Spatiotemporal and Long Lasting Modulation of 11 Key Nogo Signaling Genes in Response to Strong Neuroexcitation.

abstract：:Neuronal identity is generated by the cell-surface expression of clustered protocadherin (Pcdh) isoforms. In mice, 58 isoforms from three gene clusters, Pcdhα, Pcdhβ, and Pcdhγ, are differentially expressed in neurons. Since cis-heteromeric Pcdh oligomers on the cell surface interact homophilically with that in other ...

journal_title：Frontiers in molecular neuroscience

authors： Hasegawa S,Kobayashi H,Kumagai M,Nishimaru H,Tarusawa E,Kanda H,Sanbo M,Yoshimura Y,Hirabayashi M,Hirabayashi T,Yagi T

更新日期：2017-04-24 00:00:00

abstract：:Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα itself has many physiological properties that suggest its great po...

journal_title：Frontiers in molecular neuroscience

authors： Mockett BG,Richter M,Abraham WC,Müller UC

更新日期：2017-02-07 00:00:00

abstract：:The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are major excitatory receptors that mediate fast neurotransmission in the mammalian brain. The surface expression of functional AMPARs is crucial for synaptic transmission and plasticity. AMPAR auxiliary subunits control ...

journal_title：Frontiers in molecular neuroscience

authors： Wei M,Jia M,Zhang J,Yu L,Zhao Y,Chen Y,Ma Y,Zhang W,Shi YS,Zhang C

更新日期：2017-03-02 00:00:00

abstract：:Studies on the association between post-traumatic stress disorder (PTSD) and levels of catecholamines have yielded inconsistent results. The aim of this study was to conduct a systematic review and meta-analysis to assess whether concentrations of the catecholamines dopamine, norepinephrine, and epinephrine are associ...

journal_title：Frontiers in molecular neuroscience

authors： Pan X,Kaminga AC,Wen SW,Liu A

更新日期：2018-12-04 00:00:00

abstract：:Oxidative stress-induced neuronal damage has been implicated to play a dominant role in neurodegenerative disorders, such as Alzheimer's disease (AD). Nicotine, a principal additive compound for tobacco users, is thought as a candidate to attenuate amyloid-β-mediated neurotoxicity and NMDA-induced excitotoxicity. Prev...

journal_title：Frontiers in molecular neuroscience

authors： Dong Y,Bi W,Zheng K,Zhu E,Wang S,Xiong Y,Chang J,Jiang J,Liu B,Lu Z,Cheng Y

更新日期：2020-11-12 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of gliomas are not fully understood. With the development of deep sequencing analyses, an extensive...

journal_title：Frontiers in molecular neuroscience

authors： Yan Y,Xu Z,Li Z,Sun L,Gong Z

更新日期：2017-02-28 00:00:00

abstract：:Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment, and severely affects the quality of life of cancer survivors. Clinically, chemotherapy-induced peripheral neuropathy presents as deficits i...

journal_title：Frontiers in molecular neuroscience

authors： Starobova H,Vetter I

更新日期：2017-05-31 00:00:00

abstract：:γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from 19 different subunits. As dysfunctional GABAergic neurotransmission mani...

journal_title：Frontiers in molecular neuroscience

authors： Kasaragod VB,Schindelin H

更新日期：2019-08-07 00:00:00

abstract：:Unbiased "omics" techniques, such as next generation RNA-sequencing, can provide entirely novel insights into biological systems. However, cellular heterogeneity presents a significant barrier to analysis and interpretation of these datasets. The neurons of the dorsal root ganglia (DRG) are an important model for stud...

journal_title：Frontiers in molecular neuroscience

authors： Thakur M,Crow M,Richards N,Davey GI,Levine E,Kelleher JH,Agley CC,Denk F,Harridge SD,McMahon SB

更新日期：2014-11-11 00:00:00

abstract：:MicroRNAs (miRNAs) are key post transcriptional regulators of their multiple target genes. However, the detailed profile of miRNA expression in Parkinson's disease, the second most common neurodegenerative disease worldwide and the first motor disorder has not been charted yet. Here, we report comprehensive miRNA prof...

