Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation.

abstract：:The ventrolateral hypothalamic parvafox (formerly called PV1-Foxb1) nucleus is an anatomical entity of recent discovery and unknown function. With a view to gaining an insight into its putative functional role(s), we conducted a gene-microarray analysis and, armed with the forthcoming data, controlled the results with...

journal_title：Frontiers in molecular neuroscience

authors： Szabolcsi V,Albisetti GW,Celio MR

更新日期：2017-01-23 00:00:00

abstract：:Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Her...

journal_title：Frontiers in molecular neuroscience

authors： Huang C,Lu F,Li P,Cao C,Liu Z

更新日期：2017-06-28 00:00:00

abstract：:Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease ...

journal_title：Frontiers in molecular neuroscience

authors： Peterson AR,Binder DK

更新日期：2019-07-09 00:00:00

abstract：:In the brain, de novo gene expression driven by learning-associated neuronal activities is critical for the formation of long-term memories. However, the signaling machinery mediating neuronal activity-induced gene expression, especially the rapid transcription of immediate-early genes (IEGs) remains unclear. Cyclin-d...

journal_title：Frontiers in molecular neuroscience

authors： He G,Yang X,Wang G,Qi J,Mao R,Wu Z,Zhou Z

更新日期：2017-11-07 00:00:00

abstract：:Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory function is unclear due to conflicts in published results. To addres...

journal_title：Frontiers in molecular neuroscience

authors： Zorzi V,Paciello F,Ziraldo G,Peres C,Mazzarda F,Nardin C,Pasquini M,Chiani F,Raspa M,Scavizzi F,Carrer A,Crispino G,Ciubotaru CD,Monyer H,Fetoni AR,M Salvatore A,Mammano F

更新日期：2017-11-28 00:00:00

abstract：:Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology of neurological dis...

journal_title：Frontiers in molecular neuroscience

authors： Kakraba S,Ayyadevara S,Penthala NR,Balasubramaniam M,Ganne A,Liu L,Alla R,Bommagani SB,Barger SW,Griffin WST,Crooks PA,Shmookler Reis RJ

更新日期：2019-12-12 00:00:00

abstract：:Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid peptides (Aβ) that accumulate in Alzheimer's disease (AD), structural analyses suggested that the holoprotein resembles a transmembrane receptor. Initial studies using reconstituted membranes demonstrated that APP can directly ...

journal_title：Frontiers in molecular neuroscience

authors： Copenhaver PF,Kögel D

更新日期：2017-01-31 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are ...

journal_title：Frontiers in molecular neuroscience

authors： Fisher NM,Seto M,Lindsley CW,Niswender CM

更新日期：2018-10-23 00:00:00

abstract：:We earlier reported that the male mice lacking the Wdr13 gene (Wdr13-/0) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of Wdr13 in stress response, we investigated its ro...

journal_title：Frontiers in molecular neuroscience

authors： Mitra S,Sameer Kumar GS,Jyothi Lakshmi B,Thakur S,Kumar S

更新日期：2018-04-25 00:00:00

abstract：:In the past two decades, yeast models have delivered profound insights into basic mechanisms of protein misfolding and the dysfunction of key cellular pathways associated with amyotrophic lateral sclerosis (ALS). Expressing ALS-associated proteins, such as superoxide dismutase (SOD1), TAR DNA binding protein 43 (TDP-4...

journal_title：Frontiers in molecular neuroscience

authors： Di Gregorio SE,Duennwald ML

更新日期：2018-10-30 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of gliomas are not fully understood. With the development of deep sequencing analyses, an extensive...

journal_title：Frontiers in molecular neuroscience

authors： Yan Y,Xu Z,Li Z,Sun L,Gong Z

更新日期：2017-02-28 00:00:00

abstract：:Corticotropin releasing factor (CRF) has been shown to induce various behavioral changes related to adaptation to stress. Dysregulation of the CRF system at any point can lead to a variety of psychiatric disorders, including substance use disorders (SUDs). CRF has been associated with stress-induced drug reinforcement...

journal_title：Frontiers in molecular neuroscience

authors： Haass-Koffler CL,Bartlett SE

更新日期：2012-09-06 00:00:00

abstract：:Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain. The α2-chain is a major component of the laminin-211 and laminin-221 isoforms, the p...

journal_title：Frontiers in molecular neuroscience

authors： Barraza-Flores P,Bates CR,Oliveira-Santos A,Burkin DJ

更新日期：2020-02-11 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking. To identify the abrogated lncRNAs in primary neuroblastoma and i...

journal_title：Frontiers in molecular neuroscience

authors： Prajapati B,Fatma M,Fatima M,Khan MT,Sinha S,Seth PK

更新日期：2019-12-12 00:00:00

abstract：:Neuroblastoma, the major cause of infant cancer deaths, results from fast proliferation of undifferentiated neuroblasts. Treatment of high-risk neuroblastoma includes differentiation with retinoic acid (RA); however, the resistance of many of these tumors to RA-induced differentiation poses a considerable challenge. H...

journal_title：Frontiers in molecular neuroscience

authors： Kasim M,Heß V,Scholz H,Persson PB,Fähling M

更新日期：2016-12-21 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE). Efficacy of these drugs depends on available amount of ACh, which is biosynthesized by...

journal_title：Frontiers in molecular neuroscience

authors： Karami A,Eriksdotter M,Kadir A,Almkvist O,Nordberg A,Darreh-Shori T

更新日期：2019-10-11 00:00:00

abstract：:Human achaete-scute homolog-1 (hASH1), encoded by the human ASCL1 gene, belongs to the family of basic helix-loop-helix transcription factors. hASH1 and its mammalian homolog Mash1 are expressed in the central and peripheral nervous system during development, and promote early neuronal differentiation. Furthermore, hA...

