Transcription Factor NFAT5 Promotes Glioblastoma Cell-driven Angiogenesis via SBF2-AS1/miR-338-3p-Mediated EGFL7 Expression Change.

abstract：:Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are ...

journal_title：Frontiers in molecular neuroscience

authors： Fisher NM,Seto M,Lindsley CW,Niswender CM

更新日期：2018-10-23 00:00:00

abstract：:The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and skeletal muscle fibers. NMJs allow all voluntary movements, and ensure vital functions like breathing. Changes in the structure and function of NMJs are hallmarks of numerous pathological conditions that affect muscle function includ...

journal_title：Frontiers in molecular neuroscience

authors： Castets P,Ham DJ,Rüegg MA

更新日期：2020-08-28 00:00:00

abstract：:Among all organs of an adult animal, the central nervous system stands out because of its vast complexity and morphological diversity. During early development, the entire central nervous system develops from an apparently homogenous group of progenitors that differentiate into all neural cell types. Therefore, unders...

journal_title：Frontiers in molecular neuroscience

authors： Contreras EG,Sierralta J,Oliva C

更新日期：2019-05-31 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors that act as transcription factors in response to endogenous lipid messengers. The fibrates and thiazolidinediones are synthetic PPAR agonists used clinically to treat dyslipidemia and Type 2 Diabetes Mellitus, respectively, but also impr...

journal_title：Frontiers in molecular neuroscience

authors： Ferguson LB,Zhang L,Wang S,Bridges C,Harris RA,Ponomarev I

更新日期：2018-09-19 00:00:00

abstract：:Ion channels are expressed throughout nervous system development. The type and diversity of conductances and gating mechanisms vary at different developmental stages and with the progressive maturational status of neural cells. The variety of ion channels allows for distinct signaling mechanisms in developing neural c...

journal_title：Frontiers in molecular neuroscience

authors： Goyal R,Spencer KA,Borodinsky LN

更新日期：2020-04-24 00:00:00

abstract：:Alzheimer's disease (AD) is a widely distributed neurodegenerative disease characterized clinically by cognitive deficits and pathologically by formation of amyloid-β (Aβ) plaque and neurofibrillary tangles (NFTs) in the brain. Vanadium is a biological trace element that has a function to mimic insulin for diabetes. B...

journal_title：Frontiers in molecular neuroscience

authors： He Z,Han S,Zhu H,Hu X,Li X,Hou C,Wu C,Xie Q,Li N,Du X,Ni J,Liu Q

更新日期：2020-03-10 00:00:00

abstract：:Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including hearing loss and vestibular dysfunction. Hearing is affected by both en...

journal_title：Frontiers in molecular neuroscience

authors： Mittal R,Nguyen D,Patel AP,Debs LH,Mittal J,Yan D,Eshraghi AA,Van De Water TR,Liu XZ

更新日期：2017-07-31 00:00:00

abstract：:Neuroimaging studies have demonstrated that irritable bowel syndrome (IBS)-a relapsing functional bowel disorder-presents with disrupted brain connections. However, little is known about the alterations of interhemispheric functional connectivity and underlying structural connectivity in IBS. This study combined resti...

journal_title：Frontiers in molecular neuroscience

authors： Qi R,Liu C,Weng Y,Xu Q,Chen L,Wang F,Zhang LJ,Lu GM

更新日期：2016-12-06 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of gliomas are not fully understood. With the development of deep sequencing analyses, an extensive...

journal_title：Frontiers in molecular neuroscience

authors： Yan Y,Xu Z,Li Z,Sun L,Gong Z

更新日期：2017-02-28 00:00:00

abstract：:Mitochondria are key organelles in regulating the metabolic state of a cell. In the brain, mitochondrial oxidative metabolism is the prevailing mechanism for neurons to generate ATP. While it is firmly established that neuronal function is highly dependent on mitochondrial metabolism, it is less well-understood how as...

journal_title：Frontiers in molecular neuroscience

authors： Fiebig C,Keiner S,Ebert B,Schäffner I,Jagasia R,Lie DC,Beckervordersandforth R

更新日期：2019-02-22 00:00:00

abstract：:Being the most common cause of dementia, AD is a polygenic and neurodegenerative disease. Complex and multiple factors have been shown to be involved in its pathogenesis, of which the genetics play an indispensable role. It is widely accepted that discovery of potential genes related to the pathogenesis of AD would be...

journal_title：Frontiers in molecular neuroscience

authors： Sun Q,Xie N,Tang B,Li R,Shen Y

更新日期：2017-10-06 00:00:00

abstract：:The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical foldi...

journal_title：Frontiers in molecular neuroscience

authors： Venø MT,Venø ST,Rehberg K,van Asperen JV,Clausen BH,Holm IE,Pasterkamp RJ,Finsen B,Kjems J

更新日期：2017-02-09 00:00:00

abstract：:Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA) are chronic, progressive, and age-associated neurological disorders characterized by neuronal deterioration in specific brain regions. Although the specific path...

journal_title：Frontiers in molecular neuroscience

authors： Chang X,Wang J,Jiang H,Shi L,Xie J

更新日期：2019-06-05 00:00:00

abstract：:Glycine receptors (GlyRs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. Mutations in GLRA2 are associated with autism spectrum disorder, but the unde...

