Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease.

abstract：:The complement system is a dynamic subset of the innate immune system, playing roles in host defense, clearance of immune complexes and cell debris, and priming the adaptive immune response. Over the last 40 years our understanding of the complement system has evolved from identifying its presence and recognizing its ...

journal_title：Frontiers in immunology

authors： Nauser CL,Howard MC,Fanelli G,Farrar CA,Sacks S

更新日期：2018-09-06 00:00:00

abstract：:The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class switching, and germinal center (GC) formation. The Tfh cells are characterized by the expression of CXC chemokine receptor 5 (CXCR5), ICOS, programed death 1 (PD-1), B cell lymphoma 6 (BCL-6), and IL-21. They are involved in...

journal_title：Frontiers in immunology

authors： Jogdand GM,Mohanty S,Devadas S

更新日期：2016-11-23 00:00:00

abstract：:T follicular helper (Tfh) cells are a subset of CD4 T cells that provide critical signals to antigen-primed B cells in germinal centers to undergo proliferation, isotype switching, and somatic hypermutation to generate long-lived plasma cells and memory B cells during an immune response. The quantity and quality of Tf...

journal_title：Frontiers in immunology

authors： Pallikkuth S,de Armas L,Rinaldi S,Pahwa S

更新日期：2017-10-23 00:00:00

abstract：:Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies have revealed the importance of T cells in controlling these infections. However, the specific antigens recognized by T cells that confer protective immunity and ...

journal_title：Frontiers in immunology

authors： James CA,Seshadri C

更新日期：2020-02-11 00:00:00

abstract：:Studies in the recent years have advanced the knowledge of how host and parasite factors contribute to the pathogenesis of human tegumentary leishmaniasis. Polymorphism within populations of Leishmania from the same species has been documented; indicating that infection with different strains may lead to distinct clin...

journal_title：Frontiers in immunology

authors： Carvalho LP,Passos S,Schriefer A,Carvalho EM

更新日期：2012-10-04 00:00:00

abstract：:Local irradiation of cancer through radiotherapy can induce spontaneous regression of non-directly irradiated lesions, suggesting the involvement of systemic antitumor immune responses. In oligometastatic breast cancer (BC) patients, the use of stereotactic body radiotherapy (SBRT) favors the local control of treated ...

journal_title：Frontiers in immunology

authors： Muraro E,Furlan C,Avanzo M,Martorelli D,Comaro E,Rizzo A,Fae' DA,Berretta M,Militello L,Del Conte A,Spazzapan S,Dolcetti R,Trovo' M

更新日期：2017-11-06 00:00:00

abstract：:Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high-affinity antibodies that aid both to clear and protect against reinfection of invading pathogens. Within GCs, light and ...

journal_title：Frontiers in immunology

authors： Weber TS

更新日期：2018-06-12 00:00:00

abstract：:The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficient numbers for therapeutic purposes. In particular, the development of protocols for the differentiation of populations of leu...

journal_title：Frontiers in immunology

authors： Sachamitr P,Leishman AJ,Davies TJ,Fairchild PJ

更新日期：2018-01-08 00:00:00

abstract：:Macrophages have been found to both promote liver fibrosis and contribute to its resolution by acquiring different phenotypes based on signals from the micro-environment. The best-characterized phenotypes in the macrophage spectrum are labeled M1 (classically activated) and M2 (alternatively activated). Until now the ...

journal_title：Frontiers in immunology

authors： Beljaars L,Schippers M,Reker-Smit C,Martinez FO,Helming L,Poelstra K,Melgert BN

更新日期：2014-09-08 00:00:00

abstract：:A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and infections. Therefore, it is necessary to seek novel immunosuppressive ...

journal_title：Frontiers in immunology

authors： Zeng Q,Qiu F,Chen Y,Liu C,Liu H,Liang CL,Zhang Q,Dai Z

更新日期：2019-04-01 00:00:00

abstract：:Long lasting antibody responses and immunological memory are the desired outcomes of vaccination. In general, multiple vaccine doses result in enhanced immune responses, a notable exception being booster-induced hyporesponsiveness, which has been observed with polysaccharide and glycoconjugate vaccines. In this study,...

