Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus.

abstract：:MiRNAs are key regulators of the mammalian transcriptome that have been increasingly linked to degenerative diseases of the motor neurons. Although many of the miRNAs currently incriminated as participants in the pathogenesis of these diseases are also important to the normal development and function of motor neurons,...

journal_title：Frontiers in molecular neuroscience

authors： Hawley ZCE,Campos-Melo D,Droppelmann CA,Strong MJ

更新日期：2017-05-04 00:00:00

abstract：:Hoxa5 is a member of the Hox gene family that plays critical roles in successive steps of the central nervous system formation during embryonic and fetal development. In the mouse, Hoxa5 was recently shown to be expressed in the medulla oblongata and the pons from fetal stages to adulthood. In these territories, Hoxa5...

journal_title：Frontiers in molecular neuroscience

authors： Lizen B,Moens C,Mouheiche J,Sacré T,Ahn MT,Jeannotte L,Salti A,Gofflot F

更新日期：2017-11-15 00:00:00

abstract：:[This corrects the article on p. 257 in vol. 10, PMID: 28855859.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Sun Y,Chen X,Zhang X,Shen X,Wang M,Wang X,Liu WC,Liu CF,Liu J,Liu W,Jin X

更新日期：2017-11-20 00:00:00

abstract：:Brain metabolic DNA (BMD) is continuously synthesized by reverse transcription in presynaptic synaptosomes and astroglia, and is partly transferred to nuclei after acquiring the double stranded configuration. Synthesis and turnover of BMD are markedly dependent on brain activity, as shown by circadian oscillations, en...

journal_title：Frontiers in molecular neuroscience

authors： Giuditta A,Casalino J

更新日期：2020-04-28 00:00:00

abstract：:In the brain, de novo gene expression driven by learning-associated neuronal activities is critical for the formation of long-term memories. However, the signaling machinery mediating neuronal activity-induced gene expression, especially the rapid transcription of immediate-early genes (IEGs) remains unclear. Cyclin-d...

journal_title：Frontiers in molecular neuroscience

authors： He G,Yang X,Wang G,Qi J,Mao R,Wu Z,Zhou Z

更新日期：2017-11-07 00:00:00

abstract：:The basic helix-loop-helix (bHLH) protein family has previously been shown to be involved in the development of mesodiencephalic dopaminergic (mdDA) neurons in the murine midbrain. Specifically, Ngn2 and Mash1 are known to have a role in the specification of neural progenitors in the ventricular zone (VZ) of the midbr...

journal_title：Frontiers in molecular neuroscience

authors： Mesman S,Smidt MP

更新日期：2017-11-01 00:00:00

abstract：:Blast induced neurotrauma (BINT) is a prevalent injury within military and civilian populations. The injury is characterized by persistent inflammation at the cellular level which manifests as a multitude of cognitive and functional impairments. Epigenetic regulation of transcription offers an important control mechan...

journal_title：Frontiers in molecular neuroscience

authors： Bailey ZS,Grinter MB,VandeVord PJ

更新日期：2016-08-08 00:00:00

abstract：:Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory function is unclear due to conflicts in published results. To addres...

journal_title：Frontiers in molecular neuroscience

authors： Zorzi V,Paciello F,Ziraldo G,Peres C,Mazzarda F,Nardin C,Pasquini M,Chiani F,Raspa M,Scavizzi F,Carrer A,Crispino G,Ciubotaru CD,Monyer H,Fetoni AR,M Salvatore A,Mammano F

更新日期：2017-11-28 00:00:00

abstract：:Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/- ). We demonstrated for the first time, that Ptch1+...

journal_title：Frontiers in molecular neuroscience

authors： Antonelli F,Casciati A,Tanori M,Tanno B,Linares-Vidal MV,Serra N,Bellés M,Pannicelli A,Saran A,Pazzaglia S

更新日期：2018-05-23 00:00:00

abstract：:Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disorder caused by loss-of-function mutations in the cystatin B (CSTB) gene. Progression of the clinical symptoms in EPM1 patients, including stimulus-sensitive myoclonus, tonic-clonic seizures, and ataxia, are well described. How...

journal_title：Frontiers in molecular neuroscience

authors： Gorski K,Spoljaric A,Nyman TA,Kaila K,Battersby BJ,Lehesjoki AE

更新日期：2020-11-13 00:00:00

abstract：:Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease ...

journal_title：Frontiers in molecular neuroscience

authors： Peterson AR,Binder DK

更新日期：2019-07-09 00:00:00

abstract：:Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology of neurological dis...

journal_title：Frontiers in molecular neuroscience

authors： Kakraba S,Ayyadevara S,Penthala NR,Balasubramaniam M,Ganne A,Liu L,Alla R,Bommagani SB,Barger SW,Griffin WST,Crooks PA,Shmookler Reis RJ

更新日期：2019-12-12 00:00:00

abstract：:Epilepsy, one of the most prevalent neurological conditions, presents as a complex disorder of network homeostasis characterized by spontaneous non-provoked seizures and associated comorbidities. Currently used antiepileptic drugs have been designed to suppress neuronal hyperexcitability and thereby to suppress epilep...

journal_title：Frontiers in molecular neuroscience

authors： Boison D

更新日期：2016-04-13 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of GluN1/GluN2 subunits. Previous studies showed that GluN1/GluN2 receptors...

journal_title：Frontiers in molecular neuroscience

authors： Skrenkova K,Lee S,Lichnerova K,Kaniakova M,Hansikova H,Zapotocky M,Suh YH,Horak M