journal_title：Frontiers in molecular neuroscience

authors： Comhair J,Devoght J,Morelli G,Harvey RJ,Briz V,Borrie SC,Bagni C,Rigo JM,Schiffmann SN,Gall D,Brône B,Molchanova SM

更新日期：2018-10-15 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of GluN1/GluN2 subunits. Previous studies showed that GluN1/GluN2 receptors...

journal_title：Frontiers in molecular neuroscience

authors： Skrenkova K,Lee S,Lichnerova K,Kaniakova M,Hansikova H,Zapotocky M,Suh YH,Horak M

更新日期：2018-06-04 00:00:00

abstract：:Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in ...

journal_title：Frontiers in molecular neuroscience

authors： Schlichting M,Rieger D,Cusumano P,Grebler R,Costa R,Mazzotta GM,Helfrich-Förster C

更新日期：2018-07-18 00:00:00

abstract：:Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of eukaryotic initiation factor-2α (eIF2α). Evidence is accumulating that persistent eIF2α phosphorylation at Ser51 through prolonged overactivation of regulatory kinases occurs in neurodegenerative diseases such as Alzhe...

journal_title：Frontiers in molecular neuroscience

authors： Ohno M

更新日期：2014-04-16 00:00:00

abstract：:Rod and cone phosphodiesterase 6 (PDE6) are key effector enzymes of the vertebrate phototransduction pathway. Rod PDE6 consists of two catalytic subunits PDE6α and PDE6β and two identical inhibitory PDE6γ subunits, while cone PDE6 is composed of two identical PDE6α' catalytic subunits and two identical cone-specific P...

journal_title：Frontiers in molecular neuroscience

authors： Deng WT,Kolandaivelu S,Dinculescu A,Li J,Zhu P,Chiodo VA,Ramamurthy V,Hauswirth WW

更新日期：2018-07-09 00:00:00

abstract：:Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment, and severely affects the quality of life of cancer survivors. Clinically, chemotherapy-induced peripheral neuropathy presents as deficits i...

journal_title：Frontiers in molecular neuroscience

authors： Starobova H,Vetter I

更新日期：2017-05-31 00:00:00

abstract：:Mecp2 is a DNA methylation reader that plays a critical role in experience-dependent plasticity. Increasing evidence supports a role for epigenetic modifications in activity-induced gene expression. Hence, candidate genes related to such phenomena are of great interest. Ryanodine receptors are intracellular calcium ch...

journal_title：Frontiers in molecular neuroscience

authors： Torres RF,Hidalgo C,Kerr B

更新日期：2017-06-13 00:00:00

abstract：:[This corrects the article on p. 116 in vol. 9, PMID: 27867348.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Jackson KL,Dayton RD,Deverman BE,Klein RL

更新日期：2016-12-22 00:00:00

abstract：:In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interac...

journal_title：Frontiers in molecular neuroscience

authors： Secondo A,Bagetta G,Amantea D

更新日期：2018-03-22 00:00:00

abstract：:GABAergic inhibitory neurotransmission contributes to diverse aspects of brain development and adult plasticity, including the expression of complex cognitive processes. This is afforded for in part by the dynamic adaptations occurring at inhibitory synapses, which show great heterogeneity both in terms of upstream si...

journal_title：Frontiers in molecular neuroscience

authors： Campbell BFN,Tyagarajan SK

更新日期：2019-08-13 00:00:00

abstract：:The polycomb group proteins (PcGs) are a group of epigenetic factors associated with gene silencing. They are found in several families of multiprotein complexes, including polycomb repressive complex 2 (PRC2). EZH2, EED and SUZ12 form the core components of the PRC2 complex, which is responsible for the mono, di- and...

journal_title：Frontiers in molecular neuroscience

authors： Wever I,Wagemans CMRJ,Smidt MP

更新日期：2019-04-09 00:00:00

abstract：:Epilepsy, one of the most prevalent neurological conditions, presents as a complex disorder of network homeostasis characterized by spontaneous non-provoked seizures and associated comorbidities. Currently used antiepileptic drugs have been designed to suppress neuronal hyperexcitability and thereby to suppress epilep...

journal_title：Frontiers in molecular neuroscience

authors： Boison D

更新日期：2016-04-13 00:00:00

abstract：:The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolate...

journal_title：Frontiers in molecular neuroscience

authors： Phamluong K,Darcq E,Wu S,Sakhai SA,Ron D

更新日期：2017-08-31 00:00:00

abstract：:Aquatic vertebrates possess diverse types of sensory cells in their skin to detect stimuli in the water. In the adult zebrafish, a common model organism, the presence of such cells in fins has only rarely been studied. Here, we identified scattered serotonin (5-HT)-positive cells in the epidermis of the caudal fin. Th...

journal_title：Frontiers in molecular neuroscience

authors： König D,Dagenais P,Senk A,Djonov V,Aegerter CM,Jaźwińska A

更新日期：2019-09-19 00:00:00

abstract：:Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an a...

journal_title：Frontiers in molecular neuroscience

authors： Falcón-Moya R,Sihra TS,Rodríguez-Moreno A

更新日期：2018-06-22 00:00:00

abstract：:Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, a...

journal_title：Frontiers in molecular neuroscience

authors： Del Turco D,Paul MH,Beeg Moreno VJ,Hildebrandt-Einfeldt L,Deller T

更新日期：2019-11-12 00:00:00