journal_title：Frontiers in immunology

authors： Mantile F,Capasso A,De Berardinis P,Prisco A

更新日期：2019-03-19 00:00:00

abstract：:Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

journal_title：Frontiers in immunology

authors： Weiskopf D,Sette A

更新日期：2014-03-07 00:00:00

abstract：:The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow outputs measurement have been widely implemented in newborn screenin...

journal_title：Frontiers in immunology

authors： Kwok JSY,Cheung SKF,Ho JCY,Tang IWH,Chu PWK,Leung EYS,Lee PPW,Cheuk DKL,Lee V,Ip P,Lau YL

更新日期：2020-07-16 00:00:00

abstract：:Intact (146S) foot-and-mouth disease virus (FMDVs) can dissociate into specific (12S) viral capsid degradation products. FMD vaccines normally consist of inactivated virions. Vaccine quality is dependent on 146S virus particles rather than 12S particles. We earlier isolated two llama single-domain antibody fragments (...

journal_title：Frontiers in immunology

authors： Harmsen MM,Seago J,Perez E,Charleston B,Eblé PL,Dekker A

更新日期：2017-08-17 00:00:00

abstract：:Acute graft-vs.-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific socioeconomic factors on ...

journal_title：Frontiers in immunology

authors： Frankiewicz A,Peczynski C,Giebel S,Harrington A,Socié G,Niederwieser D,Scheid C,Bornhäuser M,Kröger N,Elmaagacli A,Afanasyev B,Dreger P,Rössig C,Blaise D,Kratz C,Yakoub-Agha I,Kremens B,Niemeyer CM,Wulf G,Blau I,P

更新日期：2020-07-23 00:00:00

abstract：UNLABELLED:Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Accumulation of brain damage in progressive MS is partly the result of mononuclear phagocytes (MPs) attacking myelin sheaths in the CNS. Although there is no cure yet for MS, significant advances have be...

journal_title：Frontiers in immunology

authors： Tannahill GM,Iraci N,Gaude E,Frezza C,Pluchino S

更新日期：2015-03-11 00:00:00

abstract：:The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid cancer 1, in intratumoral activated CD8+ T cells ...

journal_title：Frontiers in immunology

authors： Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA

更新日期：2017-03-22 00:00:00

abstract：:Chimeric antigen receptor (CAR)-engineered T cells represent a breakthrough in personalized medicine. In this strategy, a patient's own T lymphocytes are genetically reprogrammed to encode a synthetic receptor that binds a tumor antigen, allowing T cells to recognize and kill antigen-expressing cancer cells. As a resu...

journal_title：Frontiers in immunology

authors： Long KB,Young RM,Boesteanu AC,Davis MM,Melenhorst JJ,Lacey SF,DeGaramo DA,Levine BL,Fraietta JA

更新日期：2018-12-03 00:00:00

abstract：:The catabolic process of autophagy plays important functions in inflammatory and immune responses by modulating innate immunity and adaptive immunity. Over the last decade, a cell-intrinsic role for autophagy in modulating CD4 T cell functions and differentiation was revealed. After the initial observation of autophag...

journal_title：Frontiers in immunology

authors： Jacquin E,Apetoh L

更新日期：2018-05-09 00:00:00

abstract：:Eosinophils are an enigmatic white blood cell, whose immune functions are still under intense investigation. Classically, the eosinophil was considered to fulfill a protective role against parasitic infections, primarily large multicellular helminths. Although eosinophils are predominantly associated with parasite inf...

journal_title：Frontiers in immunology

authors： Mukherjee M,Lacy P,Ueki S

更新日期：2018-11-26 00:00:00

abstract：:Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN...