journal_title：Frontiers in molecular neuroscience

authors： Soreq L,Salomonis N,Bronstein M,Greenberg DS,Israel Z,Bergman H,Soreq H

更新日期：2013-05-13 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain. It has been found that a synergistic relationship between these two proteins may contribute to their roles in disease progression. However, how Aβ...

journal_title：Frontiers in molecular neuroscience

authors： Shin WS,Di J,Murray KA,Sun C,Li B,Bitan G,Jiang L

更新日期：2019-11-08 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. We have previously demonstrated that dipotassium bisperoxo (picolinato) oxovanadate (V), (bpV[pic]) inhibits phosphatase and tensin homolog (PTEN) and activates extracellular signal-regulated kinase (ERK)1/2. In this study, we ...

journal_title：Frontiers in molecular neuroscience

authors： Zhao D,Qin XP,Chen SF,Liao XY,Cheng J,Liu R,Lei Y,Zhang ZF,Wan Q

更新日期：2019-12-05 00:00:00

abstract：:Although several agents have been identified to provide therapeutic benefits in Huntington disease (HD), the number of conventionally used treatments remains limited and only symptomatic. Thus, it is plausible that the need to identify new therapeutic targets for the development of alternative and more effective treat...

journal_title：Frontiers in molecular neuroscience

authors： Di Pardo A,Pepe G,Castaldo S,Marracino F,Capocci L,Amico E,Madonna M,Giova S,Jeong SK,Park BM,Park BD,Maglione V

更新日期：2019-04-24 00:00:00

abstract：:The tetrameric capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) in mammals has evolved the capability to integrate pain signal arising from harmful temperature and chemical irritants. The four repetitions of TRPV1 subunits result in an ion channel with excellent pain sensitivity, allowing this ionot...

journal_title：Frontiers in molecular neuroscience

authors： Liu TY,Chu Y,Mei HR,Chang D,Chuang HH

更新日期：2020-01-09 00:00:00

abstract：:M/Kv7 potassium channels play a key role in regulation of neuronal excitability. Modulation of neuronal excitability of primary sensory neurons determines the itch sensation induced by a variety of itch-causing substances including chloroquine (CQ). In the present study, we demonstrate that suppression of M/Kv7 channe...

journal_title：Frontiers in molecular neuroscience

authors： Zhang D,Men H,Zhang L,Gao X,Wang J,Li L,Zhu Q,Zhang H,Jia Z

更新日期：2020-06-30 00:00:00

abstract：:Glycogen synthase kinase-3 (GSK-3) is central to multiple intracellular pathways including those activated by Wnt/β-catenin, Sonic Hedgehog, Notch, growth factor/RTK, and G protein-coupled receptor signals. All of these signals importantly contribute to neural development. Early attention on GSK-3 signaling in neural ...

journal_title：Frontiers in molecular neuroscience

authors： Kim WY,Snider WD

更新日期：2011-11-17 00:00:00

abstract：:Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI). Transcriptional activation of genes that limit secondary damage to the CNS are mediated by a cis-acting element called the antioxidant responsive element ...

journal_title：Frontiers in molecular neuroscience

authors： Chen X,Wang H,Zhou M,Li X,Fang Z,Gao H,Li Y,Hu W

更新日期：2018-04-17 00:00:00

abstract：:SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during a critical developmental window. Heterozygous mutation in SYNGAP1 (SYNGAP1-/+) has been shown to cause Intellectual Disability (ID) in children. Recent studies have provided evidence for altered neuronal protein synthesis in a mouse...

journal_title：Frontiers in molecular neuroscience

authors： Paul A,Nawalpuri B,Shah D,Sateesh S,Muddashetty RS,Clement JP

更新日期：2019-05-09 00:00:00

abstract：:In the brain, de novo gene expression driven by learning-associated neuronal activities is critical for the formation of long-term memories. However, the signaling machinery mediating neuronal activity-induced gene expression, especially the rapid transcription of immediate-early genes (IEGs) remains unclear. Cyclin-d...