journal_title：Frontiers in molecular neuroscience

authors： Benko E,Winkelmann A,Meier JC,Persson PB,Scholz H,Fähling M

更新日期：2011-02-07 00:00:00

abstract：:Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the central nervous system formation during embryonic and fetal development. In the mouse, Hoxa5 was recently shown to be expressed in the medulla oblongata and the pons from fetal stages to adulthood. In these territories, Hoxa5...

journal_title：Frontiers in molecular neuroscience

authors： Lizen B,Moens C,Mouheiche J,Sacré T,Ahn MT,Jeannotte L,Salti A,Gofflot F

更新日期：2017-11-15 00:00:00

abstract：:Autism spectrum disorders (ASD) have a higher prevalence in male individuals compared to females, with a ratio of affected boys compared to girls of 4:1 for ASD and 11:1 for Asperger syndrome. Mutations in the SHANK genes (comprising SHANK1, SHANK2 and SHANK3) coding for postsynaptic scaffolding proteins have been tig...

journal_title：Frontiers in molecular neuroscience

authors： Berkel S,Eltokhi A,Fröhlich H,Porras-Gonzalez D,Rafiullah R,Sprengel R,Rappold GA

更新日期：2018-09-25 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair cell (HC) damage in vitro. The formation of parkin particles (a mar...

journal_title：Frontiers in molecular neuroscience

authors： Yang Q,Zhou Y,Yin H,Li H,Zhou M,Sun G,Cao Z,Man R,Wang H,Li J

更新日期：2018-11-12 00:00:00

abstract：:γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from 19 different subunits. As dysfunctional GABAergic neurotransmission mani...

journal_title：Frontiers in molecular neuroscience

authors： Kasaragod VB,Schindelin H

更新日期：2019-08-07 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and phy...

journal_title：Frontiers in molecular neuroscience

authors： Zajac MS,Renoir T,Perreau VM,Li S,Adams W,van den Buuse M,Hannan AJ

更新日期：2018-12-10 00:00:00

abstract：:We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's disease (AD) that requires closer attention in the development of AD therapeutics. Our rationale is fourfold: (i) Glucose uptake is lower in the frontal cortex of people >65 years-old despite cognitive scores that are normal fo...

journal_title：Frontiers in molecular neuroscience

authors： Cunnane SC,Courchesne-Loyer A,Vandenberghe C,St-Pierre V,Fortier M,Hennebelle M,Croteau E,Bocti C,Fulop T,Castellano CA

更新日期：2016-07-08 00:00:00

abstract：:Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets. The neurons of the dorsal root ganglia (DRG) are an important model for stud...

journal_title：Frontiers in molecular neuroscience

authors： Thakur M,Crow M,Richards N,Davey GI,Levine E,Kelleher JH,Agley CC,Denk F,Harridge SD,McMahon SB

更新日期：2014-11-11 00:00:00

abstract：:The cells of the neural crest, often referred to as neural crest stem cells, give rise to a number of sub-lineages, one of which is Schwann cells, the glial cells of peripheral nerves. Crest cells transform to adult Schwann cells through the generation of two well defined intermediate stages, the Schwann cell precurso...

journal_title：Frontiers in molecular neuroscience

authors： Jessen KR,Mirsky R

更新日期：2019-03-26 00:00:00

abstract：:Blast induced neurotrauma (BINT) is a prevalent injury within military and civilian populations. The injury is characterized by persistent inflammation at the cellular level which manifests as a multitude of cognitive and functional impairments. Epigenetic regulation of transcription offers an important control mechan...

journal_title：Frontiers in molecular neuroscience

authors： Bailey ZS,Grinter MB,VandeVord PJ

更新日期：2016-08-08 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of GluN1/GluN2 subunits. Previous studies showed that GluN1/GluN2 receptors...

journal_title：Frontiers in molecular neuroscience

authors： Skrenkova K,Lee S,Lichnerova K,Kaniakova M,Hansikova H,Zapotocky M,Suh YH,Horak M

更新日期：2018-06-04 00:00:00

abstract：:Inhibition of nerve growth and plasticity in the CNS is to a large part mediated by Nogo-like signaling, now encompassing a plethora of ligands, receptors, co-receptors and modulators. Here we describe the distribution and levels of mRNA encoding 11 key genes involved in Nogo-like signaling (Nogo-A, Oligodendrocyte-My...

journal_title：Frontiers in molecular neuroscience

authors： Karlsson TE,Wellfelt K,Olson L

更新日期：2017-04-11 00:00:00

abstract：:GABAergic interneuron diversity is a key feature in the brain that helps to create different brain activity patterns and behavioral states. Cell type classification schemes-based on anatomical, physiological and molecular features-have provided us with a detailed understanding of the distinct types that constitute thi...

journal_title：Frontiers in molecular neuroscience

authors： Que L,Winterer J,Földy C

更新日期：2019-05-07 00:00:00

abstract：:Rod and cone phosphodiesterase 6 (PDE6) are key effector enzymes of the vertebrate phototransduction pathway. Rod PDE6 consists of two catalytic subunits PDE6α and PDE6β and two identical inhibitory PDE6γ subunits, while cone PDE6 is composed of two identical PDE6α' catalytic subunits and two identical cone-specific P...

journal_title：Frontiers in molecular neuroscience

authors： Deng WT,Kolandaivelu S,Dinculescu A,Li J,Zhu P,Chiodo VA,Ramamurthy V,Hauswirth WW

更新日期：2018-07-09 00:00:00