_title：Frontiers in immunology

authors： Dalai SK,Yadav N,Patidar M,Patel H,Singh AP

更新日期：2015-06-22 00:00:00

abstract：:Background: Critically ill patients, especially following trauma or extensive surgery, experience a systemic immune response, consisting of a pro-inflammatory as well as a counterbalancing anti-inflammatory response. Pro-inflammation is necessary for the initiation of homeostatic control and wound healing of the organ...

journal_title：Frontiers in immunology

authors： Tamulyte S,Kopplin J,Brenner T,Weigand MA,Uhle F

更新日期：2019-03-12 00:00:00

abstract：:New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of injection, responsible for the installation of a durable and oriented protective response. We performed a detailed characterization of very early infection and host re...

journal_title：Frontiers in immunology

authors： Rosenbaum P,Tchitchek N,Joly C,Stimmer L,Hocini H,Dereuddre-Bosquet N,Beignon AS,Chapon C,Levy Y,Le Grand R,Martinon F

更新日期：2018-04-25 00:00:00

abstract：:Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its frequency and severity, prevention of pertussis has been considered an important public health issue for many years. The development of the whole-cell pertussis vaccine (wPV) and its introduction into the pediatric immunization schedu...

journal_title：Frontiers in immunology

authors： Esposito S,Stefanelli P,Fry NK,Fedele G,He Q,Paterson P,Tan T,Knuf M,Rodrigo C,Weil Olivier C,Flanagan KL,Hung I,Lutsar I,Edwards K,O'Ryan M,Principi N,World Association of Infectious Diseases and Immunological Disorders

更新日期：2019-07-03 00:00:00

abstract：:Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

journal_title：Frontiers in immunology

authors： Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

更新日期：2019-03-27 00:00:00

abstract：:The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects. It is now necessary to understand the contradictory data associated with how Th17 cells play a role in melanoma. This review will ...

journal_title：Frontiers in immunology

authors： Chen C,Gao FH

更新日期：2019-02-08 00:00:00

abstract：:γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...

journal_title：Frontiers in immunology

authors： Wan F,Hu CB,Ma JX,Gao K,Xiang LX,Shao JZ

更新日期：2017-01-09 00:00:00

abstract：:According to the "two-step model," the intrathymic generation of CD4⁺ regulatory T (T(reg)) cells segregates into a first, T cell receptor (TCR)-driven phase and a second, cytokine-dependent phase. The initial TCR stimulus gives rise to a CD25⁺Foxp3⁻ developmental intermediate. These precursors subsequently require cy...

journal_title：Frontiers in immunology

authors： Hinterberger M,Wirnsberger G,Klein L

更新日期：2011-07-25 00:00:00

abstract：:Vaccination with CD1d-binding glycolipid adjuvants and co-administered protein, lipid, and carbohydrate antigens leads to invariant natural killer T (NKT) cell-dependent enhancement of protective B cell responses. NKT cell activation boosts the establishment of protein antigen-specific B cell memory and long-lived pla...

journal_title：Frontiers in immunology

authors： Lang ML

更新日期：2018-02-22 00:00:00

abstract：:Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones. The aim of this study was to examine the role of miR-155 in controlling PAD4-dependent generation of NETs. Bone marr...

journal_title：Frontiers in immunology

authors： Hawez A,Al-Haidari A,Madhi R,Rahman M,Thorlacius H

更新日期：2019-11-01 00:00:00

abstract：:[This corrects the article on p. 998 in vol. 9, PMID: 29867975.]. ...

journal_title：Frontiers in immunology

authors： Varesano S,Zocchi MR,Poggi A

更新日期：2018-06-13 00:00:00

abstract：:Fish red blood cells (RBCs), are integral in several biologic processes relevant to immunity, such as pathogen recognition, pathogen binding and clearance, and production of effector molecules and cytokines. So far, one of the best strategies to control and prevent viral diseases in aquaculture is DNA immunization. DN...

journal_title：Frontiers in immunology

authors： Puente-Marin S,Nombela I,Chico V,Ciordia S,Mena MC,Coll J,Mercado L,Ortega-Villaizan MDM

更新日期：2018-10-29 00:00:00

abstract：:Currently, inflammatory bowel disease (IBD) is a serious public health problem on the rise worldwide. In this work, we utilized the zebrafish to introduce a new model of intestinal inflammation triggered by food intake. Taking advantage of the translucency of the larvae and the availability of transgenic zebrafish lin...

journal_title：Frontiers in immunology

authors： Coronado M,Solis CJ,Hernandez PP,Feijóo CG

更新日期：2019-04-02 00:00:00

abstract：:Anemia of inflammation (AI) is the second most prevalent anemia after iron deficiency anemia and results in persistent low blood erythrocytes and hemoglobin, fatigue, weakness, and early death. Anemia of inflammation is common in people with chronic inflammation, chronic infections, or sepsis. Although several studies...

journal_title：Frontiers in immunology

authors： Bisht K,Tay J,Wellburn RN,McGirr C,Fleming W,Nowlan B,Barbier V,Winkler IG,Levesque JP

更新日期：2020-10-06 00:00:00

abstract：:TLR8 is an endosomal sensor of RNA degradation products in human phagocytes, and is involved in the recognition of viral and bacterial pathogens. We previously showed that in human primary monocytes and monocyte derived macrophages, TLR8 senses entire Staphylococcus aureus and Streptococcus agalactiae (group B strepto...