更新日期：2018-06-04 00:00:00

abstract：:Drosophila CRYPTOCHROME (CRY) is a blue light sensitive protein with a key role in circadian photoreception. A main feature of CRY is that light promotes an interaction with the circadian protein TIMELESS (TIM) resulting in their ubiquitination and degradation, a mechanism that contributes to the synchronization of th...

journal_title：Frontiers in molecular neuroscience

authors： Damulewicz M,Mazzotta GM,Sartori E,Rosato E,Costa R,Pyza EM

更新日期：2017-05-30 00:00:00

abstract：:The importance of catecholamines in post-traumatic stress disorder (PTSD) still needs to be explored. We aimed to evaluate epinephrine's (EPI) causal role and molecular mechanism for the persistence of PTSD traumatic memories. Wild-type (WT) and EPI-deficient mice (phenylethanolamine-N-methyltransferase-knockout mice,...

journal_title：Frontiers in molecular neuroscience

authors： Martinho R,Oliveira A,Correia G,Marques M,Seixas R,Serrão P,Moreira-Rodrigues M

更新日期：2020-10-26 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are two major forms of synaptic plasticity that are widely accepted as cellular mechanisms involved in learning and memory. Metaplasticity is a process whereby modifications in synaptic processes shift the threshold for subsequent plasticity. While metaplasti...

journal_title：Frontiers in molecular neuroscience

authors： Zhong L,Gerges NZ

更新日期：2020-01-24 00:00:00

abstract：:The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation. Previous studies indicate that secretases form binary complex and the interactions ...

journal_title：Frontiers in molecular neuroscience

authors： Wang X,Pei G

更新日期：2018-11-27 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and malignant primary tumor. Angiogenesis plays a critical role in the progression of GBM. Previous studies have indicated that long non-coding RNAs (lncRNAs) are abnormally expressed in various cancers and participate in the regulation of the malignant behaviors of tumors. Th...

journal_title：Frontiers in molecular neuroscience

authors： Yang C,Zheng J,Xue Y,Yu H,Liu X,Ma J,Liu L,Wang P,Li Z,Cai H,Liu Y

更新日期：2018-01-09 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00099.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Yadav SC,Tetenborg S,Dedek K

更新日期：2019-06-12 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain. It has been found that a synergistic relationship between these two proteins may contribute to their roles in disease progression. However, how Aβ...

journal_title：Frontiers in molecular neuroscience

authors： Shin WS,Di J,Murray KA,Sun C,Li B,Bitan G,Jiang L

更新日期：2019-11-08 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00177.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Belin S,Herron J,VerPlank JJS,Park Y,Feltri LM,Poitelon Y

更新日期：2019-10-18 00:00:00

abstract：:The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer's disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain. AQP4 polarity can be influenced by the ratio of two AQP4 isoforms M1 and M23 (AQP4-M1/M23), however, it is unknown whether the ra...

journal_title：Frontiers in molecular neuroscience

authors： Zhang J,Zhan Z,Li X,Xing A,Jiang C,Chen Y,Shi W,An L

更新日期：2017-11-29 00:00:00

abstract：:Transcription factors regulate multiple processes during brain development and in the adult brain, from brain patterning to differentiation and maturation of highly specialized neurons as well as establishing and maintaining the functional neuronal connectivity. The members of the zinc-finger transcription factor fami...

journal_title：Frontiers in molecular neuroscience

authors： Simon R,Wiegreffe C,Britsch S

更新日期：2020-04-08 00:00:00

abstract：:Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS. Under the influence of the local environment and cell-cell interaction, microglia exhibit a multidimensional and context-dependent phenotypes that can be cytotoxic and neuroprot...

journal_title：Frontiers in molecular neuroscience

authors： Siew JJ,Chern Y

更新日期：2018-05-14 00:00:00

abstract：:Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. It is caused by the overexpansion of cytosine-guanine-guanine (CGG) trinucleotide in Fmr1 gene, resulting in complete loss of the fragile X mental retardation protein (FMRP). Previous studies using Fmr1 knockout (Fmr1 KO) mice have ...

journal_title：Frontiers in molecular neuroscience

authors： Yau SY,Bettio L,Chiu J,Chiu C,Christie BR

更新日期：2019-01-17 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:Alzheimer's disease (AD) is the most common type of senile dementia, characterized by neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were devoted to the interference with the production and accumulation of amyloid-β peptide (Aβ), which plays a causal role in the pathogenesis of ...

journal_title：Frontiers in molecular neuroscience

authors： Zhao J,Liu X,Xia W,Zhang Y,Wang C

更新日期：2020-08-04 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive primary intracranial tumor of adults and confers a poor prognosis due to high vascularization. Hence anti-angiogenic therapy has become a promising strategy for GBM treatment. In this study, the transcription factor nuclear factor of activated T-cells 5 (NFAT5) was significant...

journal_title：Frontiers in molecular neuroscience

authors： Yu H,Zheng J,Liu X,Xue Y,Shen S,Zhao L,Li Z,Liu Y

更新日期：2017-09-21 00:00:00

abstract：:MicroRNAs (miRNAs) are key post transcriptional regulators of their multiple target genes. However, the detailed profile of miRNA expression in Parkinson's disease, the second most common neurodegenerative disease worldwide and the first motor disorder has not been charted yet. Here, we report comprehensive miRNA prof...

journal_title：Frontiers in molecular neuroscience

authors： Soreq L,Salomonis N,Bronstein M,Greenberg DS,Israel Z,Bergman H,Soreq H

更新日期：2013-05-13 00:00:00