Abstract:
:MiRNAs are key regulators of the mammalian transcriptome that have been increasingly linked to degenerative diseases of the motor neurons. Although many of the miRNAs currently incriminated as participants in the pathogenesis of these diseases are also important to the normal development and function of motor neurons, at present there is no knowledge of the complete miRNA profile of motor neurons. In this review, we examine the current understanding with respect to miRNAs that are specifically required for motor neuron development, function and viability, and provide evidence that these should be considered as a functional network of miRNAs which we have collectively termed MotomiRs. We will also summarize those MotomiRs currently known to be associated with both amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), and discuss their potential use as biomarkers.
journal_name
Front Mol Neuroscijournal_title
Frontiers in molecular neuroscienceauthors
Hawley ZCE,Campos-Melo D,Droppelmann CA,Strong MJdoi
10.3389/fnmol.2017.00127subject
Has Abstractpub_date
2017-05-04 00:00:00pages
127issn
1662-5099journal_volume
10pub_type
杂志文章,评审abstract::A fundamental characteristic of neurons is the relationship between the architecture of the polarized neuron and synaptic transmission between neurons. Intracellular membrane trafficking is paramount to establish and maintain neuronal structure; perturbation in trafficking results in defects in neurodevelopment and ne...
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journal_title:Frontiers in molecular neuroscience
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journal_title:Frontiers in molecular neuroscience
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journal_title:Frontiers in molecular neuroscience
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journal_title:Frontiers in molecular neuroscience
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journal_title:Frontiers in molecular neuroscience
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