Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders.

abstract：:GABA(A) receptors are located on the majority of neurons in the central and peripheral nervous system, where they mediate important actions of the neurotransmitter gamma-aminobutyric acid. Early in development the trophic properties of GABA allow a healthy development of the nervous system. Most neurons have a high in...

journal_title：Frontiers in molecular neuroscience

authors： Tretter V,Moss SJ

更新日期：2008-05-30 00:00:00

abstract：:Neuroendocrine cells store and secrete bulk amounts of neuropeptides, and display morphological and molecular characteristics distinct from neurons signaling with classical neurotransmitters. In Drosophila the transcription factor Dimmed (Dimm), is a prime organizer of neuroendocrine capacity in a majority of the pept...

journal_title：Frontiers in molecular neuroscience

authors： Luo J,Liu Y,Nässel DR

更新日期：2017-08-14 00:00:00

abstract：:Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling. The wide range of cross-interactions between Trk receptors and neurot...

journal_title：Frontiers in molecular neuroscience

authors： Haddad Y,Adam V,Heger Z

更新日期：2017-05-03 00:00:00

abstract：:Emerging studies have demonstrated that interleukin (IL)-33 and its receptor ST2 act as key factors in inflammatory diseases. Moreover, accumulating evidence has suggested that cytokines, including tumor necrosis factor (TNF)-α and IL-1β, trigger an inflammatory cascade. SIRT1 has been shown to suppress the expression...

journal_title：Frontiers in molecular neuroscience

authors： Zeng Y,Shi Y,Zhan H,Liu W,Cai G,Zhong H,Wang Y,Chen S,Huang S,Wu W

更新日期：2020-02-12 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This leads to decreased synaptic efficacy, cell death, and, consequently, brain atrophy in patients. Behaviorally, this manifests as memory loss and confusion. Using a...

journal_title：Frontiers in molecular neuroscience

authors： Greene AN,Parks LG,Solomon MB,Privette Vinnedge LM

更新日期：2020-11-16 00:00:00

abstract：:Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα itself has many physiological properties that suggest its great po...

journal_title：Frontiers in molecular neuroscience

authors： Mockett BG,Richter M,Abraham WC,Müller UC

更新日期：2017-02-07 00:00:00

abstract：:The molecular mechanisms underlying plastic changes in the strength and connectivity of excitatory synapses have been studied extensively for the past few decades and remain the most attractive cellular models of learning and memory. One of the major mechanisms that regulate synaptic plasticity is the dynamic adjustme...

journal_title：Frontiers in molecular neuroscience

authors： Widagdo J,Guntupalli S,Jang SE,Anggono V

更新日期：2017-10-26 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2018.00312.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Lima da Cruz RV,Moulin TC,Petiz LL,Leão RN

更新日期：2019-04-04 00:00:00

abstract：:Inhibition of nerve growth and plasticity in the CNS is to a large part mediated by Nogo-like signaling, now encompassing a plethora of ligands, receptors, co-receptors and modulators. Here we describe the distribution and levels of mRNA encoding 11 key genes involved in Nogo-like signaling (Nogo-A, Oligodendrocyte-My...

journal_title：Frontiers in molecular neuroscience

authors： Karlsson TE,Wellfelt K,Olson L

更新日期：2017-04-11 00:00:00

abstract：:Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the unde...

journal_title：Frontiers in molecular neuroscience

authors： Comhair J,Devoght J,Morelli G,Harvey RJ,Briz V,Borrie SC,Bagni C,Rigo JM,Schiffmann SN,Gall D,Brône B,Molchanova SM

更新日期：2018-10-15 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive disease with early degeneration of the central cholinergic neurons. Currently, three of four AD drugs act by inhibiting the acetylcholine (ACh) degrading enzyme, acetylcholinesterase (AChE). Efficacy of these drugs depends on available amount of ACh, which is biosynthesized by...

journal_title：Frontiers in molecular neuroscience

authors： Karami A,Eriksdotter M,Kadir A,Almkvist O,Nordberg A,Darreh-Shori T

更新日期：2019-10-11 00:00:00

abstract：:Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an involvement of the ...

journal_title：Frontiers in molecular neuroscience

authors： Janzen D,Schaefer N,Delto C,Schindelin H,Villmann C

更新日期：2017-10-09 00:00:00

abstract：:Human achaete-scute homolog-1 (hASH1), encoded by the human ASCL1 gene, belongs to the family of basic helix-loop-helix transcription factors. hASH1 and its mammalian homolog Mash1 are expressed in the central and peripheral nervous system during development, and promote early neuronal differentiation. Furthermore, hA...

journal_title：Frontiers in molecular neuroscience

authors： Benko E,Winkelmann A,Meier JC,Persson PB,Scholz H,Fähling M

更新日期：2011-02-07 00:00:00

abstract：:Background: An imbalance between total training load and total recovery may cause overtraining (OT). The purpose of the present study was to verify the effects of OT on the expression of brain-derived neurotrophic factor (BDNF), its receptor tropomyosin receptor kinase B (TrkB) and p75 and the dynamic expression patte...

journal_title：Frontiers in molecular neuroscience

authors： Xu L,Zheng YL,Yin X,Xu SJ,Tian D,Zhang CY,Wang S,Ma JZ

更新日期：2020-01-30 00:00:00

abstract：:Previous reports have shown that running wheel activity or voluntary exercise prevents hyperphagia and obesity in various animal models of obesity, but such effects seem only minimal in obese animals lacking leptin or leptin receptors. The mechanisms underlying this ineffectiveness remain unclear. Here, we identified ...

