Isolation of Single-Domain Antibody Fragments That Preferentially Detect Intact (146S) Particles of Foot-and-Mouth Disease Virus for Use in Vaccine Quality Control.

abstract：:Retinoic acid inducible gene I (RIG-I) is associated to the DExD/H box RNA helicases. It is a pattern recognition receptor (PRR), playing a crucial role in the system and is a germ line encoded host sensor to perceive pathogen-associated molecular patterns (PAMPs). So far, reports are available for the role of RIG-I i...

journal_title：Frontiers in immunology

authors： Banerjee S,Pal A,Pal A,Mandal SC,Chatterjee PN,Chatterjee JK

更新日期：2021-01-08 00:00:00

abstract：:The clinical experience gathered throughout the years has raised awareness of primary immunodeficiency diseases (PIDD). T cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) assays for thymic and bone marrow outputs measurement have been widely implemented in newborn screenin...

journal_title：Frontiers in immunology

authors： Kwok JSY,Cheung SKF,Ho JCY,Tang IWH,Chu PWK,Leung EYS,Lee PPW,Cheuk DKL,Lee V,Ip P,Lau YL

更新日期：2020-07-16 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a breakdown of self-tolerance, production of auto-antibodies and immune-mediated injury, resulting in damage accrual in multiple organs. Kidney involvement, termed lupus nephritis, is a major cause of morbidity and mortality that affects over...

journal_title：Frontiers in immunology

authors： Yung S,Chan TM

更新日期：2015-09-15 00:00:00

abstract：:Cancer neoantigens derived from random somatic mutations in tumor tissue represent an attractive type of targets for the cancer immunotherapies including cancer vaccine. Vaccination against the tumor-specific neoantigens minimizes the potential induction of central and peripheral tolerance as well as the risk of autoi...

journal_title：Frontiers in immunology

authors： Guo Y,Lei K,Tang L

更新日期：2018-07-02 00:00:00

abstract：:In this study we demonstrate the feasibility of direct, quantitative measurement of cytokine proteins in single human CD8 lymphocytes from fresh peripheral blood of healthy donors following a brief ex vivo stimulation. Cytokine-secreting cells were identified using cell surface "catch" reagents and single cell data we...

journal_title：Frontiers in immunology

authors： Saxena A,Dagur PK,Desai A,McCoy JP Jr

更新日期：2018-10-23 00:00:00

abstract：:Mucosal-associated invariant T (MAIT) cells, which are enriched in human blood and express a semi-invariant TCR chain, play important roles in conditions such as infectious diseases and cancer. The influence of age on levels and functional characteristics of circulating MAIT cells have not been fully addressed. Here w...

journal_title：Frontiers in immunology

authors： Chen P,Deng W,Li D,Zeng T,Huang L,Wang Q,Wang J,Zhang W,Yu X,Duan D,Wang J,Xia H,Chen H,Huang W,Li J,Zhang D,Zhong XP,Gao J

更新日期：2019-02-19 00:00:00

abstract：:Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a given NK cell is stochastically established, KIR repertoire perturbations reflect a dominance of discrete NK-cell subsets as the conse...

journal_title：Frontiers in immunology

authors： Zambello R,Teramo A,Barilà G,Gattazzo C,Semenzato G

更新日期：2014-02-26 00:00:00

abstract：:Gastrointestinal nematodes are among the most prevalent parasites infecting humans and livestock worldwide. Infective larvae of the soil-transmitted nematode Ascaris spp. enter the host and start tissue migration by crossing the intestinal epithelial barrier. The initial interaction of the intestinal epithelium with t...

journal_title：Frontiers in immunology

authors： Ebner F,Kuhring M,Radonić A,Midha A,Renard BY,Hartmann S

更新日期：2018-08-15 00:00:00

abstract：:Pertussis or whooping cough, mainly caused by Bordetella pertussis, is a severe respiratory disease that can affect all age groups but is most severe and can be life-threatening in young children. Vaccines against this disease are widely available since the 1950s. Despite high global vaccination coverage, the disease ...

journal_title：Frontiers in immunology

authors： Solans L,Locht C

更新日期：2019-01-14 00:00:00

abstract：:Cysteine cathepsins are key regulators of the innate and adaptive arms of the immune system. Their expression, activity, and subcellular localization are associated with the distinct development and differentiation stages of immune cells. They promote the activation of innate myeloid immune cells since they contribute...

journal_title：Frontiers in immunology

authors： Jakoš T,Pišlar A,Jewett A,Kos J

更新日期：2019-08-28 00:00:00

abstract：:The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed...

journal_title：Frontiers in immunology

authors： Grosche L,Knippertz I,König C,Royzman D,Wild AB,Zinser E,Sticht H,Muller YA,Steinkasserer A,Lechmann M

更新日期：2020-04-17 00:00:00

abstract：:The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance i...

journal_title：Frontiers in immunology

authors： Antonini M,Lo Conte M,Sorini C,Falcone M

更新日期：2019-08-16 00:00:00

abstract：:The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function involving directly or indirectly in the rehabilitation of the diseases. γδ T cells represent a minor population of T cells that express a distinct T cell receptor (TCR) composed of γδ chains i...

journal_title：Frontiers in immunology

authors： Latha TS,Reddy MC,Durbaka PV,Rachamallu A,Pallu R,Lomada D

更新日期：2014-11-10 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Influenza A virus (IAV) remains a significant global health issue causing annual epidemics, pandemics, and sporadic human infections with highly pathogenic avian or swine influenza viruses. Current inactivated and live vaccines are the mainstay of the public health response to influenza, although vaccine efficacy is l...

