Corrigendum: Zoledronate Triggers Vδ2 T Cells to Destroy and Kill Spheroids of Colon Carcinoma: Quantitative Image Analysis of Three-Dimensional Cultures.

abstract：:A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) results in one of the strongest genetic traits associated with autoimmune disease outside of the Major Histocompatibility Complex (MHC) genes. However, the consequences of this polymorphism, whi...

journal_title：Frontiers in immunology

authors： Bray C,Wright D,Haupt S,Thomas S,Stauss H,Zamoyska R

更新日期：2018-11-12 00:00:00

abstract：:Increased levels of myeloid cells, especially myeloid-derived suppressor cells (MDSCs), have been reported to correlate with bad prognosis and reduced survival in cancer patients. However, limited data are available on their conclusive phenotypes and their correlation with clinical settings. The aim of this study was ...

journal_title：Frontiers in immunology

authors： Toor SM,Syed Khaja AS,El Salhat H,Bekdache O,Kanbar J,Jaloudi M,Elkord E

更新日期：2016-12-08 00:00:00

abstract：:The role of macrophages during regeneration in zebrafish has been well-documented. Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous population of cells, and that they can play different roles during immune responses and in tissue restoration after damage and infection. In this work, ...

journal_title：Frontiers in immunology

authors： Morales RA,Allende ML

更新日期：2019-02-15 00:00:00

abstract：:Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, CD4+ T cells mount an immune response against invading pathogens. Therefore, mechanistic identificatio...

journal_title：Frontiers in immunology

authors： Degoot AM,Chirove F,Ndifon W

更新日期：2018-06-20 00:00:00

abstract：:Autoimmune bullous dermatoses (AIBD) are characterized by circulating autoantibodies that are either directed against epidermal antigens or deposited as immune complexes in the basement membrane zone (BMZ). The complement system (CS) can be activated by autoantibodies, thereby triggering activation of specific complem...

journal_title：Frontiers in immunology

authors： Edwards G,Diercks GFH,Seelen MAJ,Horvath B,van Doorn MBA,Damman J

更新日期：2019-06-26 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage. MDSCs expand in pathological situations, such as chronic infection, cancer, autoimmunity, and allograft rejection. As chronic lung allograft dysfunction (CLAD) limits long-term survival after lung transplantatio...

journal_title：Frontiers in immunology

authors： Heigl T,Singh A,Saez-Gimenez B,Kaes J,Van Herck A,Sacreas A,Beeckmans H,Vanstapel A,Verleden SE,Van Raemdonck DE,Verleden G,Vanaudenaerde BM,Hartl D,Vos R

更新日期：2019-04-26 00:00:00

abstract：:Autoinflammatory diseases are caused by defects in genes that regulate the innate immunity. Recently, the scope of autoinflammation has been broadened to include diseases that result from dysregulations in protein modifications by the highly conserved ubiquitin (Ub) peptides. Thus far these diseases consist of linear ...

journal_title：Frontiers in immunology

authors： Aksentijevich I,Zhou Q

更新日期：2017-04-19 00:00:00

abstract：:Nutrition plays a major role in the management of both acute and chronic diseases, in terms of body's response to the pathogenic organism. An array of nutrients like macro- and micro-nutrients, vitamins, etc., are associated with boosting the host's immune responses against intracellular pathogens including mycobacter...

journal_title：Frontiers in immunology

authors： Chandrasekaran P,Saravanan N,Bethunaickan R,Tripathy S

更新日期：2017-10-18 00:00:00

abstract：:The dendritic cell (DC) compartment comprises subsets of cells with distinct phenotypes. Previously this lab reported methodology for hematopoiesis of dendritic-like cells in vitro dependent on a murine splenic stromal cell line (5G3). Co-cultures of lineage-depleted bone marrow (Lin(-) BM) over 5G3 continuously produ...