journal_title：Frontiers in immunology

authors： Moen SH,Ehrnström B,Kojen JF,Yurchenko M,Beckwith KS,Afset JE,Damås JK,Hu Z,Yin H,Espevik T,Stenvik J

更新日期：2019-05-31 00:00:00

abstract：:IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retinoic acid receptor-related orphan receptor gamma t (RORγt) but only a ...

journal_title：Frontiers in immunology

authors： Cole S,Murray J,Simpson C,Okoye R,Tyson K,Griffiths M,Baeten D,Shaw S,Maroof A

更新日期：2020-11-20 00:00:00

abstract：:The buccal mucosa (BM) of vertebrates is a critical mucosal barrier constantly exposed to rich and diverse pathogens from air, water, and food. While mammals are known to contain a mucosal associated lymphoid tissue (MALT) in the buccal cavity which induces B-cells and immunoglobulins (Igs) responses against bacterial...

journal_title：Frontiers in immunology

authors： Xu HY,Dong F,Zhai X,Meng KF,Han GK,Cheng GF,Wu ZB,Li N,Xu Z

更新日期：2020-09-23 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and eventually die by pyroptosis. In human adenovirus-5 (Ad5) infected THP-1 cells, inhibition of NLRP3 inflammasome activation was demonstrated by a decreased secretion ...

journal_title：Frontiers in immunology

authors： Darweesh M,Kamel W,Gavrilin MA,Akusjärvi G,Svensson C

更新日期：2019-11-28 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key con...

journal_title：Frontiers in immunology

authors： Mi Y,Guo N,Luan J,Cheng J,Hu Z,Jiang P,Jin W,Gao X

更新日期：2020-04-24 00:00:00

abstract：:Antibody deficiency or hypogammaglobulinemia can have primary or secondary etiologies. Primary antibody deficiency (PAD) is the result of intrinsic genetic defects, whereas secondary antibody deficiency may arise as a consequence of underlying conditions or medication use. On a global level, malnutrition, HIV, and mal...

journal_title：Frontiers in immunology

authors： Patel SY,Carbone J,Jolles S

更新日期：2019-02-08 00:00:00

abstract：:Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy. Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA-secreting plasma ...

journal_title：Frontiers in immunology

authors： Carsetti R,Di Sabatino A,Rosado MM,Cascioli S,Piano Mortari E,Milito C,Grimsholm O,Aranburu A,Giorda E,Tinozzi FP,Pulvirenti F,Donato G,Morini F,Bagolan P,Corazza GR,Quinti I

更新日期：2020-01-08 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs capable of rapidly producing copious amounts of type I IFN (IFN-I) in response to viral infections. The mechanism regulating rapid production of IFN-I after pDCs are exposed to viral nucleic acids remains elusive. Here, we show that the transcription ...

journal_title：Frontiers in immunology

authors： Ko YA,Chan YH,Liu CH,Liang JJ,Chuang TH,Hsueh YP,Lin YL,Lin KI

更新日期：2018-08-07 00:00:00

abstract：:Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae, a debilitating disease that affects the skin and peripheral nerves. It is possible that tissue changes during infection with leprosy are related to alterations in the activity of the Notch signaling pathway, an innate signaling pathway in t...

journal_title：Frontiers in immunology

authors： Serrano-Coll H,Ospina JP,Salazar-Peláez L,Cardona-Castro N

更新日期：2020-03-19 00:00:00

abstract：:Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli. The basic mechanism of signal initiation is a stepwise process in which an agonist cytokine binds its cognate receptor. Together, this cytokin...

journal_title：Frontiers in immunology

authors： Fields JK,Günther S,Sundberg EJ

更新日期：2019-06-20 00:00:00

abstract：:Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the effects of available analgesics, including opioids. Converging evidence indicates the functional interactions between chemokine and opioid receptors and their influence on nociceptive processes. Recent studies highlight that...

journal_title：Frontiers in immunology

authors： Kwiatkowski K,Pawlik K,Ciapała K,Piotrowska A,Makuch W,Mika J

更新日期：2020-12-21 00:00:00

abstract：:The immune system and inflammation plays a significant role in tumour immune evasion enhancing disease progression and reducing survival in colorectal cancer (CRC). Patients with advanced stages of colorectal cancer will all undergo treatment with cytotoxic chemotherapy which may alter the complexity of immune cell po...

journal_title：Frontiers in immunology

authors： Shinko D,McGuire HM,Diakos CI,Pavlakis N,Clarke SJ,Byrne SN,Charles KA

更新日期：2019-11-05 00:00:00

abstract：:Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Although the role of IDO1 is largely understood, the function of IDO2 is not yet well-elucidated. IDO2 overexpression was documented in some human tumors, but the linkage betw...

journal_title：Frontiers in immunology

authors： Mandarano M,Bellezza G,Belladonna ML,Vannucci J,Gili A,Ferri I,Lupi C,Ludovini V,Falabella G,Metro G,Mondanelli G,Chiari R,Cagini L,Stracci F,Roila F,Puma F,Volpi C,Sidoni A

更新日期：2020-05-27 00:00:00

abstract：:Combination therapy with inhibitors of cytotoxic T lymphocyte-associated protein (CTLA)4 and programmed death (PD)-1 has demonstrated efficacy in cancer patients. However, there is little information on CTLA4 and PD-1 expression levels and their clinical significance across diverse cancers. In this study, we addressed...

journal_title：Frontiers in immunology

authors： Liu JN,Kong XS,Huang T,Wang R,Li W,Chen QF

更新日期：2020-09-10 00:00:00