journal_title：Frontiers in immunology

authors： Sridhar S

更新日期：2016-05-19 00:00:00

abstract：:The identification and tracking of antigen-specific immunoglobulin (Ig) sequences within total Ig repertoires is central to high-throughput sequencing (HTS) studies of infections or vaccinations. In this context, public Ig sequences shared by different individuals exposed to the same antigen could be valuable markers ...

journal_title：Frontiers in immunology

authors： Bürckert JP,Dubois ARSX,Faison WJ,Farinelle S,Charpentier E,Sinner R,Wienecke-Baldacchino A,Muller CP

更新日期：2017-12-22 00:00:00

abstract：:The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alteratio...

journal_title：Frontiers in immunology

authors： Silva CAM,Belisle JT

更新日期：2018-02-02 00:00:00

abstract：:Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are...

journal_title：Frontiers in immunology

authors： Lukens JR,Gross JM,Kanneganti TD

更新日期：2012-10-09 00:00:00

abstract：:The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows t...

journal_title：Frontiers in immunology

authors： Hoeffel G,Ginhoux F

更新日期：2015-09-22 00:00:00

abstract：:Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations with inactivated protein-based vaccines. Studies in the past decades have suggested that the B cell respon...

journal_title：Frontiers in immunology

authors： Nelson SA,Sant AJ

更新日期：2019-05-07 00:00:00

abstract：:The Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, only clinically diagnosed since the lack of reliable biomarkers. Autism etiology is probably attributable to the combination of genetic vulnerability and environmental factors, and recently, maternal immune activation has been...

journal_title：Frontiers in immunology

authors： Balestrieri E,Cipriani C,Matteucci C,Benvenuto A,Coniglio A,Argaw-Denboba A,Toschi N,Bucci I,Miele MT,Grelli S,Curatolo P,Sinibaldi-Vallebona P

更新日期：2019-09-26 00:00:00

abstract：:Background: This retrospective study assessed the use and long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with severe autoimmune diseases (ADs), reported to the European Society for Blood and Marrow Transplantation (EBMT) registry. Methods: Between 1997 and 2014, 128 patients...

journal_title：Frontiers in immunology

authors： Greco R,Labopin M,Badoglio M,Veys P,Furtado Silva JM,Abinun M,Gualandi F,Bornhauser M,Ciceri F,Saccardi R,Lankester A,Alexander T,Gennery AR,Bader P,Farge D,Snowden JA

更新日期：2019-07-04 00:00:00

abstract：:Pleural effusions, when benign, are attributed to cardiac events and suffusion of fluid within the pleural space. When malignant, lymphatic obstruction by tumor and failure to absorb constitutively produced fluid is the predominant formulation. The prevailing view has been challenged recently, namely that the lymphati...

journal_title：Frontiers in immunology

authors： Soloff AC,Jones KE,Powers AA,Murthy P,Wang Y,Russell KL,Byrne-Steele M,Lund AW,Yuan JM,Monaco SE,Han J,Dhupar R,Lotze MT

更新日期：2020-09-04 00:00:00

abstract：:Overcoming the first line of the innate immune system is a general hallmark of pathogenic microbes to avoid recognition and to enter the human host. In particular, spirochetes belonging to the Borrelia burgdorferi sensu lato complex have developed various means to counter the immune response and to successfully surviv...

journal_title：Frontiers in immunology

authors： Kraiczy P

更新日期：2016-09-26 00:00:00

abstract：:Kawasaki disease (KD) was first described by Dr. Tomisaku Kawasaki in 1967. The etiology of KD has been studied comprehensively but remains largely unknown. The disease seems to result from the interplay of genetic and environmental susceptibility factors with infectious triggers, followed by a subsequent abnormal imm...

journal_title：Frontiers in immunology

authors： Kaneko K,Akagawa S,Akagawa Y,Kimata T,Tsuji S

更新日期：2020-07-24 00:00:00

abstract：:Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in promoting the differentiation of immature precursors into polymorphonuclear neutrophils (PMNs), monocytes/macrophages (MØs) and dendritic cells (DCs), but also in controlling the function ...

journal_title：Frontiers in immunology

authors： Zhan Y,Lew AM,Chopin M

更新日期：2019-11-15 00:00:00

abstract：:A major obstacle in kidney transplantation for primary focal segmental glomerulosclerosis (FSGS) is the risk of disease recurrence. Recurrent FSGS affects up to 60% of first kidney grafts and exceeds 80% in patients who have lost their first graft due to recurrent FSGS. Clinical and experimental evidence support the h...

journal_title：Frontiers in immunology

authors： Kienzl-Wagner K,Waldegger S,Schneeberger S

更新日期：2019-07-17 00:00:00

abstract：:Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent...

journal_title：Frontiers in immunology

authors： Liu R,Nikolajczyk BS

更新日期：2019-07-17 00:00:00

abstract：:Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix (ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan present in tissues are indicative of a healthy or inflamed tissue, and the interactions of hyaluronan with immune cells can influence thei...

journal_title：Frontiers in immunology

authors： Lee-Sayer SS,Dong Y,Arif AA,Olsson M,Brown KL,Johnson P

更新日期：2015-04-14 00:00:00

abstract：:Increasing prevalence in obesity has become a significant public concern. C57BL/6J mice are prone to diet-induced obesity (DIO) when fed high-fat diet (HFD), and develop chronic inflammation and metabolic syndrome, making them a good model to analyze mechanisms whereby obesity elicits pathologies. DIO mice demonstrate...

journal_title：Frontiers in immunology

authors： Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

更新日期：2018-09-11 00:00:00