journal_title：Frontiers in immunology

authors： Petvises S,O'Neill HC

更新日期：2014-01-02 00:00:00

abstract：:Intrarenal robust inflammatory response following ischemia-reperfusion injury (IRI) is a major factor in the pathogenesis of renal injury in ischemic acute kidney injury (AKI). Although numerous studies have investigated various agents of immune modulation or suppression for ischemic AKI, few showed reproducible effec...

journal_title：Frontiers in immunology

authors： Jang HR,Lee K,Jeon J,Kim JR,Lee JE,Kwon GY,Kim YG,Kim DJ,Ko JW,Huh W

更新日期：2020-10-14 00:00:00

abstract：:The diseases caused by African trypanosomes (AT) are of both medical and veterinary importance and have adversely influenced the economic development of sub-Saharan Africa. Moreover, so far not a single field applicable vaccine exists, and chemotherapy is the only strategy available to treat the disease. These strictl...

journal_title：Frontiers in immunology

authors： Stijlemans B,Caljon G,Van Den Abbeele J,Van Ginderachter JA,Magez S,De Trez C

更新日期：2016-06-24 00:00:00

abstract：:Innate immunity is one of the main protection mechanisms against viral infections, but how this system works at the maternal-fetal interface, especially during HIV infection, is still poorly known. In this study, we investigated the relationship between pregnancy and innate mechanisms associated with HIV immunity by e...

journal_title：Frontiers in immunology

authors： Pereira NZ,Branco ACCC,Manfrere KCG,de Lima JF,Yoshikawa FSY,Milanez HMBPM,Pereira NV,Sotto MN,Duarte AJDS,Sato MN

更新日期：2020-08-25 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with curative potential for certain aggressive hematopoietic malignancies. Its success is limited by acute graft-versus-host disease (GVHD), a life-threatening complication that occurs when allo-reactive donor T cells attack recipient...

journal_title：Frontiers in immunology

authors： Heidegger S,van den Brink MR,Haas T,Poeck H

更新日期：2014-07-18 00:00:00

abstract：:Studies in the recent years have advanced the knowledge of how host and parasite factors contribute to the pathogenesis of human tegumentary leishmaniasis. Polymorphism within populations of Leishmania from the same species has been documented; indicating that infection with different strains may lead to distinct clin...

journal_title：Frontiers in immunology

authors： Carvalho LP,Passos S,Schriefer A,Carvalho EM

更新日期：2012-10-04 00:00:00

abstract：:The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a ...

journal_title：Frontiers in immunology

authors： Simões AE,Di Lorenzo B,Silva-Santos B

更新日期：2018-04-27 00:00:00

abstract：:S100A12 is a calcium-binding protein of the S100 subfamily of myeloid-related proteins that acts as an alarmin to induce a pro-inflammatory innate immune response. It has been linked to several chronic inflammatory diseases, however its role in the common oral immunopathology periodontitis is largely unknown. Previous...

journal_title：Frontiers in immunology

authors： Lira-Junior R,Holmström SB,Clark R,Zwicker S,Majster M,Johannsen G,Axtelius B,Åkerman S,Svensson M,Klinge B,Boström EA

更新日期：2020-01-31 00:00:00

abstract：:Anti-parasitic treatment for Chagas disease mainly relies on benznidazole, which is virtually the only drug available in the market. Besides its anti-parasitic effects, benznidazole has anti-inflammatory properties. In this work we studied the mechanisms involved in the latter, demonstrating the participation of the I...

journal_title：Frontiers in immunology

authors： Cevey ÁC,Penas FN,Alba Soto CD,Mirkin GA,Goren NB

更新日期：2019-06-04 00:00:00

abstract：:Secretion of extracellular vesicles (EVs) is a ubiquitous mechanism of intercellular communication based on the exchange of effector molecules, such as growth factors, cytokines, and nucleic acids. Recent studies identified tumor-derived EVs as central players in tumor progression and the establishment of the tumor mi...

journal_title：Frontiers in immunology

authors： Dörsam B,Bösl T,Reiners KS,Barnert S,Schubert R,Shatnyeva O,Zigrino P,Engert A,Hansen HP,von Strandmann EP