journal_title：Frontiers in molecular neuroscience

authors： He G,Yang X,Wang G,Qi J,Mao R,Wu Z,Zhou Z

更新日期：2017-11-07 00:00:00

abstract：:Numerous animal studies have demonstrated that commonly used general anesthetics may result in cognitive impairment in the immature brain. The prevailing theory is that general anesthetics could induce developmental neurotoxicity via enhanced apoptosis. In addition, inhibited proliferation induced by anesthetics has a...

journal_title：Frontiers in molecular neuroscience

authors： Li X,Wu Z,Zhang Y,Xu Y,Han G,Zhao P

更新日期：2017-12-22 00:00:00

abstract：:The polycomb group proteins (PcGs) are a group of epigenetic factors associated with gene silencing. They are found in several families of multiprotein complexes, including polycomb repressive complex 2 (PRC2). EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and...

journal_title：Frontiers in molecular neuroscience

authors： Wever I,Wagemans CMRJ,Smidt MP

更新日期：2019-04-09 00:00:00

abstract：:Ca2+ signaling plays a significant role in the development of the vertebrate nervous system where it regulates neurite growth as well as synapse and neurotransmitter specification. Elucidating the role of Ca2+ signaling in mammalian neuronal development has been largely restricted to either small animal models or prim...

journal_title：Frontiers in molecular neuroscience

authors： Gopurappilly R,Deb BK,Chakraborty P,Hasan G

更新日期：2018-06-11 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00099.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Yadav SC,Tetenborg S,Dedek K

更新日期：2019-06-12 00:00:00

abstract：:ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD+) triggers cell death. Since NAD+ is released as a danger signal during tissue damage, this NAD+-induced cell death (NICD) may impact th...

journal_title：Frontiers in molecular neuroscience

authors： Rissiek B,Stabernack J,Cordes M,Duan Y,Behr S,Menzel S,Magnus T,Koch-Nolte F

更新日期：2020-01-14 00:00:00

abstract：:In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interac...

journal_title：Frontiers in molecular neuroscience

authors： Secondo A,Bagetta G,Amantea D

更新日期：2018-03-22 00:00:00

abstract：:The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale. These disorders are heterogeneous, yet they share common behavioral symptomatology as well as o...

journal_title：Frontiers in molecular neuroscience

authors： Ali Rodriguez R,Joya C,Hines RM

更新日期：2018-04-24 00:00:00

abstract：:Membrane fusion is one of the most fundamental physiological processes in eukaryotes for triggering the fusion of lipid and content, as well as the neurotransmission. However, the architecture features of neurotransmitter release machinery and interdependent mechanism of synaptic membrane fusion have not been extensiv...

journal_title：Frontiers in molecular neuroscience

authors： Yang Z,Gou L,Chen S,Li N,Zhang S,Zhang L

更新日期：2017-06-07 00:00:00

abstract：:Aging cognitive decline has been associated to impairment of the Hypothalamus Pituitary Adrenals (HPA) axis activity and a higher level of the systemic inflammation. However, little is known about the molecules driving this process at peripheral level. In addition, the cognitive function is to some extent modifiable w...

journal_title：Frontiers in molecular neuroscience

authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Verrocchio MC,De Lutiis MA,Felaco M,Grilli A

更新日期：2017-07-24 00:00:00

abstract：:Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/- ). We demonstrated for the first time, that Ptch1+...

journal_title：Frontiers in molecular neuroscience

authors： Antonelli F,Casciati A,Tanori M,Tanno B,Linares-Vidal MV,Serra N,Bellés M,Pannicelli A,Saran A,Pazzaglia S

更新日期：2018-05-23 00:00:00

abstract：:Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the unde...

journal_title：Frontiers in molecular neuroscience

authors： Comhair J,Devoght J,Morelli G,Harvey RJ,Briz V,Borrie SC,Bagni C,Rigo JM,Schiffmann SN,Gall D,Brône B,Molchanova SM

更新日期：2018-10-15 00:00:00