journal_title：Frontiers in molecular neuroscience

authors： Zhang N,Yang L,Guo L,Bi S

更新日期：2018-05-29 00:00:00

abstract：:Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied in the field of endocrinology, the bioactivity of the proinsulin ...

journal_title：Frontiers in molecular neuroscience

authors： de Pablo F,Hernández-Sánchez C,de la Rosa EJ

更新日期：2018-11-26 00:00:00

abstract：:We propose that brain energy deficit is an important pre-symptomatic feature of Alzheimer's disease (AD) that requires closer attention in the development of AD therapeutics. Our rationale is fourfold: (i) Glucose uptake is lower in the frontal cortex of people >65 years-old despite cognitive scores that are normal fo...

journal_title：Frontiers in molecular neuroscience

authors： Cunnane SC,Courchesne-Loyer A,Vandenberghe C,St-Pierre V,Fortier M,Hennebelle M,Croteau E,Bocti C,Fulop T,Castellano CA

更新日期：2016-07-08 00:00:00

abstract：:The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation. Previous studies indicate that secretases form binary complex and the interactions ...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Pei G

更新日期：2018-11-27 00:00:00

abstract：:Cell-non-autonomous signals dictate the functional state of cellular quality control systems, remodeling the ability of cells to cope with stress and maintain protein homeostasis (proteostasis). One highly regulated cell-non-autonomous switch controls proteostatic capacity in Caenorhabditis elegans adulthood. Signals ...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Meshnik L,Shpigel N,Ben-Zvi A

更新日期：2017-08-09 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is crucial for intracellular protein homeostasis and for degradation of aberrant and damaged proteins. The accumulation of ubiquitinated proteins is a hallmark of many neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's, and Huntington's d...

journal_title：Frontiers in molecular neuroscience

authors： Jansen AH,Reits EA,Hol EM

更新日期：2014-08-08 00:00:00

abstract：:Huntington's disease (HD) is a neurodegenerative disorder caused by a tandem repeat mutation encoding an expanded polyglutamine tract in the huntingtin protein, which leads to cognitive, psychiatric and motor dysfunction. Exposure to environmental enrichment (EE), which enhances levels of cognitive stimulation and phy...

journal_title：Frontiers in molecular neuroscience

authors： Zajac MS,Renoir T,Perreau VM,Li S,Adams W,van den Buuse M,Hannan AJ

更新日期：2018-12-10 00:00:00

abstract：:Despite numerous clinical studies, which have investigated the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) in various brain diseases, our knowledge of the cellular and molecular mechanisms underlying rTMS-based therapies remains limited. Thus, a deeper understanding of rTMS-induced neu...

journal_title：Frontiers in molecular neuroscience

authors： Müller-Dahlhaus F,Vlachos A

更新日期：2013-12-17 00:00:00

abstract：:Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, a...

journal_title：Frontiers in molecular neuroscience

authors： Del Turco D,Paul MH,Beeg Moreno VJ,Hildebrandt-Einfeldt L,Deller T

更新日期：2019-11-12 00:00:00

abstract：:Although second harmonic generation (SHG) microscopy provides unique imaging advantages for voltage imaging and other biological applications, genetically-encoded SHG chromophores remain relatively unexplored. SHG only arises from non-centrosymmetric media, so an anisotropic arrangement of chromophores is essential to...

journal_title：Frontiers in molecular neuroscience

authors： Jinno Y,Shoda K,Rial-Verde E,Yuste R,Miyawaki A,Tsutsui H

更新日期：2014-11-27 00:00:00

abstract：:Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatec...

journal_title：Frontiers in molecular neuroscience

authors： Zhu J,Chen Z,Meng Z,Ju M,Zhang M,Wu G,Guo H,Tian Z

更新日期：2017-09-27 00:00:00

abstract：:Unlike a number of amyloid-forming proteins, stefins, and in particular stefin B (cystatin B) form amyloids under conditions where the native state predominates. In order to trigger oligomerization processes, the stability of the protein needs to be compromised, favoring structural re-arrangement however, accelerating...

journal_title：Frontiers in molecular neuroscience

authors： Paramore R,Morgan GJ,Davis PJ,Sharma CA,Hounslow A,Taler-Verčič A,Zerovnik E,Waltho JP,Cliff MJ,Staniforth RA

更新日期：2012-10-12 00:00:00

abstract：:It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative disorder caused by genetic and environmental factors including aging, nutrition, pesticides and exposure to heavy metals. DNA methylation ...

journal_title：Frontiers in molecular neuroscience

authors： Miranda-Morales E,Meier K,Sandoval-Carrillo A,Salas-Pacheco J,Vázquez-Cárdenas P,Arias-Carrión O

更新日期：2017-07-18 00:00:00

abstract：:Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the central nervous system formation during embryonic and fetal development. In the mouse, Hoxa5 was recently shown to be expressed in the medulla oblongata and the pons from fetal stages to adulthood. In these territories, Hoxa5...

journal_title：Frontiers in molecular neuroscience

authors： Lizen B,Moens C,Mouheiche J,Sacré T,Ahn MT,Jeannotte L,Salti A,Gofflot F

更新日期：2017-11-15 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory. Metaplasticity is a process whereby modifications in synaptic processes shift the threshold for subsequent plasticity. While metaplasti...

journal_title：Frontiers in molecular neuroscience

authors： Zhong L,Gerges NZ

更新日期：2020-01-24 00:00:00

abstract：:Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid peptides (Aβ) that accumulate in Alzheimer's disease (AD), structural analyses suggested that the holoprotein resembles a transmembrane receptor. Initial studies using reconstituted membranes demonstrated that APP can directly ...

journal_title：Frontiers in molecular neuroscience

authors： Copenhaver PF,Kögel D

更新日期：2017-01-31 00:00:00