更新日期：2018-06-18 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key con...

journal_title：Frontiers in immunology

authors： Mi Y,Guo N,Luan J,Cheng J,Hu Z,Jiang P,Jin W,Gao X

更新日期：2020-04-24 00:00:00

abstract：:Mouse allergy has become increasingly common, mainly affecting laboratory workers and inner-city households. To date, only one major allergen, namely Mus m 1, has been described. We sought to identify T cell targets in mouse allergic patients. PBMC from allergic donors were expanded with either murine urine or epithel...

journal_title：Frontiers in immunology

authors： Schulten V,Westernberg L,Birrueta G,Sidney J,Paul S,Busse P,Peters B,Sette A

更新日期：2018-02-13 00:00:00

abstract：:Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) ...

journal_title：Frontiers in immunology

authors： Vecellio M,Cohen CJ,Roberts AR,Wordsworth PB,Kenna TJ

更新日期：2019-01-10 00:00:00

abstract：:Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in a...

journal_title：Frontiers in immunology

authors： Ran Z,Yue-Bei L,Qiu-Ming Z,Huan Y

更新日期：2020-08-20 00:00:00

abstract：:[This corrects the article on p. 1376 in vol. 8, PMID: 29104576.]. ...

journal_title：Frontiers in immunology

authors： Kim JH,Sim JH,Lee S,Seol MA,Ye SK,Shin HM,Lee EB,Lee YJ,Choi YJ,Yoo WH,Kim JH,Kim WU,Lee DS,Kim JH,Kang I,Kang SW,Kim HR

更新日期：2017-12-07 00:00:00

abstract：:The lung is a primary organ for gas exchange in mammals that represents the largest epithelial surface in direct contact with the external environment. It also serves as a crucial immune organ, which harbors both innate and adaptive immune cells to induce a potent immune response. Due to its direct contact with the ou...

journal_title：Frontiers in immunology

authors： Kumar V

更新日期：2020-08-04 00:00:00

abstract：:Loss-of-function mutations in the Autoimmune Regulator (AIRE) gene cause a rare inherited form of autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, also known as autoimmune polyglandular syndrome type 1. The patients suffer from multiple endocrine deficiencies, the most common manifes...

journal_title：Frontiers in immunology

authors： Arstila TP,Jarva H

更新日期：2013-10-07 00:00:00

abstract：:Neutrophil granulocytes are the most numerous type of leukocyte in humans bearing an enormous, yet largely unexplored therapeutic potential. Scientists have very recently increased their efforts to study and understand these cells which contribute to various types of inflammatory diseases and cancer. The mechanisms th...

journal_title：Frontiers in immunology

authors： Bartneck M,Wang J

更新日期：2019-09-20 00:00:00

abstract：:Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

journal_title：Frontiers in immunology

authors： Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

更新日期：2019-03-27 00:00:00

abstract：:Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their associa...

journal_title：Frontiers in immunology

authors： Almeida JS,Couceiro P,López-Sejas N,Alves V,Růžičková L,Tarazona R,Solana R,Freitas-Tavares P,Santos-Rosa M,Rodrigues-Santos P

更新日期：2019-10-22 00:00:00

abstract：:The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic allografts could be accepted across MHC-mismatch without the use of immunosuppression, and that transplantation of livers from the same donor was capable of inducing t...

journal_title：Frontiers in immunology

authors： McCaughan GW,Bowen DG,Bertolino PJ

更新日期：2020-09-11 00:00:00

abstract：:Dendritic cells (DCs) are antigen-presenting cells essential for the induction of adaptive immune responses. Their unprecedented ability to present antigens to T cells has made them excellent targets for vaccine development. In the last years, a new technology based on antigen delivery directly to different DC subsets...

journal_title：Frontiers in immunology

authors： Antonialli R,Sulczewski FB,Amorim KNDS,Almeida BDS,Ferreira NS,Yamamoto MM,Soares IS,Ferreira LCS,Rosa DS,Boscardin SB

更新日期：2017-12-04 00:00:00