Abstract:
UNLABELLED:Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Accumulation of brain damage in progressive MS is partly the result of mononuclear phagocytes (MPs) attacking myelin sheaths in the CNS. Although there is no cure yet for MS, significant advances have been made in the development of disease modifying agents. Unfortunately, most of these drugs fail to reverse established neurological deficits and can have adverse effects. Recent evidence suggests that MPs polarization is accompanied by profound metabolic changes, whereby pro-inflammatory MPs (M1) switch toward glycolysis, whereas anti-inflammatory MPs (M2) become more oxidative. It is therefore possible that reprograming MPs metabolism could affect their function and repress immune cell activation. This mini review describes the metabolic changes underpinning macrophages polarization and anticipates how metabolic re-education of MPs could be used for the treatment of MS. KEY POINTS:Inflammation in progressive MS is mediated primarily by MPs.Cell metabolism regulates the function of MPs.DMAs can re-educate the metabolism of MPs to promote healing.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Tannahill GM,Iraci N,Gaude E,Frezza C,Pluchino Sdoi
10.3389/fimmu.2015.00106subject
Has Abstractpub_date
2015-03-11 00:00:00pages
106issn
1664-3224journal_volume
6pub_type
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abstract::[This corrects the article DOI: 10.3389/fimmu.2020.562282.]. ...
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