journal_title：Frontiers in immunology

authors： Koyasu S,Moro K

更新日期：2012-05-07 00:00:00

abstract：:The role of intestinal epithelial cells (IECs) in mucosal tolerance and immunity remains poorly understood. We present a method for inducing MHC class II (MHC-II) in human enteroids, "mini-guts" derived from small intestinal crypt stem cells, and show that the intracellular MHC-II peptide-pathway is intact and functio...

journal_title：Frontiers in immunology

authors： Wosen JE,Ilstad-Minnihan A,Co JY,Jiang W,Mukhopadhyay D,Fernandez-Becker NQ,Kuo CJ,Amieva MR,Mellins ED

更新日期：2019-08-20 00:00:00

abstract：:The study of molecular host-parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require a clear understanding of the molecular crosstalk between parasites and their hosts. Yet, large-scale experimental iden...

journal_title：Frontiers in immunology

authors： Cuesta-Astroz Y,Santos A,Oliveira G,Jensen LJ

更新日期：2019-02-13 00:00:00

abstract：:Background: Butyric acid (BA) is a short-chain fatty acid (SCFA) with anti-inflammatory properties, which promotes intestinal barrier function. Medium-chain fatty acids (MCFA), including caproic acid (CA), promote TH1 and TH17 differentiation, thus supporting inflammation. Aim: Since most SCFAs are absorbed in the cec...

journal_title：Frontiers in immunology

authors： Saresella M,Marventano I,Barone M,La Rosa F,Piancone F,Mendozzi L,d'Arma A,Rossi V,Pugnetti L,Roda G,Casagni E,Cas MD,Paroni R,Brigidi P,Turroni S,Clerici M

更新日期：2020-07-07 00:00:00

abstract：:Introduction: Leprosy is an infectious disease caused by Mycobacterium leprae, a debilitating disease that affects the skin and peripheral nerves. It is possible that tissue changes during infection with leprosy are related to alterations in the activity of the Notch signaling pathway, an innate signaling pathway in t...

journal_title：Frontiers in immunology

authors： Serrano-Coll H,Ospina JP,Salazar-Peláez L,Cardona-Castro N

更新日期：2020-03-19 00:00:00

abstract：:Cerebral malaria is a life-threatening complication of malaria in humans, and the underlying pathogenic mechanisms are widely analyzed in a murine model of experimental cerebral malaria (ECM). Here, we show abrogation of ECM by hemocoel sporozoite-induced infection of a transgenic Plasmodium berghei line that overexpr...

journal_title：Frontiers in immunology

authors： Sato Y,Ries S,Stenzel W,Fillatreau S,Matuschewski K

更新日期：2019-11-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why ...

journal_title：Frontiers in immunology

authors： Messingham KN,Crowe TP,Fairley JA

更新日期：2019-10-04 00:00:00

abstract：:Under normal conditions our intestines are inhabited by trillions of diverse microorganisms composing the intestinal microbiota, which are mostly non-pathogenic anaerobic commensal bacteria vital for the maintenance of immune homeostasis. The composition and diversity of the intestinal microbiota can be disturbed by v...

journal_title：Frontiers in immunology

authors： Köhler N,Zeiser R

更新日期：2019-01-17 00:00:00

abstract：:Blood-borne monocyte derived cells play a pivotal, initially unrecognized, role in most central nervous system disorders, including diseases initially classified as purely neurodegenerative (i.e., Alzheimer's disease, Parkinson's disease, and ALS). Their trafficking to the brain and spinal cord has been extensively st...

journal_title：Frontiers in immunology

authors： Nigro A,Colombo F,Casella G,Finardi A,Verderio C,Furlan R

更新日期：2016-01-29 00:00:00

abstract：:Due to limited sepsis patient cohort size and extreme heterogeneity, only one significant locus and suggestive associations at several independent loci were implicated by three genome-wide association studies. However, genes from such suggestive loci may also provide crucial information to unravel genetic mechanisms t...

journal_title：Frontiers in immunology

authors： Le KTT,Matzaraki V,Netea MG,Wijmenga C,Moser J,Kumar V

更新日期：2019-08-14 00:00:00